YDR173C / ARG82

Inositol polyphosphate multikinase (IPMK), sequentially phosphorylates Ins(1,4,5)P3 to form Ins(1,3,4,5,6)P5; also has diphosphoinositol polyphosphate synthase activity; regulates arginine-, phosphate-, and nitrogen-responsive genes

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR173C / ARG82

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:5.41|P-value:1.47E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:3.27|P-value:8.74E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.28|P-value:8.58E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.88|P-value:1.78E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:5.68|P-value:3.74E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:3.28|P-value:8.56E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.63|P-value:2.71E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.51|P-value:3.73E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:4.11|P-value:4.56E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.77|P-value:1.63E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.47|P-value:4.61E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.49|P-value:1.00E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.54|P-value:3.67E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.14|P-value:7.17E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.97|P-value:1.19E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.74|P-value:3.10E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.31|P-value:2.12E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.22|P-value:7.43E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.54|P-value:3.71E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.15|P-value:7.10E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:7.10|P-value:1.01E-11 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.26|P-value:4.62E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.71|P-value:2.04E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.92|P-value:1.49E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.08|P-value:9.16E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:4.11|P-value:4.55E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:-5.08|P-value:1.47E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:4.11|P-value:4.61E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.35|P-value:1.77E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.72|P-value:1.94E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.05|P-value:9.99E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.94|P-value:8.71E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.04|P-value:5.98E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.40|P-value:1.47E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.47|P-value:1.97E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.29|P-value:2.62E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:6.05|P-value:5.09E-9 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.51|P-value:4.11E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.48|P-value:4.50E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.94|P-value:1.36E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.12|P-value:4.38E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.19|P-value:3.42E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.67|P-value:3.82E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.84|P-value:5.10E-11 ID:SGTC_1694|Compound:st024011|FD-Score:6.55|P-value:2.90E-10 ID:SGTC_1715|Compound:st032160|FD-Score:-3.42|P-value:8.78E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.96|P-value:8.02E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.31|P-value:7.88E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.40|P-value:5.88E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.31|P-value:7.71E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.47|P-value:4.56E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.55|P-value:5.82E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.50|P-value:9.62E-6 ID:SGTC_2176|Compound:5809774|FD-Score:3.72|P-value:1.96E-4 