YDR162C / NBP2

Protein involved in the HOG (high osmolarity glycerol) pathway; negatively regulates Hog1p by recruitment of phosphatase Ptc1p the Pbs2p-Hog1p complex; interacts with Bck1p and down regulates the cell wall integrity pathway; found in the nucleus and cytoplasm, contains an SH3 domain and a Ptc1p binding domain (PBM)

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR162C / NBP2

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:5.22|P-value:5.50E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.78|P-value:1.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.59|P-value:1.86E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:-4.28|P-value:4.49E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.43|P-value:2.99E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.25|P-value:4.98E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:9.08|P-value:5.96E-12 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.18|P-value:3.15E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:5.88|P-value:6.31E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:5.46|P-value:2.58E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.48|P-value:1.17E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.60|P-value:7.47E-9 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.01|P-value:5.42E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:5.05|P-value:9.29E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-8.09|P-value:2.75E-10 ID:SGTC_301|Compound:4119-0100|FD-Score:5.17|P-value:6.49E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-10.80|P-value:8.01E-17 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.18|P-value:5.82E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:7.22|P-value:3.70E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:5.12|P-value:7.45E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.35|P-value:6.76E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:10.70|P-value:7.18E-16 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.00|P-value:5.55E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.03|P-value:9.96E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:4.45|P-value:5.14E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.23|P-value:9.05E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:6.75|P-value:2.59E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:5.49|P-value:2.33E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.10|P-value:8.12E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.23|P-value:5.11E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.85|P-value:1.70E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.40|P-value:3.22E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.02|P-value:5.23E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.08|P-value:8.47E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:4.35|P-value:6.73E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:4.51|P-value:4.32E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.27|P-value:4.70E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:4.71|P-value:2.50E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:8.42|P-value:1.62E-10 ID:SGTC_928|Compound:2764-0428|FD-Score:8.42|P-value:1.61E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:8.61|P-value:6.43E-11 ID:SGTC_953|Compound:1188-0045|FD-Score:-10.40|P-value:8.89E-16 ID:SGTC_958|Compound:1222-0007|FD-Score:8.45|P-value:1.43E-10 ID:SGTC_962|Compound:1254-0300|FD-Score:-8.43|P-value:5.26E-11 ID:SGTC_963|Compound:1269-2853|FD-Score:4.64|P-value:3.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:39.70|P-value:1.21E-197 ID:SGTC_965|Compound:1291-5240|FD-Score:5.44|P-value:2.77E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:9.20|P-value:3.09E-12 ID:SGTC_999|Compound:4022-0066|FD-Score:5.83|P-value:7.61E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.34|P-value:6.92E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.57|P-value:2.01E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.22|P-value:5.24E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.72|P-value:2.44E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.53|P-value:4.18E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.38|P-value:6.12E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.87|P-value:6.57E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-6.57|P-value:2.14E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.89|P-value:1.50E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:5.00|P-value:1.07E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.65|P-value:2.94E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.31|P-value:4.21E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.21|P-value:9.60E-4 ID:SGTC_1608|Compound:st001473|FD-Score:6.10|P-value:2.99E-6 ID:SGTC_1627|Compound:st003713|FD-Score:6.38|P-value:1.04E-6 ID:SGTC_1632|Compound:st005650|FD-Score:4.87|P-value:1.60E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.77|P-value:2.10E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.21|P-value:5.68E-5 ID:SGTC_1760|Compound:st045453|FD-Score:7.66|P-value:5.57E-9 ID:SGTC_1773|Compound:st048542|FD-Score:5.89|P-value:6.06E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.28|P-value:1.55E-6 ID:SGTC_1797|Compound:st048695|FD-Score:7.28|P-value:2.90E-8 ID:SGTC_1800|Compound:st050079|FD-Score:4.58|P-value:3.59E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.90|P-value:6.00E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-5.04|P-value:4.83E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.04|P-value:9.87E-10 ID:SGTC_1884|Compound:5633444|FD-Score:4.99|P-value:1.11E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-5.41|P-value:1.48E-5 ID:SGTC_1903|Compound:st060211|FD-Score:5.08|P-value:8.40E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-4.57|P-value:2.02E-4 ID:SGTC_1962|Compound:st076595|FD-Score:6.39|P-value:1.01E-6 ID:SGTC_2055|Compound:5235184|FD-Score:4.67|P-value:2.85E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.22|P-value:9.29E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.55|P-value:3.93E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.66|P-value:2.87E-4 ID:SGTC_2242|Compound:6630449|FD-Score:6.80|P-value:2.14E-7 ID:SGTC_2254|Compound:7938975|FD-Score:6.42|P-value:9.18E-7 ID:SGTC_2277|Compound:7947813|FD-Score:4.30|P-value:7.61E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.84|P-value:1.76E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.93|P-value:1.35E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.41|P-value:5.74E-4 ID:SGTC_2485|Compound:5633444|FD-Score:6.69|P-value:3.26E-7 ID:SGTC_2526|Compound:patulin|FD-Score:9.16|P-value:3.84E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:5.13|P-value:7.38E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.20|P-value:5.84E-5 ID:SGTC_2601|Compound:securinine|FD-Score:5.33|P-value:3.93E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.32|P-value:7.22E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.41|P-value:3.07E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.42|P-value:5.62E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.29|P-value:2.83E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:-5.14|P-value:3.61E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.70|P-value:4.87E-16 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.85|P-value:1.74E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:6.53|P-value:5.99E-7 ID:SGTC_2781|Compound:5567276|FD-Score:8.77|P-value:2.85E-11 ID:SGTC_2790|Compound:5423970|FD-Score:6.91|P-value:1.33E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-4.33|P-value:3.94E-4 ID:SGTC_2912|Compound:7964298|FD-Score:12.30|P-value:1.29E-20 ID:SGTC_2947|Compound:9072639|FD-Score:4.91|P-value:1.40E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.59|P-value:3.50E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.68|P-value:2.75E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.74|P-value:1.04E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.09|P-value:7.39E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.27|P-value:8.22E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.33|P-value:1.26E-6 ID:SGTC_3204|Compound:9114183|FD-Score:7.93|P-value:1.68E-9 ID:SGTC_3219|Compound:9131112|FD-Score:10.10|P-value:2.54E-14 ID:SGTC_3234|Compound:9132280|FD-Score:5.77|P-value:9.41E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-5.99|P-value:1.95E-6 ID:SGTC_3303|Compound:9125618|FD-Score:4.46|P-value:4.97E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:5.22|P-value:5.50E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:-4.78|P-value:1.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.59|P-value:1.86E-4 ID:SGTC_63|Compound:0099-0242|FD-Score:-4.28|P-value:4.49E-4 ID:SGTC_67|Compound:0335-0847|FD-Score:-4.43|P-value:2.99E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:5.25|P-value:4.98E-5 ID:SGTC_71|Compound:0417-1750|FD-Score:9.08|P-value:5.96E-12 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.18|P-value:3.15E-5 ID:SGTC_77|Compound:0828-0286|FD-Score:5.88|P-value:6.31E-6 ID:SGTC_138|Compound:0850-0259|FD-Score:5.46|P-value:2.58E-5 ID:SGTC_163|Compound:1327-0036|FD-Score:-5.48|P-value:1.17E-5 ID:SGTC_221|Compound:trifluoperazine|FD-Score:7.60|P-value:7.47E-9 ID:SGTC_255|Compound:tunicamycin|FD-Score:-5.01|P-value:5.42E-5 ID:SGTC_270|Compound:tamoxifen|FD-Score:5.05|P-value:9.29E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-8.09|P-value:2.75E-10 ID:SGTC_301|Compound:4119-0100|FD-Score:5.17|P-value:6.49E-5 ID:SGTC_310|Compound:1273-0058|FD-Score:-10.80|P-value:8.01E-17 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.18|P-value:5.82E-4 ID:SGTC_360|Compound:0957-0399|FD-Score:7.22|P-value:3.70E-8 ID:SGTC_384|Compound:k007-0144|FD-Score:5.12|P-value:7.45E-5 ID:SGTC_426|Compound:0988-0037|FD-Score:4.35|P-value:6.76E-4 ID:SGTC_439|Compound:amiodarone|FD-Score:10.70|P-value:7.18E-16 ID:SGTC_513|Compound:4245-1575|FD-Score:-5.00|P-value:5.55E-5 ID:SGTC_514|Compound:4466-0038|FD-Score:5.03|P-value:9.96E-5 ID:SGTC_524|Compound:r073-0010|FD-Score:4.45|P-value:5.14E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.23|P-value:9.05E-4 ID:SGTC_574|Compound:1315-0397|FD-Score:6.75|P-value:2.59E-7 ID:SGTC_576|Compound:1073-0113|FD-Score:5.49|P-value:2.33E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:5.10|P-value:8.12E-5 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.23|P-value:5.11E-4 ID:SGTC_666|Compound:0272-0154|FD-Score:4.85|P-value:1.70E-4 ID:SGTC_689|Compound:0833-0039|FD-Score:-4.40|P-value:3.22E-4 ID:SGTC_690|Compound:glyoxal|FD-Score:-5.02|P-value:5.23E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:5.08|P-value:8.47E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:4.35|P-value:6.73E-4 ID:SGTC_835|Compound:0312-0010|FD-Score:4.51|P-value:4.32E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:5.27|P-value:4.70E-5 ID:SGTC_878|Compound:0828-0289|FD-Score:4.71|P-value:2.50E-4 ID:SGTC_879|Compound:0831-1030|FD-Score:8.42|P-value:1.62E-10 ID:SGTC_928|Compound:2764-0428|FD-Score:8.42|P-value:1.61E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:8.61|P-value:6.43E-11 ID:SGTC_953|Compound:1188-0045|FD-Score:-10.40|P-value:8.89E-16 ID:SGTC_958|Compound:1222-0007|FD-Score:8.45|P-value:1.43E-10 ID:SGTC_962|Compound:1254-0300|FD-Score:-8.43|P-value:5.26E-11 ID:SGTC_963|Compound:1269-2853|FD-Score:4.64|P-value:3.08E-4 ID:SGTC_964|Compound:1287-0107|FD-Score:39.70|P-value:1.21E-197 ID:SGTC_965|Compound:1291-5240|FD-Score:5.44|P-value:2.77E-5 ID:SGTC_966|Compound:1300-0360|FD-Score:9.20|P-value:3.09E-12 ID:SGTC_999|Compound:4022-0066|FD-Score:5.83|P-value:7.61E-6 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.34|P-value:6.92E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.57|P-value:2.01E-4 ID:SGTC_1044|Compound:1222-0021|FD-Score:-4.22|P-value:5.24E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:4.72|P-value:2.44E-4 ID:SGTC_1060|Compound:3448-7350|FD-Score:4.53|P-value:4.18E-4 ID:SGTC_1078|Compound:idebenone|FD-Score:4.38|P-value:6.12E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:5.87|P-value:6.57E-6 ID:SGTC_1204|Compound:4049-0315|FD-Score:-6.57|P-value:2.14E-7 ID:SGTC_1216|Compound:1165-0504|FD-Score:4.89|P-value:1.50E-4 ID:SGTC_1420|Compound:4'-methoxyflavone|FD-Score:5.00|P-value:1.07E-4 ID:SGTC_1494|Compound:4358-1428|FD-Score:4.65|P-value:2.94E-4 