YDR155C / CPR1

Cytoplasmic peptidyl-prolyl cis-trans isomerase (cyclophilin); catalyzes the cis-trans isomerization of peptide bonds N-terminal to proline residues; binds the drug cyclosporin A; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR155C / CPR1

Click on Significant Values for Screen Details ID:SGTC_45|Compound:0kpi-0036|FD-Score:6.43|P-value:3.05E-12 ID:SGTC_115|Compound:0527-0192|FD-Score:5.44|P-value:3.12E-9 ID:SGTC_128|Compound:0906-2981|FD-Score:2.95|P-value:8.68E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.53|P-value:8.76E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.10|P-value:5.08E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.47|P-value:1.14E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.42|P-value:3.11E-12 ID:SGTC_203|Compound:k066-0004|FD-Score:3.06|P-value:5.87E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.56|P-value:7.68E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.65|P-value:3.49E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.07|P-value:5.62E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.44|P-value:6.68E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:4.31|P-value:2.18E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.25|P-value:1.85E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.99|P-value:7.45E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.34|P-value:1.32E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:2.96|P-value:8.45E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:2.93|P-value:9.40E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.76|P-value:3.11E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.04|P-value:6.23E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.18|P-value:3.60E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.05|P-value:8.05E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.91|P-value:1.58E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.95|P-value:8.68E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.36|P-value:1.68E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.96|P-value:5.96E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.96|P-value:1.24E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.32|P-value:2.01E-6 ID:SGTC_1521|Compound:st012942|FD-Score:2.95|P-value:8.63E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.74|P-value:3.45E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.61|P-value:3.97E-5 ID:SGTC_1651|Compound:st011928|FD-Score:2.95|P-value:8.73E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-2.82|P-value:9.81E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.02|P-value:6.90E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.11|P-value:4.89E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.46|P-value:7.74E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.53|P-value:1.41E-12 ID:SGTC_2585|Compound:alliin|FD-Score:3.14|P-value:4.32E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.62|P-value:5.96E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.64|P-value:5.34E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.68|P-value:4.41E-5 ID:SGTC_3046|Compound:9092212|FD-Score:-3.01|P-value:4.89E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.37|P-value:1.69E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.53|P-value:8.53E-5 ID:SGTC_45|Compound:0kpi-0036|FD-Score:6.43|P-value:3.05E-12 ID:SGTC_115|Compound:0527-0192|FD-Score:5.44|P-value:3.12E-9 ID:SGTC_128|Compound:0906-2981|FD-Score:2.95|P-value:8.68E-4 ID:SGTC_131|Compound:0141-0277|FD-Score:3.53|P-value:8.76E-5 ID:SGTC_143|Compound:4032-1194|FD-Score:3.10|P-value:5.08E-4 ID:SGTC_144|Compound:4161-2749|FD-Score:3.47|P-value:1.14E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:6.42|P-value:3.11E-12 ID:SGTC_203|Compound:k066-0004|FD-Score:3.06|P-value:5.87E-4 ID:SGTC_205|Compound:1486-1330|FD-Score:3.56|P-value:7.68E-5 ID:SGTC_214|Compound:4373-3496|FD-Score:4.65|P-value:3.49E-7 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.07|P-value:5.62E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:-4.44|P-value:6.68E-7 ID:SGTC_379|Compound:3970-0972|FD-Score:4.31|P-value:2.18E-6 ID:SGTC_385|Compound:1494-0393|FD-Score:-3.25|P-value:1.85E-4 ID:SGTC_403|Compound:arphamenine a|FD-Score:2.99|P-value:7.45E-4 ID:SGTC_404|Compound:fumagillin|FD-Score:-3.34|P-value:1.32E-4 ID:SGTC_428|Compound:3448-4153|FD-Score:2.96|P-value:8.45E-4 ID:SGTC_537|Compound:1334-0398|FD-Score:2.93|P-value:9.40E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:3.76|P-value:3.11E-5 ID:SGTC_574|Compound:1315-0397|FD-Score:4.00|P-value:1.02E-5 ID:SGTC_583|Compound:1488-1091|FD-Score:3.04|P-value:6.23E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:3.18|P-value:3.60E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:4.05|P-value:8.05E-6 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.91|P-value:1.58E-5 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:2.95|P-value:8.68E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.36|P-value:1.68E-6 ID:SGTC_1154|Compound:4088-0362|FD-Score:-2.96|P-value:5.96E-4 ID:SGTC_1227|Compound:3909-8010|FD-Score:3.96|P-value:1.24E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:4.32|P-value:2.01E-6 ID:SGTC_1521|Compound:st012942|FD-Score:2.95|P-value:8.63E-4 ID:SGTC_1547|Compound:harmine|FD-Score:3.74|P-value:3.45E-5 ID:SGTC_1575|Compound:cyproterone acetate|FD-Score:-3.61|P-value:3.97E-5 ID:SGTC_1651|Compound:st011928|FD-Score:2.95|P-value:8.73E-4 ID:SGTC_1727|Compound:st034309|FD-Score:-2.82|P-value:9.81E-4 ID:SGTC_1735|Compound:st034310|FD-Score:3.02|P-value:6.90E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.29|P-value:2.36E-4 ID:SGTC_1980|Compound:st071811|FD-Score:3.11|P-value:4.89E-4 ID:SGTC_2127|Compound:5253358|FD-Score:3.32|P-value:2.11E-4 ID:SGTC_2314|Compound:7727897|FD-Score:-3.46|P-value:7.74E-5 ID:SGTC_2564|Compound:betulinic acid|FD-Score:6.53|P-value:1.41E-12 ID:SGTC_2585|Compound:alliin|FD-Score:3.14|P-value:4.32E-4 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.62|P-value:5.96E-5 ID:SGTC_2707|Compound:st078556|FD-Score:3.64|P-value:5.34E-5 ID:SGTC_3037|Compound:9091026|FD-Score:3.68|P-value:4.41E-5 ID:SGTC_3046|Compound:9092212|FD-Score:-3.01|P-value:4.89E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:3.37|P-value:1.69E-4 ID:SGTC_3065|Compound:9113888|FD-Score:3.53|P-value:8.53E-5

Top fitness defect scores for YDR155C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2564 betulinic acid 6.53 100.0 µM 1.41E-12 6 3.32E-11
2 SGTC_45 0kpi-0036 6.43 14.9 µM 3.05E-12 excess fatty acid 3 6.50E-11
3 SGTC_145 3737-0113 6.42 38.4 µM 3.11E-12 DNA intercalators 21 6.62E-11
4 SGTC_115 0527-0192 5.44 112.0 µM 3.12E-9 19 2.71E-8
5 SGTC_214 4373-3496 4.65 70.0 µM 3.49E-7 38 1.65E-6
6 SGTC_1153 4055-0057 4.36 267.0 µM 1.68E-6 16 6.53E-6
7 SGTC_1232 0279-0259 4.32 161.0 µM 2.01E-6 7 7.65E-6
8 SGTC_379 3970-0972 4.31 5.9 µM 2.18E-6 tubulin folding & SWR complex 29 8.20E-6
9 SGTC_684 1140-0066 4.05 328.0 µM 8.05E-6 Golgi 20 2.57E-5
10 SGTC_574 1315-0397 4.00 40.0 µM 1.02E-5 36 3.16E-5
11 SGTC_1227 3909-8010 3.96 46.6 µM 1.24E-5 18 3.76E-5
12 SGTC_905 2-aminofluorene 3.91 215.0 µM 1.58E-5 cell wall signaling 29 4.64E-5
13 SGTC_566 0958-0068 3.76 16.5 µM 3.11E-5 RSC & ERG11 21 8.40E-5
14 SGTC_1547 harmine 3.74 94.2 µM 3.45E-5 ergosterol biosynthesis 55 9.22E-5
15 SGTC_3037 9091026 3.68 49.5 µM 4.41E-5 NEO1-PIK1 140 1.14E-4
16 SGTC_2707 st078556 3.64 66.6 µM 5.34E-5 16 1.35E-4
17 SGTC_2611 pyromycin 3.62 23.9 µM 5.96E-5 42 1.49E-4
18 SGTC_205 1486-1330 3.56 71.9 µM 7.68E-5 25 1.86E-4
19 SGTC_3065 9113888 3.53 49.5 µM 8.53E-5 36 2.04E-4
20 SGTC_131 0141-0277 3.53 33.9 µM 8.76E-5 56 2.09E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 8.19E-36 YNL124W NAF1 het RNA-binding protein required for the assembly of box H/ACA snoRNPs and thus for pre-rRNA processing, forms a complex with Shq1p and interacts with H/ACA snoRNP components Nhp2p and Cbf5p; similar to Gar1p
0.198 6.65E-31 YDR401W_d YDR401W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.193 1.70E-29 YGL002W ERP6 hom Member of the p24 family involved in ER to Golgi transport; similar to Emp24p and Erv25p; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies; ERP6 has a paralog, ERP1, that arose from the whole genome duplication
0.190 1.42E-28 YHR149C SKG6 hom Integral membrane protein that localizes primarily to growing sites such as the bud tip or the cell periphery; potential Cdc28p substrate; Skg6p interacts with Zds1p and Zds2p
0.185 3.53E-27 YNR008W LRO1 hom Acyltransferase that catalyzes diacylglycerol esterification; one of several acyltransferases that contribute to triglyceride synthesis; putative homolog of human lecithin cholesterol acyltransferase
0.175 2.15E-24 YOR077W RTS2 het Basic zinc-finger protein, similar to human and mouse Kin17 proteins which are chromatin-associated proteins involved in UV response and DNA replication
0.163 1.92E-21 YGL118C_d YGL118C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.163 2.98E-21 YEL064C AVT2 hom Putative transporter, member of a family of seven S. cerevisiae genes (AVT1-7) related to vesicular GABA-glycine transporters
0.162 5.06E-21 YFL022C FRS2 het Alpha subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs1p to form active enzyme; evolutionarily distant from mitochondrial phenylalanyl-tRNA synthetase based on protein sequence, but substrate binding is similar
0.145 2.73E-17 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.128 9.50E-14 YNL264C PDR17 hom Phosphatidylinositol transfer protein (PITP), downregulates Plb1p-mediated turnover of phosphatidylcholine, found in the cytosol and microsomes, homologous to Pdr16p, deletion affects phospholipid composition
0.128 1.33E-13 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.127 1.66E-13 YEL017C-A PMP2 hom Proteolipid associated with plasma membrane H(+)-ATPase (Pma1p); regulates plasma membrane H(+)-ATPase activity; protein abundance increases in response to DNA replication stress; PMP2 has a paralog, PMP1, that arose from the whole genome duplication
0.126 2.94E-13 YHR020W YHR020W het Prolyl-tRNA synthetase; N-terminal domain shows weak homology to prokaryotic posttransfer editing domain, but does not possess posttransfer editing activity; may interact with ribosomes, based on co-purification experiments
0.124 5.60E-13 YDR524W-C_p YDR524W-C_p hom Putative protein of unknown function; small ORF identified by SAGE; deletion strains are moderately sensitive to the radiomimetic drug bleomycin