YDR164C / SEC1

Sm-like protein involved in docking and fusion of exocytic vesicles; binds to assembled SNARE complexes at the membrane and stimulates membrane fusion; localization to sites of secretion (bud neck and bud tip) is dependent on SNARE function

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR164C / SEC1

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:3.37|P-value:3.58E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.28|P-value:4.48E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:7.63|P-value:7.93E-15 ID:SGTC_68|Compound:0986-0284|FD-Score:4.21|P-value:1.17E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.60|P-value:1.50E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:10.80|P-value:4.27E-28 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.23|P-value:5.86E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.95|P-value:3.57E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.21|P-value:5.81E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.90|P-value:4.44E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.50|P-value:3.04E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:3.43|P-value:2.87E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.06|P-value:9.75E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.42|P-value:2.70E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.48|P-value:2.12E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.69|P-value:9.52E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.87|P-value:4.72E-7 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.53|P-value:1.92E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.30|P-value:4.29E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.86|P-value:4.75E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:3.45|P-value:2.64E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.40|P-value:3.16E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.38|P-value:3.13E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.84|P-value:5.57E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.98|P-value:3.10E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.23|P-value:5.43E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.56|P-value:1.61E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.44|P-value:2.74E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.60|P-value:1.48E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.09|P-value:8.76E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.40|P-value:3.13E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.96|P-value:3.00E-7 ID:SGTC_2313|Compound:7726885|FD-Score:4.81|P-value:6.61E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.63|P-value:1.61E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.68|P-value:1.07E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.60|P-value:1.66E-6 ID:SGTC_2525|Compound:harmine|FD-Score:4.53|P-value:2.58E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.21|P-value:6.17E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-5.81|P-value:2.23E-9 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.18|P-value:1.20E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.34|P-value:3.64E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.76|P-value:7.26E-5 ID:SGTC_2625|Compound:euphol|FD-Score:5.36|P-value:3.39E-8 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.37|P-value:3.26E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.64|P-value:1.14E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.52|P-value:2.72E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-4.24|P-value:9.10E-6 ID:SGTC_2909|Compound:7941780|FD-Score:-3.75|P-value:7.33E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-4.13|P-value:1.46E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.17|P-value:7.14E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.63|P-value:1.21E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:3.37|P-value:3.58E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:-3.28|P-value:4.48E-4 ID:SGTC_52|Compound:0329-0193|FD-Score:7.63|P-value:7.93E-15 ID:SGTC_68|Compound:0986-0284|FD-Score:4.21|P-value:1.17E-5 ID:SGTC_85|Compound:0868-0259|FD-Score:3.60|P-value:1.50E-4 ID:SGTC_219|Compound:mitoxanthrone|FD-Score:10.80|P-value:4.27E-28 ID:SGTC_239|Compound:5hr heat shock (37°C) + mitomycin C|FD-Score:3.23|P-value:5.86E-4 ID:SGTC_264|Compound:promethazine|FD-Score:3.95|P-value:3.57E-5 ID:SGTC_307|Compound:1501-1223|FD-Score:-3.21|P-value:5.81E-4 ID:SGTC_512|Compound:prima-1|FD-Score:3.90|P-value:4.44E-5 ID:SGTC_523|Compound:1934-0222|FD-Score:3.65|P-value:1.21E-4 ID:SGTC_585|Compound:0kpi-0023|FD-Score:4.50|P-value:3.04E-6 ID:SGTC_827|Compound:3253-0474|FD-Score:3.43|P-value:2.87E-4 ID:SGTC_880|Compound:0833-0487|FD-Score:-3.06|P-value:9.75E-4 ID:SGTC_999|Compound:4022-0066|FD-Score:-3.42|P-value:2.70E-4 ID:SGTC_1028|Compound:k015-0029|FD-Score:-3.48|P-value:2.12E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-3.69|P-value:9.52E-5 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.33|P-value:4.14E-4 ID:SGTC_1252|Compound:0493-0875|FD-Score:4.87|P-value:4.72E-7 ID:SGTC_1314|Compound:1222-0010|FD-Score:3.53|P-value:1.92E-4 ID:SGTC_1335|Compound:1486-0900|FD-Score:-3.30|P-value:4.29E-4 ID:SGTC_1339|Compound:1486-1321|FD-Score:-3.86|P-value:4.75E-5 ID:SGTC_1581|Compound:himbacine|FD-Score:3.45|P-value:2.64E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:3.40|P-value:3.16E-4 ID:SGTC_1638|Compound:st008370|FD-Score:-3.38|P-value:3.13E-4 ID:SGTC_1656|Compound:st012921|FD-Score:3.84|P-value:5.57E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.98|P-value:3.10E-5 ID:SGTC_1800|Compound:st050079|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_1838|Compound:st055369|FD-Score:-3.23|P-value:5.43E-4 ID:SGTC_1893|Compound:st059353|FD-Score:-3.56|P-value:1.61E-4 ID:SGTC_2053|Compound:5265679|FD-Score:3.44|P-value:2.74E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.60|P-value:1.48E-4 ID:SGTC_2179|Compound:6298986|FD-Score:-3.09|P-value:8.76E-4 ID:SGTC_2286|Compound:7945697|FD-Score:3.40|P-value:3.13E-4 ID:SGTC_2288|Compound:7946289|FD-Score:4.96|P-value:3.00E-7 ID:SGTC_2313|Compound:7726885|FD-Score:4.81|P-value:6.61E-7 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.63|P-value:1.61E-6 ID:SGTC_2407|Compound:paclitaxel|FD-Score:3.68|P-value:1.07E-4 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.48|P-value:2.35E-4 ID:SGTC_2510|Compound:benzyl isothiocyanate|FD-Score:-4.60|P-value:1.66E-6 ID:SGTC_2525|Compound:harmine|FD-Score:4.53|P-value:2.58E-6 ID:SGTC_2592|Compound:piperlongumine|FD-Score:3.21|P-value:6.17E-4 ID:SGTC_2599|Compound:2',3-dihydroxy-4,4',6'-trimethoxychalcone|FD-Score:-5.81|P-value:2.23E-9 ID:SGTC_2606|Compound:farnesol|FD-Score:-4.18|P-value:1.20E-5 ID:SGTC_2610|Compound:ononetin|FD-Score:-3.34|P-value:3.64E-4 ID:SGTC_2613|Compound:3',4'-dimethoxydalbergione|FD-Score:-3.76|P-value:7.26E-5 ID:SGTC_2625|Compound:euphol|FD-Score:5.36|P-value:3.39E-8 ID:SGTC_2648|Compound:atorvastatin|FD-Score:-3.37|P-value:3.26E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:-3.64|P-value:1.14E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:4.52|P-value:2.72E-6 ID:SGTC_2832|Compound:7992762|FD-Score:-4.24|P-value:9.10E-6 ID:SGTC_2909|Compound:7941780|FD-Score:-3.75|P-value:7.33E-5 ID:SGTC_2973|Compound:9094665|FD-Score:-4.13|P-value:1.46E-5 ID:SGTC_3142|Compound:9086498|FD-Score:3.17|P-value:7.14E-4 ID:SGTC_3194|Compound:9111903|FD-Score:-3.63|P-value:1.21E-4

Top fitness defect scores for YDR164C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_219 mitoxanthrone 10.80 164.4 µM 4.27E-28 DNA intercalators 2 1.03E-27 2.52
2 SGTC_52 0329-0193 7.63 875.0 nM 7.93E-15 TSC3-RPN4 1 1.20E-14 1.45
3 SGTC_2625 euphol 5.36 100.0 µM 3.39E-8 3 4.10E-8 0.54
4 SGTC_2288 7946289 4.96 167.3 µM 3.00E-7 3 3.51E-7 0.35
5 SGTC_1252 0493-0875 4.87 34.8 µM 4.72E-7 3 5.49E-7 0.26
6 SGTC_2313 7726885 4.81 200.0 µM 6.61E-7 RPP1 & pyrimidine depletion 3 7.66E-7 0.27
7 SGTC_2405 ticlatone 4.63 3.5 µM 1.61E-6 18 1.84E-6 0.17
8 SGTC_2525 harmine 4.53 47.9 µM 2.58E-6 ergosterol biosynthesis 4 2.93E-6 0.58
9 SGTC_2658 polymyxin b sulfate 4.52 77.0 µM 2.72E-6 NEO1 10 3.09E-6 0.43
10 SGTC_585 0kpi-0023 4.50 191.0 µM 3.04E-6 1 3.45E-6 0.78
11 SGTC_68 0986-0284 4.21 82.8 µM 1.17E-5 8 1.30E-5 0.06
12 SGTC_1672 st016598 3.98 6.5 µM 3.10E-5 endomembrane recycling 18 3.41E-5 0.06
13 SGTC_264 promethazine 3.95 12.5 mM 3.57E-5 DNA intercalators 21 3.92E-5 0.04
14 SGTC_512 prima-1 3.90 270.0 µM 4.44E-5 DNA intercalators 14 4.86E-5 0.12
15 SGTC_1656 st012921 3.84 11.0 µM 5.57E-5 2 6.07E-5 0.11
16 SGTC_2407 paclitaxel 3.68 400.0 µM 1.07E-4 8 1.16E-4 0.24
17 SGTC_1800 st050079 3.66 29.1 µM 1.18E-4 NEO1-PIK1 33 1.28E-4 0.21
18 SGTC_523 1934-0222 3.65 13.7 µM 1.21E-4 6 1.31E-4 0.18
19 SGTC_2133 5320837 3.60 200.0 µM 1.48E-4 ERG2 9 1.60E-4 0.01
20 SGTC_85 0868-0259 3.60 160.1 µM 1.50E-4 60S ribosome export 8 1.61E-4 0.15

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.207 7.02E-34 YMR168C CEP3 het Essential kinetochore protein, component of the CBF3 complex that binds the CDEIII region of the centromere; contains an N-terminal Zn2Cys6 type zinc finger domain, a C-terminal acidic domain, and a putative coiled coil dimerization domain
0.197 8.19E-31 YHL039W EFM1 hom Lysine methyltransferase involved in the monomethylation of eEF1A (Tef1p/Tef2p); SET-domain family member; predicted involvement in ribosome biogenesis; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.175 1.58E-24 YMR166C_p YMR166C_p hom Predicted transporter of the mitochondrial inner membrane; has similarity to human mitochondrial ATP-Mg/Pi carriers; YMR166C is not an essential gene
0.162 3.32E-21 YDR406W PDR15 hom Plasma membrane ATP binding cassette (ABC) transporter, multidrug transporter and general stress response factor implicated in cellular detoxification; regulated by Pdr1p, Pdr3p and Pdr8p; promoter contains a PDR responsive element
0.141 3.09E-16 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.139 8.32E-16 YPL262W FUM1 hom Fumarase, converts fumaric acid to L-malic acid in the TCA cycle; cytosolic and mitochondrial distribution determined by the N-terminal targeting sequence, protein conformation, and status of glyoxylate shunt; phosphorylated in mitochondria
0.134 6.50E-15 YMR044W IOC4 hom Member of a complex (Isw1b) with Isw1p and Ioc2p; interacts directly with H3K36me3 nucleosomes through its PWWP domain to recruit the Isw1b complex to open reading frames in a Set2p-dependent manner; Isw1b exhibits nucleosome-stimulated ATPase activity and acts within coding regions to coordinate transcription elongation with termination and processing
0.121 2.08E-12 YDR113C PDS1 het Securin, inhibits anaphase by binding separin Esp1p; blocks cyclin destruction and mitotic exit, essential for meiotic progression and mitotic cell cycle arrest; localization is cell-cycle dependent and regulated by Cdc28p phosphorylation
0.119 4.50E-12 YKL084W HOT13 hom Zinc-binding mitochondrial intermembrane space (IMS) protein involved in a disulfide relay system for IMS import of cysteine-containing proteins; binds Mia40p and stimulates its Erv1p-dependent oxidation, probably by sequestering zinc
0.116 1.89E-11 YJR115W_p YJR115W_p hom Putative protein of unknown function; YJR115W has a paralog, ECM13, that arose from the whole genome duplication
0.113 5.68E-11 YPR140W TAZ1 hom Lyso-phosphatidylcholine acyltransferase, required for normal phospholipid content of mitochondrial membranes; may remodel acyl groups of cardiolipin in the inner membrane; human ortholog tafazzin is implicated in Barth syndrome
0.113 5.79E-11 YBR253W SRB6 het Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; essential for transcriptional regulation
0.110 2.10E-10 YGR070W ROM1 hom GDP/GTP exchange protein (GEP) for Rho1p; mutations are synthetically lethal with mutations in rom2, which also encodes a GEP
0.108 3.74E-10 YPL075W GCR1 het Transcriptional activator of genes involved in glycolysis; DNA-binding protein that interacts and functions with the transcriptional activator Gcr2p
0.107 4.33E-10 YJR154W_p YJR154W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm