YDR167W / TAF10

Subunit (145 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR167W / TAF10

Click on Significant Values for Screen Details ID:SGTC_119|Compound:0121-0043|FD-Score:3.57|P-value:8.10E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.88|P-value:3.01E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.72|P-value:5.12E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.85|P-value:3.36E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-4.07|P-value:1.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-5.04|P-value:4.02E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.66|P-value:6.08E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.66|P-value:6.05E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.86|P-value:3.22E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.88|P-value:2.97E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.63|P-value:2.17E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.69|P-value:5.57E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:6.74|P-value:1.31E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:4.00|P-value:2.04E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.98|P-value:6.24E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.98|P-value:5.48E-6 ID:SGTC_1494|Compound:4358-1428|FD-Score:-4.45|P-value:4.15E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.50|P-value:9.65E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-3.67|P-value:5.85E-4 ID:SGTC_1704|Compound:st028805|FD-Score:4.14|P-value:1.26E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.72|P-value:2.14E-7 ID:SGTC_1848|Compound:st056003|FD-Score:4.27|P-value:8.04E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.81|P-value:3.86E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-3.57|P-value:7.99E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.14|P-value:1.28E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.67|P-value:5.86E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.59|P-value:7.58E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.80|P-value:3.98E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.14|P-value:2.79E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.49|P-value:9.91E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.53|P-value:3.07E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.12|P-value:3.08E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.17|P-value:1.14E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.73|P-value:4.98E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.63|P-value:6.55E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-3.52|P-value:9.23E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.53|P-value:3.08E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.56|P-value:8.26E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.73|P-value:1.45E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.74|P-value:4.80E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.14|P-value:1.22E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:3.57|P-value:8.10E-4 ID:SGTC_128|Compound:0906-2981|FD-Score:3.88|P-value:3.01E-4 ID:SGTC_133|Compound:0724-0033|FD-Score:3.72|P-value:5.12E-4 ID:SGTC_184|Compound:1494-0393|FD-Score:3.85|P-value:3.36E-4 ID:SGTC_226|Compound:1,3-diallylurea|FD-Score:-4.07|P-value:1.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:-5.04|P-value:4.02E-6 ID:SGTC_238|Compound:5hr heat shock (37°C) + nsc-638432|FD-Score:3.66|P-value:6.08E-4 ID:SGTC_293|Compound:4049-0273|FD-Score:3.66|P-value:6.05E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:3.86|P-value:3.22E-4 ID:SGTC_444|Compound:curcumin|FD-Score:-3.88|P-value:2.97E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:4.63|P-value:2.17E-5 ID:SGTC_515|Compound:4092-1064|FD-Score:3.69|P-value:5.57E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:6.74|P-value:1.31E-9 ID:SGTC_902|Compound:1120-0002|FD-Score:4.00|P-value:2.04E-4 ID:SGTC_1129|Compound:3453-1384|FD-Score:5.98|P-value:6.24E-8 ID:SGTC_1201|Compound:1889-3372|FD-Score:4.98|P-value:5.48E-6 ID:SGTC_1494|Compound:4358-1428|FD-Score:-4.45|P-value:4.15E-5 ID:SGTC_1683|Compound:st010134|FD-Score:-3.50|P-value:9.65E-4 ID:SGTC_1688|Compound:st021091|FD-Score:-3.67|P-value:5.85E-4 ID:SGTC_1704|Compound:st028805|FD-Score:4.14|P-value:1.26E-4 ID:SGTC_1844|Compound:rapamycin|FD-Score:5.72|P-value:2.14E-7 ID:SGTC_1848|Compound:st056003|FD-Score:4.27|P-value:8.04E-5 ID:SGTC_1965|Compound:Pectolinarigenin|FD-Score:3.81|P-value:3.86E-4 ID:SGTC_1979|Compound:st071809|FD-Score:-3.57|P-value:7.99E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.14|P-value:1.28E-4 ID:SGTC_2129|Compound:girgensonine|FD-Score:3.67|P-value:5.86E-4 ID:SGTC_2133|Compound:5320837|FD-Score:3.59|P-value:7.58E-4 ID:SGTC_2179|Compound:6298986|FD-Score:3.80|P-value:3.98E-4 ID:SGTC_2248|Compound:tofa|FD-Score:5.14|P-value:2.79E-6 ID:SGTC_2330|Compound:7979373|FD-Score:-3.49|P-value:9.91E-4 ID:SGTC_2539|Compound:epi(13)torulosol|FD-Score:-4.53|P-value:3.07E-5 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.12|P-value:3.08E-6 ID:SGTC_2584|Compound:androsterone|FD-Score:4.17|P-value:1.14E-4 ID:SGTC_2743|Compound:auranofin|FD-Score:3.73|P-value:4.98E-4 ID:SGTC_2937|Compound:9044753|FD-Score:-3.63|P-value:6.55E-4 ID:SGTC_3033|Compound:9090887|FD-Score:-3.52|P-value:9.23E-4 ID:SGTC_3077|Compound:9117319|FD-Score:-4.53|P-value:3.08E-5 ID:SGTC_3124|Compound:9127567|FD-Score:3.56|P-value:8.26E-4 ID:SGTC_3166|Compound:9102297|FD-Score:4.73|P-value:1.45E-5 ID:SGTC_3211|Compound:9128781|FD-Score:3.74|P-value:4.80E-4 ID:SGTC_3249|Compound:9135183|FD-Score:-4.14|P-value:1.22E-4