ID:SGTC_1581|Compound:himbacine|FD-Score:5.31|P-value:4.21E-5 ID:SGTC_1595|Compound:6-ethoxy-3(4'-hydroxyphenyl)-4-methylcoumarin|FD-Score:4.21|P-value:9.60E-4 ID:SGTC_1608|Compound:st001473|FD-Score:6.10|P-value:2.99E-6 ID:SGTC_1627|Compound:st003713|FD-Score:6.38|P-value:1.04E-6 ID:SGTC_1632|Compound:st005650|FD-Score:4.87|P-value:1.60E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:4.77|P-value:2.10E-4 ID:SGTC_1754|Compound:st042065|FD-Score:5.21|P-value:5.68E-5 ID:SGTC_1760|Compound:st045453|FD-Score:7.66|P-value:5.57E-9 ID:SGTC_1773|Compound:st048542|FD-Score:5.89|P-value:6.06E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:6.28|P-value:1.55E-6 ID:SGTC_1797|Compound:st048695|FD-Score:7.28|P-value:2.90E-8 ID:SGTC_1800|Compound:st050079|FD-Score:4.58|P-value:3.59E-4 ID:SGTC_1803|Compound:st050068|FD-Score:5.90|P-value:6.00E-6 ID:SGTC_1829|Compound:berberine|FD-Score:-5.04|P-value:4.83E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:8.04|P-value:9.87E-10 ID:SGTC_1884|Compound:5633444|FD-Score:4.99|P-value:1.11E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:-5.41|P-value:1.48E-5 ID:SGTC_1903|Compound:st060211|FD-Score:5.08|P-value:8.40E-5 ID:SGTC_1958|Compound:st076513|FD-Score:-4.57|P-value:2.02E-4 ID:SGTC_1962|Compound:st076595|FD-Score:6.39|P-value:1.01E-6 ID:SGTC_2055|Compound:5235184|FD-Score:4.67|P-value:2.85E-4 ID:SGTC_2068|Compound:5226020|FD-Score:4.22|P-value:9.29E-4 ID:SGTC_2085|Compound:5307070|FD-Score:4.55|P-value:3.93E-4 ID:SGTC_2137|Compound:5261020|FD-Score:4.66|P-value:2.87E-4 ID:SGTC_2242|Compound:6630449|FD-Score:6.80|P-value:2.14E-7 ID:SGTC_2254|Compound:7938975|FD-Score:6.42|P-value:9.18E-7 ID:SGTC_2277|Compound:7947813|FD-Score:4.30|P-value:7.61E-4 ID:SGTC_2315|Compound:7733312|FD-Score:4.84|P-value:1.76E-4 ID:SGTC_2322|Compound:7413319|FD-Score:4.93|P-value:1.35E-4 ID:SGTC_2385|Compound:9074692|FD-Score:4.41|P-value:5.74E-4 ID:SGTC_2485|Compound:5633444|FD-Score:6.69|P-value:3.26E-7 ID:SGTC_2526|Compound:patulin|FD-Score:9.16|P-value:3.84E-12 ID:SGTC_2584|Compound:androsterone|FD-Score:5.13|P-value:7.38E-5 ID:SGTC_2592|Compound:piperlongumine|FD-Score:5.20|P-value:5.84E-5 ID:SGTC_2601|Compound:securinine|FD-Score:5.33|P-value:3.93E-5 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.32|P-value:7.22E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.41|P-value:3.07E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:4.42|P-value:5.62E-4 ID:SGTC_2619|Compound:obliquin|FD-Score:7.29|P-value:2.83E-8 ID:SGTC_2651|Compound:1327-0036|FD-Score:-5.14|P-value:3.61E-5 ID:SGTC_2688|Compound:kanamycin b|FD-Score:10.70|P-value:4.87E-16 ID:SGTC_2697|Compound:mebhydrolin|FD-Score:6.85|P-value:1.74E-7 ID:SGTC_2776|Compound:terbinafine|FD-Score:6.53|P-value:5.99E-7 ID:SGTC_2781|Compound:5567276|FD-Score:8.77|P-value:2.85E-11 ID:SGTC_2790|Compound:5423970|FD-Score:6.91|P-value:1.33E-7 ID:SGTC_2858|Compound:9025781|FD-Score:-4.33|P-value:3.94E-4 ID:SGTC_2912|Compound:7964298|FD-Score:12.30|P-value:1.29E-20 ID:SGTC_2947|Compound:9072639|FD-Score:4.91|P-value:1.40E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.59|P-value:3.50E-4 ID:SGTC_3003|Compound:9075612|FD-Score:4.68|P-value:2.75E-4 ID:SGTC_3037|Compound:9091026|FD-Score:5.74|P-value:1.04E-5 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.09|P-value:7.39E-4 ID:SGTC_3098|Compound:9119039|FD-Score:4.27|P-value:8.22E-4 ID:SGTC_3152|Compound:9099253|FD-Score:6.33|P-value:1.26E-6 ID:SGTC_3204|Compound:9114183|FD-Score:7.93|P-value:1.68E-9 ID:SGTC_3219|Compound:9131112|FD-Score:10.10|P-value:2.54E-14 ID:SGTC_3234|Compound:9132280|FD-Score:5.77|P-value:9.41E-6 ID:SGTC_3286|Compound:9117135|FD-Score:-5.99|P-value:1.95E-6 ID:SGTC_3303|Compound:9125618|FD-Score:4.46|P-value:4.97E-4

Top fitness defect scores for YDR162C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_964 1287-0107 39.70 19.4 µM 1.21E-197 cell wall 1 0
2 SGTC_2912 7964298 12.30 10.9 µM 1.29E-20 cell wall 10 3.56E-35
3 SGTC_2688 kanamycin b 10.70 96.7 µM 4.87E-16 calcium & mitochondrial duress 19 3.83E-27
4 SGTC_439 amiodarone 10.70 34.4 µM 7.18E-16 NEO1-PIK1 12 7.55E-27
5 SGTC_3219 9131112 10.10 49.5 µM 2.54E-14 Golgi 4 3.95E-24
6 SGTC_966 1300-0360 9.20 30.2 µM 3.09E-12 heme requiring 2 1.79E-20
7 SGTC_2526 patulin 9.16 37.6 µM 3.84E-12 10 2.62E-20
8 SGTC_71 0417-1750 9.08 47.8 µM 5.96E-12 Golgi 7 5.67E-20
9 SGTC_2781 5567276 8.77 71.4 µM 2.85E-11 5 8.83E-19
10 SGTC_934 2950-0684 8.61 338.0 µM 6.43E-11 1 3.67E-18
11 SGTC_958 1222-0007 8.45 33.0 µM 1.43E-10 1 1.49E-17
12 SGTC_928 2764-0428 8.42 58.7 µM 1.61E-10 cell wall 6 1.84E-17
13 SGTC_879 0831-1030 8.42 162.0 µM 1.62E-10 6 1.85E-17
14 SGTC_1844 rapamycin 8.04 4.0 nM 9.87E-10 56 4.40E-16
15 SGTC_3204 9114183 7.93 49.5 µM 1.68E-9 3 1.12E-15
16 SGTC_1760 st045453 7.66 10.4 µM 5.57E-9 NEO1-PIK1 58 9.12E-15
17 SGTC_221 trifluoperazine 7.60 10.3 µM 7.47E-9 NEO1-PIK1 90 1.53E-14
18 SGTC_2619 obliquin 7.29 87.9 µM 2.83E-8 cell wall 52 1.57E-13
19 SGTC_1797 st048695 7.28 56.8 µM 2.90E-8 NEO1 27 1.64E-13
20 SGTC_360 0957-0399 7.22 1.0 µM 3.70E-8 cell wall 8 2.52E-13

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.252 1.26E-49 YDL006W PTC1 hom Type 2C protein phosphatase (PP2C); dephosphorylates Hog1p, inactivating osmosensing MAPK cascade; involved in Fus3p activation during pheromone response; deletion affects precursor tRNA splicing, mitochondrial inheritance, and sporulation
0.237 7.24E-44 YBR023C CHS3 hom Chitin synthase III, catalyzes the transfer of N-acetylglucosamine (GlcNAc) to chitin; required for synthesis of the majority of cell wall chitin, the chitin ring during bud emergence, and spore wall chitosan
0.236 1.39E-43 YDR389W SAC7 hom GTPase activating protein (GAP) for Rho1p, involved in signaling to the actin cytoskeleton, null mutations suppress tor2 mutations and temperature sensitive mutations in actin; potential Cdc28p substrate
0.232 3.83E-42 YPL066W RGL1 hom Regulator of Rho1p signaling, cofactor of Tus1p; required for the localization of Tus1p during all phases of cytokinesis; green fluorescent protein (GFP)-fusion protein localizes to the bud neck and cytoplasm; null mutant is viable and exhibits growth defect on a non-fermentable (respiratory) carbon source
0.228 9.81E-41 YPL065W VPS28 hom Component of the ESCRT-I complex (Stp22p, Srn2p, Vps28p, and Mvb12p), which is involved in ubiquitin-dependent sorting of proteins into the endosome; conserved C-terminal domain interacts with ESCRT-III subunit Vps20p
0.228 1.43E-40 YBL061C SKT5 hom Activator of Chs3p (chitin synthase III) during vegetative growth; recruits Chs3p to the bud neck via interaction with Bni4p; SKT5 has a paralog, SHC1, that arose from the whole genome duplication
0.227 2.22E-40 YJR102C VPS25 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome
0.222 1.44E-38 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.220 5.01E-38 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.215 2.89E-36 YCL008C STP22 hom Component of the ESCRT-I complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; homologous to the mouse and human Tsg101 tumor susceptibility gene; mutants exhibit a Class E Vps phenotype
0.211 3.99E-35 YJL053W PEP8 hom Vacuolar protein component of the retromer; forms part of the multimeric membrane-associated retromer complex involved in vacuolar protein sorting along with Vps35p, Vps29p, Vps17p, and Vps5p; essential for endosome-to-Golgi retrograde protein transport; interacts with Ypt7p; protein abundance increases in response to DNA replication stress
0.211 8.43E-35 YHR004C NEM1 hom Probable catalytic subunit of Nem1p-Spo7p phosphatase holoenzyme; regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology and sporulation; homolog of the human protein Dullard
0.209 2.03E-34 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.209 2.65E-34 YJL124C LSM1 hom Lsm (Like Sm) protein; forms heteroheptameric complex (with Lsm2p, Lsm3p, Lsm4p, Lsm5p, Lsm6p, and Lsm7p) involved in degradation of cytoplasmic mRNAs; unlike most Sm-like proteins, Lsm1p requires both its SM-domain and C-terminal domain for RNA-binding; forms cytoplasmic foci upon DNA replication stress
0.209 3.00E-34 YLR025W SNF7 hom One of four subunits of the endosomal sorting complex required for transport III (ESCRT-III); involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes