Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YDR160W deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.126 | 2.37E-13 | YNR018W | RCF2 | hom | Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast |
0.125 | 4.32E-13 | YMR151W_d | YIM2_d | hom | Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1 |
0.123 | 1.03E-12 | YLR038C | COX12 | hom | Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV |
0.119 | 4.11E-12 | YGR183C | QCR9 | hom | Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex |
0.107 | 4.91E-10 | YKL155C | RSM22 | hom | Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase |
0.107 | 5.97E-10 | YKL115C_d | YKL115C_d | hom | Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1 |
0.105 | 1.06E-9 | YLL009C | COX17 | hom | Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs |
0.104 | 1.52E-9 | YBR120C | CBP6 | hom | Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex |
0.103 | 2.23E-9 | YEL059C-A | SOM1 | hom | Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs |
0.103 | 2.24E-9 | YCR011C | ADP1 | hom | Putative ATP-dependent permease of the ABC transporter family of proteins |
0.097 | 1.68E-8 | YKL188C | PXA2 | hom | Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder |
0.097 | 2.13E-8 | YGR161W-C_p | YGR161W-C_p | hom | Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species |
0.096 | 2.27E-8 | YPL189C-A | COA2 | hom | Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p |
0.095 | 2.99E-8 | YGL122C | NAB2 | het | Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress |
0.092 | 8.63E-8 | YMR132C_p | JLP2_p | hom | Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein) |