YDR160W / SSY1

Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR160W / SSY1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.51|P-value:9.93E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:2.94|P-value:9.08E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.51|P-value:9.80E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.24|P-value:3.52E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:3.25|P-value:2.78E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.99|P-value:7.62E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.00|P-value:7.35E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.76|P-value:4.08E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.94|P-value:1.45E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:5.09|P-value:3.54E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:3.03|P-value:6.42E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.00|P-value:8.37E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.64|P-value:4.46E-7 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.09|P-value:5.25E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.58|P-value:7.42E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.17|P-value:4.93E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-3.09|P-value:6.01E-4 ID:SGTC_1689|Compound:st020265|FD-Score:2.92|P-value:9.78E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.64|P-value:5.59E-5 ID:SGTC_1721|Compound:st082152|FD-Score:3.77|P-value:3.16E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.99|P-value:7.52E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.18|P-value:4.74E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.77|P-value:2.23E-7 ID:SGTC_1967|Compound:st070177|FD-Score:-3.68|P-value:5.57E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.86|P-value:1.34E-7 ID:SGTC_2012|Compound:4023501|FD-Score:5.17|P-value:2.23E-8 ID:SGTC_2064|Compound:5220758|FD-Score:3.78|P-value:3.06E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.81|P-value:2.64E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.26|P-value:2.76E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.12|P-value:4.60E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.92|P-value:9.65E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.20|P-value:3.98E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.42|P-value:1.46E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.94|P-value:8.65E-8 ID:SGTC_2450|Compound:5739737|FD-Score:3.54|P-value:8.73E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.72|P-value:4.07E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.35|P-value:1.88E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.16|P-value:4.02E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.32|P-value:2.51E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.05|P-value:6.14E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.19|P-value:4.54E-6 ID:SGTC_2915|Compound:7971052|FD-Score:2.98|P-value:7.74E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.30|P-value:3.26E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.17|P-value:3.79E-4 ID:SGTC_2983|Compound:9022671|FD-Score:2.95|P-value:8.76E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.73|P-value:3.91E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-2.99|P-value:8.55E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.23|P-value:3.06E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.18|P-value:4.80E-6 ID:SGTC_3132|Compound:9126706|FD-Score:-3.47|P-value:1.36E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.16|P-value:4.01E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.03|P-value:9.61E-6 ID:SGTC_58|Compound:0957-0393|FD-Score:3.37|P-value:1.75E-4 ID:SGTC_373|Compound:0844-0104|FD-Score:3.51|P-value:9.93E-5 ID:SGTC_386|Compound:1509-0011|FD-Score:2.94|P-value:9.08E-4 ID:SGTC_529|Compound:4076-0302|FD-Score:3.51|P-value:9.80E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:4.24|P-value:3.52E-6 ID:SGTC_542|Compound:3381-0244|FD-Score:3.25|P-value:2.78E-4 ID:SGTC_565|Compound:1418-0001|FD-Score:2.99|P-value:7.62E-4 ID:SGTC_891|Compound:0929-0073|FD-Score:3.00|P-value:7.35E-4 ID:SGTC_906|Compound:1165-0455|FD-Score:-3.76|P-value:4.08E-5 ID:SGTC_977|Compound:1348-1378|FD-Score:3.94|P-value:1.45E-5 ID:SGTC_983|Compound:1491-0821|FD-Score:5.09|P-value:3.54E-8 ID:SGTC_987|Compound:1497-1013|FD-Score:3.03|P-value:6.42E-4 ID:SGTC_1018|Compound:4259-0013|FD-Score:-3.00|P-value:8.37E-4 ID:SGTC_1290|Compound:0986-0249|FD-Score:4.64|P-value:4.46E-7 ID:SGTC_1435|Compound:4092-0789|FD-Score:3.09|P-value:5.25E-4 ID:SGTC_1634|Compound:st006576|FD-Score:3.58|P-value:7.42E-5 ID:SGTC_1635|Compound:st007035|FD-Score:4.17|P-value:4.93E-6 ID:SGTC_1660|Compound:st012960|FD-Score:-3.09|P-value:6.01E-4 ID:SGTC_1689|Compound:st020265|FD-Score:2.92|P-value:9.78E-4 ID:SGTC_1717|Compound:st033143|FD-Score:3.64|P-value:5.59E-5 ID:SGTC_1721|Compound:st082152|FD-Score:3.77|P-value:3.16E-5 ID:SGTC_1740|Compound:st038286|FD-Score:2.99|P-value:7.52E-4 ID:SGTC_1820|Compound:st053765|FD-Score:4.18|P-value:4.74E-6 ID:SGTC_1923|Compound:st058458|FD-Score:4.77|P-value:2.23E-7 ID:SGTC_1967|Compound:st070177|FD-Score:-3.68|P-value:5.57E-5 ID:SGTC_1970|Compound:st070122|FD-Score:4.86|P-value:1.34E-7 ID:SGTC_2012|Compound:4023501|FD-Score:5.17|P-value:2.23E-8 ID:SGTC_2064|Compound:5220758|FD-Score:3.78|P-value:3.06E-5 ID:SGTC_2073|Compound:5212005|FD-Score:3.81|P-value:2.64E-5 ID:SGTC_2106|Compound:5357045|FD-Score:3.26|P-value:2.76E-4 ID:SGTC_2198|Compound:6589944|FD-Score:3.12|P-value:4.60E-4 ID:SGTC_2309|Compound:7664088|FD-Score:2.92|P-value:9.65E-4 ID:SGTC_2334|Compound:9017922|FD-Score:-3.20|P-value:3.98E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.42|P-value:1.46E-4 ID:SGTC_2447|Compound:5741742|FD-Score:4.94|P-value:8.65E-8 ID:SGTC_2450|Compound:5739737|FD-Score:3.54|P-value:8.73E-5 ID:SGTC_2453|Compound:5731132|FD-Score:3.72|P-value:4.07E-5 ID:SGTC_2488|Compound:5268135|FD-Score:3.35|P-value:1.88E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.16|P-value:4.02E-4 ID:SGTC_2643|Compound:anethole|FD-Score:-3.32|P-value:2.51E-4 ID:SGTC_2707|Compound:st078556|FD-Score:3.05|P-value:6.14E-4 ID:SGTC_2816|Compound:7982706|FD-Score:4.19|P-value:4.54E-6 ID:SGTC_2915|Compound:7971052|FD-Score:2.98|P-value:7.74E-4 ID:SGTC_2931|Compound:9014674|FD-Score:-4.30|P-value:3.26E-6 ID:SGTC_2933|Compound:9026794|FD-Score:3.17|P-value:3.79E-4 ID:SGTC_2983|Compound:9022671|FD-Score:2.95|P-value:8.76E-4 ID:SGTC_2991|Compound:9074669|FD-Score:3.73|P-value:3.91E-5 ID:SGTC_2992|Compound:9074591|FD-Score:-2.99|P-value:8.55E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.23|P-value:3.06E-4 ID:SGTC_3131|Compound:9127911|FD-Score:4.18|P-value:4.80E-6 ID:SGTC_3132|Compound:9126706|FD-Score:-3.47|P-value:1.36E-4 ID:SGTC_3137|Compound:9097352|FD-Score:3.16|P-value:4.01E-4 ID:SGTC_3242|Compound:9133940|FD-Score:4.03|P-value:9.61E-6

Top fitness defect scores for YDR160W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2012 4023501 5.17 200.0 µM 2.23E-8 4 1.18E-7 0.29
2 SGTC_983 1491-0821 5.09 12.2 µM 3.54E-8 2 1.79E-7 0.64
3 SGTC_2447 5741742 4.94 33.8 µM 8.65E-8 5 3.98E-7 0.51
4 SGTC_1970 st070122 4.86 35.8 µM 1.34E-7 TSC3-RPN4 6 5.90E-7 0.63
5 SGTC_1923 st058458 4.77 19.1 µM 2.23E-7 7 9.34E-7 0.22
6 SGTC_1290 0986-0249 4.64 10.2 µM 4.46E-7 DNA intercalators 6 1.74E-6 0.05
7 SGTC_540 1187-0821 4.24 17.3 µM 3.52E-6 6 1.12E-5 0.33
8 SGTC_2816 7982706 4.19 58.4 µM 4.54E-6 azole & statin 8 1.40E-5 0.07
9 SGTC_1820 st053765 4.18 18.6 µM 4.74E-6 RPP1 & pyrimidine depletion 5 1.46E-5 0.15
10 SGTC_3131 9127911 4.18 49.5 µM 4.80E-6 7 1.47E-5 0.34
11 SGTC_1635 st007035 4.17 42.4 µM 4.93E-6 18 1.51E-5 0.10
12 SGTC_3242 9133940 4.03 49.5 µM 9.61E-6 3 2.75E-5 0.35
13 SGTC_977 1348-1378 3.94 135.0 µM 1.45E-5 10 4.00E-5 0.34
14 SGTC_2073 5212005 3.81 126.0 µM 2.64E-5 4 6.83E-5 0.00
15 SGTC_2064 5220758 3.78 200.0 µM 3.06E-5 11 7.80E-5 0.08
16 SGTC_1721 st082152 3.77 9.3 µM 3.16E-5 60S ribosome export 11 8.05E-5 0.12
17 SGTC_2991 9074669 3.73 71.4 µM 3.91E-5 azole & statin 21 9.72E-5 0.01
18 SGTC_2453 5731132 3.72 22.2 µM 4.07E-5 5 1.01E-4 8.06E-4
19 SGTC_1717 st033143 3.64 58.0 µM 5.59E-5 7 1.34E-4 0.02
20 SGTC_1634 st006576 3.58 41.0 µM 7.42E-5 TSC3-RPN4 12 1.73E-4 0.11

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 2.37E-13 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.125 4.32E-13 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.123 1.03E-12 YLR038C COX12 hom Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.119 4.11E-12 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.107 4.91E-10 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.107 5.97E-10 YKL115C_d YKL115C_d hom Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.105 1.06E-9 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.104 1.52E-9 YBR120C CBP6 hom Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.103 2.23E-9 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.103 2.24E-9 YCR011C ADP1 hom Putative ATP-dependent permease of the ABC transporter family of proteins
0.097 1.68E-8 YKL188C PXA2 hom Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.097 2.13E-8 YGR161W-C_p YGR161W-C_p hom Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.096 2.27E-8 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.095 2.99E-8 YGL122C NAB2 het Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.092 8.63E-8 YMR132C_p JLP2_p hom Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)