HIPHOP chemogenomics database

YDR164C / SEC1

Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR164C / SEC1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR164C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_219	mitoxanthrone	10.80	164.4 µM	4.27E-28	DNA intercalators	2	1.03E-27	2.52
2	SGTC_52	0329-0193	7.63	875.0 nM	7.93E-15	TSC3-RPN4	1	1.20E-14	1.45
3	SGTC_2625	euphol	5.36	100.0 µM	3.39E-8		3	4.10E-8	0.54
4	SGTC_2288	7946289	4.96	167.3 µM	3.00E-7		3	3.51E-7	0.35
5	SGTC_1252	0493-0875	4.87	34.8 µM	4.72E-7		3	5.49E-7	0.26
6	SGTC_2313	7726885	4.81	200.0 µM	6.61E-7	RPP1 & pyrimidine depletion	3	7.66E-7	0.27
7	SGTC_2405	ticlatone	4.63	3.5 µM	1.61E-6		18	1.84E-6	0.17
8	SGTC_2525	harmine	4.53	47.9 µM	2.58E-6	ergosterol biosynthesis	4	2.93E-6	0.58
9	SGTC_2658	polymyxin b sulfate	4.52	77.0 µM	2.72E-6	NEO1	10	3.09E-6	0.43
10	SGTC_585	0kpi-0023	4.50	191.0 µM	3.04E-6		1	3.45E-6	0.78
11	SGTC_68	0986-0284	4.21	82.8 µM	1.17E-5		8	1.30E-5	0.06
12	SGTC_1672	st016598	3.98	6.5 µM	3.10E-5	endomembrane recycling	18	3.41E-5	0.06
13	SGTC_264	promethazine	3.95	12.5 mM	3.57E-5	DNA intercalators	21	3.92E-5	0.04
14	SGTC_512	prima-1	3.90	270.0 µM	4.44E-5	DNA intercalators	14	4.86E-5	0.12
15	SGTC_1656	st012921	3.84	11.0 µM	5.57E-5		2	6.07E-5	0.11
16	SGTC_2407	paclitaxel	3.68	400.0 µM	1.07E-4		8	1.16E-4	0.24
17	SGTC_1800	st050079	3.66	29.1 µM	1.18E-4	NEO1-PIK1	33	1.28E-4	0.21
18	SGTC_523	1934-0222	3.65	13.7 µM	1.21E-4		6	1.31E-4	0.18
19	SGTC_2133	5320837	3.60	200.0 µM	1.48E-4	ERG2	9	1.60E-4	0.01
20	SGTC_85	0868-0259	3.60	160.1 µM	1.50E-4	60S ribosome export	8	1.61E-4	0.15

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.207	7.02E-34	YMR168C	CEP3	het	Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.197	8.19E-31	YHL039W	EFM1	hom	Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.175	1.58E-24	YMR166C_p	YMR166C_p	hom	Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.162	3.32E-21	YDR406W	PDR15	hom	Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.141	3.09E-16	YOR282W_d	YOR282W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.139	8.32E-16	YPL262W	FUM1	hom	Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.134	6.50E-15	YMR044W	IOC4	hom	Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.121	2.08E-12	YDR113C	PDS1	het	Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.119	4.50E-12	YKL084W	HOT13	hom	Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
0.116	1.89E-11	YJR115W_p	YJR115W_p	hom	Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.113	5.68E-11	YPR140W	TAZ1	hom	Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
0.113	5.79E-11	YBR253W	SRB6	het	Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.110	2.10E-10	YGR070W	ROM1	hom	GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.108	3.74E-10	YPL075W	GCR1	het	Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
0.107	4.33E-10	YJR154W_p	YJR154W_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm