YDR168W / CDC37

Essential Hsp90p co-chaperone; necessary for passage through the START phase of the cell cycle; stabilizes protein kinase nascent chains and participates along with Hsp90p in their folding

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR168W / CDC37

Click on Significant Values for Screen Details ID:SGTC_254|Compound:nsc-64875|FD-Score:3.15|P-value:9.39E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.73|P-value:1.43E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:5.24|P-value:1.09E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.29|P-value:5.78E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.84|P-value:7.28E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:5.26|P-value:1.00E-7 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.92|P-value:5.31E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.17|P-value:1.86E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.50|P-value:2.75E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.85|P-value:6.98E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.70|P-value:1.30E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.10|P-value:2.54E-5 ID:SGTC_2380|Compound:9035439|FD-Score:-3.19|P-value:7.51E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.30|P-value:5.57E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.07|P-value:2.86E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.10|P-value:2.57E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.42|P-value:3.66E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.34|P-value:4.78E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.51|P-value:2.35E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.09|P-value:8.54E-10 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.28|P-value:5.37E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.38|P-value:3.75E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.41|P-value:6.62E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.51|P-value:2.64E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.77|P-value:1.18E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.69|P-value:1.34E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.12|P-value:9.35E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.42|P-value:3.61E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.72|P-value:1.06E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.10|P-value:2.56E-5 ID:SGTC_3285|Compound:9112818|FD-Score:4.61|P-value:2.60E-6 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.15|P-value:9.39E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:4.73|P-value:1.43E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:5.24|P-value:1.09E-7 ID:SGTC_704|Compound:1310-0270|FD-Score:3.29|P-value:5.78E-4 ID:SGTC_756|Compound:0508-1999|FD-Score:3.38|P-value:4.20E-4 ID:SGTC_948|Compound:3448-0295|FD-Score:3.24|P-value:6.77E-4 ID:SGTC_978|Compound:1416-0512|FD-Score:3.84|P-value:7.28E-5 ID:SGTC_1175|Compound:0741-0056|FD-Score:5.26|P-value:1.00E-7 ID:SGTC_1181|Compound:1222-0449|FD-Score:3.70|P-value:1.27E-4 ID:SGTC_1192|Compound:1488-0095|FD-Score:3.92|P-value:5.31E-5 ID:SGTC_1304|Compound:1165-0502|FD-Score:4.17|P-value:1.86E-5 ID:SGTC_1507|Compound:4075-3230|FD-Score:3.50|P-value:2.75E-4 ID:SGTC_1830|Compound:st055982|FD-Score:3.85|P-value:6.98E-5 ID:SGTC_1868|Compound:st057644|FD-Score:3.31|P-value:5.40E-4 ID:SGTC_2016|Compound:5121758|FD-Score:3.70|P-value:1.30E-4 ID:SGTC_2063|Compound:5246145|FD-Score:4.10|P-value:2.54E-5 ID:SGTC_2380|Compound:9035439|FD-Score:-3.19|P-value:7.51E-4 ID:SGTC_2390|Compound:9097792|FD-Score:3.30|P-value:5.57E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:4.07|P-value:2.86E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:4.10|P-value:2.57E-5 ID:SGTC_2577|Compound:2',4'-dihydroxy-4-methoxychalcone|FD-Score:3.42|P-value:3.66E-4 ID:SGTC_2594|Compound:a-mangostin|FD-Score:3.34|P-value:4.78E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:-3.51|P-value:2.35E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:6.09|P-value:8.54E-10 ID:SGTC_2614|Compound:arthonioic acid|FD-Score:3.23|P-value:7.11E-4 ID:SGTC_2629|Compound:bisabolol|FD-Score:-3.28|P-value:5.37E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.68|P-value:1.40E-4 ID:SGTC_2740|Compound:felodipine|FD-Score:-3.38|P-value:3.75E-4 ID:SGTC_2818|Compound:7996756|FD-Score:4.41|P-value:6.62E-6 ID:SGTC_2821|Compound:7996764|FD-Score:3.51|P-value:2.64E-4 ID:SGTC_2842|Compound:9000675|FD-Score:4.77|P-value:1.18E-6 ID:SGTC_2905|Compound:7799065|FD-Score:3.69|P-value:1.34E-4 ID:SGTC_2941|Compound:9056145|FD-Score:-3.12|P-value:9.35E-4 ID:SGTC_3087|Compound:9117406|FD-Score:3.42|P-value:3.61E-4 ID:SGTC_3150|Compound:9097574|FD-Score:-3.33|P-value:4.52E-4 ID:SGTC_3200|Compound:9114385|FD-Score:-3.72|P-value:1.06E-4 ID:SGTC_3206|Compound:9114350|FD-Score:4.10|P-value:2.56E-5 ID:SGTC_3285|Compound:9112818|FD-Score:4.61|P-value:2.60E-6

Top fitness defect scores for YDR168W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 6.09 70.0 µM 8.54E-10 redox potentiating 4 5.78E-10 1.17
2 SGTC_1175 0741-0056 5.26 27.6 µM 1.00E-7 1 7.39E-8 0.64
3 SGTC_685 1278-0033 5.24 54.9 µM 1.09E-7 60S ribosome export 4 8.05E-8 0.49
4 SGTC_2842 9000675 4.77 19.5 µM 1.18E-6 7 9.07E-7 0.42
5 SGTC_670 4204-0025 4.73 119.0 µM 1.43E-6 copper-dependent oxidative stress 1 1.11E-6 0.51
6 SGTC_3285 9112818 4.61 20.9 µM 2.60E-6 cell wall 9 2.04E-6 0.24
7 SGTC_2818 7996756 4.41 13.0 µM 6.62E-6 6 5.27E-6 0.53
8 SGTC_1304 1165-0502 4.17 251.0 µM 1.86E-5 4 1.51E-5 0.16
9 SGTC_2063 5246145 4.10 200.0 µM 2.54E-5 5 2.07E-5 0.04
10 SGTC_3206 9114350 4.10 49.5 µM 2.56E-5 1 2.09E-5 0.30
11 SGTC_2554 13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one 4.10 66.7 µM 2.57E-5 2 2.10E-5 0.41
12 SGTC_2513 baicalein 4.07 25.6 µM 2.86E-5 calcium & mitochondrial duress 4 2.34E-5 0.38
13 SGTC_1192 1488-0095 3.92 21.4 µM 5.31E-5 1 4.40E-5 0.50
14 SGTC_1830 st055982 3.85 50.3 µM 6.98E-5 4 5.81E-5 0.11
15 SGTC_978 1416-0512 3.84 87.4 µM 7.28E-5 redox potentiating 9 6.06E-5 0.02
16 SGTC_1181 1222-0449 3.70 220.0 µM 1.27E-4 3 1.07E-4 0.23
17 SGTC_2016 5121758 3.70 140.0 µM 1.30E-4 redox potentiating 22 1.09E-4 0.12
18 SGTC_2905 7799065 3.69 20.1 µM 1.34E-4 8 1.13E-4 0.03
19 SGTC_2722 naftopidil 3.68 47.2 µM 1.40E-4 2 1.18E-4 0.25
20 SGTC_2821 7996764 3.51 71.4 µM 2.64E-4 13 2.25E-4 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.108 3.57E-10 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.101 5.03E-9 YDR267C CIA1 het Component of cytosolic iron-sulfur protein assembly (CIA) machinery; acts at a late step of Fe-S cluster assembly; forms the CIA targeting complex with Cia2p and Met18p that directs Fe-S cluster incorporation into a subset of proteins involved in methionine biosynthesis, DNA replication and repair, transcription, and telomere maintenance; contains WD40 repeats; ortholog of human Ciao1 protein
0.091 1.31E-7 YDR098C GRX3 hom Hydroperoxide and superoxide-radical responsive glutathione-dependent oxidoreductase; monothiol glutaredoxin subfamily member along with Grx4p and Grx5p; protects cells from oxidative damage; evidence exists indicating that the translation start site is not Met1 as currently annotated, but rather Met36
0.087 5.02E-7 YLR176C RFX1 hom Major transcriptional repressor of DNA-damage-regulated genes, recruits repressors Tup1p and Cyc8p to their promoters; involved in DNA damage and replication checkpoint pathway; similar to a family of mammalian DNA binding RFX1-4 proteins
0.083 1.30E-6 YNL212W VID27 hom Cytoplasmic protein of unknown function; possibly involved in vacuolar protein degradation; not essential for proteasome-dependent degradation of fructose-1,6-bisphosphatase (FBPase); null mutants exhibit normal growth
0.083 1.43E-6 YDR192C NUP42 hom FG-nucleoporin component of central core of the nuclear pore complex (NPC); also part of the NPC cytoplasmic filaments; contributes directly to nucleocytoplasmic transport and maintenance of the NPC permeability barrier and is involved in gene tethering at the nuclear periphery; interacts with Gle1p
0.082 1.86E-6 YLR273C PIG1 hom Putative targeting subunit for the type-1 protein phosphatase Glc7p that tethers it to the Gsy2p glycogen synthase
0.080 3.60E-6 YPL008W CHL1 hom Probable DNA helicase; involved in sister-chromatid cohesion and genome integrity and interstrand cross-link repair; interacts with ECO1 and CTF18; mutants are defective in silencing, rDNA recombination, aging and the heat shock response; FANCJ-like helicase family member; mutations in the human homolog, DDX11/ChLR1, cause Warsaw breakage syndrome
0.076 9.60E-6 YDR176W NGG1 hom Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex
0.076 1.08E-5 YPL002C SNF8 hom Component of the ESCRT-II complex, which is involved in ubiquitin-dependent sorting of proteins into the endosome; appears to be functionally related to SNF7; involved in glucose derepression
0.075 1.34E-5 YJR003C_p YJR003C_p hom Putative protein of unknown function; detected in highly purified mitochondria in high-throughput studies; predicted to be involved in ribosome biogenesis
0.074 1.63E-5 YBR173C UMP1 hom Short-lived chaperone required for correct maturation of the 20S proteasome; may inhibit premature dimerization of proteasome half-mers; degraded by proteasome upon completion of its assembly
0.072 2.92E-5 YHL020C OPI1 hom Transcriptional regulator of a variety of genes; phosphorylation by protein kinase A stimulates Opi1p function in negative regulation of phospholipid biosynthetic genes; involved in telomere maintenance
0.071 3.76E-5 YPR084W_p YPR084W_p hom Putative protein of unknown function
0.069 5.77E-5 YPR165W RHO1 het GTP-binding protein of the rho subfamily of Ras-like proteins, involved in establishment of cell polarity; regulates protein kinase C (Pkc1p) and the cell wall synthesizing enzyme 1,3-beta-glucan synthase (Fks1p and Gsc2p)