YDR174W / HMO1

Chromatin associated high mobility group (HMG) family member involved in genome maintenance; rDNA-binding component of the Pol I transcription system; associates with a 5'-3' DNA helicase and Fpr1p, a prolyl isomerase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR174W / HMO1

Click on Significant Values for Screen Details ID:SGTC_33|Compound:0986-0033|FD-Score:3.89|P-value:8.25E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.38|P-value:6.72E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.60|P-value:2.46E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.81|P-value:1.13E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.15|P-value:1.48E-9 ID:SGTC_194|Compound:1486-1323|FD-Score:4.70|P-value:2.81E-6 ID:SGTC_209|Compound:4077-0173|FD-Score:4.27|P-value:1.81E-5 ID:SGTC_232|Compound:clozapine|FD-Score:5.00|P-value:7.03E-7 ID:SGTC_325|Compound:2810-4341|FD-Score:4.82|P-value:1.62E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.23|P-value:2.28E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.41|P-value:5.96E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.56|P-value:1.26E-10 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.33|P-value:7.80E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:7.16|P-value:2.68E-12 ID:SGTC_580|Compound:1123-0028|FD-Score:3.43|P-value:4.42E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:8.28|P-value:7.42E-16 ID:SGTC_596|Compound:1155-0152|FD-Score:4.38|P-value:1.14E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.71|P-value:1.66E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.13|P-value:3.28E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.81|P-value:1.04E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:4.06|P-value:4.32E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-4.16|P-value:3.72E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.44|P-value:8.90E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:5.66|P-value:2.32E-8 ID:SGTC_740|Compound:k014-0057|FD-Score:3.23|P-value:8.69E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.88|P-value:7.25E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:3.57|P-value:2.76E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.26|P-value:8.05E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.20|P-value:9.73E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.61|P-value:2.39E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.24|P-value:8.39E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.29|P-value:7.12E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.69|P-value:2.25E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.61|P-value:2.96E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.92|P-value:7.52E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.76|P-value:1.35E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:7.35|P-value:7.05E-13 ID:SGTC_1430|Compound:4049-0248|FD-Score:6.60|P-value:9.79E-11 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.37|P-value:5.42E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.70|P-value:2.81E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.42|P-value:5.81E-4 ID:SGTC_1642|Compound:st009582|FD-Score:4.09|P-value:3.90E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.10|P-value:2.00E-9 ID:SGTC_1839|Compound:st053978|FD-Score:3.75|P-value:1.40E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.51|P-value:3.42E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.65|P-value:2.04E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.60|P-value:2.47E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.56|P-value:2.81E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.76|P-value:1.37E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.73|P-value:1.94E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.76|P-value:2.11E-6 ID:SGTC_2013|Compound:4024628|FD-Score:8.34|P-value:4.81E-16 