YDR159W / SAC3

Nuclear pore-associated protein; required for biogenesis of the small ribosomal subunit; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; similar to the human germinal center-associated nuclear protein (GANP)

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR159W / SAC3

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:-4.59|P-value:2.41E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:10.70|P-value:4.29E-20 ID:SGTC_70|Compound:0141-0289|FD-Score:4.05|P-value:3.90E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.77|P-value:8.94E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.77|P-value:9.02E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.65|P-value:5.24E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.09|P-value:1.61E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:6.50|P-value:2.33E-8 ID:SGTC_201|Compound:4262-0159|FD-Score:4.83|P-value:2.78E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.76|P-value:9.33E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.60|P-value:1.68E-19 ID:SGTC_232|Compound:clozapine|FD-Score:4.80|P-value:3.08E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.80|P-value:8.36E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.89|P-value:2.20E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:3.95|P-value:5.35E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.77|P-value:3.92E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.43|P-value:4.39E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.24|P-value:5.89E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:4.27|P-value:1.90E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.67|P-value:5.44E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.79|P-value:8.60E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.69|P-value:1.67E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:8.88|P-value:3.03E-14 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.11|P-value:1.45E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.62|P-value:1.22E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.61|P-value:2.27E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.17|P-value:2.66E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:6.01|P-value:2.29E-7 ID:SGTC_518|Compound:1021-0119|FD-Score:3.98|P-value:4.76E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.78|P-value:3.29E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:7.81|P-value:2.22E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:6.08|P-value:1.66E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:4.58|P-value:6.72E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.94|P-value:5.51E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.86|P-value:6.84E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.90|P-value:2.61E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:7.71|P-value:3.85E-11 ID:SGTC_878|Compound:0828-0289|FD-Score:3.93|P-value:5.67E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.97|P-value:2.73E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:4.51|P-value:8.53E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.45|P-value:1.04E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:6.49|P-value:2.36E-8 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.51|P-value:8.50E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.82|P-value:7.72E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.86|P-value:6.90E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:7.32|P-value:3.41E-10 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.71|P-value:4.75E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.90|P-value:2.13E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.99|P-value:1.53E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.90|P-value:6.08E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.42|P-value:2.86E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.68|P-value:4.83E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.93|P-value:5.53E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:6.24|P-value:7.97E-8 ID:SGTC_1514|Compound:1189-1591|FD-Score:7.88|P-value:1.46E-11 ID:SGTC_1567|Compound:st069303|FD-Score:3.92|P-value:5.80E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.97|P-value:1.67E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-5.56|P-value:4.88E-7 ID:SGTC_1665|Compound:st014639|FD-Score:5.61|P-value:1.27E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.32|P-value:4.18E-6 ID:SGTC_1687|Compound:st020778|FD-Score:7.42|P-value:2.00E-10 ID:SGTC_1694|Compound:st024011|FD-Score:4.21|P-value:2.34E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.49|P-value:9.18E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.94|P-value:3.08E-7 ID:SGTC_1750|Compound:st081859|FD-Score:13.90|P-value:1.67E-32 ID:SGTC_1754|Compound:st042065|FD-Score:6.80|P-value:5.19E-9 ID:SGTC_1760|Compound:st045453|FD-Score:6.41|P-value:3.56E-8 ID:SGTC_1781|Compound:st038725|FD-Score:9.29|P-value:1.86E-15 ID:SGTC_1786|Compound:berberine|FD-Score:-3.81|P-value:3.44E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.14|P-value:2.90E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.22|P-value:2.27E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.66|P-value:5.57E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.49|P-value:9.29E-5 ID:SGTC_2096|Compound:5468907|FD-Score:4.10|P-value:3.32E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.12|P-value:3.14E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.00|P-value:4.57E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.81|P-value:8.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.08|P-value:1.07E-5 ID:SGTC_2322|Compound:7413319|FD-Score:7.07|P-value:1.30E-9 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.86|P-value:6.96E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.96|P-value:5.13E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.65|P-value:5.69E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.84|P-value:7.40E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.74|P-value:9.84E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.68|P-value:4.81E-5 ID:SGTC_2951|Compound:9072950|FD-Score:6.65|P-value:1.11E-8 ID:SGTC_2954|Compound:9074818|FD-Score:3.92|P-value:5.79E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.22|P-value:2.28E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.51|P-value:8.75E-5 ID:SGTC_3098|Compound:9119039|FD-Score:5.04|P-value:1.26E-5 ID:SGTC_3155|Compound:9099265|FD-Score:7.88|P-value:1.47E-11 ID:SGTC_3237|Compound:9133362|FD-Score:5.03|P-value:1.29E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.59|P-value:2.41E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:10.70|P-value:4.29E-20 ID:SGTC_70|Compound:0141-0289|FD-Score:4.05|P-value:3.90E-4 ID:SGTC_89|Compound:0302-0250|FD-Score:3.77|P-value:8.94E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:3.77|P-value:9.02E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:4.65|P-value:5.24E-5 ID:SGTC_146|Compound:3448-8650|FD-Score:6.09|P-value:1.61E-7 ID:SGTC_156|Compound:3474-0145|FD-Score:6.50|P-value:2.33E-8 ID:SGTC_201|Compound:4262-0159|FD-Score:4.83|P-value:2.78E-5 ID:SGTC_203|Compound:k066-0004|FD-Score:3.76|P-value:9.33E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:10.60|P-value:1.68E-19 ID:SGTC_232|Compound:clozapine|FD-Score:4.80|P-value:3.08E-5 ID:SGTC_253|Compound:dyclonine|FD-Score:3.80|P-value:8.36E-4 ID:SGTC_254|Compound:nsc-64875|FD-Score:4.89|P-value:2.20E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:3.95|P-value:5.35E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.77|P-value:3.92E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.43|P-value:4.39E-5 ID:SGTC_313|Compound:3474-0040|FD-Score:5.24|P-value:5.89E-6 ID:SGTC_323|Compound:4013-0906|FD-Score:4.27|P-value:1.90E-4 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.67|P-value:5.44E-4 ID:SGTC_420|Compound:mitomycin C|FD-Score:3.79|P-value:8.60E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.69|P-value:1.67E-5 ID:SGTC_439|Compound:amiodarone|FD-Score:8.88|P-value:3.03E-14 ID:SGTC_445|Compound:e6 berbamine|FD-Score:6.11|P-value:1.45E-7 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.62|P-value:1.22E-6 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:-4.61|P-value:2.27E-5 ID:SGTC_488|Compound:nitrendipine|FD-Score:4.17|P-value:2.66E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:6.01|P-value:2.29E-7 ID:SGTC_518|Compound:1021-0119|FD-Score:3.98|P-value:4.76E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:4.78|P-value:3.29E-5 ID:SGTC_543|Compound:3844-1095|FD-Score:7.81|P-value:2.22E-11 ID:SGTC_562|Compound:3772-2733|FD-Score:6.08|P-value:1.66E-7 ID:SGTC_733|Compound:4069-0007|FD-Score:4.58|P-value:6.72E-5 ID:SGTC_751|Compound:0833-0568|FD-Score:3.94|P-value:5.51E-4 ID:SGTC_822|Compound:1487-0950|FD-Score:3.86|P-value:6.84E-4 ID:SGTC_864|Compound:0469-0573|FD-Score:-3.90|P-value:2.61E-4 ID:SGTC_870|Compound:0573-2213|FD-Score:7.71|P-value:3.85E-11 ID:SGTC_878|Compound:0828-0289|FD-Score:3.93|P-value:5.67E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:5.97|P-value:2.73E-7 ID:SGTC_888|Compound:0916-0002|FD-Score:4.51|P-value:8.53E-5 ID:SGTC_931|Compound:2812-0076|FD-Score:4.45|P-value:1.04E-4 ID:SGTC_961|Compound:1252-1571|FD-Score:6.49|P-value:2.36E-8 ID:SGTC_1008|Compound:4106-0037|FD-Score:4.51|P-value:8.50E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:3.82|P-value:7.72E-4 ID:SGTC_1055|Compound:3448-0672|FD-Score:3.86|P-value:6.90E-4 ID:SGTC_1068|Compound:loratadine|FD-Score:7.32|P-value:3.41E-10 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.71|P-value:4.75E-4 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.90|P-value:2.13E-5 ID:SGTC_1350|Compound:1495-0454|FD-Score:4.99|P-value:1.53E-5 ID:SGTC_1428|Compound:4049-0204|FD-Score:3.90|P-value:6.08E-4 ID:SGTC_1447|Compound:4239-0816|FD-Score:5.42|P-value:2.86E-6 ID:SGTC_1457|Compound:k015-0032|FD-Score:4.68|P-value:4.83E-5 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.93|P-value:5.53E-4 ID:SGTC_1472|Compound:k841-0093|FD-Score:6.24|P-value:7.97E-8 ID:SGTC_1514|Compound:1189-1591|FD-Score:7.88|P-value:1.46E-11 ID:SGTC_1567|Compound:st069303|FD-Score:3.92|P-value:5.80E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:4.97|P-value:1.67E-5 ID:SGTC_1635|Compound:st007035|FD-Score:-5.56|P-value:4.88E-7 ID:SGTC_1665|Compound:st014639|FD-Score:5.61|P-value:1.27E-6 ID:SGTC_1679|Compound:4130-1276|FD-Score:5.32|P-value:4.18E-6 ID:SGTC_1687|Compound:st020778|FD-Score:7.42|P-value:2.00E-10 ID:SGTC_1694|Compound:st024011|FD-Score:4.21|P-value:2.34E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-3.49|P-value:9.18E-4 ID:SGTC_1742|Compound:st038235|FD-Score:5.94|P-value:3.08E-7 ID:SGTC_1750|Compound:st081859|FD-Score:13.90|P-value:1.67E-32 ID:SGTC_1754|Compound:st042065|FD-Score:6.80|P-value:5.19E-9 ID:SGTC_1760|Compound:st045453|FD-Score:6.41|P-value:3.56E-8 ID:SGTC_1781|Compound:st038725|FD-Score:9.29|P-value:1.86E-15 ID:SGTC_1786|Compound:berberine|FD-Score:-3.81|P-value:3.44E-4 ID:SGTC_1847|Compound:st056231|FD-Score:4.14|P-value:2.90E-4 ID:SGTC_1854|Compound:st056233|FD-Score:4.22|P-value:2.27E-4 ID:SGTC_1889|Compound:st059080|FD-Score:-3.66|P-value:5.57E-4 ID:SGTC_2036|Compound:5160441|FD-Score:4.49|P-value:9.29E-5 ID:SGTC_2096|Compound:5468907|FD-Score:4.10|P-value:3.32E-4 ID:SGTC_2171|Compound:5739187|FD-Score:4.12|P-value:3.14E-4 ID:SGTC_2203|Compound:7227154|FD-Score:4.00|P-value:4.57E-4 ID:SGTC_2289|Compound:7946404|FD-Score:3.81|P-value:8.03E-4 ID:SGTC_2290|Compound:7904846|FD-Score:5.08|P-value:1.07E-5 ID:SGTC_2322|Compound:7413319|FD-Score:7.07|P-value:1.30E-9 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.86|P-value:6.96E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:3.96|P-value:5.13E-4 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:-3.65|P-value:5.69E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.84|P-value:7.40E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.74|P-value:9.84E-4 ID:SGTC_2912|Compound:7964298|FD-Score:4.68|P-value:4.81E-5 ID:SGTC_2951|Compound:9072950|FD-Score:6.65|P-value:1.11E-8 ID:SGTC_2954|Compound:9074818|FD-Score:3.92|P-value:5.79E-4 ID:SGTC_3077|Compound:9117319|FD-Score:4.22|P-value:2.28E-4 ID:SGTC_3078|Compound:9116413|FD-Score:4.51|P-value:8.75E-5 ID:SGTC_3098|Compound:9119039|FD-Score:5.04|P-value:1.26E-5 ID:SGTC_3155|Compound:9099265|FD-Score:7.88|P-value:1.47E-11 ID:SGTC_3237|Compound:9133362|FD-Score:5.03|P-value:1.29E-5

Top fitness defect scores for YDR159W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1750 st081859 13.90 2.4 µM 1.67E-32 endomembrane recycling 25 3.72E-44
2 SGTC_43 0570-0105 10.70 72.5 µM 4.29E-20 ERG2 9 3.44E-27
3 SGTC_221 trifluoperazine 10.60 10.3 µM 1.68E-19 NEO1-PIK1 54 2.23E-26
4 SGTC_1781 st038725 9.29 66.3 µM 1.86E-15 NEO1 21 7.64E-21
5 SGTC_439 amiodarone 8.88 34.4 µM 3.03E-14 NEO1-PIK1 17 3.48E-19
6 SGTC_1514 1189-1591 7.88 158.0 µM 1.46E-11 6 1.66E-15
7 SGTC_3155 9099265 7.88 49.5 µM 1.47E-11 2 1.66E-15
8 SGTC_543 3844-1095 7.81 191.0 µM 2.22E-11 ERG2 10 2.94E-15
9 SGTC_870 0573-2213 7.71 57.6 µM 3.85E-11 ERG2 1 6.25E-15
10 SGTC_1687 st020778 7.42 55.4 µM 2.00E-10 77 5.98E-14
11 SGTC_1068 loratadine 7.32 26.9 µM 3.41E-10 2 1.24E-13
12 SGTC_2322 7413319 7.07 38.2 µM 1.30E-9 ERAD & cell cycle 48 7.79E-13
13 SGTC_1754 st042065 6.80 16.1 µM 5.19E-9 NEO1-PIK1 79 5.21E-12
14 SGTC_2951 9072950 6.65 58.1 µM 1.11E-8 ERG2 5 1.48E-11
15 SGTC_156 3474-0145 6.50 5.6 µM 2.33E-8 endomembrane recycling 15 4.10E-11
16 SGTC_961 1252-1571 6.49 372.0 µM 2.36E-8 6 4.17E-11
17 SGTC_1760 st045453 6.41 10.4 µM 3.56E-8 NEO1-PIK1 76 7.31E-11
18 SGTC_1472 k841-0093 6.24 193.0 µM 7.97E-8 2 2.21E-10
19 SGTC_445 e6 berbamine 6.11 66.0 µM 1.45E-7 NEO1-PIK1 28 5.03E-10
20 SGTC_146 3448-8650 6.09 53.1 µM 1.61E-7 NEO1-PIK1 53 5.79E-10

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.461 9.58E-176 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.352 1.03E-97 YDR378C LSM6 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA
0.334 5.78E-88 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.317 1.17E-78 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.311 5.16E-76 YHR012W VPS29 hom Endosomal protein that is a subunit of the membrane-associated retromer complex essential for endosome-to-Golgi retrograde transport; forms a subcomplex with Vps35p and Vps26p that selects cargo proteins for endosome-to-Golgi retrieval
0.306 3.31E-73 YOR039W CKB2 hom Beta' regulatory subunit of casein kinase 2 (CK2), a Ser/Thr protein kinase with roles in cell growth and proliferation; CK2, comprised of CKA1, CKA2, CKB1 and CKB2, has many substrates including transcription factors and all RNA polymerase
0.289 2.39E-65 YNL267W PIK1 het Phosphatidylinositol 4-kinase; catalyzes first step in the biosynthesis of phosphatidylinositol-4,5-biphosphate; may control cytokinesis through the actin cytoskeleton
0.281 5.10E-62 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.280 1.71E-61 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.257 1.38E-51 YML037C_p YML037C_p hom Putative protein of unknown function with some characteristics of a transcriptional activator; may be a target of Dbf2p-Mob1p kinase; GFP-fusion protein co-localizes with clathrin-coated vesicles; YML037C is not an essential gene
0.253 3.71E-50 YHR108W GGA2 hom Protein that interacts with and regulates Arf1p and Arf2p in a GTP-dependent manner to facilitate traffic through the late Golgi; binds phosphatidylinositol 4-phosphate, which plays a role in TGN localization; has homology to gamma-adaptin
0.253 4.06E-50 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.246 1.64E-47 YBR246W RRT2 hom Protein required for last step of diphthamide biosynthesis; deletion leads to resistance to sordarin and accumulation of diphthine; WD40 domain-containing protein involved in endosomal recycling; forms a complex with Rtt10p that functions in the retromer-mediated pathway for recycling internalized cell-surface proteins; non-essential gene identified in a screen for mutants with increased levels of rDNA transcription
0.246 3.12E-47 YGR202C PCT1 hom Cholinephosphate cytidylyltransferase; a rate-determining enzyme of the CDP-choline pathway for phosphatidylcholine synthesis, inhibited by Sec14p, activated upon lipid-binding; contains an element within the regulatory domain involved in both silencing and activation of enzymatic activity
0.245 1.21E-46 YDL090C RAM1 hom Beta subunit of the CAAX farnesyltransferase (FTase) that prenylates the a-factor mating pheromone and Ras proteins; required for the membrane localization of Ras proteins and a-factor; homolog of the mammalian FTase beta subunit