ID:SGTC_2192|Compound:5915882|FD-Score:5.81|P-value:1.92E-8 ID:SGTC_2216|Compound:7189485|FD-Score:4.50|P-value:9.60E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.58|P-value:6.82E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.57|P-value:5.46E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.56|P-value:3.46E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.24|P-value:1.76E-9 ID:SGTC_2393|Compound:9031399|FD-Score:6.05|P-value:5.20E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.42|P-value:8.74E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.85|P-value:2.12E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.30|P-value:8.01E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.58|P-value:3.17E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.34|P-value:7.13E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.99|P-value:1.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.09|P-value:4.91E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.93|P-value:1.57E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:10.40|P-value:6.29E-23 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.31|P-value:7.81E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.90|P-value:1.65E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:3.51|P-value:4.00E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.62|P-value:4.56E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.99|P-value:7.19E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.41|P-value:9.13E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.56|P-value:3.39E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.41|P-value:1.37E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.81|P-value:2.41E-4 ID:SGTC_3209|Compound:9113616|FD-Score:5.36|P-value:1.90E-7 ID:SGTC_3219|Compound:9131112|FD-Score:3.23|P-value:9.98E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.03|P-value:1.09E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:5.41|P-value:1.47E-7 ID:SGTC_16|Compound:erodoxin|FD-Score:3.27|P-value:8.74E-4 ID:SGTC_72|Compound:0744-0168|FD-Score:3.28|P-value:8.58E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:4.88|P-value:1.78E-6 ID:SGTC_108|Compound:0509-0257|FD-Score:5.68|P-value:3.74E-8 ID:SGTC_117|Compound:lucigenin|FD-Score:3.28|P-value:8.56E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:3.63|P-value:2.71E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:6.51|P-value:3.73E-10 ID:SGTC_188|Compound:3229-0966|FD-Score:4.11|P-value:4.56E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:3.77|P-value:1.63E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:3.47|P-value:4.61E-4 ID:SGTC_218|Compound:alverine citrate|FD-Score:5.49|P-value:1.00E-7 ID:SGTC_242|Compound:5hr heat shock (37°C) + 5-fluorouracil|FD-Score:3.54|P-value:3.67E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.14|P-value:7.17E-5 ID:SGTC_351|Compound:caspofungin|FD-Score:4.97|P-value:1.19E-6 ID:SGTC_374|Compound:0880-0231|FD-Score:-3.74|P-value:3.10E-4 ID:SGTC_398|Compound:bronopol|FD-Score:4.31|P-value:2.12E-5 ID:SGTC_431|Compound:k089-0097|FD-Score:-5.22|P-value:7.43E-7 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.54|P-value:3.71E-4 ID:SGTC_467|Compound:ro 31-8220|FD-Score:7.15|P-value:7.10E-12 ID:SGTC_528|Compound:3492-0019|FD-Score:7.10|P-value:1.01E-11 ID:SGTC_569|Compound:4130-2812|FD-Score:-4.26|P-value:4.62E-5 ID:SGTC_684|Compound:1140-0066|FD-Score:3.71|P-value:2.04E-4 ID:SGTC_687|Compound:k029-0044|FD-Score:4.92|P-value:1.49E-6 ID:SGTC_690|Compound:glyoxal|FD-Score:-4.08|P-value:9.16E-5 ID:SGTC_730|Compound:1436-0052|FD-Score:4.11|P-value:4.55E-5 ID:SGTC_739|Compound:1486-1183|FD-Score:-5.08|P-value:1.47E-6 ID:SGTC_759|Compound:3486-0358|FD-Score:4.11|P-value:4.61E-5 ID:SGTC_800|Compound:3448-7362|FD-Score:4.35|P-value:1.77E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:3.72|P-value:1.94E-4 ID:SGTC_887|Compound:0885-0007|FD-Score:-4.05|P-value:9.99E-5 ID:SGTC_1073|Compound:triclabendazole|FD-Score:3.94|P-value:8.71E-5 ID:SGTC_1080|Compound:nisoldipine|FD-Score:4.04|P-value:5.98E-5 