YDR172W / SUP35

Translation termination factor eRF3, has a role in mRNA deadenylation and decay; altered protein conformation creates the [PSI(+)] prion that alters translational fidelity and results in a nonsense suppressor phenotype

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR172W / SUP35

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:13.30|P-value:9.65E-35 ID:SGTC_103|Compound:0844-0104|FD-Score:6.14|P-value:7.47E-9 ID:SGTC_104|Compound:0074-0074|FD-Score:6.18|P-value:6.27E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:3.83|P-value:2.08E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:6.09|P-value:1.01E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:12.10|P-value:6.00E-29 ID:SGTC_138|Compound:0850-0259|FD-Score:5.44|P-value:2.66E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:5.94|P-value:2.18E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:3.46|P-value:7.06E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.32|P-value:3.37E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.56|P-value:1.32E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.99|P-value:1.24E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.37|P-value:5.69E-12 ID:SGTC_332|Compound:4112-0506|FD-Score:5.95|P-value:2.02E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:3.75|P-value:2.71E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.35|P-value:9.91E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.52|P-value:9.19E-10 ID:SGTC_534|Compound:k292-0788|FD-Score:4.66|P-value:8.75E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.89|P-value:3.22E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:4.07|P-value:8.80E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:6.04|P-value:1.31E-8 ID:SGTC_605|Compound:1315-0399|FD-Score:3.97|P-value:1.25E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.11|P-value:7.48E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.36|P-value:9.62E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.76|P-value:5.77E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.37|P-value:9.25E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.55|P-value:5.68E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.62|P-value:1.01E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.81|P-value:2.18E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.06|P-value:1.55E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:3.51|P-value:5.98E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.96|P-value:1.29E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.77|P-value:5.33E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:4.68|P-value:7.89E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:11.00|P-value:1.38E-24 ID:SGTC_933|Compound:2914-0560|FD-Score:6.90|P-value:1.04E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:4.22|P-value:4.88E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.61|P-value:1.18E-7 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.38|P-value:9.08E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.44|P-value:1.50E-9 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.40|P-value:8.43E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.59|P-value:1.16E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:9.88|P-value:4.40E-20 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.94|P-value:1.38E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.36|P-value:9.72E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.70|P-value:3.15E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.09|P-value:3.18E-11 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.75|P-value:2.73E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.42|P-value:7.85E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.42|P-value:7.87E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.87|P-value:1.90E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.33|P-value:3.59E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.89|P-value:1.06E-10 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.11|P-value:9.04E-9 ID:SGTC_1633|Compound:st005664|FD-Score:-3.62|P-value:4.52E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.14|P-value:6.81E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.72|P-value:2.95E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.57|P-value:4.89E-4 ID:SGTC_1707|Compound:st032323|FD-Score:10.50|P-value:2.06E-22 ID:SGTC_1732|Compound:st034308|FD-Score:3.69|P-value:3.32E-4 ID:SGTC_1933|Compound:st074711|FD-Score:6.20|P-value:5.43E-9 ID:SGTC_2017|Compound:5132927|FD-Score:-4.88|P-value:3.71E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.56|P-value:5.06E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.38|P-value:9.01E-4 ID:SGTC_2348|Compound:9022543|FD-Score:5.94|P-value:2.21E-8 ID:SGTC_2396|Compound:5342950|FD-Score:4.58|P-value:1.19E-5 ID:SGTC_2488|Compound:5268135|FD-Score:4.07|P-value:8.81E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.55|P-value:5.29E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.03|P-value:1.79E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:4.58|P-value:1.18E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.91|P-value:2.58E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:6.74|P-value:2.63E-10 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.46|P-value:6.97E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.71|P-value:7.14E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.75|P-value:2.74E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.79|P-value:2.56E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:5.49|P-value:2.04E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.02|P-value:1.14E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-5.02|P-value:2.02E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-4.18|P-value:6.15E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.66|P-value:9.15E-8 ID:SGTC_2919|Compound:7978188|FD-Score:3.35|P-value:9.78E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.94|P-value:1.40E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.11|P-value:8.10E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-3.71|P-value:3.33E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.88|P-value:1.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.31|P-value:4.99E-7 ID:SGTC_3317|Compound:9138495|FD-Score:3.74|P-value:2.82E-4 ID:SGTC_3321|Compound:9137793|FD-Score:5.25|P-value:6.36E-7 ID:SGTC_3327|Compound:9140648|FD-Score:6.64|P-value:4.71E-10 ID:SGTC_3335|Compound:9143315|FD-Score:5.68|P-value:8.23E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:13.30|P-value:9.65E-35 ID:SGTC_103|Compound:0844-0104|FD-Score:6.14|P-value:7.47E-9 ID:SGTC_104|Compound:0074-0074|FD-Score:6.18|P-value:6.27E-9 ID:SGTC_108|Compound:0509-0257|FD-Score:3.83|P-value:2.08E-4 ID:SGTC_119|Compound:0121-0043|FD-Score:6.09|P-value:1.01E-8 ID:SGTC_124|Compound:0136-0217|FD-Score:12.10|P-value:6.00E-29 ID:SGTC_138|Compound:0850-0259|FD-Score:5.44|P-value:2.66E-7 ID:SGTC_157|Compound:1348-1695|FD-Score:5.94|P-value:2.18E-8 ID:SGTC_173|Compound:1273-0061|FD-Score:3.46|P-value:7.06E-4 ID:SGTC_181|Compound:1447-1644|FD-Score:4.32|P-value:3.37E-5 ID:SGTC_184|Compound:1494-0393|FD-Score:4.56|P-value:1.32E-5 ID:SGTC_255|Compound:tunicamycin|FD-Score:-3.99|P-value:1.24E-4 ID:SGTC_268|Compound:camptothecin|FD-Score:7.37|P-value:5.69E-12 ID:SGTC_332|Compound:4112-0506|FD-Score:5.95|P-value:2.02E-8 ID:SGTC_354|Compound:2783-3500|FD-Score:3.75|P-value:2.71E-4 ID:SGTC_429|Compound:1112-0049|FD-Score:3.35|P-value:9.91E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.52|P-value:9.19E-10 ID:SGTC_534|Compound:k292-0788|FD-Score:4.66|P-value:8.75E-6 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:4.89|P-value:3.22E-6 ID:SGTC_580|Compound:1123-0028|FD-Score:4.07|P-value:8.80E-5 ID:SGTC_586|Compound:0957-0265|FD-Score:6.04|P-value:1.31E-8 ID:SGTC_605|Compound:1315-0399|FD-Score:3.97|P-value:1.25E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:4.11|P-value:7.48E-5 ID:SGTC_666|Compound:0272-0154|FD-Score:3.36|P-value:9.62E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:4.76|P-value:5.77E-6 ID:SGTC_779|Compound:1360-0071|FD-Score:3.37|P-value:9.25E-4 ID:SGTC_783|Compound:0848-0141|FD-Score:-3.55|P-value:5.68E-4 ID:SGTC_784|Compound:4579-0127|FD-Score:4.62|P-value:1.01E-5 ID:SGTC_795|Compound:0685-0265|FD-Score:3.81|P-value:2.18E-4 ID:SGTC_829|Compound:1635-0120|FD-Score:5.06|P-value:1.55E-6 ID:SGTC_851|Compound:0394-0702|FD-Score:3.51|P-value:5.98E-4 ID:SGTC_852|Compound:0418-0143|FD-Score:3.96|P-value:1.29E-4 ID:SGTC_863|Compound:0466-0191|FD-Score:4.77|P-value:5.33E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:4.68|P-value:7.89E-6 ID:SGTC_916|Compound:4466-0038|FD-Score:11.00|P-value:1.38E-24 ID:SGTC_933|Compound:2914-0560|FD-Score:6.90|P-value:1.04E-10 ID:SGTC_934|Compound:2950-0684|FD-Score:4.22|P-value:4.88E-5 ID:SGTC_951|Compound:1171-0579|FD-Score:5.61|P-value:1.18E-7 ID:SGTC_1016|Compound:4226-1401|FD-Score:3.38|P-value:9.08E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:6.44|P-value:1.50E-9 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.40|P-value:8.43E-4 ID:SGTC_1050|Compound:3232-1156|FD-Score:4.59|P-value:1.16E-5 ID:SGTC_1133|Compound:3473-0247|FD-Score:9.88|P-value:4.40E-20 ID:SGTC_1140|Compound:3229-1848|FD-Score:3.94|P-value:1.38E-4 ID:SGTC_1151|Compound:3909-8316|FD-Score:3.36|P-value:9.72E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.70|P-value:3.15E-4 ID:SGTC_1239|Compound:0337-0584|FD-Score:7.09|P-value:3.18E-11 ID:SGTC_1243|Compound:0416-0003|FD-Score:3.75|P-value:2.73E-4 ID:SGTC_1288|Compound:0973-0013|FD-Score:3.42|P-value:7.85E-4 ID:SGTC_1343|Compound:1487-0095|FD-Score:3.42|P-value:7.87E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:-3.87|P-value:1.90E-4 ID:SGTC_1353|Compound:1498-1206|FD-Score:-4.33|P-value:3.59E-5 ID:SGTC_1374|Compound:2889-5571|FD-Score:6.89|P-value:1.06E-10 ID:SGTC_1493|Compound:4348-0038|FD-Score:6.11|P-value:9.04E-9 ID:SGTC_1633|Compound:st005664|FD-Score:-3.62|P-value:4.52E-4 ID:SGTC_1652|Compound:st011932|FD-Score:4.14|P-value:6.81E-5 ID:SGTC_1672|Compound:st016598|FD-Score:3.72|P-value:2.95E-4 ID:SGTC_1704|Compound:st028805|FD-Score:3.57|P-value:4.89E-4 ID:SGTC_1707|Compound:st032323|FD-Score:10.50|P-value:2.06E-22 ID:SGTC_1732|Compound:st034308|FD-Score:3.69|P-value:3.32E-4 ID:SGTC_1933|Compound:st074711|FD-Score:6.20|P-value:5.43E-9 ID:SGTC_2017|Compound:5132927|FD-Score:-4.88|P-value:3.71E-6 ID:SGTC_2041|Compound:5107442|FD-Score:3.56|P-value:5.06E-4 ID:SGTC_2223|Compound:6903751|FD-Score:3.38|P-value:9.01E-4 ID:SGTC_2348|Compound:9022543|FD-Score:5.94|P-value:2.21E-8 ID:SGTC_2396|Compound:5342950|FD-Score:4.58|P-value:1.19E-5 ID:SGTC_2488|Compound:5268135|FD-Score:4.07|P-value:8.81E-5 ID:SGTC_2519|Compound:cryptotanshinone|FD-Score:3.55|P-value:5.29E-4 ID:SGTC_2541|Compound:muurolladie-3-one|FD-Score:5.03|P-value:1.79E-6 ID:SGTC_2544|Compound:sphondin|FD-Score:4.58|P-value:1.18E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:5.91|P-value:2.58E-8 ID:SGTC_2584|Compound:androsterone|FD-Score:6.74|P-value:2.63E-10 ID:SGTC_2662|Compound:daunorubicin|FD-Score:3.46|P-value:6.97E-4 ID:SGTC_2700|Compound:st077718|FD-Score:4.71|P-value:7.14E-6 ID:SGTC_2713|Compound:st079149|FD-Score:3.75|P-value:2.74E-4 ID:SGTC_2715|Compound:st079500|FD-Score:-3.79|P-value:2.56E-4 ID:SGTC_2756|Compound:carbadox|FD-Score:5.49|P-value:2.04E-7 ID:SGTC_2779|Compound:methotrexate|FD-Score:-4.02|P-value:1.14E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-5.02|P-value:2.02E-6 ID:SGTC_2835|Compound:9006588|FD-Score:-4.18|P-value:6.15E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.66|P-value:9.15E-8 ID:SGTC_2919|Compound:7978188|FD-Score:3.35|P-value:9.78E-4 ID:SGTC_2940|Compound:9060638|FD-Score:3.94|P-value:1.40E-4 ID:SGTC_2942|Compound:9052777|FD-Score:-4.11|P-value:8.10E-5 ID:SGTC_3038|Compound:9091290|FD-Score:-3.71|P-value:3.33E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:3.88|P-value:1.73E-4 ID:SGTC_3311|Compound:9131146|FD-Score:5.31|P-value:4.99E-7 ID:SGTC_3317|Compound:9138495|FD-Score:3.74|P-value:2.82E-4 ID:SGTC_3321|Compound:9137793|FD-Score:5.25|P-value:6.36E-7 ID:SGTC_3327|Compound:9140648|FD-Score:6.64|P-value:4.71E-10 ID:SGTC_3335|Compound:9143315|FD-Score:5.68|P-value:8.23E-8

Top fitness defect scores for YDR172W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_58 0957-0393 13.30 9.0 µM 9.65E-35 cell wall 3 1.32E-40 0.52
2 SGTC_124 0136-0217 12.10 7.1 µM 6.00E-29 mitochondrial stress 1 8.90E-34 3.05
3 SGTC_916 4466-0038 11.00 42.0 nM 1.38E-24 cell wall 5 1.23E-28 0.02
4 SGTC_1707 st032323 10.50 6.3 µM 2.06E-22 DNA damage response 6 4.48E-26 0.12
5 SGTC_1133 3473-0247 9.88 50.0 µM 4.40E-20 RSC complex & mRNA processing 8 2.48E-23 1.02
6 SGTC_268 camptothecin 7.37 39.6 µM 5.69E-12 DNA damage response 14 8.76E-14 0.10
7 SGTC_1239 0337-0584 7.09 35.4 µM 3.18E-11 unfolded protein response 11 6.64E-13 0.16
8 SGTC_933 2914-0560 6.90 114.0 µM 1.04E-10 1 2.66E-12 1.95
9 SGTC_1374 2889-5571 6.89 141.0 µM 1.06E-10 RSC complex & mRNA processing 18 2.72E-12 0.78
10 SGTC_2584 androsterone 6.74 48.7 µM 2.63E-10 cell wall 9 7.94E-12 0.17
11 SGTC_3327 9140648 6.64 26.9 µM 4.71E-10 3 1.58E-11 1.34
12 SGTC_514 4466-0038 6.52 2.6 nM 9.19E-10 cell wall 12 3.46E-11 0.26
13 SGTC_1026 k007-1105 6.44 30.6 µM 1.50E-9 ERAD & cell cycle 13 6.16E-11 0.11
14 SGTC_1933 st074711 6.20 15.9 µM 5.43E-9 2 2.78E-10 0.97
15 SGTC_104 0074-0074 6.18 591.0 µM 6.27E-9 4 3.29E-10 0.71
16 SGTC_103 0844-0104 6.14 51.8 µM 7.47E-9 ERAD & cell cycle 23 4.05E-10 0.06
17 SGTC_1493 4348-0038 6.11 111.0 µM 9.04E-9 RSC complex & mRNA processing 16 5.07E-10 0.03
18 SGTC_119 0121-0043 6.09 24.8 µM 1.01E-8 mitochondrial stress 6 5.79E-10 0.10
19 SGTC_586 0957-0265 6.04 8.2 µM 1.31E-8 cell wall 21 7.84E-10 0.14
20 SGTC_332 4112-0506 5.95 40.9 µM 2.02E-8 11 1.30E-9 0.21

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.369 4.25E-109 YBR091C TIM12 het Essential protein of the inner mitochondrial membrane, peripherally localized; component of the TIM22 complex, which is a twin-pore translocase that mediates insertion of numerous multispanning inner membrane proteins
0.363 5.04E-105 YNR016C ACC1 het Acetyl-CoA carboxylase, biotin containing enzyme; catalyzes the carboxylation of cytosolic acetyl-CoA to form malonyl-CoA and regulates histone acetylation by regulating the availablity of acetyl-CoA; required for de novo biosynthesis of long-chain fatty acids;
0.359 1.02E-102 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.358 3.98E-102 YBR020W GAL1 hom Galactokinase; phosphorylates alpha-D-galactose to alpha-D-galactose-1-phosphate in the first step of galactose catabolism; expression regulated by Gal4p; GAL1 has a paralog, GAL3, that arose from the whole genome duplication
0.341 2.82E-92 YPR104C FHL1 het Regulator of ribosomal protein (RP) transcription; has forkhead associated domain that binds phosphorylated proteins; recruits coactivator Ifh1p or corepressor Crf1p to RP gene promoters; also has forkhead DNA-binding domain though in vitro DNA binding assays give inconsistent results; computational analyses suggest it binds DNA directly at highly active RP genes and indirectly through Rap1p motifs at others; suppresses RNA pol III and splicing factor prp4 mutants
0.339 4.43E-91 YLR321C SFH1 het Component of the RSC chromatin remodeling complex; essential gene required for cell cycle progression and maintenance of proper ploidy; phosphorylated in the G1 phase of the cell cycle; Snf5p paralog
0.322 1.33E-81 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.314 2.23E-77 YMR124W_p YMR124W_p hom Protein of unknown function; GFP-fusion protein localizes to the cell periphery, cytoplasm, bud, and bud neck; interacts with Crm1p in two-hybrid assay; YMR124W is not an essential gene; predicted to have a role in organelle organization
0.310 1.86E-75 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes
0.308 1.78E-74 YOR236W DFR1 het Dihydrofolate reductase involved in tetrahydrofolate biosynthesis; required for respiratory metabolism
0.299 2.13E-70 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.298 1.27E-69 YLL032C YLL032C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; YLL032C is not an essential gene
0.284 2.54E-63 YJR142W_p YJR142W_p hom Putative protein of unknown function; GST fusion protein is a Dbf2p-Mob1p phosphorylation target in a proteome chip analysis; synthetic lethal with PH085 deletion; plays a role in restricting Ty1 transposition; nudix hydrolase family member
0.282 2.41E-62 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.279 7.37E-61 YPR107C YTH1 het Essential RNA-binding component of cleavage and polyadenylation factor, contains five zinc fingers; required for pre-mRNA 3'-end processing and polyadenylation