YDR169C-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR169C-A / YDR169C-A

Click on Significant Values for Screen Details ID:SGTC_140|Compound:0062-0056|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.12|P-value:3.25E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.12|P-value:3.36E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.99|P-value:5.52E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:3.68|P-value:1.84E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.21|P-value:9.50E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.85|P-value:4.25E-9 ID:SGTC_939|Compound:1165-0479|FD-Score:8.27|P-value:4.02E-16 ID:SGTC_942|Compound:3253-1115|FD-Score:10.50|P-value:4.37E-25 ID:SGTC_943|Compound:3253-1379|FD-Score:7.62|P-value:6.34E-14 ID:SGTC_949|Compound:1165-0505|FD-Score:-6.77|P-value:1.34E-11 ID:SGTC_999|Compound:4022-0066|FD-Score:4.57|P-value:4.65E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.52|P-value:3.29E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.30|P-value:7.10E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.56|P-value:2.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.02|P-value:2.48E-9 ID:SGTC_1673|Compound:st016611|FD-Score:5.69|P-value:1.61E-8 ID:SGTC_1676|Compound:st018489|FD-Score:3.43|P-value:4.54E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-5.89|P-value:3.35E-9 ID:SGTC_1750|Compound:st081859|FD-Score:-3.42|P-value:3.56E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.44|P-value:4.40E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.36|P-value:5.77E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.03|P-value:4.78E-5 ID:SGTC_1900|Compound:st060200|FD-Score:3.48|P-value:3.84E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.07|P-value:4.02E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_2387|Compound:9077560|FD-Score:5.21|P-value:2.14E-7 ID:SGTC_2404|Compound:5161160|FD-Score:-3.14|P-value:9.24E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.19|P-value:7.98E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.69|P-value:2.74E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.33|P-value:6.39E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.37|P-value:4.28E-4 ID:SGTC_2785|Compound:7756463|FD-Score:5.27|P-value:1.59E-7 ID:SGTC_2786|Compound:7743617|FD-Score:4.59|P-value:4.23E-6 ID:SGTC_2986|Compound:9022445|FD-Score:-3.89|P-value:6.07E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.64|P-value:2.17E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.49|P-value:3.64E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.66|P-value:1.97E-4 ID:SGTC_140|Compound:0062-0056|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_166|Compound:k072-0058|FD-Score:4.12|P-value:3.25E-5 ID:SGTC_727|Compound:3032-0951|FD-Score:4.12|P-value:3.36E-5 ID:SGTC_769|Compound:0302-0231|FD-Score:3.99|P-value:5.52E-5 ID:SGTC_771|Compound:0250-0039|FD-Score:3.68|P-value:1.84E-4 ID:SGTC_855|Compound:0428-0020|FD-Score:3.21|P-value:9.50E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-5.85|P-value:4.25E-9 ID:SGTC_939|Compound:1165-0479|FD-Score:8.27|P-value:4.02E-16 ID:SGTC_942|Compound:3253-1115|FD-Score:10.50|P-value:4.37E-25 ID:SGTC_943|Compound:3253-1379|FD-Score:7.62|P-value:6.34E-14 ID:SGTC_949|Compound:1165-0505|FD-Score:-6.77|P-value:1.34E-11 ID:SGTC_999|Compound:4022-0066|FD-Score:4.57|P-value:4.65E-6 ID:SGTC_1037|Compound:k284-1091|FD-Score:3.52|P-value:3.29E-4 ID:SGTC_1286|Compound:0929-0070|FD-Score:3.30|P-value:7.10E-4 ID:SGTC_1453|Compound:4237-0541|FD-Score:-3.56|P-value:2.15E-4 ID:SGTC_1635|Compound:st007035|FD-Score:6.02|P-value:2.48E-9 ID:SGTC_1673|Compound:st016611|FD-Score:5.69|P-value:1.61E-8 ID:SGTC_1676|Compound:st018489|FD-Score:3.43|P-value:4.54E-4 ID:SGTC_1724|Compound:st037281|FD-Score:3.54|P-value:3.12E-4 ID:SGTC_1746|Compound:st038117|FD-Score:-5.89|P-value:3.35E-9 ID:SGTC_1750|Compound:st081859|FD-Score:-3.42|P-value:3.56E-4 ID:SGTC_1770|Compound:st043884|FD-Score:3.44|P-value:4.40E-4 ID:SGTC_1792|Compound:st045773|FD-Score:3.36|P-value:5.77E-4 ID:SGTC_1838|Compound:st055369|FD-Score:4.03|P-value:4.78E-5 ID:SGTC_1900|Compound:st060200|FD-Score:3.48|P-value:3.84E-4 ID:SGTC_2038|Compound:4100038|FD-Score:3.27|P-value:7.85E-4 ID:SGTC_2274|Compound:7947094|FD-Score:4.07|P-value:4.02E-5 ID:SGTC_2377|Compound:9073351|FD-Score:3.36|P-value:5.76E-4 ID:SGTC_2387|Compound:9077560|FD-Score:5.21|P-value:2.14E-7 ID:SGTC_2404|Compound:5161160|FD-Score:-3.14|P-value:9.24E-4 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-3.19|P-value:7.98E-4 ID:SGTC_2692|Compound:st077426|FD-Score:4.69|P-value:2.74E-6 ID:SGTC_2701|Compound:st077767|FD-Score:3.33|P-value:6.39E-4 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:-3.37|P-value:4.28E-4 ID:SGTC_2785|Compound:7756463|FD-Score:5.27|P-value:1.59E-7 ID:SGTC_2786|Compound:7743617|FD-Score:4.59|P-value:4.23E-6 ID:SGTC_2986|Compound:9022445|FD-Score:-3.89|P-value:6.07E-5 ID:SGTC_3158|Compound:9100007|FD-Score:3.64|P-value:2.17E-4 ID:SGTC_3319|Compound:9138450|FD-Score:3.49|P-value:3.64E-4 ID:SGTC_3326|Compound:9140064|FD-Score:3.66|P-value:1.97E-4

Top fitness defect scores for YDR169C-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_942 3253-1115 10.50 227.0 µM 4.37E-25 1 2.55E-26
2 SGTC_939 1165-0479 8.27 45.3 µM 4.02E-16 1 6.47E-17
3 SGTC_943 3253-1379 7.62 105.0 µM 6.34E-14 1 1.31E-14
4 SGTC_1635 st007035 6.02 42.4 µM 2.48E-9 136 8.76E-10
5 SGTC_1673 st016611 5.69 27.3 µM 1.61E-8 16 6.24E-9
6 SGTC_2785 7756463 5.27 72.7 µM 1.59E-7 7 6.91E-8
7 SGTC_2387 9077560 5.21 195.1 µM 2.14E-7 5 9.47E-8
8 SGTC_2692 st077426 4.69 47.7 µM 2.74E-6 10 1.39E-6
9 SGTC_2786 7743617 4.59 45.5 µM 4.23E-6 14 2.19E-6
10 SGTC_999 4022-0066 4.57 22.7 µM 4.65E-6 Golgi 25 2.42E-6
11 SGTC_166 k072-0058 4.12 166.4 µM 3.25E-5 DNA intercalators 28 1.87E-5
12 SGTC_727 3032-0951 4.12 202.0 µM 3.36E-5 26 1.93E-5
13 SGTC_2274 7947094 4.07 46.1 µM 4.02E-5 36 2.33E-5
14 SGTC_1838 st055369 4.03 84.5 µM 4.78E-5 16 2.80E-5
15 SGTC_769 0302-0231 3.99 76.0 µM 5.52E-5 38 3.26E-5
16 SGTC_140 0062-0056 3.78 502.5 µM 1.26E-4 27 7.75E-5
17 SGTC_771 0250-0039 3.68 27.3 µM 1.84E-4 19 1.16E-4
18 SGTC_3326 9140064 3.66 16.4 µM 1.97E-4 28 1.24E-4
19 SGTC_3158 9100007 3.64 49.5 µM 2.17E-4 29 1.38E-4
20 SGTC_1724 st037281 3.54 8.3 µM 3.12E-4 56 2.02E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.169 7.26E-23 YNR018W RCF2 hom Cytochrome c oxidase subunit; has a role in assembly of respiratory supercomplexes; similar to Rcf1p, and either Rcf1p or Rcf2p is required for late-stage assembly of the Cox12p and Cox13p subunits and for cytochrome c oxidase activity; associates with the cytochrome c oxidase - cytochrome bc1 supercomplex; null mutant accumulates reactive oxygen species; member of the conserved hypoxia induced gene family; C. elegans homolog is functional in yeast
0.161 4.92E-21 YPR111W DBF20 hom Ser/Thr kinase involved in late nuclear division, one of the mitotic exit network (MEN) proteins; necessary for the execution of cytokinesis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs
0.144 4.66E-17 YOL048C RRT8 hom Protein of unknown function; identified in a screen for mutants with increased levels of rDNA transcription; green fluorescent protein (GFP)-fusion protein localizes to lipid particles; protein abundance increases in response to DNA replication stress
0.143 1.00E-16 YKL155C RSM22 hom Mitochondrial ribosomal protein of the small subunit; also predicted to be an S-adenosylmethionine-dependent methyltransferase
0.142 1.28E-16 YMR151W_d YIM2_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 5% of ORF overlaps the verified gene IMP1
0.134 5.61E-15 YGL191W COX13 hom Subunit VIa of cytochrome c oxidase; present in a subclass of cytochrome c oxidase complexes that may have a role in mimimizing generation of reactive oxygen species; not essential for cytochrome c oxidase activity but may modulate activity in response to ATP; required for assembly of Rcf2p into cytochrome c oxidase - cytochrome bc1 supercomplexes
0.130 3.62E-14 YLL009C COX17 hom Copper metallochaperone that transfers copper to Sco1p and Cox11p for eventual delivery to cytochrome c oxidase; contains twin cysteine-x9-cysteine motifs
0.125 3.57E-13 YPL189C-A COA2 hom Cytochrome oxidase assembly factor; null mutation results in respiratory deficiency with specific loss of cytochrome oxidase activity; functions downstream of assembly factors Mss51p and Coa1p and interacts with assembly factor Shy1p
0.118 7.13E-12 YEL059C-A SOM1 hom Subunit of the mitochondrial inner membrane peptidase, which is required for maturation of mitochondrial proteins of the intermembrane space; Som1p facilitates cleavage of a subset of substrates; contains twin cysteine-x9-cysteine motifs
0.117 1.00E-11 YMR101C SRT1 hom Cis-prenyltransferase involved in synthesis of long-chain dolichols (19-22 isoprene units; as opposed to Rer2p which synthesizes shorter-chain dolichols); localizes to lipid bodies; transcription is induced during stationary phase
0.116 1.55E-11 YGR183C QCR9 hom Subunit 9 of the ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; required for electron transfer at the ubiquinol oxidase site of the complex
0.110 1.58E-10 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.108 3.57E-10 YDR170C SEC7 het Guanine nucleotide exchange factor (GEF) for ADP ribosylation factors involved in proliferation of the Golgi, intra-Golgi transport and ER-to-Golgi transport; found in the cytoplasm and on Golgi-associated coated vesicles
0.107 5.78E-10 YGR053C_p YGR053C_p hom Putative protein of unknown function
0.103 2.12E-9 YJR141W_p YJR141W_p het Essential protein of unknown function