ID:SGTC_1087|Compound:pterostilbene|FD-Score:4.40|P-value:1.47E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-4.47|P-value:1.97E-5 ID:SGTC_1117|Compound:retinoic acid|FD-Score:5.29|P-value:2.62E-7 ID:SGTC_1121|Compound:fusaric acid|FD-Score:6.05|P-value:5.09E-9 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.51|P-value:4.11E-4 ID:SGTC_1228|Compound:0124-0032|FD-Score:3.48|P-value:4.50E-4 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.94|P-value:1.36E-6 ID:SGTC_1371|Compound:2421-0008|FD-Score:4.12|P-value:4.38E-5 ID:SGTC_1495|Compound:4469-0029|FD-Score:4.19|P-value:3.42E-5 ID:SGTC_1500|Compound:4488-1866|FD-Score:3.69|P-value:2.18E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:-3.67|P-value:3.82E-4 ID:SGTC_1536|Compound:cytidine-2',3'-monophosphoric acid;  3'-cytidylic acid|FD-Score:3.64|P-value:2.61E-4 ID:SGTC_1679|Compound:4130-1276|FD-Score:6.84|P-value:5.10E-11 ID:SGTC_1694|Compound:st024011|FD-Score:6.55|P-value:2.90E-10 ID:SGTC_1715|Compound:st032160|FD-Score:-3.42|P-value:8.78E-4 ID:SGTC_1727|Compound:st034309|FD-Score:3.96|P-value:8.02E-5 ID:SGTC_1750|Compound:st081859|FD-Score:3.31|P-value:7.88E-4 ID:SGTC_1762|Compound:st045503|FD-Score:3.40|P-value:5.88E-4 ID:SGTC_1773|Compound:st048542|FD-Score:3.31|P-value:7.71E-4 ID:SGTC_1809|Compound:st050081|FD-Score:3.47|P-value:4.56E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.55|P-value:5.82E-4 ID:SGTC_1932|Compound:st074806|FD-Score:4.50|P-value:9.62E-6 ID:SGTC_2176|Compound:5809774|FD-Score:3.72|P-value:1.96E-4 ID:SGTC_2192|Compound:5915882|FD-Score:5.81|P-value:1.92E-8 ID:SGTC_2216|Compound:7189485|FD-Score:4.50|P-value:9.60E-6 ID:SGTC_2250|Compound:alverine citrate|FD-Score:4.58|P-value:6.82E-6 ID:SGTC_2291|Compound:7917025|FD-Score:-3.57|P-value:5.46E-4 ID:SGTC_2346|Compound:9031566|FD-Score:3.56|P-value:3.46E-4 ID:SGTC_2348|Compound:9022543|FD-Score:6.24|P-value:1.76E-9 ID:SGTC_2393|Compound:9031399|FD-Score:6.05|P-value:5.20E-9 ID:SGTC_2408|Compound:sulbentine|FD-Score:-3.42|P-value:8.74E-4 ID:SGTC_2483|Compound:5729050|FD-Score:4.85|P-value:2.12E-6 ID:SGTC_2489|Compound:cantharidin|FD-Score:3.30|P-value:8.01E-4 ID:SGTC_2504|Compound:purpurogallin|FD-Score:3.58|P-value:3.17E-4 ID:SGTC_2513|Compound:baicalein|FD-Score:3.34|P-value:7.13E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:-3.99|P-value:1.27E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.09|P-value:4.91E-5 ID:SGTC_2584|Compound:androsterone|FD-Score:-3.93|P-value:1.57E-4 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:10.40|P-value:6.29E-23 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.31|P-value:7.81E-4 ID:SGTC_2737|Compound:bleomycin|FD-Score:4.90|P-value:1.65E-6 ID:SGTC_2743|Compound:auranofin|FD-Score:3.51|P-value:4.00E-4 ID:SGTC_2792|Compound:7535235|FD-Score:-3.62|P-value:4.56E-4 ID:SGTC_2829|Compound:7992743|FD-Score:3.99|P-value:7.19E-5 ID:SGTC_2832|Compound:7992762|FD-Score:-3.41|P-value:9.13E-4 ID:SGTC_2995|Compound:9067767|FD-Score:3.56|P-value:3.39E-4 ID:SGTC_3013|Compound:9080133|FD-Score:3.82|P-value:1.35E-4 ID:SGTC_3123|Compound:9126162|FD-Score:4.41|P-value:1.37E-5 ID:SGTC_3208|Compound:9114115|FD-Score:-3.81|P-value:2.41E-4 ID:SGTC_3209|Compound:9113616|FD-Score:5.36|P-value:1.90E-7 ID:SGTC_3219|Compound:9131112|FD-Score:3.23|P-value:9.98E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.03|P-value:1.09E-4

Top fitness defect scores for YDR173C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2615 purpurogallin-4-carboxylic acid 10.40 100.0 µM 6.29E-23 redox potentiating 7 1.27E-25
2 SGTC_467 ro 31-8220 7.15 72.8 µM 7.10E-12 calcium & mitochondrial duress 21 4.23E-13
3 SGTC_528 3492-0019 7.10 172.0 µM 1.01E-11 calcium & mitochondrial duress 93 6.33E-13
4 SGTC_1679 4130-1276 6.84 6.7 µM 5.10E-11 Golgi 18 3.93E-12
5 SGTC_1694 st024011 6.55 44.9 µM 2.90E-10 ERG2 10 2.80E-11
6 SGTC_178 4092-0806 6.51 87.5 µM 3.73E-10 ergosterol depletion effects on membrane 34 3.71E-11
7 SGTC_2348 9022543 6.24 33.4 µM 1.76E-9 mitochondrial processes 5 2.14E-10
8 SGTC_1121 fusaric acid 6.05 630.5 nM 5.09E-9 11 7.09E-10
9 SGTC_2393 9031399 6.05 185.9 µM 5.20E-9 RNA processing & uracil transport 4 7.26E-10
