YDR158W / HOM2

Aspartic beta semi-aldehyde dehydrogenase, catalyzes the second step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR158W / HOM2

Click on Significant Values for Screen Details ID:SGTC_4|Compound:0960-0234|FD-Score:3.48|P-value:5.68E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:6.32|P-value:1.35E-9 ID:SGTC_113|Compound:0099-0221|FD-Score:3.60|P-value:3.81E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.37|P-value:2.21E-7 ID:SGTC_125|Compound:0133-0007|FD-Score:4.34|P-value:2.39E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:4.73|P-value:4.54E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.61|P-value:3.72E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.94|P-value:1.14E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.34|P-value:1.17E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:11.60|P-value:1.78E-28 ID:SGTC_236|Compound:1509-0011|FD-Score:8.32|P-value:1.98E-15 ID:SGTC_310|Compound:1273-0058|FD-Score:5.34|P-value:2.55E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.36|P-value:8.50E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.55|P-value:4.54E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:9.04|P-value:6.87E-18 ID:SGTC_386|Compound:1509-0011|FD-Score:15.90|P-value:1.32E-51 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.44|P-value:1.57E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.61|P-value:7.65E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.37|P-value:8.25E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.02|P-value:8.49E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.30|P-value:2.73E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.56|P-value:4.46E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.37|P-value:8.13E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.51|P-value:5.16E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.82|P-value:1.76E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.29|P-value:2.84E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.51|P-value:1.15E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.36|P-value:5.73E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.43|P-value:6.72E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.32|P-value:2.52E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.58|P-value:4.14E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.60|P-value:3.78E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.79|P-value:3.45E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.42|P-value:7.07E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.57|P-value:8.91E-6 ID:SGTC_1635|Compound:st007035|FD-Score:9.28|P-value:9.33E-19 ID:SGTC_1746|Compound:st038117|FD-Score:3.49|P-value:5.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:3.81E-31 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.92|P-value:3.49E-11 ID:SGTC_1943|Compound:st076331|FD-Score:4.74|P-value:4.33E-6 ID:SGTC_1947|Compound:st076332|FD-Score:4.83|P-value:2.84E-6 ID:SGTC_1952|Compound:st077036|FD-Score:3.49|P-value:5.50E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.64|P-value:6.66E-6 ID:SGTC_1975|Compound:st070967|FD-Score:-3.30|P-value:6.87E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.38|P-value:1.66E-12 ID:SGTC_2316|Compound:5844804|FD-Score:4.42|P-value:1.71E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.12|P-value:5.76E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.72|P-value:2.55E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.81|P-value:1.82E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.34|P-value:2.36E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.81|P-value:9.49E-21 ID:SGTC_2679|Compound:rapamycin|FD-Score:18.10|P-value:3.16E-66 ID:SGTC_2782|Compound:7736369|FD-Score:4.07|P-value:6.93E-5 ID:SGTC_2902|Compound:5787006|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_2914|Compound:7968218|FD-Score:4.25|P-value:3.38E-5 