YDR144C / MKC7

GPI-anchored aspartyl protease, member of the yapsin family of proteases involved in cell wall growth and maintenance; shares functions with Yap3p and Kex2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR144C / MKC7

Click on Significant Values for Screen Details ID:SGTC_15|Compound:0266-0086|FD-Score:3.29|P-value:2.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.32|P-value:1.62E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.20|P-value:1.76E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.61|P-value:5.23E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.92|P-value:1.23E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.14|P-value:2.28E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.03|P-value:5.77E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:12.20|P-value:1.57E-40 ID:SGTC_320|Compound:4092-0846|FD-Score:5.52|P-value:1.17E-9 ID:SGTC_422|Compound:cantharidin|FD-Score:3.02|P-value:6.03E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.43|P-value:1.16E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.03|P-value:5.86E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.84|P-value:8.36E-8 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.21|P-value:1.42E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.66|P-value:2.23E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:4.61|P-value:3.24E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.86|P-value:1.63E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.46|P-value:5.70E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.19|P-value:3.07E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.88|P-value:1.51E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:2.94|P-value:8.34E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.48|P-value:9.40E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.53|P-value:7.55E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.24|P-value:2.55E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.77|P-value:2.55E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.62|P-value:4.98E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.01|P-value:6.25E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:2.97|P-value:7.50E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.81|P-value:1.00E-7 ID:SGTC_1736|Compound:st036774|FD-Score:3.84|P-value:1.81E-5 ID:SGTC_1744|Compound:st037937|FD-Score:-2.77|P-value:9.66E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.13|P-value:4.38E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-3.66|P-value:2.27E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.84|P-value:1.77E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.08|P-value:4.89E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.19|P-value:3.15E-4 ID:SGTC_1854|Compound:st056233|FD-Score:5.27|P-value:5.97E-9 ID:SGTC_1942|Compound:st076330|FD-Score:3.02|P-value:6.19E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.16|P-value:3.47E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.16|P-value:2.07E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.20|P-value:3.03E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.06|P-value:3.06E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.04|P-value:6.75E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-3.40|P-value:7.26E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.26|P-value:2.34E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.70|P-value:1.89E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-3.15|P-value:2.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.42|P-value:1.21E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.12|P-value:4.14E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.04|P-value:3.40E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.59|P-value:3.64E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.18|P-value:1.09E-11 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:2.95|P-value:7.91E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.62|P-value:2.70E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.08|P-value:2.05E-8 ID:SGTC_2591|Compound:skatole|FD-Score:-2.79|P-value:8.94E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.33|P-value:9.85E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.31|P-value:1.92E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.28|P-value:2.98E-24 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.92|P-value:9.01E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.60|P-value:3.49E-7 ID:SGTC_2960|Compound:9079389|FD-Score:3.01|P-value:6.28E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.48|P-value:9.27E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.37|P-value:1.48E-4 ID:SGTC_15|Compound:0266-0086|FD-Score:3.29|P-value:2.06E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:4.32|P-value:1.62E-6 ID:SGTC_132|Compound:0417-1715|FD-Score:-3.20|P-value:1.76E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.61|P-value:5.23E-5 ID:SGTC_262|Compound:fenpropimorph|FD-Score:3.92|P-value:1.23E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:-3.14|P-value:2.28E-4 ID:SGTC_269|Compound:exalamide|FD-Score:3.03|P-value:5.77E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:12.20|P-value:1.57E-40 ID:SGTC_320|Compound:4092-0846|FD-Score:5.52|P-value:1.17E-9 ID:SGTC_422|Compound:cantharidin|FD-Score:3.02|P-value:6.03E-4 ID:SGTC_459|Compound:nigericin|FD-Score:3.43|P-value:1.16E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.03|P-value:5.86E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.84|P-value:8.36E-8 ID:SGTC_531|Compound:3788-1495|FD-Score:-4.21|P-value:1.42E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-3.66|P-value:2.23E-5 ID:SGTC_722|Compound:3534-0461|FD-Score:4.61|P-value:3.24E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.86|P-value:1.63E-5 ID:SGTC_752|Compound:1896-0090|FD-Score:-3.46|P-value:5.70E-5 ID:SGTC_923|Compound:1900-2434|FD-Score:3.19|P-value:3.07E-4 ID:SGTC_940|Compound:3232-1287|FD-Score:3.88|P-value:1.51E-5 ID:SGTC_946|Compound:3434-1334|FD-Score:2.94|P-value:8.34E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.48|P-value:9.40E-5 ID:SGTC_1128|Compound:3448-9350|FD-Score:3.53|P-value:7.55E-5 ID:SGTC_1180|Compound:1193-0155|FD-Score:3.24|P-value:2.55E-4 ID:SGTC_1226|Compound:3909-7979|FD-Score:3.77|P-value:2.55E-5 ID:SGTC_1236|Compound:0330-0013|FD-Score:3.62|P-value:4.98E-5 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.01|P-value:6.25E-4 ID:SGTC_1398|Compound:3558-0053|FD-Score:2.97|P-value:7.50E-4 ID:SGTC_1448|Compound:4255-0083|FD-Score:4.81|P-value:1.00E-7 ID:SGTC_1736|Compound:st036774|FD-Score:3.84|P-value:1.81E-5 ID:SGTC_1744|Compound:st037937|FD-Score:-2.77|P-value:9.66E-4 ID:SGTC_1776|Compound:st049249|FD-Score:4.13|P-value:4.38E-6 ID:SGTC_1786|Compound:berberine|FD-Score:-3.66|P-value:2.27E-5 ID:SGTC_1789|Compound:tunicamycin|FD-Score:3.84|P-value:1.77E-5 ID:SGTC_1845|Compound:st056753|FD-Score:3.08|P-value:4.89E-4 ID:SGTC_1851|Compound:st056236|FD-Score:3.19|P-value:3.15E-4 ID:SGTC_1854|Compound:st056233|FD-Score:5.27|P-value:5.97E-9 ID:SGTC_1942|Compound:st076330|FD-Score:3.02|P-value:6.19E-4 ID:SGTC_1950|Compound:st077106|FD-Score:3.16|P-value:3.47E-4 ID:SGTC_2012|Compound:4023501|FD-Score:-3.16|P-value:2.07E-4 ID:SGTC_2065|Compound:5221596|FD-Score:3.20|P-value:3.03E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:-3.06|P-value:3.06E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.04|P-value:6.75E-6 ID:SGTC_2282|Compound:7944268|FD-Score:-3.40|P-value:7.26E-5 ID:SGTC_2289|Compound:7946404|FD-Score:3.26|P-value:2.34E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.70|P-value:1.89E-5 ID:SGTC_2343|Compound:7990716|FD-Score:-3.15|P-value:2.13E-4 ID:SGTC_2426|Compound:5582046|FD-Score:3.42|P-value:1.21E-4 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:3.12|P-value:4.14E-4 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.04|P-value:3.40E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:4.59|P-value:3.64E-7 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:6.18|P-value:1.09E-11 ID:SGTC_2565|Compound:isoliquiritigenin|FD-Score:2.95|P-value:7.91E-4 ID:SGTC_2575|Compound:plumbagin|FD-Score:-3.62|P-value:2.70E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.08|P-value:2.05E-8 ID:SGTC_2591|Compound:skatole|FD-Score:-2.79|P-value:8.94E-4 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:-3.33|P-value:9.85E-5 ID:SGTC_2631|Compound:bromo-3-hydroxy-4-(succin-2-yl)-caryolane gamma-lactone|FD-Score:3.31|P-value:1.92E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:9.28|P-value:2.98E-24 ID:SGTC_2752|Compound:diclazuril|FD-Score:2.92|P-value:9.01E-4 ID:SGTC_2958|Compound:9077254|FD-Score:4.60|P-value:3.49E-7 ID:SGTC_2960|Compound:9079389|FD-Score:3.01|P-value:6.28E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.48|P-value:9.27E-5 ID:SGTC_3289|Compound:9119912|FD-Score:3.37|P-value:1.48E-4

Top fitness defect scores for YDR144C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_312 4092-0653 12.20 6.8 µM 1.57E-40 ergosterol depletion effects on membrane 7 1.75E-34
2 SGTC_2688 kanamycin b 9.28 96.7 µM 2.98E-24 calcium & mitochondrial duress 38 8.27E-21
3 SGTC_2539 epi(13)torulosol 6.18 80.0 µM 1.09E-11 4 3.23E-10
4 SGTC_320 4092-0846 5.52 5.3 µM 1.17E-9 ergosterol depletion effects on membrane 20 1.70E-8
5 SGTC_1854 st056233 5.27 32.9 µM 5.97E-9 amide catabolism 7 6.75E-8
6 SGTC_2582 agaric acid 5.08 100.0 µM 2.05E-8 redox potentiating 218 1.92E-7
7 SGTC_528 3492-0019 4.84 172.0 µM 8.36E-8 calcium & mitochondrial duress 161 6.35E-7
8 SGTC_1448 4255-0083 4.81 152.0 µM 1.00E-7 ERG2 6 7.39E-7
9 SGTC_722 3534-0461 4.61 190.0 µM 3.24E-7 PDR1 22 2.01E-6
10 SGTC_2958 9077254 4.60 16.7 µM 3.49E-7 12 2.14E-6
11 SGTC_2532 xanthone 4.59 78.9 µM 3.64E-7 17 2.22E-6
12 SGTC_58 0957-0393 4.32 9.0 µM 1.62E-6 cell wall 343 7.93E-6
13 SGTC_1776 st049249 4.13 45.9 µM 4.38E-6 14 1.85E-5
14 SGTC_2249 haloperidol 4.04 116.4 µM 6.75E-6 ergosterol depletion effects on membrane 105 2.67E-5
15 SGTC_262 fenpropimorph 3.92 62.5 µM 1.23E-5 ergosterol depletion effects on membrane 26 4.47E-5
16 SGTC_940 3232-1287 3.88 54.8 µM 1.51E-5 NEO1 42 5.31E-5
17 SGTC_738 1315-0003 3.86 72.4 µM 1.63E-5 24 5.68E-5
18 SGTC_1789 tunicamycin 3.84 25.0 nM 1.77E-5 unfolded protein response 55 6.08E-5
19 SGTC_1736 st036774 3.84 51.0 µM 1.81E-5 37 6.20E-5
20 SGTC_1226 3909-7979 3.77 35.4 µM 2.55E-5 47 8.32E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.244 9.43E-47 YDR407C TRS120 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in endoplasmic reticulum (ER) to Golgi membrane traffic
0.211 4.13E-35 YDR335W MSN5 hom Karyopherin involved in nuclear import and export of proteins, including import of replication protein A and export of Swi6p, Far1p, and Pho4p; required for re-export of mature tRNAs after their retrograde import from the cytoplasm
0.205 3.88E-33 YIL068C SEC6 het Essential 88kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; anchors the assembled complex to sites of secretion; interacts with SM-like protein and SNARE regulator Sec1p and may recruit it to sites of secretion; interacts with Sec9p and inhibits formation of the t-SNARE complex between Sec9p and Sso1p
0.204 5.89E-33 YLR169W_d YLR169W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.203 1.87E-32 YKL051W SFK1 hom Plasma membrane protein that may act together with or upstream of Stt4p to generate normal levels of the essential phospholipid PI4P, at least partially mediates proper localization of Stt4p to the plasma membrane
0.198 6.89E-31 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.197 1.34E-30 YER180C-A SLO1 hom Protein interacting with Arl3p, which is a GTPase of the Ras superfamily involved in vesicle-tethering at the Golgi; putative ortholog of human SCOCO
0.195 3.19E-30 YLR443W ECM7 hom Non-essential putative integral membrane protein with a role in calcium uptake; mutant has cell wall defects and Ca+ uptake deficiencies; transcription is induced under conditions of zinc deficiency
0.195 3.82E-30 YBR102C EXO84 het Exocyst subunit with dual roles in exocytosis and spliceosome assembly; subunit of the the exocyst complex which mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane (PM) prior to SNARE-mediated fusion; required for exocyst assembly and targeting the complex to specific sites on the bud tip PM; associates the U1 snRNP; role in pre-mRNA splicing and prespliceosome formation; possible Cdc28 substrate
0.189 1.96E-28 YPR055W SEC8 het Essential 121 kDa subunit of the exocyst complex; the exocyst mediates polarized targeting and tethering of post-Golgi secretory vesicles to active sites of exocytosis at the plasma membrane prior to SNARE-mediated fusion; involved in ER and Golgi inheritance in small buds; relocalizes away from bud neck upon DNA replication stress
0.183 9.01E-27 YIL107C PFK26 hom 6-phosphofructo-2-kinase, inhibited by phosphoenolpyruvate and sn-glycerol 3-phosphate; has negligible fructose-2,6-bisphosphatase activity; transcriptional regulation involves protein kinase A
0.181 3.53E-26 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.179 1.37E-25 YMR218C TRS130 het One of 10 subunits of the transport protein particle (TRAPP) complex of the cis-Golgi which mediates vesicle docking and fusion; involved in ER to Golgi membrane traffic; mutation activates transcription of OCH1; mutants are defective in cytoplasm-to-vacuole targeting (Cvt) pathway and starvation-induced autophagy
0.178 2.06E-25 YFL005W SEC4 het Rab family GTPase essential for vesicle-mediated exocytic secretion and autophagy; associates with the exocyst component Sec15p and may regulate polarized delivery of transport vesicles to the exocyst at the plasma membrane
0.168 1.12E-22 YNL293W MSB3 hom Rab GTPase-activating protein; regulates endocytosis via activation of Vps21p and Ypt7p; also acts on Ypt52p and Sec4p; also required for proper actin organization; localizes to the plasma membrane and sites of polarized growth, and a portion localizes to endosomes and vacuoles; similar to Msb4p; relocalizes from bud neck to cytoplasm upon DNA replication stress