YDR180W / SCC2

Subunit of cohesin loading factor (Scc2p-Scc4p), a complex required for loading of cohesin complexes onto chromosomes; involved in establishing sister chromatid cohesion during DSB repair via histone H2AX; evolutionarily-conserved adherin

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR180W / SCC2

Click on Significant Values for Screen Details ID:SGTC_63|Compound:0099-0242|FD-Score:4.41|P-value:2.20E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:4.04|P-value:1.28E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:4.65|P-value:6.38E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.41|P-value:1.89E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.48|P-value:1.33E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.73|P-value:5.10E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:5.31|P-value:1.60E-8 ID:SGTC_404|Compound:fumagillin|FD-Score:3.79|P-value:3.96E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.05|P-value:6.85E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.20|P-value:3.93E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.73|P-value:5.23E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.38|P-value:1.96E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.21|P-value:4.10E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.20|P-value:4.31E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.18|P-value:4.20E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.35|P-value:2.58E-6 ID:SGTC_1118|Compound:chelidonine|FD-Score:-2.99|P-value:8.68E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.26|P-value:3.45E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-2.97|P-value:9.14E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.06|P-value:6.59E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.43|P-value:1.76E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.38|P-value:2.14E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.14|P-value:4.85E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.04|P-value:7.94E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.03|P-value:7.37E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.33|P-value:3.23E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.22|P-value:4.04E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.33|P-value:2.60E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.09|P-value:6.51E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:2.99|P-value:9.33E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.96|P-value:1.86E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-3.51|P-value:1.17E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.50|P-value:1.22E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.45|P-value:1.47E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.35|P-value:2.18E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.83|P-value:3.31E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-4.05|P-value:1.08E-5 ID:SGTC_3153|Compound:9100258|FD-Score:4.81|P-value:2.73E-7 ID:SGTC_3248|Compound:9135562|FD-Score:3.76|P-value:4.43E-5 ID:SGTC_3295|Compound:9122362|FD-Score:4.43|P-value:1.93E-6 ID:SGTC_63|Compound:0099-0242|FD-Score:4.41|P-value:2.20E-6 ID:SGTC_206|Compound:4546-0025|FD-Score:4.04|P-value:1.28E-5 ID:SGTC_268|Compound:camptothecin|FD-Score:4.65|P-value:6.38E-7 ID:SGTC_273|Compound:hydroxyurea|FD-Score:3.41|P-value:1.89E-4 ID:SGTC_359|Compound:0081-0058|FD-Score:-3.48|P-value:1.33E-4 ID:SGTC_398|Compound:bronopol|FD-Score:3.73|P-value:5.10E-5 ID:SGTC_402|Compound:epigallocatechin gallate|FD-Score:5.31|P-value:1.60E-8 ID:SGTC_404|Compound:fumagillin|FD-Score:3.79|P-value:3.96E-5 ID:SGTC_778|Compound:3456-2434|FD-Score:-3.05|P-value:6.85E-4 ID:SGTC_892|Compound:0929-0076|FD-Score:-3.20|P-value:3.93E-4 ID:SGTC_895|Compound:0964-0006|FD-Score:3.73|P-value:5.23E-5 ID:SGTC_897|Compound:1000-0139|FD-Score:-3.38|P-value:1.96E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:3.09|P-value:6.54E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:3.21|P-value:4.10E-4 ID:SGTC_1020|Compound:4335-0961|FD-Score:3.20|P-value:4.31E-4 ID:SGTC_1032|Compound:k061-1018|FD-Score:-3.18|P-value:4.20E-4 ID:SGTC_1040|Compound:k898-0338|FD-Score:-4.35|P-value:2.58E-6 ID:SGTC_1118|Compound:chelidonine|FD-Score:-2.99|P-value:8.68E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.26|P-value:3.45E-4 ID:SGTC_1755|Compound:st041960|FD-Score:-2.97|P-value:9.14E-4 ID:SGTC_1795|Compound:st049545|FD-Score:-3.06|P-value:6.59E-4 ID:SGTC_1849|Compound:st056239|FD-Score:3.43|P-value:1.76E-4 ID:SGTC_1854|Compound:st056233|FD-Score:3.38|P-value:2.14E-4 ID:SGTC_2013|Compound:4024628|FD-Score:-3.14|P-value:4.85E-4 ID:SGTC_2210|Compound:7115885|FD-Score:3.04|P-value:7.94E-4 ID:SGTC_2270|Compound:7924575|FD-Score:-3.03|P-value:7.37E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:4.33|P-value:3.23E-6 ID:SGTC_2451|Compound:5856223|FD-Score:3.22|P-value:4.04E-4 ID:SGTC_2452|Compound:5863136|FD-Score:3.33|P-value:2.60E-4 ID:SGTC_2462|Compound:5162487|FD-Score:3.09|P-value:6.51E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:2.99|P-value:9.33E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.96|P-value:1.86E-5 ID:SGTC_2794|Compound:7785382|FD-Score:-3.51|P-value:1.17E-4 ID:SGTC_2823|Compound:7987624|FD-Score:-3.50|P-value:1.22E-4 ID:SGTC_2876|Compound:9059903|FD-Score:-3.45|P-value:1.47E-4 ID:SGTC_2939|Compound:9044578|FD-Score:3.13|P-value:5.73E-4 ID:SGTC_3041|Compound:9091929|FD-Score:-3.35|P-value:2.18E-4 ID:SGTC_3047|Compound:9092122|FD-Score:3.83|P-value:3.31E-5 ID:SGTC_3146|Compound:9095609|FD-Score:-4.05|P-value:1.08E-5 ID:SGTC_3153|Compound:9100258|FD-Score:4.81|P-value:2.73E-7 ID:SGTC_3248|Compound:9135562|FD-Score:3.76|P-value:4.43E-5 ID:SGTC_3295|Compound:9122362|FD-Score:4.43|P-value:1.93E-6

Top fitness defect scores for YDR180W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_402 epigallocatechin gallate 5.31 10.0 µM 1.60E-8 4 5.62E-8 1.76
2 SGTC_3153 9100258 4.81 49.5 µM 2.73E-7 1 7.66E-7 0.44
3 SGTC_268 camptothecin 4.65 39.6 µM 6.38E-7 DNA damage response 34 1.67E-6 0.04
4 SGTC_3295 9122362 4.43 53.6 µM 1.93E-6 5 4.63E-6 0.34
5 SGTC_63 0099-0242 4.41 26.7 µM 2.20E-6 mitochondrial stress 18 5.24E-6 0.02
6 SGTC_2420 aureobasidin a 4.33 50.0 nM 3.23E-6 4 7.46E-6 1.01
7 SGTC_206 4546-0025 4.04 72.0 µM 1.28E-5 NEO1 11 2.65E-5 0.46
8 SGTC_2782 7736369 3.96 71.4 µM 1.86E-5 9 3.76E-5 0.27
9 SGTC_3047 9092122 3.83 49.5 µM 3.31E-5 6 6.37E-5 0.01
10 SGTC_404 fumagillin 3.79 50.0 µM 3.96E-5 6 7.54E-5 0.20
11 SGTC_3248 9135562 3.76 49.5 µM 4.43E-5 1 8.36E-5 0.28
12 SGTC_398 bronopol 3.73 33.3 µM 5.10E-5 RNA processing & uracil transport 14 9.50E-5 0.02
13 SGTC_895 0964-0006 3.73 13.7 µM 5.23E-5 16 9.73E-5 0.13
14 SGTC_1849 st056239 3.43 19.2 µM 1.76E-4 RPP1 & pyrimidine depletion 6 2.98E-4 0.01
15 SGTC_273 hydroxyurea 3.41 18.1 mM 1.89E-4 heme biosynthesis & mitochondrial translocase 31 3.19E-4 0.14
16 SGTC_1854 st056233 3.38 32.9 µM 2.14E-4 amide catabolism 6 3.58E-4 0.18
17 SGTC_2452 5863136 3.33 48.4 µM 2.60E-4 5 4.28E-4 0.05
18 SGTC_1718 roemerine 3.26 11.9 µM 3.45E-4 redox potentiating 24 5.56E-4 0.04
19 SGTC_2451 5856223 3.22 45.7 µM 4.04E-4 15 6.43E-4 0.01
20 SGTC_1010 4112-3296 3.21 15.2 µM 4.10E-4 15 6.52E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 3.85E-13 YNL260C LTO1 het Essential protein that forms a complex with Rli1p and Yae1p; ortholog of human ORAOV1, which is overexpressed in solid tumors; inviability of null mutant under standard conditions is complemented by overexpression of ORAOV1; essential for growth under standard (aerobic) conditions but not under anaerobic conditions; may have a role in protection of ribosomal assembly and function from damage due to reactive oxygen species
0.114 4.38E-11 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.113 4.47E-11 YDR217C RAD9 hom DNA damage-dependent checkpoint protein; required for cell-cycle arrest in G1/S, intra-S, and G2/M; transmits checkpoint signal by activating Rad53p and Chk1p; hyperphosphorylated by Mec1p and Tel1p; multiple cyclin dependent kinase consensus sites and the C-terminal BRCT domain contribute to DNA damage checkpoint activation; potential Cdc28p substrate
0.106 7.36E-10 YJL027C_p YJL027C_p hom Putative protein of unknown function
0.104 1.66E-9 YPL194W DDC1 hom DNA damage checkpoint protein; part of a PCNA-like complex required for DNA damage response, required for pachytene checkpoint to inhibit cell cycle in response to unrepaired recombination intermediates; potential Cdc28p substrate; forms nuclear foci upon DNA replication stress
0.096 2.57E-8 YBR098W MMS4 hom Subunit of the structure-specific Mms4p-Mus81p endonuclease that cleaves branched DNA; involved in recombination, DNA repair, and joint molecule formation/resolution during meiotic recombination; phosphorylation of the non-catalytic subunit Mms4p by Cdc28p and Cdcp during mitotic cell cycle activates the function of Mms4p-Mus81p
0.091 1.46E-7 YPL159C PET20 hom Mitochondrial protein, required for respiratory growth under some conditions and for stability of the mitochondrial genome
0.085 7.14E-7 YPL231W FAS2 het Alpha subunit of fatty acid synthetase, which catalyzes the synthesis of long-chain saturated fatty acids; contains the acyl-carrier protein domain and beta-ketoacyl reductase, beta-ketoacyl synthase and self-pantetheinylation activities
0.083 1.61E-6 YDR047W HEM12 het Uroporphyrinogen decarboxylase, catalyzes the fifth step in the heme biosynthetic pathway; localizes to both the cytoplasm and nucleus; a hem12 mutant has phenotypes similar to patients with porphyria cutanea tarda
0.082 2.06E-6 YDR031W MIC14 hom Mitochondrial intermembrane space protein of unknown function; required for normal oxygen consumption; contains twin cysteine-x9-cysteine motifs; protein abundance increases in response to DNA replication stress
0.081 2.30E-6 YOR325W_d YOR325W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps the verified ORF FRT1
0.079 4.73E-6 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.079 5.28E-6 YJL074C SMC3 het Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
0.078 6.76E-6 YBR143C SUP45 het Polypeptide release factor (eRF1) in translation termination; mutant form acts as a recessive omnipotent suppressor; methylated by Mtq2p-Trm112p in ternary complex eRF1-eRF3-GTP; mutation of methylation site confers resistance to zymocin; has a role in cytokinesis through interaction with Mlc1p
0.078 6.78E-6 YDR224C HTB1 het Histone H2B, core histone protein required for chromatin assembly and chromosome function; nearly identical to HTB2; Rad6p-Bre1p-Lge1p mediated ubiquitination regulates transcriptional activation, meiotic DSB formation and H3 methylation