10 SGTC_2192 5915882 5.81 198.5 µM 1.92E-8 RNA processing & uracil transport 13 3.16E-9
11 SGTC_108 0509-0257 5.68 621.1 µM 3.74E-8 14 6.70E-9
12 SGTC_218 alverine citrate 5.49 93.8 µM 1.00E-7 fatty acid desaturase (OLE1) 17 2.03E-8
13 SGTC_3 0833-0587 5.41 95.6 µM 1.47E-7 redox potentiating 10 3.12E-8
14 SGTC_3209 9113616 5.36 49.5 µM 1.90E-7 3 4.17E-8
15 SGTC_1117 retinoic acid 5.29 1.1 µM 2.62E-7 5 6.01E-8
16 SGTC_351 caspofungin 4.97 25.0 nM 1.19E-6 cell wall 57 3.28E-7
17 SGTC_1246 0422-0085 4.94 105.0 µM 1.36E-6 10 3.82E-7
18 SGTC_687 k029-0044 4.92 34.9 µM 1.49E-6 PDR1 8 4.24E-7
19 SGTC_2737 bleomycin 4.90 30.5 nM 1.65E-6 Golgi 62 4.74E-7
20 SGTC_90 0870-0863 4.88 4.6 µM 1.78E-6 24 5.18E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.166 4.15E-22 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.158 3.77E-20 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.151 1.35E-18 YHR064C SSZ1 hom Hsp70 protein that interacts with Zuo1p (a DnaJ homolog) to form a ribosome-associated complex that binds the ribosome via the Zuo1p subunit; also involved in pleiotropic drug resistance via sequential activation of PDR1 and PDR5; binds ATP
0.149 3.97E-18 YLR304C ACO1 hom Aconitase, required for the tricarboxylic acid (TCA) cycle and also independently required for mitochondrial genome maintenance; phosphorylated; component of the mitochondrial nucleoid; mutation leads to glutamate auxotrophy
0.144 6.97E-17 YLR374C_d YLR374C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF STP3/YLR375W
0.143 9.16E-17 YDL160C DHH1 hom Cytoplasmic DExD/H-box helicase, stimulates mRNA decapping; coordinates distinct steps in mRNA function and decay, interacts with both the decapping and deadenylase complexes, may have a role in mRNA export and translation; C-terminus of Dhh1p interacts with Ngr1p and promotes POR1, but not EDC1 mRNA decay; forms cytoplasmic foci upon DNA replication stress
0.141 2.52E-16 YGR197C SNG1 hom Protein involved in resistance to nitrosoguanidine (MNNG) and 6-azauracil (6-AU); expression is regulated by transcription factors involved in multidrug resistance
0.139 5.63E-16 YBL007C SLA1 hom Cytoskeletal protein binding protein required for assembly of the cortical actin cytoskeleton; interacts with proteins regulating actin dynamics and proteins required for endocytosis; found in the nucleus and cell cortex; has 3 SH3 domains
0.138 9.80E-16 YOL072W THP1 hom Nuclear pore-associated protein; component of TREX-2 complex (Sac3p-Thp1p-Sus1p-Cdc31p) involved in transcription elongation and mRNA export from the nucleus; involved in post-transcriptional tethering of active genes to the nuclear periphery and to non-nascent mRNP; contains a PAM domain implicated in protein-protein binding
0.138 1.05E-15 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.136 2.22E-15 YML112W CTK3 hom Gamma subunit of C-terminal domain kinase I; CTDK-I phosphorylates RNA polymerase II subunit Rpo21p to affect transcription and pre-mRNA 3' end processing, and also phosphorylates ribosomal protein Rps2p to increase translational fidelity; protein abundance increases in response to DNA replication stress
0.134 7.56E-15 YOR162C YRR1 hom Zn2-Cys6 zinc-finger transcription factor; activates genes involved in multidrug resistance; paralog of Yrm1p, acting on an overlapping set of target genes; YRR1 has a paralog, PDR8, that arose from the whole genome duplication
0.131 2.76E-14 YFL033C RIM15 hom Glucose-repressible protein kinase involved in signal transduction during cell proliferation in response to nutrients, specifically the establishment of stationary phase; identified as a regulator of IME2; substrate of Pho80p-Pho85p kinase
0.131 2.75E-14 YMR079W SEC14 het Phosphatidylinositol/phosphatidylcholine transfer protein; involved in regulating PtdIns, PtdCho, and ceramide metabolism, products of which regulate intracellular transport and UPR; has a role in localization of lipid raft proteins; functionally homologous to mammalian PITPs
0.129 7.86E-14 YDR290W_d YDR290W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RTT103