YDR176W / NGG1

Transcriptional regulator involved in glucose repression of Gal4p-regulated genes; component of transcriptional adaptor and histone acetyltransferase complexes, the ADA complex, the SAGA complex, and the SLIK complex

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR176W / NGG1

Click on Significant Values for Screen Details ID:SGTC_7|Compound:0192-1582|FD-Score:4.16|P-value:1.67E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.61|P-value:9.46E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.58|P-value:3.80E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.60|P-value:8.36E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:7.17|P-value:2.84E-10 ID:SGTC_201|Compound:4262-0159|FD-Score:4.24|P-value:1.25E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:6.78|P-value:2.26E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-6.02|P-value:7.91E-8 ID:SGTC_253|Compound:dyclonine|FD-Score:4.56|P-value:4.18E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:7.28|P-value:1.51E-10 ID:SGTC_268|Compound:camptothecin|FD-Score:9.45|P-value:1.43E-16 ID:SGTC_269|Compound:exalamide|FD-Score:5.31|P-value:2.25E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:4.48|P-value:5.51E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.80|P-value:4.50E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.81|P-value:5.05E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.95|P-value:3.26E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.75|P-value:6.06E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.59|P-value:3.74E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.58|P-value:3.82E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:6.07|P-value:7.71E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.40|P-value:6.12E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.98|P-value:8.55E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.88|P-value:1.29E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.27|P-value:9.69E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.91|P-value:3.76E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.32|P-value:8.29E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.24|P-value:1.28E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.98|P-value:8.72E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.67|P-value:7.81E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.73|P-value:6.52E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.59|P-value:9.94E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.62|P-value:3.34E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.89|P-value:3.99E-4 ID:SGTC_1627|Compound:st003713|FD-Score:5.24|P-value:3.01E-6 ID:SGTC_1638|Compound:st008370|FD-Score:4.27|P-value:1.13E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.35|P-value:2.52E-13 ID:SGTC_1773|Compound:st048542|FD-Score:-3.77|P-value:4.97E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.59|P-value:9.85E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.40|P-value:1.62E-8 ID:SGTC_2074|Compound:5212007|FD-Score:3.86|P-value:4.42E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.00|P-value:2.43E-4 ID:SGTC_2220|Compound:6782180|FD-Score:4.74|P-value:2.13E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:12.60|P-value:5.40E-28 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.58|P-value:5.89E-14 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.20|P-value:1.48E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.06|P-value:2.29E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.05|P-value:2.02E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.00|P-value:2.84E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.74|P-value:3.53E-7 ID:SGTC_2342|Compound:7990637|FD-Score:4.53|P-value:4.68E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.68|P-value:6.65E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.61|P-value:9.39E-4 ID:SGTC_2383|Compound:9036125|FD-Score:4.87|P-value:1.31E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.94|P-value:9.95E-6 ID:SGTC_2416|Compound:tofa|FD-Score:4.56|P-value:4.11E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.13|P-value:4.76E-6 ID:SGTC_2485|Compound:5633444|FD-Score:3.66|P-value:8.04E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.43|P-value:6.59E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-5.15|P-value:3.52E-6 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.64|P-value:7.32E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.22|P-value:1.38E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:9.59|P-value:5.26E-17 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:5.16|P-value:4.17E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.78|P-value:5.63E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.67|P-value:2.81E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.66|P-value:7.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.89|P-value:4.02E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-4.09|P-value:1.81E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.66|P-value:8.07E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.94|P-value:9.90E-10 ID:SGTC_2902|Compound:5787006|FD-Score:5.21|P-value:3.43E-6 ID:SGTC_2905|Compound:7799065|FD-Score:9.11|P-value:1.58E-15 ID:SGTC_2912|Compound:7964298|FD-Score:8.44|P-value:1.39E-13 ID:SGTC_2916|Compound:7875993|FD-Score:9.96|P-value:3.45E-18 ID:SGTC_2929|Compound:9013348|FD-Score:3.66|P-value:8.04E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.72|P-value:5.82E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.75|P-value:5.25E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.83|P-value:4.75E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.68|P-value:7.67E-4 ID:SGTC_3177|Compound:9107506|FD-Score:4.04|P-value:2.44E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.75|P-value:5.31E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.31|P-value:9.98E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.61|P-value:9.29E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.74|P-value:6.41E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.43|P-value:1.36E-6 ID:SGTC_7|Compound:0192-1582|FD-Score:4.16|P-value:1.67E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:3.61|P-value:9.46E-4 ID:SGTC_121|Compound:0557-0495|FD-Score:4.58|P-value:3.80E-5 ID:SGTC_137|Compound:0438-0332|FD-Score:-3.60|P-value:8.36E-4 ID:SGTC_178|Compound:4092-0806|FD-Score:7.17|P-value:2.84E-10 ID:SGTC_201|Compound:4262-0159|FD-Score:4.24|P-value:1.25E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:6.78|P-value:2.26E-9 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-6.02|P-value:7.91E-8 ID:SGTC_253|Compound:dyclonine|FD-Score:4.56|P-value:4.18E-5 ID:SGTC_266|Compound:formosanin C|FD-Score:7.28|P-value:1.51E-10 ID:SGTC_268|Compound:camptothecin|FD-Score:9.45|P-value:1.43E-16 ID:SGTC_269|Compound:exalamide|FD-Score:5.31|P-value:2.25E-6 ID:SGTC_312|Compound:4092-0653|FD-Score:4.48|P-value:5.51E-5 ID:SGTC_318|Compound:1488-0629|FD-Score:-3.80|P-value:4.50E-4 ID:SGTC_320|Compound:4092-0846|FD-Score:3.81|P-value:5.05E-4 ID:SGTC_324|Compound:1315-0088|FD-Score:3.95|P-value:3.26E-4 ID:SGTC_351|Compound:caspofungin|FD-Score:3.75|P-value:6.06E-4 ID:SGTC_576|Compound:1073-0113|FD-Score:4.59|P-value:3.74E-5 ID:SGTC_582|Compound:0987-0078|FD-Score:4.58|P-value:3.82E-5 ID:SGTC_608|Compound:k048-0125|FD-Score:6.07|P-value:7.71E-8 ID:SGTC_617|Compound:3770-0098|FD-Score:-4.40|P-value:6.12E-5 ID:SGTC_710|Compound:3448-4187|FD-Score:4.98|P-value:8.55E-6 ID:SGTC_740|Compound:k014-0057|FD-Score:4.88|P-value:1.29E-5 ID:SGTC_906|Compound:1165-0455|FD-Score:-4.27|P-value:9.69E-5 ID:SGTC_978|Compound:1416-0512|FD-Score:3.91|P-value:3.76E-4 ID:SGTC_1033|Compound:k072-0102|FD-Score:-4.32|P-value:8.29E-5 ID:SGTC_1122|Compound:capsaicin|FD-Score:4.24|P-value:1.28E-4 ID:SGTC_1223|Compound:0764-0573|FD-Score:4.98|P-value:8.72E-6 ID:SGTC_1279|Compound:0874-0590|FD-Score:3.67|P-value:7.81E-4 ID:SGTC_1308|Compound:1187-1617|FD-Score:3.73|P-value:6.52E-4 ID:SGTC_1320|Compound:1313-0481|FD-Score:3.59|P-value:9.94E-4 ID:SGTC_1410|Compound:3909-8106|FD-Score:4.62|P-value:3.34E-5 ID:SGTC_1432|Compound:4049-0298|FD-Score:3.89|P-value:3.99E-4 ID:SGTC_1627|Compound:st003713|FD-Score:5.24|P-value:3.01E-6 ID:SGTC_1638|Compound:st008370|FD-Score:4.27|P-value:1.13E-4 ID:SGTC_1750|Compound:st081859|FD-Score:8.35|P-value:2.52E-13 ID:SGTC_1773|Compound:st048542|FD-Score:-3.77|P-value:4.97E-4 ID:SGTC_1944|Compound:st076371|FD-Score:3.59|P-value:9.85E-4 ID:SGTC_2006|Compound:4011487|FD-Score:6.40|P-value:1.62E-8 ID:SGTC_2074|Compound:5212007|FD-Score:3.86|P-value:4.42E-4 ID:SGTC_2085|Compound:5307070|FD-Score:-4.00|P-value:2.43E-4 ID:SGTC_2220|Compound:6782180|FD-Score:4.74|P-value:2.13E-5 ID:SGTC_2249|Compound:haloperidol|FD-Score:12.60|P-value:5.40E-28 ID:SGTC_2250|Compound:alverine citrate|FD-Score:8.58|P-value:5.89E-14 ID:SGTC_2251|Compound:lansoprazole|FD-Score:4.20|P-value:1.48E-4 ID:SGTC_2264|Compound:7948757|FD-Score:4.06|P-value:2.29E-4 ID:SGTC_2273|Compound:7815444|FD-Score:-4.05|P-value:2.02E-4 ID:SGTC_2297|Compound:7971671|FD-Score:4.00|P-value:2.84E-4 ID:SGTC_2323|Compound:6148992|FD-Score:5.74|P-value:3.53E-7 ID:SGTC_2342|Compound:7990637|FD-Score:4.53|P-value:4.68E-5 ID:SGTC_2344|Compound:7990960|FD-Score:-3.68|P-value:6.65E-4 ID:SGTC_2354|Compound:9060492|FD-Score:3.61|P-value:9.39E-4 ID:SGTC_2383|Compound:9036125|FD-Score:4.87|P-value:1.31E-5 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.94|P-value:9.95E-6 ID:SGTC_2416|Compound:tofa|FD-Score:4.56|P-value:4.11E-5 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:5.13|P-value:4.76E-6 ID:SGTC_2485|Compound:5633444|FD-Score:3.66|P-value:8.04E-4 ID:SGTC_2548|Compound:3',4'-didesmethyl-5-deshydroxy-3'-ethoxyscleroin|FD-Score:4.43|P-value:6.59E-5 ID:SGTC_2556|Compound:citropten|FD-Score:-5.15|P-value:3.52E-6 ID:SGTC_2559|Compound:tetrahydrosappanone a trimethyl ether|FD-Score:-3.64|P-value:7.32E-4 ID:SGTC_2603|Compound:homopterocarpin|FD-Score:4.22|P-value:1.38E-4 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:9.59|P-value:5.26E-17 ID:SGTC_2660|Compound:2',4'-dihydroxychalcone|FD-Score:5.16|P-value:4.17E-6 ID:SGTC_2682|Compound:pyrogallin|FD-Score:3.78|P-value:5.63E-4 ID:SGTC_2683|Compound:piperine|FD-Score:4.67|P-value:2.81E-5 ID:SGTC_2687|Compound:chenodiol|FD-Score:3.66|P-value:7.99E-4 ID:SGTC_2688|Compound:kanamycin b|FD-Score:3.89|P-value:4.02E-4 ID:SGTC_2702|Compound:st077768|FD-Score:-4.09|P-value:1.81E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.66|P-value:8.07E-4 ID:SGTC_2858|Compound:9025781|FD-Score:6.94|P-value:9.90E-10 ID:SGTC_2902|Compound:5787006|FD-Score:5.21|P-value:3.43E-6 ID:SGTC_2905|Compound:7799065|FD-Score:9.11|P-value:1.58E-15 ID:SGTC_2912|Compound:7964298|FD-Score:8.44|P-value:1.39E-13 ID:SGTC_2916|Compound:7875993|FD-Score:9.96|P-value:3.45E-18 ID:SGTC_2929|Compound:9013348|FD-Score:3.66|P-value:8.04E-4 ID:SGTC_3027|Compound:9089541|FD-Score:-3.72|P-value:5.82E-4 ID:SGTC_3104|Compound:9120930|FD-Score:-3.75|P-value:5.25E-4 ID:SGTC_3112|Compound:9123419|FD-Score:3.83|P-value:4.75E-4 ID:SGTC_3114|Compound:9122766|FD-Score:3.68|P-value:7.67E-4 ID:SGTC_3177|Compound:9107506|FD-Score:4.04|P-value:2.44E-4 ID:SGTC_3178|Compound:9107506|FD-Score:-3.75|P-value:5.31E-4 ID:SGTC_3186|Compound:9110464|FD-Score:4.31|P-value:9.98E-5 ID:SGTC_3228|Compound:9131799|FD-Score:3.61|P-value:9.29E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.74|P-value:6.41E-4 ID:SGTC_3350|Compound:9150499|FD-Score:5.43|P-value:1.36E-6