ID:SGTC_2029|Compound:5175081|FD-Score:-3.28|P-value:9.29E-4 ID:SGTC_2123|Compound:5259487|FD-Score:4.67|P-value:3.16E-6 ID:SGTC_2154|Compound:5570129|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.28|P-value:7.41E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.15|P-value:3.89E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.66|P-value:1.97E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.88|P-value:8.76E-5 ID:SGTC_2523|Compound:spermine|FD-Score:4.42|P-value:9.57E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.41|P-value:4.84E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.74|P-value:1.53E-8 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.24|P-value:2.09E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.25|P-value:8.28E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.79|P-value:1.23E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.88|P-value:8.87E-5 ID:SGTC_3044|Compound:9093193|FD-Score:5.85|P-value:8.37E-9 ID:SGTC_3102|Compound:9121669|FD-Score:-4.35|P-value:1.76E-5 ID:SGTC_3104|Compound:9120930|FD-Score:4.12|P-value:3.37E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.76|P-value:1.40E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.22|P-value:9.11E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.60|P-value:2.43E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.50|P-value:6.95E-6 ID:SGTC_3178|Compound:9107506|FD-Score:3.22|P-value:9.06E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.30|P-value:7.00E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.24|P-value:8.59E-4 ID:SGTC_33|Compound:0986-0033|FD-Score:3.89|P-value:8.25E-5 ID:SGTC_51|Compound:1013-0126|FD-Score:-3.38|P-value:6.72E-4 ID:SGTC_84|Compound:0443-0269|FD-Score:3.60|P-value:2.46E-4 ID:SGTC_99|Compound:0109-0120|FD-Score:3.81|P-value:1.13E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:6.15|P-value:1.48E-9 ID:SGTC_194|Compound:1486-1323|FD-Score:4.70|P-value:2.81E-6 ID:SGTC_209|Compound:4077-0173|FD-Score:4.27|P-value:1.81E-5 ID:SGTC_232|Compound:clozapine|FD-Score:5.00|P-value:7.03E-7 ID:SGTC_325|Compound:2810-4341|FD-Score:4.82|P-value:1.62E-6 ID:SGTC_449|Compound:xestospongin c|FD-Score:5.23|P-value:2.28E-7 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.41|P-value:5.96E-4 ID:SGTC_519|Compound:k048-0011|FD-Score:3.27|P-value:7.68E-4 ID:SGTC_525|Compound:k781-2675|FD-Score:6.56|P-value:1.26E-10 ID:SGTC_533|Compound:1222-0222|FD-Score:-3.33|P-value:7.80E-4 ID:SGTC_535|Compound:2293-4129|FD-Score:7.16|P-value:2.68E-12 ID:SGTC_580|Compound:1123-0028|FD-Score:3.43|P-value:4.42E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:8.28|P-value:7.42E-16 ID:SGTC_596|Compound:1155-0152|FD-Score:4.38|P-value:1.14E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:3.71|P-value:1.66E-4 ID:SGTC_620|Compound:0109-0052|FD-Score:4.13|P-value:3.28E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:5.81|P-value:1.04E-8 ID:SGTC_651|Compound:3253-0966|FD-Score:4.06|P-value:4.32E-5 ID:SGTC_695|Compound:3505-6186|FD-Score:-4.16|P-value:3.72E-5 ID:SGTC_708|Compound:3448-5400|FD-Score:4.44|P-value:8.90E-6 ID:SGTC_712|Compound:r015-0009|FD-Score:5.66|P-value:2.32E-8 ID:SGTC_740|Compound:k014-0057|FD-Score:3.23|P-value:8.69E-4 ID:SGTC_831|Compound:k061-1017|FD-Score:5.88|P-value:7.25E-9 ID:SGTC_832|Compound:4083-0019|FD-Score:3.57|P-value:2.76E-4 ID:SGTC_833|Compound:3852-0053|FD-Score:3.26|P-value:8.05E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.20|P-value:9.73E-4 ID:SGTC_949|Compound:1165-0505|FD-Score:3.83|P-value:1.04E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:3.61|P-value:2.39E-4 ID:SGTC_1173|Compound:0443-0020|FD-Score:3.24|P-value:8.39E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.29|P-value:7.12E-4 ID:SGTC_1213|Compound:1315-0166|FD-Score:-3.69|P-value:2.25E-4 ID:SGTC_1345|Compound:1488-0192|FD-Score:-3.61|P-value:2.96E-4 ID:SGTC_1362|Compound:1611-0397|FD-Score:3.92|P-value:7.52E-5 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.76|P-value:1.35E-4 ID:SGTC_1424|Compound:4048-1941|FD-Score:7.35|P-value:7.05E-13 ID:SGTC_1430|Compound:4049-0248|FD-Score:6.60|P-value:9.79E-11 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.37|P-value:5.42E-4 ID:SGTC_1508|Compound:1080-0625|FD-Score:4.70|P-value:2.81E-6 ID:SGTC_1544|Compound:7-methoxy-4-methylcoumarin|FD-Score:-3.42|P-value:5.81E-4 ID:SGTC_1642|Compound:st009582|FD-Score:4.09|P-value:3.90E-5 ID:SGTC_1781|Compound:st038725|FD-Score:6.10|P-value:2.00E-9 ID:SGTC_1839|Compound:st053978|FD-Score:3.75|P-value:1.40E-4 ID:SGTC_1846|Compound:st056244|FD-Score:3.51|P-value:3.42E-4 ID:SGTC_1867|Compound:st057372|FD-Score:3.65|P-value:2.04E-4 ID:SGTC_1871|Compound:st057448|FD-Score:3.60|P-value:2.47E-4 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.56|P-value:2.81E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:3.76|P-value:1.37E-4 ID:SGTC_1948|Compound:st076329|FD-Score:-3.73|P-value:1.94E-4 ID:SGTC_1991|Compound:st073000|FD-Score:4.76|P-value:2.11E-6 ID:SGTC_2013|Compound:4024628|FD-Score:8.34|P-value:4.81E-16 ID:SGTC_2029|Compound:5175081|FD-Score:-3.28|P-value:9.29E-4 ID:SGTC_2123|Compound:5259487|FD-Score:4.67|P-value:3.16E-6 ID:SGTC_2154|Compound:5570129|FD-Score:3.83|P-value:1.06E-4 ID:SGTC_2204|Compound:7233102|FD-Score:3.28|P-value:7.41E-4 ID:SGTC_2284|Compound:7945075|FD-Score:3.71|P-value:1.63E-4 ID:SGTC_2330|Compound:7979373|FD-Score:-4.15|P-value:3.89E-5 ID:SGTC_2338|Compound:7999974|FD-Score:3.66|P-value:1.97E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.88|P-value:8.76E-5 ID:SGTC_2523|Compound:spermine|FD-Score:4.42|P-value:9.57E-6 ID:SGTC_2569|Compound:tetrandrine|FD-Score:3.41|P-value:4.84E-4 ID:SGTC_2627|Compound:acetyl isogambogic acid|FD-Score:5.74|P-value:1.53E-8 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:5.24|P-value:2.09E-7 ID:SGTC_2756|Compound:carbadox|FD-Score:3.25|P-value:8.28E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.51|P-value:3.43E-4 ID:SGTC_2981|Compound:9013952|FD-Score:3.79|P-value:1.23E-4 ID:SGTC_3016|Compound:9080866|FD-Score:3.88|P-value:8.87E-5 ID:SGTC_3044|Compound:9093193|FD-Score:5.85|P-value:8.37E-9 ID:SGTC_3102|Compound:9121669|FD-Score:-4.35|P-value:1.76E-5 ID:SGTC_3104|Compound:9120930|FD-Score:4.12|P-value:3.37E-5 ID:SGTC_3116|Compound:9124943|FD-Score:3.76|P-value:1.40E-4 ID:SGTC_3122|Compound:9126309|FD-Score:3.22|P-value:9.11E-4 ID:SGTC_3128|Compound:9127691|FD-Score:3.60|P-value:2.43E-4 ID:SGTC_3174|Compound:9107204|FD-Score:4.50|P-value:6.95E-6 ID:SGTC_3178|Compound:9107506|FD-Score:3.22|P-value:9.06E-4 ID:SGTC_3193|Compound:9111931|FD-Score:3.73|P-value:1.53E-4 ID:SGTC_3310|Compound:9130229|FD-Score:3.30|P-value:7.00E-4 ID:SGTC_3335|Compound:9143315|FD-Score:3.24|P-value:8.59E-4

Top fitness defect scores for YDR174W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2013 4024628 8.34 200.0 µM 4.81E-16 4 3.72E-17
2 SGTC_582 0987-0078 8.28 156.0 µM 7.42E-16 calcium & mitochondrial duress 11 5.95E-17
3 SGTC_1424 4048-1941 7.35 275.0 µM 7.05E-13 2 9.84E-14
4 SGTC_535 2293-4129 7.16 48.2 µM 2.68E-12 NEO1 17 4.17E-13
5 SGTC_1430 4049-0248 6.60 69.1 µM 9.79E-11 2 2.03E-11
6 SGTC_525 k781-2675 6.56 26.7 µM 1.26E-10 redox potentiating 20 2.68E-11
7 SGTC_118 0083-0097 6.15 135.3 µM 1.48E-9 translation 20 3.80E-10
8 SGTC_1781 st038725 6.10 66.3 µM 2.00E-9 NEO1 55 5.26E-10
9 SGTC_831 k061-1017 5.88 217.0 µM 7.25E-9 translation 10 2.11E-9
10 SGTC_3044 9093193 5.85 49.5 µM 8.37E-9 3 2.47E-9
11 SGTC_625 k213-0058 5.81 121.0 µM 1.04E-8 translation 37 3.11E-9
12 SGTC_2627 acetyl isogambogic acid 5.74 100.0 µM 1.53E-8 TSC3-RPN4 17 4.72E-9
13 SGTC_712 r015-0009 5.66 80.6 µM 2.32E-8 12 7.42E-9
14 SGTC_2658 polymyxin b sulfate 5.24 77.0 µM 2.09E-7 NEO1 26 7.91E-8
15 SGTC_449 xestospongin c 5.23 11.2 µM 2.28E-7 NEO1-PIK1 26 8.69E-8
16 SGTC_232 clozapine 5.00 119.0 µM 7.03E-7 NEO1 43 2.93E-7
17 SGTC_325 2810-4341 4.82 181.0 µM 1.62E-6 amide catabolism 4 7.19E-7
18 SGTC_1991 st073000 4.76 8.9 µM 2.11E-6 NEO1 58 9.56E-7
19 SGTC_194 1486-1323 4.70 56.9 µM 2.81E-6 8 1.30E-6
20 SGTC_1508 1080-0625 4.70 72.9 µM 2.81E-6 9 1.30E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.192 2.84E-29 YJL136C RPS21B hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S21, no bacterial homolog; RPS21B has a paralog, RPS21A, that arose from the whole genome duplication
0.162 3.64E-21 YDR140W MTQ2 hom S-adenosylmethionine-dependent methyltransferase of the seven beta-strand family; subunit of complex with Trm112p that methylates translation release factor Sup45p (eRF1) in the ternary complex eRF1-eRF3-GTP; similar to E.coli PrmC
0.161 7.63E-21 YLR048W RPS0B hom Protein component of the small (40S) ribosomal subunit; RPS0B has a paralog, RPS0A, that arose from the whole genome duplication; required for maturation of 18S rRNA along with Rps0Ap; deletion of either RPS0 gene reduces growth rate, deletion of both genes is lethal; homologous to human ribosomal protein SA and bacterial S2
0.152 8.39E-19 YGR162W TIF4631 hom Translation initiation factor eIF4G; subunit of the mRNA cap-binding protein complex (eIF4F) that also contains eIF4E (Cdc33p); interacts with Pab1p and with eIF4A (Tif1p); also has a role in biogenesis of the large ribosomal subunit; TIF4631 has a paralog, TIF4632, that arose from the whole genome duplication
0.151 1.47E-18 YDR455C_d YDR455C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene YDR456W
0.150 2.53E-18 YIL048W NEO1 het Putative aminophospholipid translocase (flippase) involved in endocytosis and vacuolar biogenesis; localizes to endosomes and the Golgi aparatus
0.141 2.07E-16 YCR064C_d YCR064C_d hom Dubious open reading frame unlikely to encode a protein, based on experimental and comparative sequence data; partially overlaps the verified gene BUD31
0.139 5.89E-16 YJL154C VPS35 hom Endosomal subunit of membrane-associated retromer complex required for retrograde transport; receptor that recognizes retrieval signals on cargo proteins, forms subcomplex with Vps26p and Vps29p that selects cargo proteins for retrieval; interacts with Ypt7p
0.134 8.47E-15 YAL009W SPO7 hom Putative regulatory subunit of Nem1p-Spo7p phosphatase holoenzyme, regulates nuclear growth by controlling phospholipid biosynthesis, required for normal nuclear envelope morphology, premeiotic replication, and sporulation
0.127 1.91E-13 YGL123W RPS2 het Protein component of the small (40S) subunit; essential for control of translational accuracy; phosphorylation by C-terminal domain kinase I (CTDK-I) enhances translational accuracy; methylated on one or more arginine residues by Hmt1p; homologous to mammalian ribosomal protein S2 and bacterial S5
0.123 9.38E-13 YOR293W RPS10A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S10, no bacterial homolog; RPS10A has a paralog, RPS10B, that arose from the whole genome duplication
0.121 2.02E-12 YGR271C-A EFG1 hom Essential protein required for maturation of 18S rRNA; null mutant is sensitive to hydroxyurea and is delayed in recovering from alpha-factor arrest; green fluorescent protein (GFP)-fusion protein localizes to the nucleolus
0.121 2.07E-12 YML036W CGI121 hom Component of the EKC/KEOPS complex with Bud32p, Kae1p, Pcc1p, and Gon7p; EKC/KEOPS complex is required for t6A tRNA modification and may have roles in telomere maintenance and transcription; Cgi121p is dispensable for tRNA modification
0.121 2.09E-12 YLR060W FRS1 het Beta subunit of cytoplasmic phenylalanyl-tRNA synthetase, forms a tetramer with Frs2p to generate active enzyme; able to hydrolyze mis-aminoacylated tRNA-Phe, which could contribute to translational quality control
0.118 6.11E-12 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion