YDR179C / CSN9

Subunit of the Cop9 signalosome, which is required for deneddylation, or removal of the ubiquitin-like protein Rub1p from Cdc53p (cullin); involved in adaptation to pheromone signaling

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR179C / CSN9

Click on Significant Values for Screen Details ID:SGTC_6|Compound:0844-0013|FD-Score:3.78|P-value:5.39E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.39|P-value:2.43E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.42|P-value:2.15E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-5.63|P-value:3.51E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.22|P-value:7.12E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-4.08|P-value:1.32E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.46|P-value:2.00E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.47|P-value:1.77E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.21|P-value:7.26E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.20|P-value:5.02E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.33|P-value:3.22E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.25|P-value:6.70E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.34|P-value:3.06E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.11|P-value:7.18E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.28|P-value:5.86E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-3.07|P-value:7.77E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.94|P-value:2.54E-5 ID:SGTC_2956|Compound:9076196|FD-Score:7.65|P-value:2.18E-15 ID:SGTC_2959|Compound:9079155|FD-Score:4.41|P-value:3.04E-6 ID:SGTC_2961|Compound:9083290|FD-Score:4.61|P-value:1.17E-6 ID:SGTC_3001|Compound:9076041|FD-Score:-3.15|P-value:6.01E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.59|P-value:1.18E-4 ID:SGTC_6|Compound:0844-0013|FD-Score:3.78|P-value:5.39E-5 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.39|P-value:2.43E-4 ID:SGTC_264|Compound:promethazine|FD-Score:-3.42|P-value:2.15E-4 ID:SGTC_652|Compound:0437-0092|FD-Score:-5.63|P-value:3.51E-9 ID:SGTC_658|Compound:3253-0951|FD-Score:-4.22|P-value:7.12E-6 ID:SGTC_791|Compound:1348-1292|FD-Score:-4.08|P-value:1.32E-5 ID:SGTC_972|Compound:1319-0219|FD-Score:3.46|P-value:2.00E-4 ID:SGTC_1073|Compound:triclabendazole|FD-Score:-3.47|P-value:1.77E-4 ID:SGTC_1254|Compound:0550-0035|FD-Score:-4.21|P-value:7.26E-6 ID:SGTC_1257|Compound:0669-0121|FD-Score:-3.20|P-value:5.02E-4 ID:SGTC_1347|Compound:1493-0251|FD-Score:3.12|P-value:7.04E-4 ID:SGTC_1366|Compound:1683-0113|FD-Score:3.33|P-value:3.22E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:4.25|P-value:6.70E-6 ID:SGTC_1378|Compound:2093-0007|FD-Score:3.34|P-value:3.06E-4 ID:SGTC_1782|Compound:st039423|FD-Score:3.11|P-value:7.18E-4 ID:SGTC_1911|Compound:st060208|FD-Score:4.28|P-value:5.86E-6 ID:SGTC_2329|Compound:6138490|FD-Score:-3.07|P-value:7.77E-4 ID:SGTC_2583|Compound:asiatic acid|FD-Score:-3.94|P-value:2.54E-5 ID:SGTC_2956|Compound:9076196|FD-Score:7.65|P-value:2.18E-15 ID:SGTC_2959|Compound:9079155|FD-Score:4.41|P-value:3.04E-6 ID:SGTC_2961|Compound:9083290|FD-Score:4.61|P-value:1.17E-6 ID:SGTC_3001|Compound:9076041|FD-Score:-3.15|P-value:6.01E-4 ID:SGTC_3051|Compound:9093778|FD-Score:3.59|P-value:1.18E-4

Top fitness defect scores for YDR179C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2956 9076196 7.65 2.5 µM 2.18E-15 2 1.03E-14
2 SGTC_2961 9083290 4.61 32.5 µM 1.17E-6 11 2.06E-6
3 SGTC_2959 9079155 4.41 11.0 µM 3.04E-6 17 5.09E-6
4 SGTC_1911 st060208 4.28 74.3 µM 5.86E-6 27 9.51E-6
5 SGTC_1373 2887-0003 4.25 58.5 µM 6.70E-6 Golgi 15 1.08E-5
6 SGTC_6 0844-0013 3.78 19.8 µM 5.39E-5 101 7.87E-5
7 SGTC_3051 9093778 3.59 49.5 µM 1.18E-4 6 1.66E-4
8 SGTC_972 1319-0219 3.46 195.0 µM 2.00E-4 51 2.75E-4
9 SGTC_1378 2093-0007 3.34 380.0 nM 3.06E-4 42 4.12E-4
10 SGTC_1366 1683-0113 3.33 21.9 µM 3.22E-4 25 4.33E-4
11 SGTC_1347 1493-0251 3.12 600.0 nM 7.04E-4 mitochondrial response to ROS 46 9.12E-4
12 SGTC_1782 st039423 3.11 80.6 µM 7.18E-4 61 9.30E-4
13 SGTC_830 4076-0286 3.00 57.8 µM 0.00105 translation 144 0.00134
14 SGTC_3243 9134147 2.99 49.5 µM 0.00111 18 0.00141
15 SGTC_3053 9095903 2.87 49.5 µM 0.00165 Golgi 27 0.00206
16 SGTC_2587 piperic acid 2.81 92.2 µM 0.00198 72 0.00245
17 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 2.81 70.1 µM 0.00203 114 0.00251
18 SGTC_1323 1348-1351 2.80 11.2 µM 0.00205 55 0.00253
19 SGTC_429 1112-0049 2.80 25.5 µM 0.00209 DNA damage response 106 0.00258
20 SGTC_2585 alliin 2.77 100.0 µM 0.00225 106 0.00277

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.204 6.01E-33 YKL184W SPE1 hom Ornithine decarboxylase, catalyzes the first step in polyamine biosynthesis; degraded in a proteasome-dependent manner in the presence of excess polyamines; deletion decreases lifespan, and increases necrotic cell death and ROS generation
0.173 4.54E-24 YGR011W_d YGR011W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.160 1.23E-20 YGL126W SCS3 hom Protein required for inositol prototrophy; required for normal ER membrane biosynthesis; ortholog of the FIT family of proteins involved in triglyceride droplet biosynthesis and homologous to human FIT2; disputed role in the synthesis of inositol phospholipids from inositol
0.148 7.64E-18 YDL039C PRM7 hom Pheromone-regulated protein, predicted to have one transmembrane segment; promoter contains Gcn4p binding elements
0.142 1.22E-16 YKL149C DBR1 hom RNA lariat debranching enzyme, involved in intron turnover; required for efficient Ty1 transposition
0.142 1.67E-16 YBL008W HIR1 hom Subunit of the HIR complex, a nucleosome assembly complex involved in regulation of histone gene transcription; contributes to nucleosome formation, heterochromatic gene silencing, and formation of functional kinetochores
0.140 4.00E-16 YLR257W YLR257W hom Protein of unknown function; protein abundance increases in response to DNA replication stress
0.136 2.42E-15 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.127 1.69E-13 YKL201C MNN4 hom Putative positive regulator of mannosylphosphate transferase Mnn6p; involved in mannosylphosphorylation of N-linked oligosaccharides; expression increases in late-logarithmic and stationary growth phases; MNN4 has a paralog, YJR061W, that arose from the whole genome duplication
0.116 1.53E-11 YDR497C ITR1 hom Myo-inositol transporter; has strong similarity to the minor myo-inositol transporter Itr2p, member of the sugar transporter superfamily; expression is repressed by inositol and choline via Opi1p and derepressed via Ino2p and Ino4p; relative distribution to the vacuole increases upon DNA replication stress
0.116 1.57E-11 YBL017C PEP1 hom Type I transmembrane sorting receptor for multiple vacuolar hydrolases; cycles between the late-Golgi and prevacuolar endosome-like compartments
0.115 2.90E-11 YOR215C AIM41 hom Putative protein of unknown function; the authentic protein is detected in highly purified mitochondria in high-throughput studies; null mutant displays reduced frequency of mitochondrial genome loss
0.114 3.58E-11 YKR081C RPF2 het Essential protein involved in the processing of pre-rRNA and the assembly of the 60S ribosomal subunit; interacts with ribosomal protein L11; localizes predominantly to the nucleolus; constituent of 66S pre-ribosomal particles
0.114 3.95E-11 YBL029W_p YBL029W_p hom Non-essential protein of unknown function
0.112 7.50E-11 YLR319C BUD6 hom Actin- and formin-interacting protein; stimulates actin cable nucleation by recruiting actin monomers to Bni1p; involved in polarized cell growth; isolated as bipolar budding mutant; potential Cdc28p substrate