YDR175C / RSM24

Mitochondrial ribosomal protein of the small subunit

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR175C / RSM24

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:4.11|P-value:5.28E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.58|P-value:3.56E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.20|P-value:3.64E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.51|P-value:4.55E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.36|P-value:2.08E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:7.86|P-value:6.20E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:12.40|P-value:1.29E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.95|P-value:1.47E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:6.16|P-value:3.07E-9 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.34|P-value:8.55E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.09|P-value:7.78E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.51|P-value:1.13E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.61|P-value:6.83E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.32|P-value:9.29E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.99|P-value:8.93E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.49|P-value:4.96E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.68|P-value:5.02E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.61|P-value:6.65E-6 ID:SGTC_935|Compound:2996-0153|FD-Score:3.61|P-value:3.25E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.59|P-value:3.76E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.59|P-value:3.78E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:6.24|P-value:2.02E-9 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.35|P-value:2.00E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:5.85|P-value:1.73E-8 ID:SGTC_1516|Compound:st013856|FD-Score:3.56|P-value:3.82E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.20|P-value:3.71E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-4.08|P-value:6.47E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.42|P-value:1.49E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.33|P-value:8.25E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.78|P-value:1.96E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.01|P-value:8.40E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.85|P-value:2.66E-6 ID:SGTC_1758|Compound:st042942|FD-Score:4.89|P-value:1.99E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.34|P-value:2.26E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.56|P-value:4.19E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.82|P-value:1.54E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.51|P-value:4.91E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.55|P-value:4.34E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.72|P-value:2.23E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.45|P-value:5.94E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.30|P-value:2.65E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.63|P-value:3.01E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.29|P-value:9.37E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.56|P-value:4.17E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.80|P-value:2.94E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.82|P-value:1.53E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.37|P-value:1.99E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.39|P-value:6.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.36|P-value:7.99E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.48|P-value:5.46E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.93|P-value:1.13E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.49|P-value:5.28E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.46|P-value:5.34E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:4.11|P-value:5.28E-5 ID:SGTC_70|Compound:0141-0289|FD-Score:3.58|P-value:3.56E-4 ID:SGTC_101|Compound:0490-5701|FD-Score:4.20|P-value:3.64E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:3.51|P-value:4.55E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:-4.36|P-value:2.08E-5 ID:SGTC_173|Compound:1273-0061|FD-Score:7.86|P-value:6.20E-14 ID:SGTC_236|Compound:1509-0011|FD-Score:12.40|P-value:1.29E-31 ID:SGTC_275|Compound:trichlorophene|FD-Score:4.95|P-value:1.47E-6 ID:SGTC_310|Compound:1273-0058|FD-Score:6.16|P-value:3.07E-9 ID:SGTC_339|Compound:3091-4833|FD-Score:-3.34|P-value:8.55E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:5.09|P-value:7.78E-7 ID:SGTC_431|Compound:k089-0097|FD-Score:-4.51|P-value:1.13E-5 ID:SGTC_625|Compound:k213-0058|FD-Score:4.61|P-value:6.83E-6 ID:SGTC_660|Compound:4031-1742|FD-Score:-3.32|P-value:9.29E-4 ID:SGTC_669|Compound:0108-0021|FD-Score:-3.99|P-value:8.93E-5 ID:SGTC_673|Compound:1082-0474|FD-Score:3.49|P-value:4.96E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:3.84|P-value:1.44E-4 ID:SGTC_685|Compound:1278-0033|FD-Score:4.68|P-value:5.02E-6 ID:SGTC_832|Compound:4083-0019|FD-Score:4.61|P-value:6.65E-6 ID:SGTC_935|Compound:2996-0153|FD-Score:3.61|P-value:3.25E-4 ID:SGTC_1262|Compound:0737-0114|FD-Score:-3.59|P-value:3.76E-4 ID:SGTC_1265|Compound:0819-1001|FD-Score:-3.59|P-value:3.78E-4 ID:SGTC_1278|Compound:0874-0585|FD-Score:6.24|P-value:2.02E-9 ID:SGTC_1284|Compound:0929-0043|FD-Score:4.35|P-value:2.00E-5 ID:SGTC_1289|Compound:0976-0073|FD-Score:5.85|P-value:1.73E-8 ID:SGTC_1516|Compound:st013856|FD-Score:3.56|P-value:3.82E-4 ID:SGTC_1623|Compound:st003709|FD-Score:4.20|P-value:3.71E-5 ID:SGTC_1656|Compound:st012921|FD-Score:-4.08|P-value:6.47E-5 ID:SGTC_1681|Compound:tripelennamine|FD-Score:4.42|P-value:1.49E-5 ID:SGTC_1683|Compound:st010134|FD-Score:3.33|P-value:8.25E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.78|P-value:1.96E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.01|P-value:8.40E-5 ID:SGTC_1754|Compound:st042065|FD-Score:-4.85|P-value:2.66E-6 ID:SGTC_1758|Compound:st042942|FD-Score:4.89|P-value:1.99E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.34|P-value:2.26E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-3.56|P-value:4.19E-4 ID:SGTC_1816|Compound:st051957|FD-Score:3.82|P-value:1.54E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-3.51|P-value:4.91E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-3.55|P-value:4.34E-4 ID:SGTC_1915|Compound:st067105|FD-Score:3.72|P-value:2.23E-4 ID:SGTC_1916|Compound:st067606|FD-Score:-3.45|P-value:5.94E-4 ID:SGTC_1917|Compound:st066507|FD-Score:-4.30|P-value:2.65E-5 ID:SGTC_2113|Compound:5491891|FD-Score:3.63|P-value:3.01E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:3.29|P-value:9.37E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.56|P-value:4.17E-4 ID:SGTC_2313|Compound:7726885|FD-Score:4.80|P-value:2.94E-6 ID:SGTC_2509|Compound:methyl 7-deshydroxypyrogallin-4-carboxylate|FD-Score:3.82|P-value:1.53E-4 ID:SGTC_2526|Compound:patulin|FD-Score:5.37|P-value:1.99E-7 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.39|P-value:6.71E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.36|P-value:7.99E-4 ID:SGTC_2780|Compound:5215298|FD-Score:-3.48|P-value:5.46E-4 ID:SGTC_2896|Compound:9052656|FD-Score:-3.93|P-value:1.13E-4 ID:SGTC_3345|Compound:9148410|FD-Score:-3.49|P-value:5.28E-4 ID:SGTC_3348|Compound:9149464|FD-Score:3.46|P-value:5.34E-4

Top fitness defect scores for YDR175C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 12.40 5.3 µM 1.29E-31 143 2.40E-35
2 SGTC_173 1273-0061 7.86 2.7 µM 6.20E-14 mitochondrial stress 70 1.91E-15
3 SGTC_1278 0874-0585 6.24 172.0 µM 2.02E-9 1 2.24E-10
4 SGTC_310 1273-0058 6.16 1.1 µM 3.07E-9 mitochondrial stress 140 3.59E-10
5 SGTC_1289 0976-0073 5.85 69.1 µM 1.73E-8 1 2.50E-9
6 SGTC_2526 patulin 5.37 37.6 µM 1.99E-7 35 3.86E-8
7 SGTC_358 0075-0058 5.09 9.4 µM 7.78E-7 29 1.78E-7
8 SGTC_275 trichlorophene 4.95 5.7 µM 1.47E-6 mitochondrial stress 171 3.63E-7
9 SGTC_1758 st042942 4.89 75.2 µM 1.99E-6 9 5.11E-7
10 SGTC_2313 7726885 4.80 200.0 µM 2.94E-6 RPP1 & pyrimidine depletion 18 7.92E-7
11 SGTC_685 1278-0033 4.68 54.9 µM 5.02E-6 60S ribosome export 8 1.44E-6
12 SGTC_832 4083-0019 4.61 164.0 µM 6.65E-6 translation 55 1.98E-6
13 SGTC_625 k213-0058 4.61 121.0 µM 6.83E-6 translation 68 2.04E-6
14 SGTC_1681 tripelennamine 4.42 100.0 µM 1.49E-5 11 4.88E-6
15 SGTC_1284 0929-0043 4.35 16.0 µM 2.00E-5 17 6.79E-6
16 SGTC_101 0490-5701 4.20 117.5 µM 3.64E-5 8 1.32E-5
17 SGTC_1623 st003709 4.20 20.3 µM 3.71E-5 calcium & mitochondrial duress 59 1.35E-5
18 SGTC_10 0279-0212 4.11 42.6 µM 5.28E-5 TRP & mitochondrial translation 111 2.01E-5
19 SGTC_679 0422-0091 3.84 41.4 µM 1.44E-4 Golgi 33 6.17E-5
20 SGTC_2509 methyl 7-deshydroxypyrogallin-4-carboxylate 3.82 54.6 µM 1.53E-4 RPP1 & pyrimidine depletion 33 6.59E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.447 1.10E-163 YMR287C DSS1 hom 3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.423 2.02E-145 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.411 6.88E-137 YNL177C MRPL22 hom Mitochondrial ribosomal protein of the large subunit
0.410 3.65E-136 YDR298C ATP5 hom Subunit 5 of the stator stalk of mitochondrial F1F0 ATP synthase, which is an evolutionarily conserved enzyme complex required for ATP synthesis; homologous to bovine subunit OSCP (oligomycin sensitivity-conferring protein); phosphorylated
0.406 1.41E-133 YNL184C_p YNL184C_p hom Protein of unknown function; expressed at both mRNA and protein levels
0.406 1.79E-133 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.403 1.14E-130 YMR193W MRPL24 hom Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.402 2.86E-130 YML061C PIF1 hom DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.398 2.23E-127 YKL170W MRPL38 hom Mitochondrial ribosomal protein of the large subunit; appears as two protein spots (YmL34 and YmL38) on two-dimensional SDS gels; protein abundance increases in response to DNA replication stress
0.393 7.19E-124 YLR260W LCB5 hom Minor sphingoid long-chain base kinase, paralog of Lcb4p responsible for few percent of the total activity, possibly involved in synthesis of long-chain base phosphates, which function as signaling molecules
0.391 1.77E-122 YPL040C ISM1 hom Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.391 1.81E-122 YER087W AIM10 hom Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss
0.389 2.03E-121 YGR215W RSM27 hom Mitochondrial ribosomal protein of the small subunit
0.388 1.37E-120 YDR296W MHR1 hom Protein involved in homologous recombination in mitochondria; required for recombination-dependent mtDNA partitioning; involved in stimulation of mitochondrial DNA replication in response to oxidative stress
0.387 2.04E-120 YLL033W IRC19 hom Putative protein of unknown function; YLL033W is not an essential gene but mutant is defective in spore formation; null mutant displays increased levels of spontaneous Rad52p foci