YDR178W / SDH4

Membrane anchor subunit of succinate dehydrogenase (Sdh1p, Sdh2p, Sdh3p, Sdh4p), which couples the oxidation of succinate to the transfer of electrons to ubiquinone as part of the TCA cycle and the mitochondrial respiratory chain

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR178W / SDH4

Click on Significant Values for Screen Details ID:SGTC_87|Compound:0100-0052|FD-Score:4.32|P-value:3.38E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:4.71|P-value:6.82E-6 ID:SGTC_276|Compound:colchicine|FD-Score:3.46|P-value:7.31E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.64|P-value:4.03E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.21|P-value:5.16E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.46|P-value:5.34E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.38|P-value:9.24E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:6.50|P-value:8.32E-10 ID:SGTC_676|Compound:falcarinol|FD-Score:3.36|P-value:9.86E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.53|P-value:5.67E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.58|P-value:4.82E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.10|P-value:5.43E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.47|P-value:1.79E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.52|P-value:1.50E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.37|P-value:9.74E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.86|P-value:1.33E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.57|P-value:3.64E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.99|P-value:1.17E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.64|P-value:3.93E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.31|P-value:8.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.06|P-value:8.98E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.94|P-value:2.43E-6 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.94|P-value:9.69E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.96|P-value:2.28E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.85|P-value:3.60E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:4.04|P-value:9.76E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.57|P-value:5.07E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.55|P-value:5.46E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.44|P-value:2.09E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.85|P-value:1.95E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.01|P-value:1.08E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.04|P-value:9.62E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-3.33|P-value:8.05E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.60|P-value:4.62E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.56|P-value:3.78E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.36|P-value:7.33E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.31|P-value:8.52E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.13|P-value:4.76E-5 ID:SGTC_2435|Compound:5706476|FD-Score:-3.84|P-value:1.43E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.73|P-value:2.93E-4 ID:SGTC_2485|Compound:5633444|FD-Score:6.33|P-value:2.19E-9 ID:SGTC_2790|Compound:5423970|FD-Score:4.07|P-value:8.62E-5 ID:SGTC_2801|Compound:7907800|FD-Score:4.53|P-value:1.42E-5 ID:SGTC_2802|Compound:7925815|FD-Score:7.30|P-value:6.46E-12 ID:SGTC_2929|Compound:9013348|FD-Score:3.91|P-value:1.56E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.33|P-value:7.94E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.56|P-value:3.77E-4 ID:SGTC_2979|Compound:9012552|FD-Score:4.86|P-value:3.46E-6 ID:SGTC_2987|Compound:9018338|FD-Score:4.06|P-value:9.00E-5 ID:SGTC_2992|Compound:9074591|FD-Score:4.09|P-value:8.10E-5 ID:SGTC_3079|Compound:9117512|FD-Score:3.76|P-value:2.64E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.57|P-value:4.96E-4 ID:SGTC_87|Compound:0100-0052|FD-Score:4.32|P-value:3.38E-5 ID:SGTC_213|Compound:1246-0773|FD-Score:4.71|P-value:6.82E-6 ID:SGTC_276|Compound:colchicine|FD-Score:3.46|P-value:7.31E-4 ID:SGTC_385|Compound:1494-0393|FD-Score:3.64|P-value:4.03E-4 ID:SGTC_480|Compound:am 92016|FD-Score:4.21|P-value:5.16E-5 ID:SGTC_540|Compound:1187-0821|FD-Score:-3.46|P-value:5.34E-4 ID:SGTC_586|Compound:0957-0265|FD-Score:3.38|P-value:9.24E-4 ID:SGTC_600|Compound:1495-0418|FD-Score:6.50|P-value:8.32E-10 ID:SGTC_676|Compound:falcarinol|FD-Score:3.36|P-value:9.86E-4 ID:SGTC_722|Compound:3534-0461|FD-Score:3.53|P-value:5.67E-4 ID:SGTC_726|Compound:3448-4391|FD-Score:3.58|P-value:4.82E-4 ID:SGTC_739|Compound:1486-1183|FD-Score:-3.80|P-value:1.63E-4 ID:SGTC_746|Compound:1095-0025|FD-Score:-4.10|P-value:5.43E-5 ID:SGTC_756|Compound:0508-1999|FD-Score:4.03|P-value:1.02E-4 ID:SGTC_817|Compound:1391-0715|FD-Score:4.47|P-value:1.79E-5 ID:SGTC_832|Compound:4083-0019|FD-Score:4.52|P-value:1.50E-5 ID:SGTC_866|Compound:0495-0101|FD-Score:3.37|P-value:9.74E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:-3.86|P-value:1.33E-4 ID:SGTC_1007|Compound:4101-0031|FD-Score:-3.57|P-value:3.64E-4 ID:SGTC_1052|Compound:3253-3998|FD-Score:3.99|P-value:1.17E-4 ID:SGTC_1179|Compound:1021-1431|FD-Score:3.64|P-value:3.93E-4 ID:SGTC_1401|Compound:3807-4679|FD-Score:-3.31|P-value:8.67E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.06|P-value:8.98E-5 ID:SGTC_1522|Compound:st012842|FD-Score:4.94|P-value:2.43E-6 ID:SGTC_1550|Compound:gossypolone|FD-Score:-3.94|P-value:9.69E-5 ID:SGTC_1559|Compound:coumarin 343|FD-Score:4.96|P-value:2.28E-6 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:4.85|P-value:3.60E-6 ID:SGTC_1570|Compound:verbenone|FD-Score:4.04|P-value:9.76E-5 ID:SGTC_1574|Compound:spiramycin|FD-Score:3.57|P-value:5.07E-4 ID:SGTC_1647|Compound:st011722|FD-Score:3.55|P-value:5.46E-4 ID:SGTC_1863|Compound:st057641|FD-Score:4.44|P-value:2.09E-5 ID:SGTC_1873|Compound:rapamycin|FD-Score:3.85|P-value:1.95E-4 ID:SGTC_1879|Compound:gemcitabine|FD-Score:4.01|P-value:1.08E-4 ID:SGTC_1920|Compound:st075728|FD-Score:4.04|P-value:9.62E-5 ID:SGTC_1924|Compound:st058459|FD-Score:-3.33|P-value:8.05E-4 ID:SGTC_2058|Compound:5236698|FD-Score:3.60|P-value:4.62E-4 ID:SGTC_2177|Compound:5811945|FD-Score:-3.56|P-value:3.78E-4 ID:SGTC_2266|Compound:7929956|FD-Score:-3.36|P-value:7.33E-4 ID:SGTC_2305|Compound:7443522|FD-Score:-3.31|P-value:8.52E-4 ID:SGTC_2310|Compound:7668677|FD-Score:-4.13|P-value:4.76E-5 ID:SGTC_2435|Compound:5706476|FD-Score:-3.84|P-value:1.43E-4 ID:SGTC_2460|Compound:5552655|FD-Score:3.73|P-value:2.93E-4 ID:SGTC_2485|Compound:5633444|FD-Score:6.33|P-value:2.19E-9 ID:SGTC_2790|Compound:5423970|FD-Score:4.07|P-value:8.62E-5 ID:SGTC_2801|Compound:7907800|FD-Score:4.53|P-value:1.42E-5 ID:SGTC_2802|Compound:7925815|FD-Score:7.30|P-value:6.46E-12 ID:SGTC_2929|Compound:9013348|FD-Score:3.91|P-value:1.56E-4 ID:SGTC_2934|Compound:9036370|FD-Score:-3.33|P-value:7.94E-4 ID:SGTC_2938|Compound:9059746|FD-Score:-3.56|P-value:3.77E-4 ID:SGTC_2979|Compound:9012552|FD-Score:4.86|P-value:3.46E-6 ID:SGTC_2987|Compound:9018338|FD-Score:4.06|P-value:9.00E-5 ID:SGTC_2992|Compound:9074591|FD-Score:4.09|P-value:8.10E-5 ID:SGTC_3079|Compound:9117512|FD-Score:3.76|P-value:2.64E-4 ID:SGTC_3134|Compound:9127454|FD-Score:3.57|P-value:4.96E-4

Top fitness defect scores for YDR178W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2802 7925815 7.30 54.5 µM 6.46E-12 3 1.47E-13
2 SGTC_600 1495-0418 6.50 41.6 µM 8.32E-10 RPP1 & pyrimidine depletion 2 3.94E-11
3 SGTC_2485 5633444 6.33 17.8 µM 2.19E-9 redox potentiating 10 1.20E-10
4 SGTC_1559 coumarin 343 4.96 70.1 µM 2.28E-6 2 3.59E-7
5 SGTC_1522 st012842 4.94 45.6 µM 2.43E-6 RNA pol III & RNase P/MRP 10 3.85E-7
6 SGTC_2979 9012552 4.86 45.5 µM 3.46E-6 2 5.79E-7
7 SGTC_1565 sinapyl alcohol 4.85 95.1 µM 3.60E-6 9 6.05E-7
8 SGTC_213 1246-0773 4.71 967.0 nM 6.82E-6 10 1.26E-6
9 SGTC_2801 7907800 4.53 81.8 µM 1.42E-5 20 2.94E-6
10 SGTC_832 4083-0019 4.52 164.0 µM 1.50E-5 translation 61 3.13E-6
11 SGTC_817 1391-0715 4.47 46.0 µM 1.79E-5 11 3.84E-6
12 SGTC_1863 st057641 4.44 20.1 µM 2.09E-5 6 4.58E-6
13 SGTC_87 0100-0052 4.32 35.5 µM 3.38E-5 85 7.97E-6
14 SGTC_480 am 92016 4.21 50.0 µM 5.16E-5 10 1.30E-5
15 SGTC_2992 9074591 4.09 71.4 µM 8.10E-5 14 2.18E-5
16 SGTC_2790 5423970 4.07 71.4 µM 8.62E-5 endomembrane recycling 67 2.34E-5
17 SGTC_1520 flindersine 4.06 88.0 µM 8.98E-5 27 2.46E-5
18 SGTC_2987 9018338 4.06 71.4 µM 9.00E-5 RPP1 & pyrimidine depletion 15 2.46E-5
19 SGTC_1920 st075728 4.04 45.7 µM 9.62E-5 21 2.66E-5
20 SGTC_1570 verbenone 4.04 133.0 µM 9.76E-5 14 2.70E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.115 2.28E-11 YFR032C-B_p YFR032C-B_p hom Putative protein of unknown function; identified by gene-trapping, microarray-based expression analysis, and genome-wide homology searching
0.083 1.51E-6 YNL285W_d YNL285W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.082 1.75E-6 YBL032W HEK2 hom RNA binding protein involved in the asymmetric localization of ASH1 mRNA; represses translation of ASH1 mRNA, an effect reversed by Yck1p-dependent phosphoryation; regulates telomere position effect and length; similarity to hnRNP-K
0.082 1.76E-6 YMR008C PLB1 hom Phospholipase B (lysophospholipase) involved in lipid metabolism, required for deacylation of phosphatidylcholine and phosphatidylethanolamine but not phosphatidylinositol
0.077 7.41E-6 YPR136C_d YPR136C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified ORF RRP9
0.076 1.12E-5 YFL027C GYP8 hom GTPase-activating protein for yeast Rab family members; Ypt1p is the preferred in vitro substrate but also acts on Sec4p, Ypt31p and Ypt32p; involved in the regulation of ER to Golgi vesicle transport
0.074 1.85E-5 YMR130W_p YMR130W_p hom Putative protein of unknown function; YMR130W is not an essential gene
0.073 2.52E-5 YLR342W FKS1 hom Catalytic subunit of 1,3-beta-D-glucan synthase, functionally redundant with alternate catalytic subunit Gsc2p; binds to regulatory subunit Rho1p; involved in cell wall synthesis and maintenance; localizes to sites of cell wall remodeling
0.071 3.48E-5 YDR417C_d YDR417C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF RPL12B/YDR418W
0.071 3.85E-5 YJL157C FAR1 hom Cyclin-dependent kinase inhibitor; mediates cell cycle arrest in response to pheromone; also forms a complex with Cdc24p, Ste4p, and Ste18p that may specify the direction of polarized growth during mating; potential Cdc28p substrate; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.071 4.37E-5 YCR030C SYP1 hom Protein of unknown function that is involved in endocytic site formation; may regulate assembly and disassembly of the septin ring; colocalizes and interacts with septin subunits; potential role in actin cytoskeletal organization
0.070 5.57E-5 YER175C TMT1 hom Trans-aconitate methyltransferase, cytosolic enzyme that catalyzes the methyl esterification of 3-isopropylmalate, an intermediate of the leucine biosynthetic pathway, and trans-aconitate, which inhibits the citric acid cycle
0.068 7.38E-5 YFL028C CAF16 hom Part of evolutionarily-conserved CCR4-NOT regulatory complex; contains single ABC-type ATPase domain but no transmembrane domain; interacts with several subunits of Mediator
0.068 8.43E-5 YGR073C_d YGR073C_d het Dubious open reading frame unlikely to encode a functional protein, extensively overlaps essential SMD1 gene encoding a U6 snRNP protein
0.068 9.08E-5 YOR109W INP53 hom Polyphosphatidylinositol phosphatase, dephosphorylates multiple phosphatidylinositols; involved in trans Golgi network-to-early endosome pathway; hyperosmotic stress causes translocation to actin patches; contains Sac1 and 5-ptase domains