Top fitness defect scores for YDR167W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_541 4513-1321 6.74 94.0 µM 1.31E-9 2 8.12E-12 0.76
2 SGTC_1129 3453-1384 5.98 223.0 µM 6.24E-8 4 1.11E-9 0.30
3 SGTC_1844 rapamycin 5.72 4.0 nM 2.14E-7 26 5.30E-9 0.20
4 SGTC_2248 tofa 5.14 1.1 µM 2.79E-6 sphingolipid biosynthesis & PDR1 21 1.38E-7 0.34
5 SGTC_2541 muurolladie-3-one 5.12 83.1 µM 3.08E-6 excess fatty acid 9 1.56E-7 0.05
6 SGTC_1201 1889-3372 4.98 45.9 µM 5.48E-6 Golgi 4 3.24E-7 0.46
7 SGTC_3166 9102297 4.73 49.5 µM 1.45E-5 Golgi 2 1.11E-6 0.45
8 SGTC_514 4466-0038 4.63 2.6 nM 2.17E-5 cell wall 30 1.86E-6 0.09
9 SGTC_1848 st056003 4.27 16.4 µM 8.04E-5 1 9.74E-6 0.32
10 SGTC_2584 androsterone 4.17 48.7 µM 1.14E-4 cell wall 25 1.52E-5 0.14
11 SGTC_1704 st028805 4.14 70.8 µM 1.26E-4 1 1.71E-5 0.26
12 SGTC_2028 5153890 4.14 36.4 µM 1.28E-4 cell wall signaling 7 1.75E-5 0.15
13 SGTC_902 1120-0002 4.00 2.1 µM 2.04E-4 azole & statin 18 3.15E-5 0.12
14 SGTC_128 0906-2981 3.88 13.4 µM 3.01E-4 6 5.16E-5 0.01
15 SGTC_363 0455-0021 3.86 3.1 µM 3.22E-4 azole & statin 19 5.62E-5 0.20
16 SGTC_184 1494-0393 3.85 24.7 µM 3.36E-4 32 5.92E-5 0.00
17 SGTC_1965 Pectolinarigenin 3.81 58.4 µM 3.86E-4 RPP1 & pyrimidine depletion 5 7.06E-5 0.30
18 SGTC_2179 6298986 3.80 200.0 µM 3.98E-4 heme requiring 7 7.35E-5 0.22
19 SGTC_3211 9128781 3.74 49.5 µM 4.80E-4 15 9.30E-5 0.41
20 SGTC_2743 auranofin 3.73 4.3 µM 4.98E-4 RPP1 & pyrimidine depletion 12 9.73E-5 0.02

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.138 1.12E-15 YDR145W TAF12 het Subunit (61/68 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification, similar to histone H2A
0.135 3.45E-15 YBL085W BOI1 hom Protein implicated in polar growth; functionally redundant with Boi2p; interacts with bud-emergence protein Bem1p; contains an SH3 (src homology 3) domain and a PH (pleckstrin homology) domain; relocalizes from bud neck to cytoplasm upon DNA replication stress; BOI1 has a paralog, BOI2, that arose from the whole genome duplication
0.132 1.49E-14 YGL112C TAF6 het Subunit (60 kDa) of TFIID and SAGA complexes, involved in transcription initiation of RNA polymerase II and in chromatin modification, similar to histone H4
0.113 4.99E-11 YLL040C VPS13 hom Protein of unknown function; heterooligomeric or homooligomeric complex; peripherally associated with membranes; involved in sporulation, vacuolar protein sorting, prospore membrane formation and protein-Golgi retention; homologous to human CHAC and COH1 which are involved in chorea acanthocytosis and Cohen syndrome, respectively
0.112 9.34E-11 YJL054W TIM54 het Component of the mitochondrial TIM22 complex involved in insertion of polytopic proteins into the inner membrane
0.106 7.36E-10 YBR198C TAF5 het Subunit (90 kDa) of TFIID and SAGA complexes, involved in RNA polymerase II transcription initiation and in chromatin modification
0.106 8.51E-10 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.104 1.40E-9 YML114C TAF8 het TFIID subunit (65 kDa), involved in RNA polymerase II transcription initiation
0.103 2.05E-9 YBR134W_d YBR134W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.099 9.42E-9 YOL003C PFA4 hom Palmitoyltransferase with autoacylation activity, required for palmitoylation of amino acid permeases containing a C-terminal Phe-Trp-Cys site; required for modification of Chs3p; member of the DHHC family of putative palmitoyltransferases
0.098 1.11E-8 YKL110C KTI12 hom Protein that plays a role, with Elongator complex, in modification of wobble nucleosides in tRNA; involved in sensitivity to G1 arrest induced by zymocin; interacts with chromatin throughout the genome; also interacts with Cdc19p
0.098 1.16E-8 YGL260W_p YGL260W_p hom Putative protein of unknown function; transcription is significantly increased in a NAP1 deletion background; deletion mutant has increased accumulation of nickel and selenium
0.098 1.23E-8 YKL203C TOR2 het PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that regulates growth in response to nutrients and TORC2, a complex that regulates cell-cycle dependent polarization of the actin cytoskeleton; involved in meiosis; TOR2 has a paralog, TOR1, that arose from the whole genome duplication
0.098 1.50E-8 YGL073W HSF1 het Trimeric heat shock transcription factor, activates multiple genes in response to stresses that include hyperthermia; recognizes variable heat shock elements (HSEs) consisting of inverted NGAAN repeats; posttranslationally regulated
0.097 1.81E-8 YML121W GTR1 hom Cytoplasmic GTP binding protein and negative regulator of the Ran/Tc4 GTPase cycle; component of GSE complex, which is required for sorting of Gap1p; involved in phosphate transport and telomeric silencing; similar to human RagA and RagB