YDR149C_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data; overlaps the verified gene NUM1; null mutation blocks anaerobic growth

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR149C / YDR149C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:11.00|P-value:5.14E-29 ID:SGTC_62|Compound:0180-0423|FD-Score:3.16|P-value:6.97E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.35|P-value:3.46E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.83|P-value:5.42E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:4.06|P-value:1.99E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:10.10|P-value:1.24E-24 ID:SGTC_146|Compound:3448-8650|FD-Score:3.56|P-value:1.60E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.22|P-value:5.49E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.24|P-value:5.67E-8 ID:SGTC_175|Compound:3793-3120|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.22|P-value:5.56E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.00|P-value:6.14E-10 ID:SGTC_304|Compound:1310-0298|FD-Score:3.91|P-value:3.77E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.63|P-value:1.40E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.40|P-value:4.17E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.49|P-value:2.01E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.69|P-value:4.34E-9 ID:SGTC_492|Compound:tmb-8|FD-Score:4.22|P-value:9.71E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:5.60|P-value:7.40E-9 ID:SGTC_724|Compound:3910-0327|FD-Score:5.03|P-value:1.79E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:3.37|P-value:3.22E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.16|P-value:1.27E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.40|P-value:2.89E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.17|P-value:6.78E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.28|P-value:4.48E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.39|P-value:3.00E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.49|P-value:2.04E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.22|P-value:5.53E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.54|P-value:1.68E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.29|P-value:4.32E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.53|P-value:2.29E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.32|P-value:3.84E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.18|P-value:6.31E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.67|P-value:1.13E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.10|P-value:8.65E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.55|P-value:2.06E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.11|P-value:8.18E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.71|P-value:9.27E-7 ID:SGTC_1865|Compound:st057639|FD-Score:3.66|P-value:1.06E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.20|P-value:5.89E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.08|P-value:1.82E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.06|P-value:9.78E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.11|P-value:8.12E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.78|P-value:6.42E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.72|P-value:8.07E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.10|P-value:8.55E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.77|P-value:2.59E-9 ID:SGTC_2402|Compound:5553605|FD-Score:3.13|P-value:7.81E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.90|P-value:3.93E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.62|P-value:1.22E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.52|P-value:1.86E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.69|P-value:9.57E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.13|P-value:7.60E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.68|P-value:1.04E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.50|P-value:2.01E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.61|P-value:1.54E-6 ID:SGTC_2678|Compound:equilin|FD-Score:4.98|P-value:2.36E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.14|P-value:9.67E-8 ID:SGTC_2818|Compound:7996756|FD-Score:6.54|P-value:1.74E-11 ID:SGTC_2825|Compound:7998094|FD-Score:7.58|P-value:8.23E-15 ID:SGTC_3045|Compound:9092950|FD-Score:-4.12|P-value:1.49E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.19|P-value:6.23E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.50|P-value:1.99E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.60|P-value:1.35E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.64|P-value:1.35E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-4.05|P-value:2.05E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-5.46|P-value:1.63E-8 ID:SGTC_3266|Compound:9136860|FD-Score:5.51|P-value:1.20E-8 ID:SGTC_3280|Compound:9140961|FD-Score:3.39|P-value:3.06E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.08|P-value:9.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.29|P-value:9.81E-11 ID:SGTC_3321|Compound:9137793|FD-Score:4.22|P-value:9.83E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:11.00|P-value:5.14E-29 ID:SGTC_62|Compound:0180-0423|FD-Score:3.16|P-value:6.97E-4 ID:SGTC_97|Compound:0535-0701|FD-Score:3.38|P-value:3.16E-4 ID:SGTC_114|Compound:0364-0001|FD-Score:3.35|P-value:3.46E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.83|P-value:5.42E-5 ID:SGTC_135|Compound:0933-0004|FD-Score:4.06|P-value:1.99E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:10.10|P-value:1.24E-24 ID:SGTC_146|Compound:3448-8650|FD-Score:3.56|P-value:1.60E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:-3.22|P-value:5.49E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:5.24|P-value:5.67E-8 ID:SGTC_175|Compound:3793-3120|FD-Score:3.57|P-value:1.51E-4 ID:SGTC_263|Compound:alizarin|FD-Score:-3.22|P-value:5.56E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:6.00|P-value:6.14E-10 ID:SGTC_304|Compound:1310-0298|FD-Score:3.91|P-value:3.77E-5 ID:SGTC_359|Compound:0081-0058|FD-Score:4.63|P-value:1.40E-6 ID:SGTC_361|Compound:000s-0510|FD-Score:4.40|P-value:4.17E-6 ID:SGTC_362|Compound:0310-0100|FD-Score:-3.49|P-value:2.01E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:5.69|P-value:4.34E-9 ID:SGTC_492|Compound:tmb-8|FD-Score:4.22|P-value:9.71E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:5.60|P-value:7.40E-9 ID:SGTC_724|Compound:3910-0327|FD-Score:5.03|P-value:1.79E-7 ID:SGTC_858|Compound:0438-0351|FD-Score:3.37|P-value:3.22E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.16|P-value:1.27E-5 ID:SGTC_922|Compound:1866-0035|FD-Score:3.40|P-value:2.89E-4 ID:SGTC_951|Compound:1171-0579|FD-Score:3.17|P-value:6.78E-4 ID:SGTC_983|Compound:1491-0821|FD-Score:3.28|P-value:4.48E-4 ID:SGTC_1002|Compound:4049-0206|FD-Score:3.58|P-value:1.47E-4 ID:SGTC_1004|Compound:4084-0029|FD-Score:3.39|P-value:3.00E-4 ID:SGTC_1074|Compound:carmofur|FD-Score:3.55|P-value:1.66E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:3.49|P-value:2.04E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:3.22|P-value:5.53E-4 ID:SGTC_1256|Compound:0570-0116|FD-Score:3.54|P-value:1.68E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:3.29|P-value:4.32E-4 ID:SGTC_1522|Compound:st012842|FD-Score:4.53|P-value:2.29E-6 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:-3.32|P-value:3.84E-4 ID:SGTC_1526|Compound:st051518|FD-Score:-3.18|P-value:6.31E-4 ID:SGTC_1567|Compound:st069303|FD-Score:4.67|P-value:1.13E-6 ID:SGTC_1712|Compound:st032288|FD-Score:3.10|P-value:8.65E-4 ID:SGTC_1768|Compound:st044301|FD-Score:4.55|P-value:2.06E-6 ID:SGTC_1775|Compound:st081588|FD-Score:3.11|P-value:8.18E-4 ID:SGTC_1786|Compound:berberine|FD-Score:4.71|P-value:9.27E-7 ID:SGTC_1865|Compound:st057639|FD-Score:3.66|P-value:1.06E-4 ID:SGTC_1908|Compound:st060353|FD-Score:-3.20|P-value:5.89E-4 ID:SGTC_1998|Compound:st075797|FD-Score:4.08|P-value:1.82E-5 ID:SGTC_2009|Compound:4012297|FD-Score:-3.06|P-value:9.78E-4 ID:SGTC_2084|Compound:5306078|FD-Score:3.11|P-value:8.12E-4 ID:SGTC_2235|Compound:salicylic acid|FD-Score:3.78|P-value:6.42E-5 ID:SGTC_2337|Compound:9009472|FD-Score:-3.72|P-value:8.07E-5 ID:SGTC_2399|Compound:5884133|FD-Score:-3.10|P-value:8.55E-4 ID:SGTC_2400|Compound:5203494|FD-Score:5.77|P-value:2.59E-9 ID:SGTC_2402|Compound:5553605|FD-Score:3.13|P-value:7.81E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:3.90|P-value:3.93E-5 ID:SGTC_2416|Compound:tofa|FD-Score:-3.62|P-value:1.22E-4 ID:SGTC_2418|Compound:pentamidine|FD-Score:3.52|P-value:1.86E-4 ID:SGTC_2517|Compound:totarol|FD-Score:3.69|P-value:9.57E-5 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-3.13|P-value:7.60E-4 ID:SGTC_2574|Compound:2',4'-dihydroxychalcone|FD-Score:-4.68|P-value:1.04E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:3.50|P-value:2.01E-4 ID:SGTC_2584|Compound:androsterone|FD-Score:4.61|P-value:1.54E-6 ID:SGTC_2678|Compound:equilin|FD-Score:4.98|P-value:2.36E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.30|P-value:4.26E-4 ID:SGTC_2817|Compound:7995342|FD-Score:5.14|P-value:9.67E-8 ID:SGTC_2818|Compound:7996756|FD-Score:6.54|P-value:1.74E-11 ID:SGTC_2825|Compound:7998094|FD-Score:7.58|P-value:8.23E-15 ID:SGTC_3045|Compound:9092950|FD-Score:-4.12|P-value:1.49E-5 ID:SGTC_3058|Compound:9093861|FD-Score:-3.19|P-value:6.23E-4 ID:SGTC_3074|Compound:9116018|FD-Score:3.50|P-value:1.99E-4 ID:SGTC_3191|Compound:9110352|FD-Score:3.60|P-value:1.35E-4 ID:SGTC_3197|Compound:9113331|FD-Score:4.64|P-value:1.35E-6 ID:SGTC_3209|Compound:9113616|FD-Score:-4.05|P-value:2.05E-5 ID:SGTC_3259|Compound:9138485|FD-Score:-5.46|P-value:1.63E-8 ID:SGTC_3266|Compound:9136860|FD-Score:5.51|P-value:1.20E-8 ID:SGTC_3280|Compound:9140961|FD-Score:3.39|P-value:3.06E-4 ID:SGTC_3294|Compound:9122953|FD-Score:3.08|P-value:9.29E-4 ID:SGTC_3311|Compound:9131146|FD-Score:6.29|P-value:9.81E-11 ID:SGTC_3321|Compound:9137793|FD-Score:4.22|P-value:9.83E-6

Top fitness defect scores for YDR149C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_58 0957-0393 11.00 9.0 µM 5.14E-29 cell wall 67 2.35E-28
2 SGTC_138 0850-0259 10.10 40.9 µM 1.24E-24 cell wall 44 4.45E-24
3 SGTC_2825 7998094 7.58 58.4 µM 8.23E-15 fatty acid desaturase (OLE1) 5 1.70E-14
4 SGTC_2818 7996756 6.54 13.0 µM 1.74E-11 1 2.99E-11
5 SGTC_3311 9131146 6.29 2.9 µM 9.81E-11 cell wall 57 1.62E-10
6 SGTC_268 camptothecin 6.00 39.6 µM 6.14E-10 DNA damage response 28 9.69E-10
7 SGTC_2400 5203494 5.77 178.7 µM 2.59E-9 RSC complex & mRNA processing 8 3.95E-9
8 SGTC_453 enantio-paf c16 5.69 10.0 µM 4.34E-9 62 6.54E-9
9 SGTC_690 glyoxal 5.60 20.3 µM 7.40E-9 50 1.10E-8
10 SGTC_3266 9136860 5.51 49.5 µM 1.20E-8 cell wall 21 1.76E-8
11 SGTC_163 1327-0036 5.24 7.5 µM 5.67E-8 61 8.04E-8
12 SGTC_2817 7995342 5.14 71.4 µM 9.67E-8 10 1.35E-7
13 SGTC_724 3910-0327 5.03 137.0 µM 1.79E-7 ERG2 8 2.47E-7
14 SGTC_2678 equilin 4.98 100.0 µM 2.36E-7 9 3.23E-7
15 SGTC_1786 berberine 4.71 21.6 µM 9.27E-7 60S ribosome export 17 1.23E-6
16 SGTC_1567 st069303 4.67 68.4 µM 1.13E-6 mitochondrial processes 5 1.49E-6
17 SGTC_3197 9113331 4.64 49.5 µM 1.35E-6 23 1.77E-6
18 SGTC_359 0081-0058 4.63 15.9 µM 1.40E-6 60S ribosome export 26 1.83E-6
19 SGTC_2584 androsterone 4.61 48.7 µM 1.54E-6 cell wall 93 2.02E-6
20 SGTC_1768 st044301 4.55 37.2 µM 2.06E-6 7 2.68E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.395 1.06E-125 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.339 8.06E-91 YJR054W KCH1 hom Potassium transporter that mediates K+ influx; activates the high-affinity Ca2+ influx system (HACS) during the mating pheromone response; expression is up-regulated in response to alpha factor; localized to sites of polarized growth; similar to Prm6p; member of a fungal-specific gene family; potential Cdc28p substrate
0.330 5.66E-86 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.330 7.46E-86 YKL076C_d PSY1_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 69% of ORF overlaps the uncharacterized ORF YKL075C
0.317 4.00E-79 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.304 7.10E-73 YDL066W IDP1 hom Mitochondrial NADP-specific isocitrate dehydrogenase, catalyzes the oxidation of isocitrate to alpha-ketoglutarate; not required for mitochondrial respiration and may function to divert alpha-ketoglutarate to biosynthetic processes
0.302 1.28E-71 YDL203C ACK1 hom Protein that functions upstream of Pkc1p in the cell wall integrity pathway; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; non-tagged Ack1p is detected in purified mitochondria
0.300 9.39E-71 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.299 4.01E-70 YPL115C BEM3 hom Rho GTPase activating protein (RhoGAP) involved in control of the cytoskeleton organization; targets the essential Rho-GTPase Cdc42p, which controls establishment and maintenance of cell polarity, including bud-site assembly
0.299 4.53E-70 YNL314W DAL82 hom Positive regulator of allophanate inducible genes; binds a dodecanucleotide sequence upstream of all genes that are induced by allophanate; contains an UISALL DNA-binding, a transcriptional activation, and a coiled-coil domain
0.297 3.97E-69 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.294 3.89E-68 YJR111C_p YJR111C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondria
0.281 9.04E-62 YJL073W JEM1 hom DnaJ-like chaperone required for nuclear membrane fusion during mating, localizes to the ER membrane; exhibits genetic interactions with KAR2
0.278 1.27E-60 YDL021W GPM2 hom Homolog of Gpm1p phosphoglycerate mutase, which converts 3-phosphoglycerate to 2-phosphoglycerate in glycolysis; may be non-functional derivative of a gene duplication event
0.278 1.53E-60 YBL006C LDB7 hom Component of the RSC chromatin remodeling complex; interacts with Rsc3p, Rsc30p, Npl6p, and Htl1p to form a module important for a broad range of RSC functions