HIPHOP chemogenomics database

YDR160W / SSY1

Component of the SPS plasma membrane amino acid sensor system (Ssy1p-Ptr3p-Ssy5p), which senses external amino acid concentration and transmits intracellular signals that result in regulation of expression of amino acid permease genes

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR160W / SSY1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR160W deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2012	4023501	5.17	200.0 µM	2.23E-8		4	1.18E-7	0.29
2	SGTC_983	1491-0821	5.09	12.2 µM	3.54E-8		2	1.79E-7	0.64
3	SGTC_2447	5741742	4.94	33.8 µM	8.65E-8		5	3.98E-7	0.51
4	SGTC_1970	st070122	4.86	35.8 µM	1.34E-7	TSC3-RPN4	6	5.90E-7	0.63
5	SGTC_1923	st058458	4.77	19.1 µM	2.23E-7		7	9.34E-7	0.22
6	SGTC_1290	0986-0249	4.64	10.2 µM	4.46E-7	DNA intercalators	6	1.74E-6	0.05
7	SGTC_540	1187-0821	4.24	17.3 µM	3.52E-6		6	1.12E-5	0.33
8	SGTC_2816	7982706	4.19	58.4 µM	4.54E-6	azole & statin	8	1.40E-5	0.07
9	SGTC_1820	st053765	4.18	18.6 µM	4.74E-6	RPP1 & pyrimidine depletion	5	1.46E-5	0.15
10	SGTC_3131	9127911	4.18	49.5 µM	4.80E-6		7	1.47E-5	0.34
11	SGTC_1635	st007035	4.17	42.4 µM	4.93E-6		18	1.51E-5	0.10
12	SGTC_3242	9133940	4.03	49.5 µM	9.61E-6		3	2.75E-5	0.35
13	SGTC_977	1348-1378	3.94	135.0 µM	1.45E-5		10	4.00E-5	0.34
14	SGTC_2073	5212005	3.81	126.0 µM	2.64E-5		4	6.83E-5	0.00
15	SGTC_2064	5220758	3.78	200.0 µM	3.06E-5		11	7.80E-5	0.08
16	SGTC_1721	st082152	3.77	9.3 µM	3.16E-5	60S ribosome export	11	8.05E-5	0.12
17	SGTC_2991	9074669	3.73	71.4 µM	3.91E-5	azole & statin	21	9.72E-5	0.01
18	SGTC_2453	5731132	3.72	22.2 µM	4.07E-5		5	1.01E-4	8.06E-4
19	SGTC_1717	st033143	3.64	58.0 µM	5.59E-5		7	1.34E-4	0.02
20	SGTC_1634	st006576	3.58	41.0 µM	7.42E-5	TSC3-RPN4	12	1.73E-4	0.11

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.126	2.37E-13	YNR018W	RCF2	hom	Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.125	4.32E-13	YMR151W_d	YIM2_d	hom	Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.123	1.03E-12	YLR038C	COX12	hom	Subunit VIb of cytochrome c oxidase; cytochrome c oxidase is also known as respiratory Complex IV and is the terminal member of the mitochondrial inner membrane electron transport chain; required for assembly of cytochrome c oxidase but not required for activity after assembly; phosphorylated; easily released from the intermembrane space, suggesting a loose association with Complex IV
0.119	4.11E-12	YGR183C	QCR9	hom	Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.107	4.91E-10	YKL155C	RSM22	hom	Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.107	5.97E-10	YKL115C_d	YKL115C_d	hom	Dubious open reading frame, unlikely to encode a protein; partially overlaps the verified gene PRR1
0.105	1.06E-9	YLL009C	COX17	hom	Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.104	1.52E-9	YBR120C	CBP6	hom	Mitochondrial protein required for translation of the COB mRNA; forms a complex with Cbp3p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.103	2.23E-9	YEL059C-A	SOM1	hom	Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.103	2.24E-9	YCR011C	ADP1	hom	Putative ATP-dependent permease of the ABC transporter family of proteins
0.097	1.68E-8	YKL188C	PXA2	hom	Subunit of a heterodimeric peroxisomal ATP-binding cassette transporter complex (Pxa1p-Pxa2p), required for import of long-chain fatty acids into peroxisomes; similarity to human adrenoleukodystrophy transporter ABCD1 and ABCD2 and ALD-related proteins; mutations in ABCD1 cause X-linked adrenoleukodystrophy (X-ALD), a peroxisomal disorder
0.097	2.13E-8	YGR161W-C_p	YGR161W-C_p	hom	Putative protein of unknown function; identified by sequence comparison with hemiascomycetous yeast species
0.096	2.27E-8	YPL189C-A	COA2	hom	Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.095	2.99E-8	YGL122C	NAB2	het	Nuclear polyadenylated RNA-binding protein; required for nuclear mRNA export and poly(A) tail length control; binds nuclear pore protein Mlp1p; autoregulates mRNA levels; related to human hnRNPs; nuclear localization sequence binds Kap104p; protein abundance increases in response to DNA replication stress
0.092	8.63E-8	YMR132C_p	JLP2_p	hom	Protein of unknown function, contains sequence that closely resembles a J domain (typified by the E. coli DnaJ protein)