ID:SGTC_2957|Compound:9076800|FD-Score:5.65|P-value:5.41E-8 ID:SGTC_2958|Compound:9077254|FD-Score:6.24|P-value:2.13E-9 ID:SGTC_3101|Compound:9120531|FD-Score:3.59|P-value:3.98E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.58|P-value:4.15E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.53|P-value:1.08E-5 ID:SGTC_3185|Compound:9108267|FD-Score:-4.53|P-value:6.40E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.33|P-value:9.33E-4 ID:SGTC_4|Compound:0960-0234|FD-Score:3.48|P-value:5.68E-4 ID:SGTC_7|Compound:0192-1582|FD-Score:6.32|P-value:1.35E-9 ID:SGTC_113|Compound:0099-0221|FD-Score:3.60|P-value:3.81E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.37|P-value:2.21E-7 ID:SGTC_125|Compound:0133-0007|FD-Score:4.34|P-value:2.39E-5 ID:SGTC_126|Compound:0417-1624|FD-Score:4.73|P-value:4.54E-6 ID:SGTC_131|Compound:0141-0277|FD-Score:3.61|P-value:3.72E-4 ID:SGTC_145|Compound:3737-0113|FD-Score:3.94|P-value:1.14E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:6.34|P-value:1.17E-9 ID:SGTC_184|Compound:1494-0393|FD-Score:11.60|P-value:1.78E-28 ID:SGTC_236|Compound:1509-0011|FD-Score:8.32|P-value:1.98E-15 ID:SGTC_310|Compound:1273-0058|FD-Score:5.34|P-value:2.55E-7 ID:SGTC_366|Compound:0181-0206|FD-Score:3.36|P-value:8.50E-4 ID:SGTC_370|Compound:0180-0345|FD-Score:3.55|P-value:4.54E-4 ID:SGTC_371|Compound:0195-0006|FD-Score:9.04|P-value:6.87E-18 ID:SGTC_386|Compound:1509-0011|FD-Score:15.90|P-value:1.32E-51 ID:SGTC_412|Compound:gemfibrozil|FD-Score:4.44|P-value:1.57E-5 ID:SGTC_471|Compound:1-acyl-paf|FD-Score:4.61|P-value:7.65E-6 ID:SGTC_854|Compound:0422-0053|FD-Score:3.37|P-value:8.25E-4 ID:SGTC_858|Compound:0438-0351|FD-Score:4.02|P-value:8.49E-5 ID:SGTC_885|Compound:0865-0106|FD-Score:4.30|P-value:2.73E-5 ID:SGTC_947|Compound:3447-0010|FD-Score:3.56|P-value:4.46E-4 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.37|P-value:8.13E-4 ID:SGTC_1051|Compound:3253-3903|FD-Score:3.51|P-value:5.16E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:3.82|P-value:1.76E-4 ID:SGTC_1109|Compound:tnp00067|FD-Score:4.29|P-value:2.84E-5 ID:SGTC_1225|Compound:1216-0074|FD-Score:4.51|P-value:1.15E-5 ID:SGTC_1233|Compound:0325-0408|FD-Score:-3.36|P-value:5.73E-4 ID:SGTC_1282|Compound:0886-0010|FD-Score:3.43|P-value:6.72E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.32|P-value:2.52E-5 ID:SGTC_1390|Compound:3413-2614|FD-Score:3.58|P-value:4.14E-4 ID:SGTC_1415|Compound:3966-0071|FD-Score:3.60|P-value:3.78E-4 ID:SGTC_1459|Compound:k035-0031|FD-Score:4.79|P-value:3.45E-6 ID:SGTC_1515|Compound:3460-0031|FD-Score:3.42|P-value:7.07E-4 ID:SGTC_1625|Compound:st003711|FD-Score:4.57|P-value:8.91E-6 ID:SGTC_1635|Compound:st007035|FD-Score:9.28|P-value:9.33E-19 ID:SGTC_1746|Compound:st038117|FD-Score:3.49|P-value:5.63E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:12.20|P-value:3.81E-31 ID:SGTC_1926|Compound:methyl fluorone black|FD-Score:6.92|P-value:3.49E-11 ID:SGTC_1943|Compound:st076331|FD-Score:4.74|P-value:4.33E-6 ID:SGTC_1947|Compound:st076332|FD-Score:4.83|P-value:2.84E-6 ID:SGTC_1952|Compound:st077036|FD-Score:3.49|P-value:5.50E-4 ID:SGTC_1964|Compound:st076914|FD-Score:4.64|P-value:6.66E-6 ID:SGTC_1975|Compound:st070967|FD-Score:-3.30|P-value:6.87E-4 ID:SGTC_2233|Compound:sulbentine|FD-Score:7.38|P-value:1.66E-12 ID:SGTC_2316|Compound:5844804|FD-Score:4.42|P-value:1.71E-5 ID:SGTC_2340|Compound:7987427|FD-Score:4.12|P-value:5.76E-5 ID:SGTC_2382|Compound:9035899|FD-Score:3.72|P-value:2.55E-4 ID:SGTC_2437|Compound:5741531|FD-Score:3.81|P-value:1.82E-4 ID:SGTC_2478|Compound:5763493|FD-Score:4.34|P-value:2.36E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:9.81|P-value:9.49E-21 ID:SGTC_2679|Compound:rapamycin|FD-Score:18.10|P-value:3.16E-66 ID:SGTC_2782|Compound:7736369|FD-Score:4.07|P-value:6.93E-5 ID:SGTC_2902|Compound:5787006|FD-Score:3.92|P-value:1.22E-4 ID:SGTC_2914|Compound:7968218|FD-Score:4.25|P-value:3.38E-5 ID:SGTC_2957|Compound:9076800|FD-Score:5.65|P-value:5.41E-8 ID:SGTC_2958|Compound:9077254|FD-Score:6.24|P-value:2.13E-9 ID:SGTC_3101|Compound:9120531|FD-Score:3.59|P-value:3.98E-4 ID:SGTC_3170|Compound:9103054|FD-Score:3.58|P-value:4.15E-4 ID:SGTC_3178|Compound:9107506|FD-Score:4.53|P-value:1.08E-5 ID:SGTC_3185|Compound:9108267|FD-Score:-4.53|P-value:6.40E-6 ID:SGTC_3197|Compound:9113331|FD-Score:3.33|P-value:9.33E-4

Top fitness defect scores for YDR158W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2679 rapamycin 18.10 1.0 nM 3.16E-66 3 1.72E-73
2 SGTC_386 1509-0011 15.90 3.1 µM 1.32E-51 18 2.87E-57
3 SGTC_1844 rapamycin 12.20 4.0 nM 3.81E-31 22 1.48E-34
4 SGTC_184 1494-0393 11.60 24.7 µM 1.78E-28 6 1.36E-31
5 SGTC_2651 1327-0036 9.81 5.0 µM 9.49E-21 27 5.24E-23
6 SGTC_1635 st007035 9.28 42.4 µM 9.33E-19 84 8.59E-21
7 SGTC_371 0195-0006 9.04 7.4 µM 6.87E-18 3 7.91E-20
8 SGTC_236 1509-0011 8.32 5.3 µM 1.98E-15 239 4.29E-17
9 SGTC_2233 sulbentine 7.38 40.4 µM 1.66E-12 17 7.67E-14
10 SGTC_1926 methyl fluorone black 6.92 53.6 µM 3.49E-11 DNA intercalators 13 2.27E-12
11 SGTC_163 1327-0036 6.34 7.5 µM 1.17E-9 40 1.13E-10
12 SGTC_7 0192-1582 6.32 4.2 µM 1.35E-9 21 1.33E-10
13 SGTC_2958 9077254 6.24 16.7 µM 2.13E-9 6 2.21E-10
14 SGTC_2957 9076800 5.65 11.5 µM 5.41E-8 7 8.13E-9
15 SGTC_115 0527-0192 5.37 112.0 µM 2.21E-7 23 3.90E-8
16 SGTC_310 1273-0058 5.34 1.1 µM 2.55E-7 mitochondrial stress 168 4.57E-8
17 SGTC_1947 st076332 4.83 61.6 µM 2.84E-6 6 6.71E-7
18 SGTC_1459 k035-0031 4.79 35.7 µM 3.45E-6 DNA intercalators 10 8.33E-7
19 SGTC_1943 st076331 4.74 65.2 µM 4.33E-6 8 1.08E-6
20 SGTC_126 0417-1624 4.73 672.5 µM 4.54E-6 DNA intercalators 13 1.13E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.494 3.34E-205 YCR053W THR4 hom Threonine synthase, conserved protein that catalyzes formation of threonine from O-phosphohomoserine; expression is regulated by the GCN4-mediated general amino acid control pathway
0.472 4.70E-185 YER052C HOM3 hom Aspartate kinase (L-aspartate 4-P-transferase); cytoplasmic enzyme that catalyzes the first step in the common pathway for methionine and threonine biosynthesis; expression regulated by Gcn4p and the general control of amino acid synthesis
0.357 1.29E-100 YOR184W SER1 hom 3-phosphoserine aminotransferase; catalyzes the formation of phosphoserine from 3-phosphohydroxypyruvate, required for serine and glycine biosynthesis; regulated by the general control of amino acid biosynthesis mediated by Gcn4p; protein abundance increases in response to DNA replication stress
0.349 1.82E-96 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.349 4.88E-96 YGR208W SER2 hom Phosphoserine phosphatase of the phosphoglycerate pathway, involved in serine and glycine biosynthesis, expression is regulated by the available nitrogen source
0.347 4.89E-95 YJL022W_d YJL022W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene PET130
0.327 5.05E-84 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.325 5.41E-83 YHR116W COX23 hom Mitochondrial intermembrane space protein that functions in mitochondrial copper homeostasis, essential for functional cytochrome oxidase expression; homologous to Cox17p; contains twin cysteine-x9-cysteine motifs
0.321 5.43E-81 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.317 6.92E-79 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.304 1.42E-72 YKL194C MST1 hom Mitochondrial threonyl-tRNA synthetase; aminoacylates both the canonical threonine tRNA tT(UGU)Q1 and the unusual threonine tRNA tT(XXX)Q2 in vitro
0.296 1.65E-68 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.295 5.58E-68 YPL132W COX11 hom Mitochondrial inner membrane protein required for delivery of copper to the Cox1p subunit of cytochrome c oxidase; association with mitochondrial ribosomes suggests that copper delivery may occur during translation of Cox1p
0.288 4.37E-65 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.288 4.66E-65 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs