YDR163W / CWC15

Non-essential protein involved in pre-mRNA splicing, component of a complex containing Cef1p; has similarity to S. pombe Cwf15p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR163W / CWC15

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:2.98|P-value:7.83E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.78|P-value:2.94E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.14|P-value:1.23E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.06|P-value:4.20E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.27|P-value:1.70E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.04|P-value:6.24E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.30|P-value:1.60E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.10|P-value:3.56E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.93|P-value:9.25E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.07|P-value:3.96E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.51|P-value:6.44E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.45|P-value:8.26E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:-3.13|P-value:3.11E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.12|P-value:3.25E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.92|P-value:1.49E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.56|P-value:7.72E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.23|P-value:2.15E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.10|P-value:4.97E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.27|P-value:1.80E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.21|P-value:3.64E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.96|P-value:6.21E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.79|P-value:1.62E-7 ID:SGTC_2193|Compound:5925765|FD-Score:2.99|P-value:7.49E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.75|P-value:3.33E-5 ID:SGTC_2570|Compound:licareol|FD-Score:4.18|P-value:4.27E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.82|P-value:8.06E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:1.90E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.94|P-value:9.20E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.61|P-value:6.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.74|P-value:2.36E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.48|P-value:7.28E-5 ID:SGTC_2698|Compound:st077697|FD-Score:2.92|P-value:9.69E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.97|P-value:8.16E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.03|P-value:4.65E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.55|P-value:7.95E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.38|P-value:1.65E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.57|P-value:4.93E-5 ID:SGTC_2948|Compound:9070189|FD-Score:4.62|P-value:4.12E-7 ID:SGTC_2968|Compound:9090663|FD-Score:8.23|P-value:6.23E-19 ID:SGTC_2970|Compound:9090938|FD-Score:5.79|P-value:3.07E-10 ID:SGTC_2988|Compound:9073640|FD-Score:4.99|P-value:5.11E-8 ID:SGTC_3098|Compound:9119039|FD-Score:4.04|P-value:8.60E-6 ID:SGTC_3141|Compound:9094609|FD-Score:4.47|P-value:9.42E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-5.24|P-value:6.24E-9 ID:SGTC_3192|Compound:9110362|FD-Score:-3.27|P-value:1.81E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.84|P-value:2.19E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-2.93|P-value:6.92E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.87|P-value:1.88E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-3.09|P-value:3.67E-4 ID:SGTC_3344|Compound:9148862|FD-Score:2.94|P-value:9.17E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:2.98|P-value:7.83E-4 ID:SGTC_50|Compound:0929-0078|FD-Score:3.78|P-value:2.94E-5 ID:SGTC_58|Compound:0957-0393|FD-Score:-5.14|P-value:1.23E-8 ID:SGTC_62|Compound:0180-0423|FD-Score:-3.06|P-value:4.20E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.27|P-value:1.70E-6 ID:SGTC_571|Compound:k831-0106|FD-Score:3.04|P-value:6.24E-4 ID:SGTC_877|Compound:0771-0151|FD-Score:-3.30|P-value:1.60E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.10|P-value:3.56E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:-3.93|P-value:9.25E-6 ID:SGTC_1190|Compound:1486-1332|FD-Score:-3.07|P-value:3.96E-4 ID:SGTC_1316|Compound:1272-0050|FD-Score:-3.51|P-value:6.44E-5 ID:SGTC_1336|Compound:1486-0901|FD-Score:-3.45|P-value:8.26E-5 ID:SGTC_1344|Compound:1488-0097|FD-Score:-3.13|P-value:3.11E-4 ID:SGTC_1350|Compound:1495-0454|FD-Score:-3.12|P-value:3.25E-4 ID:SGTC_1359|Compound:1582-0056|FD-Score:3.92|P-value:1.49E-5 ID:SGTC_1360|Compound:1598-0022|FD-Score:3.56|P-value:7.72E-5 ID:SGTC_1370|Compound:2001-0092|FD-Score:-3.23|P-value:2.15E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:3.10|P-value:4.97E-4 ID:SGTC_1682|Compound:st012968|FD-Score:-3.27|P-value:1.80E-4 ID:SGTC_1747|Compound:st037496|FD-Score:3.18|P-value:3.64E-4 ID:SGTC_1892|Compound:st058411|FD-Score:4.21|P-value:3.64E-6 ID:SGTC_1984|Compound:st072354|FD-Score:-2.96|P-value:6.21E-4 ID:SGTC_2048|Compound:5246248|FD-Score:2.95|P-value:8.67E-4 ID:SGTC_2049|Compound:5262831|FD-Score:4.79|P-value:1.62E-7 ID:SGTC_2193|Compound:5925765|FD-Score:2.99|P-value:7.49E-4 ID:SGTC_2255|Compound:7941087|FD-Score:3.75|P-value:3.33E-5 ID:SGTC_2570|Compound:licareol|FD-Score:4.18|P-value:4.27E-6 ID:SGTC_2582|Compound:agaric acid|FD-Score:-4.82|P-value:8.06E-8 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:3.35|P-value:1.90E-4 ID:SGTC_2645|Compound:abamectin|FD-Score:2.94|P-value:9.20E-4 ID:SGTC_2647|Compound:atorvastatin|FD-Score:3.61|P-value:6.12E-5 ID:SGTC_2651|Compound:1327-0036|FD-Score:-3.74|P-value:2.36E-5 ID:SGTC_2665|Compound:lovastatin|FD-Score:-3.48|P-value:7.28E-5 ID:SGTC_2698|Compound:st077697|FD-Score:2.92|P-value:9.69E-4 ID:SGTC_2713|Compound:st079149|FD-Score:2.97|P-value:8.16E-4 ID:SGTC_2763|Compound:lisinopril|FD-Score:-3.03|P-value:4.65E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.55|P-value:7.95E-5 ID:SGTC_2824|Compound:7998404|FD-Score:3.38|P-value:1.65E-4 ID:SGTC_2900|Compound:5328528|FD-Score:-3.57|P-value:4.93E-5 ID:SGTC_2948|Compound:9070189|FD-Score:4.62|P-value:4.12E-7 ID:SGTC_2968|Compound:9090663|FD-Score:8.23|P-value:6.23E-19 ID:SGTC_2970|Compound:9090938|FD-Score:5.79|P-value:3.07E-10 ID:SGTC_2988|Compound:9073640|FD-Score:4.99|P-value:5.11E-8 ID:SGTC_3098|Compound:9119039|FD-Score:4.04|P-value:8.60E-6 ID:SGTC_3141|Compound:9094609|FD-Score:4.47|P-value:9.42E-7 ID:SGTC_3144|Compound:9087057|FD-Score:-5.24|P-value:6.24E-9 ID:SGTC_3192|Compound:9110362|FD-Score:-3.27|P-value:1.81E-4 ID:SGTC_3198|Compound:9112019|FD-Score:3.84|P-value:2.19E-5 ID:SGTC_3245|Compound:9134821|FD-Score:3.27|P-value:2.55E-4 ID:SGTC_3301|Compound:9125354|FD-Score:-2.93|P-value:6.92E-4 ID:SGTC_3308|Compound:9128332|FD-Score:3.87|P-value:1.88E-5 ID:SGTC_3318|Compound:9139014|FD-Score:-3.09|P-value:3.67E-4 ID:SGTC_3344|Compound:9148862|FD-Score:2.94|P-value:9.17E-4

Top fitness defect scores for YDR163W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2968 9090663 8.23 33.4 µM 6.23E-19 2 9.39E-17
2 SGTC_2970 9090938 5.79 41.9 µM 3.07E-10 RNA processing & uracil transport 5 3.48E-9
3 SGTC_2988 9073640 4.99 71.4 µM 5.11E-8 12 3.03E-7
4 SGTC_2049 5262831 4.79 67.2 µM 1.62E-7 14 8.29E-7
5 SGTC_2948 9070189 4.62 9.4 µM 4.12E-7 plasma membrane duress 36 1.88E-6
6 SGTC_3141 9094609 4.47 49.5 µM 9.42E-7 iron homeostasis 27 3.88E-6
7 SGTC_1892 st058411 4.21 7.4 µM 3.64E-6 16 1.27E-5
8 SGTC_2570 licareol 4.18 100.0 µM 4.27E-6 25 1.46E-5
9 SGTC_3098 9119039 4.04 49.5 µM 8.60E-6 Golgi 33 2.70E-5
10 SGTC_1359 1582-0056 3.92 520.0 nM 1.49E-5 19 4.37E-5
11 SGTC_3308 9128332 3.87 17.6 µM 1.88E-5 plasma membrane duress 79 5.35E-5
12 SGTC_3198 9112019 3.84 49.5 µM 2.19E-5 mitochondrial processes 17 6.12E-5
13 SGTC_50 0929-0078 3.78 56.4 µM 2.94E-5 52 7.94E-5
14 SGTC_2255 7941087 3.75 197.4 µM 3.33E-5 37 8.85E-5
15 SGTC_2647 atorvastatin 3.61 60.2 µM 6.12E-5 azole & statin 25 1.51E-4
16 SGTC_1360 1598-0022 3.56 39.8 µM 7.72E-5 ERG2 47 1.86E-4
17 SGTC_2823 7987624 3.55 58.4 µM 7.95E-5 47 1.90E-4
18 SGTC_2824 7998404 3.38 52.0 µM 1.65E-4 52 3.62E-4
19 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 3.35 70.0 µM 1.90E-4 redox potentiating 101 4.10E-4
20 SGTC_3245 9134821 3.27 49.5 µM 2.55E-4 39 5.31E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.149 4.32E-18 YNL067W RPL9B hom Ribosomal 60S subunit protein L9B; nearly identical to paralog Rpl9Ap; homologous to mammalian ribosomal protein L9 and bacterial L6
0.146 2.16E-17 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.144 4.13E-17 YDR156W RPA14 hom RNA polymerase I subunit A14
0.126 2.40E-13 YDR500C RPL37B hom Ribosomal 60S subunit protein L37B; protein abundance increases in response to DNA replication stress; homologous to mammalian ribosomal protein L37, no bacterial homolog; RPL37B has a paralog, RPL37A, that arose from the whole genome duplication
0.116 1.33E-11 YDR050C TPI1 het Triose phosphate isomerase, abundant glycolytic enzyme; mRNA half-life is regulated by iron availability; transcription is controlled by activators Reb1p, Gcr1p, and Rap1p through binding sites in the 5' non-coding region; inhibition of Tpi1p activity by PEP (phosphoenolpyruvate) stimulates redox metabolism in respiring cells; E104D mutation in human TPI causes a rare autosomal disease
0.114 2.94E-11 YGR159C NSR1 hom Nucleolar protein that binds nuclear localization sequences, required for pre-rRNA processing and ribosome biogenesis
0.114 3.24E-11 YOL079W_d YOL079W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.110 2.03E-10 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.106 6.17E-10 YLR367W RPS22B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S15A and bacterial S8; RPS22B has a paralog, RPS22A, that arose from the whole genome duplication
0.097 1.71E-8 YKL074C MUD2 hom Protein involved in early pre-mRNA splicing; component of the pre-mRNA-U1 snRNP complex, the commitment complex; interacts with Msl5p/BBP splicing factor and Sub2p; similar to metazoan splicing factor U2AF65
0.096 2.31E-8 YBR249C ARO4 hom 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP) synthase; catalyzes the first step in aromatic amino acid biosynthesis and is feedback-inhibited by tyrosine or high concentrations of phenylalanine or tryptophan; relative distribution to the nucleus increases upon DNA replication stress
0.092 9.60E-8 YDR496C PUF6 hom Pumilio-homology domain protein that binds the 3' UTR of ASH1 mRNA and represses its translation, resulting in proper asymmetric localization of ASH1 mRNA; also co-sediments with the 60S ribosomal subunit and is required for its biogenesis
0.090 1.77E-7 YDL196W_d YDL196W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; open reading frame is located in promoter region of essential gene SEC31
0.089 2.11E-7 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.089 2.15E-7 YER007C-A TMA20 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress