YDR145W / TAF12

Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR145W / TAF12

Click on Significant Values for Screen Details ID:SGTC_64|Compound:000l-0018|FD-Score:-4.40|P-value:3.43E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-4.25|P-value:5.21E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.53|P-value:2.40E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.29|P-value:4.66E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.38|P-value:2.02E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.24|P-value:5.35E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.56|P-value:2.94E-11 ID:SGTC_184|Compound:1494-0393|FD-Score:6.94|P-value:5.54E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:10.50|P-value:3.46E-16 ID:SGTC_230|Compound:MPP+|FD-Score:4.22|P-value:6.48E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.92|P-value:8.78E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:4.75|P-value:1.46E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:7.83|P-value:1.05E-9 ID:SGTC_320|Compound:4092-0846|FD-Score:5.61|P-value:9.28E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.20|P-value:3.04E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-4.33|P-value:4.16E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.08|P-value:1.73E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.70|P-value:1.65E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.33|P-value:4.13E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-4.83|P-value:9.85E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-4.88|P-value:8.43E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:7.57|P-value:3.52E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:4.45|P-value:3.43E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.30|P-value:4.46E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:6.75|P-value:1.26E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:6.81|P-value:9.62E-8 ID:SGTC_609|Compound:0986-0026|FD-Score:6.51|P-value:3.30E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:-4.81|P-value:1.04E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.48|P-value:2.74E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:10.00|P-value:8.43E-15 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.68|P-value:1.52E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:6.42|P-value:4.61E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:4.59|P-value:2.32E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.99|P-value:6.91E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:8.04|P-value:3.92E-10 ID:SGTC_863|Compound:0466-0191|FD-Score:5.08|P-value:5.32E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:4.45|P-value:3.44E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.82|P-value:9.46E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:5.27|P-value:2.88E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:5.57|P-value:1.06E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:7.12|P-value:2.59E-8 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.29|P-value:5.39E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.67|P-value:2.24E-9 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.89|P-value:9.45E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.48|P-value:3.17E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.58|P-value:1.01E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.13|P-value:8.23E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.76|P-value:1.41E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.80|P-value:1.08E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.40|P-value:3.90E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.80|P-value:1.06E-4 ID:SGTC_1547|Compound:harmine|FD-Score:5.52|P-value:1.25E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.72|P-value:1.60E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.84|P-value:1.10E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.51|P-value:3.29E-7 ID:SGTC_1638|Compound:st008370|FD-Score:5.79|P-value:4.82E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.04|P-value:9.01E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.98|P-value:2.42E-6 ID:SGTC_1707|Compound:st032323|FD-Score:5.72|P-value:6.14E-6 ID:SGTC_1729|Compound:st035615|FD-Score:5.60|P-value:9.50E-6 ID:SGTC_1734|Compound:st037168|FD-Score:5.20|P-value:3.58E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:5.27|P-value:2.89E-5 ID:SGTC_1897|Compound:st060201|FD-Score:5.14|P-value:4.28E-5 ID:SGTC_1915|Compound:st067105|FD-Score:5.35|P-value:2.21E-5 ID:SGTC_1950|Compound:st077106|FD-Score:4.66|P-value:1.90E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-5.06|P-value:4.83E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.80|P-value:1.26E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.45|P-value:3.41E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.58|P-value:2.34E-4 ID:SGTC_2110|Compound:5483698|FD-Score:4.75|P-value:1.46E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.13|P-value:8.12E-4 ID:SGTC_2248|Compound:tofa|FD-Score:10.30|P-value:2.05E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:11.20|P-value:5.96E-18 ID:SGTC_2291|Compound:7917025|FD-Score:-5.02|P-value:5.34E-5 ID:SGTC_2348|Compound:9022543|FD-Score:6.55|P-value:2.75E-7 ID:SGTC_2377|Compound:9073351|FD-Score:5.30|P-value:2.60E-5 ID:SGTC_2387|Compound:9077560|FD-Score:4.60|P-value:2.26E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.74|P-value:1.47E-4 ID:SGTC_2468|Compound:5987765|FD-Score:4.45|P-value:3.39E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:8.65|P-value:1.82E-11 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.40|P-value:3.90E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:6.99|P-value:4.64E-8 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.91|P-value:9.04E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.75|P-value:5.64E-6 ID:SGTC_2845|Compound:9003024|FD-Score:7.25|P-value:1.51E-8 ID:SGTC_3004|Compound:9076122|FD-Score:-5.09|P-value:4.31E-5 ID:SGTC_3057|Compound:9095946|FD-Score:4.93|P-value:8.48E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-4.32|P-value:4.26E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.13|P-value:7.17E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.89|P-value:8.02E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.36|P-value:4.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.97|P-value:2.50E-6 ID:SGTC_3167|Compound:9103034|FD-Score:4.14|P-value:7.96E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.93|P-value:7.26E-5 ID:SGTC_3247|Compound:9135149|FD-Score:6.35|P-value:6.02E-7 ID:SGTC_3249|Compound:9135183|FD-Score:-5.23|P-value:2.81E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.90|P-value:9.33E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.96|P-value:7.58E-5 ID:SGTC_3351|Compound:9150312|FD-Score:5.51|P-value:1.28E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:-4.40|P-value:3.43E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:-4.25|P-value:5.21E-4 ID:SGTC_103|Compound:0844-0104|FD-Score:-4.53|P-value:2.40E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-4.29|P-value:4.66E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:5.38|P-value:2.02E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.24|P-value:5.35E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:8.56|P-value:2.94E-11 ID:SGTC_184|Compound:1494-0393|FD-Score:6.94|P-value:5.54E-8 ID:SGTC_227|Compound:fluconazole|FD-Score:10.50|P-value:3.46E-16 ID:SGTC_230|Compound:MPP+|FD-Score:4.22|P-value:6.48E-4 ID:SGTC_257|Compound:daunorubicin|FD-Score:4.92|P-value:8.78E-5 ID:SGTC_305|Compound:1682-2595|FD-Score:4.75|P-value:1.46E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:7.83|P-value:1.05E-9 ID:SGTC_320|Compound:4092-0846|FD-Score:5.61|P-value:9.28E-6 ID:SGTC_339|Compound:3091-4833|FD-Score:-5.20|P-value:3.04E-5 ID:SGTC_444|Compound:curcumin|FD-Score:-4.33|P-value:4.16E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:6.08|P-value:1.73E-6 ID:SGTC_481|Compound:bay k-8644|FD-Score:4.70|P-value:1.65E-4 ID:SGTC_495|Compound:decylubiquinone|FD-Score:-4.33|P-value:4.13E-4 ID:SGTC_502|Compound:l-744,832|FD-Score:-4.83|P-value:9.85E-5 ID:SGTC_511|Compound:blebbistatin|FD-Score:-4.88|P-value:8.43E-5 ID:SGTC_541|Compound:4513-1321|FD-Score:7.57|P-value:3.52E-9 ID:SGTC_555|Compound:4296-0685|FD-Score:4.45|P-value:3.43E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-4.30|P-value:4.46E-4 ID:SGTC_584|Compound:0986-0246|FD-Score:6.75|P-value:1.26E-7 ID:SGTC_601|Compound:0986-0029|FD-Score:6.81|P-value:9.62E-8 ID:SGTC_609|Compound:0986-0026|FD-Score:6.51|P-value:3.30E-7 ID:SGTC_610|Compound:4215-0184|FD-Score:-4.81|P-value:1.04E-4 ID:SGTC_618|Compound:k072-0232|FD-Score:-4.48|P-value:2.74E-4 ID:SGTC_707|Compound:0865-0008|FD-Score:10.00|P-value:8.43E-15 ID:SGTC_765|Compound:1319-0117|FD-Score:-4.68|P-value:1.52E-4 ID:SGTC_820|Compound:1582-0060|FD-Score:6.42|P-value:4.61E-7 ID:SGTC_821|Compound:1114-0266|FD-Score:4.59|P-value:2.32E-4 ID:SGTC_826|Compound:1683-5028|FD-Score:4.99|P-value:6.91E-5 ID:SGTC_829|Compound:1635-0120|FD-Score:8.04|P-value:3.92E-10 ID:SGTC_863|Compound:0466-0191|FD-Score:5.08|P-value:5.32E-5 ID:SGTC_901|Compound:1112-0062|FD-Score:4.45|P-value:3.44E-4 ID:SGTC_902|Compound:1120-0002|FD-Score:6.82|P-value:9.46E-8 ID:SGTC_923|Compound:1900-2434|FD-Score:5.27|P-value:2.88E-5 ID:SGTC_961|Compound:1252-1571|FD-Score:5.57|P-value:1.06E-5 ID:SGTC_964|Compound:1287-0107|FD-Score:7.12|P-value:2.59E-8 ID:SGTC_1003|Compound:4049-0218|FD-Score:4.29|P-value:5.39E-4 ID:SGTC_1019|Compound:4262-0212|FD-Score:7.67|P-value:2.24E-9 ID:SGTC_1067|Compound:clotrimazole|FD-Score:4.89|P-value:9.45E-5 ID:SGTC_1090|Compound:efavirenz|FD-Score:4.48|P-value:3.17E-4 ID:SGTC_1098|Compound:clofazimine|FD-Score:5.58|P-value:1.01E-5 ID:SGTC_1113|Compound:artemisinin|FD-Score:4.75|P-value:1.43E-4 ID:SGTC_1237|Compound:0330-0133|FD-Score:4.13|P-value:8.23E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:4.76|P-value:1.41E-4 ID:SGTC_1330|Compound:1469-0054|FD-Score:-4.80|P-value:1.08E-4 ID:SGTC_1423|Compound:4048-0112|FD-Score:4.40|P-value:3.90E-4 ID:SGTC_1522|Compound:st012842|FD-Score:-4.80|P-value:1.06E-4 ID:SGTC_1547|Compound:harmine|FD-Score:5.52|P-value:1.25E-5 ID:SGTC_1556|Compound:plumbagin|FD-Score:4.72|P-value:1.60E-4 ID:SGTC_1618|Compound:st003135|FD-Score:4.84|P-value:1.10E-4 ID:SGTC_1636|Compound:st007707|FD-Score:6.51|P-value:3.29E-7 ID:SGTC_1638|Compound:st008370|FD-Score:5.79|P-value:4.82E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:-4.04|P-value:9.01E-4 ID:SGTC_1687|Compound:st020778|FD-Score:5.98|P-value:2.42E-6 ID:SGTC_1707|Compound:st032323|FD-Score:5.72|P-value:6.14E-6 ID:SGTC_1729|Compound:st035615|FD-Score:5.60|P-value:9.50E-6 ID:SGTC_1734|Compound:st037168|FD-Score:5.20|P-value:3.58E-5 ID:SGTC_1888|Compound:azatryptophan|FD-Score:5.27|P-value:2.89E-5 ID:SGTC_1897|Compound:st060201|FD-Score:5.14|P-value:4.28E-5 ID:SGTC_1915|Compound:st067105|FD-Score:5.35|P-value:2.21E-5 ID:SGTC_1950|Compound:st077106|FD-Score:4.66|P-value:1.90E-4 ID:SGTC_1985|Compound:st071382|FD-Score:-5.06|P-value:4.83E-5 ID:SGTC_2066|Compound:5222451|FD-Score:4.80|P-value:1.26E-4 ID:SGTC_2092|Compound:5303694|FD-Score:4.45|P-value:3.41E-4 ID:SGTC_2093|Compound:5331342|FD-Score:4.58|P-value:2.34E-4 ID:SGTC_2110|Compound:5483698|FD-Score:4.75|P-value:1.46E-4 ID:SGTC_2119|Compound:5528445|FD-Score:4.13|P-value:8.12E-4 ID:SGTC_2248|Compound:tofa|FD-Score:10.30|P-value:2.05E-15 ID:SGTC_2250|Compound:alverine citrate|FD-Score:11.20|P-value:5.96E-18 ID:SGTC_2291|Compound:7917025|FD-Score:-5.02|P-value:5.34E-5 ID:SGTC_2348|Compound:9022543|FD-Score:6.55|P-value:2.75E-7 ID:SGTC_2377|Compound:9073351|FD-Score:5.30|P-value:2.60E-5 ID:SGTC_2387|Compound:9077560|FD-Score:4.60|P-value:2.26E-4 ID:SGTC_2394|Compound:5221648|FD-Score:4.74|P-value:1.47E-4 ID:SGTC_2468|Compound:5987765|FD-Score:4.45|P-value:3.39E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:8.65|P-value:1.82E-11 ID:SGTC_2721|Compound:ifenprodil|FD-Score:4.40|P-value:3.90E-4 ID:SGTC_2733|Compound:amorolfine|FD-Score:6.99|P-value:4.64E-8 ID:SGTC_2765|Compound:myclobutanil|FD-Score:4.91|P-value:9.04E-5 ID:SGTC_2790|Compound:5423970|FD-Score:5.75|P-value:5.64E-6 ID:SGTC_2845|Compound:9003024|FD-Score:7.25|P-value:1.51E-8 ID:SGTC_3004|Compound:9076122|FD-Score:-5.09|P-value:4.31E-5 ID:SGTC_3057|Compound:9095946|FD-Score:4.93|P-value:8.48E-5 ID:SGTC_3126|Compound:9127922|FD-Score:-4.32|P-value:4.26E-4 ID:SGTC_3133|Compound:9127736|FD-Score:-4.13|P-value:7.17E-4 ID:SGTC_3142|Compound:9086498|FD-Score:-4.89|P-value:8.02E-5 ID:SGTC_3148|Compound:9097893|FD-Score:4.36|P-value:4.42E-4 ID:SGTC_3152|Compound:9099253|FD-Score:5.97|P-value:2.50E-6 ID:SGTC_3167|Compound:9103034|FD-Score:4.14|P-value:7.96E-4 ID:SGTC_3222|Compound:9128301|FD-Score:-4.93|P-value:7.26E-5 ID:SGTC_3247|Compound:9135149|FD-Score:6.35|P-value:6.02E-7 ID:SGTC_3249|Compound:9135183|FD-Score:-5.23|P-value:2.81E-5 ID:SGTC_3311|Compound:9131146|FD-Score:4.90|P-value:9.33E-5 ID:SGTC_3321|Compound:9137793|FD-Score:4.96|P-value:7.58E-5 ID:SGTC_3351|Compound:9150312|FD-Score:5.51|P-value:1.28E-5

Top fitness defect scores for YDR145W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2250 alverine citrate 11.20 130.0 µM 5.96E-18 6 2.74E-29 0.01
2 SGTC_227 fluconazole 10.50 33.5 µM 3.46E-16 azole & statin 12 2.66E-26 1.10
3 SGTC_2248 tofa 10.30 1.1 µM 2.05E-15 sphingolipid biosynthesis & PDR1 7 5.38E-25 2.09
4 SGTC_707 0865-0008 10.00 204.0 µM 8.43E-15 DNA damage response 1 5.89E-24 4.94
5 SGTC_2599 2',3-dihydroxy-4,4',6'-trimethoxychalcone 8.65 100.0 µM 1.82E-11 1 2.54E-18 4.02
6 SGTC_178 4092-0806 8.56 87.5 µM 2.94E-11 ergosterol depletion effects on membrane 4 5.75E-18 0.56
7 SGTC_829 1635-0120 8.04 117.0 µM 3.92E-10 DNA damage response 15 4.54E-16 0.11
8 SGTC_312 4092-0653 7.83 6.8 µM 1.05E-9 ergosterol depletion effects on membrane 10 2.42E-15 0.39
9 SGTC_1019 4262-0212 7.67 3.4 µM 2.24E-9 ergosterol depletion effects on membrane 4 8.59E-15 1.96
10 SGTC_541 4513-1321 7.57 94.0 µM 3.52E-9 1 1.85E-14 0.83
11 SGTC_2845 9003024 7.25 43.0 µM 1.51E-8 amide catabolism 3 2.13E-13 2.25
12 SGTC_964 1287-0107 7.12 19.4 µM 2.59E-8 cell wall 5 5.33E-13 0.59
13 SGTC_2733 amorolfine 6.99 100.0 µM 4.64E-8 plasma membrane duress 3 1.42E-12 2.05
14 SGTC_184 1494-0393 6.94 24.7 µM 5.54E-8 6 1.91E-12 0.26
15 SGTC_902 1120-0002 6.82 2.1 µM 9.46E-8 azole & statin 3 4.70E-12 0.66
16 SGTC_601 0986-0029 6.81 62.9 µM 9.62E-8 calcium & mitochondrial duress 7 4.84E-12 1.27
17 SGTC_584 0986-0246 6.75 15.4 µM 1.26E-7 heme requiring 6 7.61E-12 0.87
18 SGTC_2348 9022543 6.55 33.4 µM 2.75E-7 mitochondrial processes 16 2.83E-11 0.15
19 SGTC_1636 st007707 6.51 68.9 µM 3.29E-7 2 3.83E-11 1.01
20 SGTC_609 0986-0026 6.51 86.3 µM 3.30E-7 calcium & mitochondrial duress 6 3.84E-11 0.47

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.253 5.90E-50 YBR198C TAF5 het Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.154 2.60E-19 YOR174W MED4 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.149 4.61E-18 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.145 3.04E-17 YKL028W TFA1 het TFIIE large subunit, involved in recruitment of RNA polymerase II to the promoter, activation of TFIIH, and promoter opening
0.141 2.21E-16 YHR036W BRL1 het Essential nuclear envelope integral membrane protein identified as a suppressor of a conditional mutation in the major karyopherin, CRM1; homologous to and interacts with Brr6p, a nuclear envelope protein involved in nuclear export
0.140 4.86E-16 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.139 5.21E-16 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation
0.138 1.04E-15 YBR103W SIF2 hom WD40 repeat-containing subunit of the Set3C histone deacetylase complex, which represses early/middle sporulation genes; antagonizes telomeric silencing; binds specifically to the Sir4p N-terminus
0.138 1.12E-15 YDR167W TAF10 het Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.137 1.34E-15 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.133 1.06E-14 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.131 3.16E-14 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.129 7.24E-14 YOR194C TOA1 het TFIIA large subunit; involved in transcriptional activation, acts as antirepressor or as coactivator; homologous to largest and second largest subunits of human and Drosophila TFIIA
0.129 7.52E-14 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.126 2.80E-13 YGR122W YGR122W hom Protein that may be involved in pH regulation; probable ortholog of A. nidulans PalC, which is involved in pH regulation and binds to the ESCRT-III complex; null mutant does not properly process Rim101p and has decreased resistance to rapamycin; GFP-fusion protein is cytoplasmic; relative distribution to cytoplasm increases upon DNA replication stress