Top fitness defect scores for YDR176W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2249 haloperidol 12.60 116.4 µM 5.40E-28 ergosterol depletion effects on membrane 6 1.11E-36
2 SGTC_2916 7875993 9.96 68.8 µM 3.45E-18 2 1.18E-23
3 SGTC_2609 2,3,4-trihydroxy-4'-ethoxybenzophenone 9.59 70.0 µM 5.26E-17 redox potentiating 10 4.39E-22
4 SGTC_268 camptothecin 9.45 39.6 µM 1.43E-16 DNA damage response 11 1.66E-21
5 SGTC_2905 7799065 9.11 20.1 µM 1.58E-15 1 4.01E-20
6 SGTC_2250 alverine citrate 8.58 130.0 µM 5.89E-14 16 4.89E-18
7 SGTC_2912 7964298 8.44 10.9 µM 1.39E-13 cell wall 23 1.53E-17
8 SGTC_1750 st081859 8.35 2.4 µM 2.52E-13 endomembrane recycling 61 3.37E-17
9 SGTC_266 formosanin C 7.28 406.0 nM 1.51E-10 sphingolipid biosynthesis & PDR1 16 1.63E-13
10 SGTC_178 4092-0806 7.17 87.5 µM 2.84E-10 ergosterol depletion effects on membrane 24 3.75E-13
11 SGTC_2858 9025781 6.94 9.0 µM 9.90E-10 sphingolipid biosynthesis & PDR1 36 1.96E-12
12 SGTC_207 4185-0010 6.78 4.5 µM 2.26E-9 endomembrane recycling 37 5.85E-12
13 SGTC_2006 4011487 6.40 200.0 µM 1.62E-8 endomembrane recycling 39 7.95E-11
14 SGTC_608 k048-0125 6.07 159.0 µM 7.71E-8 5 6.28E-10
15 SGTC_2323 6148992 5.74 148.3 µM 3.53E-7 8 4.71E-9
16 SGTC_3350 9150499 5.43 3.6 µM 1.36E-6 cell wall 21 2.81E-8
17 SGTC_269 exalamide 5.31 29.0 µM 2.25E-6 ergosterol biosynthesis 4 5.44E-8
18 SGTC_1627 st003713 5.24 25.6 µM 3.01E-6 calcium & mitochondrial duress 38 7.99E-8
19 SGTC_2902 5787006 5.21 60.5 µM 3.43E-6 Golgi 8 9.50E-8
20 SGTC_2660 2',4'-dihydroxychalcone 5.16 17.1 µM 4.17E-6 6 1.23E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.242 5.66E-46 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.219 1.02E-37 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.201 4.82E-32 YGR252W GCN5 hom Acetyltransferase, modifies N-terminal lysines on histones H2B and H3; acetylates Rsc4p, a subunit of the RSC chromatin-remodeling complex, altering replication stress tolerance; catalytic subunit of the ADA and SAGA histone acetyltransferase complexes; mutant displays reduced transcription elongation in the G-less-based run-on (GLRO) assay; greater involvement in repression of RNAPII-dependent transcription than in activation
0.199 2.37E-31 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.198 3.87E-31 YDR289C RTT103 hom Protein that interacts with exonuclease Rat1p and Rai1p and plays a role in transcription termination by RNA polymerase II, has an RPR domain (carboxy-terminal domain interacting domain); also involved in regulation of Ty1 transposition
0.198 7.89E-31 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.174 2.93E-24 YPR029C APL4 hom Gamma-adaptin, large subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in vesicle mediated transport
0.173 7.40E-24 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.170 4.11E-23 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.168 1.00E-22 YMR126C_p DLT1_p hom Protein of unknown function, mutant sensitive to 6-azauracil (6AU) and mycophenolic acid (MPA)
0.164 1.44E-21 YDR213W UPC2 hom Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication
0.161 6.90E-21 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.150 2.87E-18 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.149 4.06E-18 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.148 7.44E-18 YJL081C ARP4 het Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes