YDR181C / SAS4

Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR181C / SAS4

Click on Significant Values for Screen Details ID:SGTC_8|Compound:0354-0001|FD-Score:3.44|P-value:9.85E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.64|P-value:1.37E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.18|P-value:7.95E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:10.70|P-value:5.93E-23 ID:SGTC_86|Compound:0417-1630|FD-Score:3.98|P-value:1.69E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.14|P-value:9.47E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.45|P-value:9.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.73|P-value:3.95E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.95|P-value:1.83E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.00|P-value:9.82E-11 ID:SGTC_363|Compound:0455-0021|FD-Score:12.20|P-value:2.35E-29 ID:SGTC_382|Compound:3229-0966|FD-Score:4.93|P-value:4.15E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.59|P-value:6.11E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.57|P-value:6.64E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.01|P-value:1.48E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.33|P-value:8.50E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.49|P-value:5.12E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.99|P-value:1.60E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:13.00|P-value:4.47E-33 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.95|P-value:1.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.83|P-value:2.80E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:26.10|P-value:5.10E-127 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.94|P-value:3.93E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.40|P-value:1.17E-25 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.91|P-value:2.11E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.87|P-value:2.46E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.03|P-value:1.38E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.40|P-value:6.97E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.58|P-value:6.42E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.65|P-value:5.13E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.99|P-value:3.10E-6 ID:SGTC_1786|Compound:berberine|FD-Score:11.20|P-value:7.44E-25 ID:SGTC_1827|Compound:berberine|FD-Score:4.09|P-value:1.14E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.13|P-value:9.75E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.99|P-value:1.59E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.53|P-value:7.53E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.92|P-value:4.20E-6 ID:SGTC_2016|Compound:5121758|FD-Score:7.49|P-value:4.79E-12 ID:SGTC_2088|Compound:5278280|FD-Score:4.42|P-value:3.29E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-4.09|P-value:6.40E-5 ID:SGTC_2181|Compound:6316240|FD-Score:5.42|P-value:4.53E-7 ID:SGTC_2283|Compound:7944793|FD-Score:3.69|P-value:4.49E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.62|P-value:1.47E-5 ID:SGTC_2511|Compound:berberine|FD-Score:6.23|P-value:7.83E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.99|P-value:1.58E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-4.43|P-value:1.70E-5 ID:SGTC_3298|Compound:9116858|FD-Score:3.50|P-value:8.22E-4 ID:SGTC_8|Compound:0354-0001|FD-Score:3.44|P-value:9.85E-4 ID:SGTC_36|Compound:0335-0881|FD-Score:4.64|P-value:1.37E-5 ID:SGTC_64|Compound:000l-0018|FD-Score:4.18|P-value:7.95E-5 ID:SGTC_67|Compound:0335-0847|FD-Score:10.70|P-value:5.93E-23 ID:SGTC_86|Compound:0417-1630|FD-Score:3.98|P-value:1.69E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:4.14|P-value:9.47E-5 ID:SGTC_130|Compound:0136-0219|FD-Score:3.45|P-value:9.61E-4 ID:SGTC_158|Compound:k038-0087|FD-Score:3.73|P-value:3.95E-4 ID:SGTC_165|Compound:k038-0023|FD-Score:3.95|P-value:1.83E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.00|P-value:9.82E-11 ID:SGTC_363|Compound:0455-0021|FD-Score:12.20|P-value:2.35E-29 ID:SGTC_382|Compound:3229-0966|FD-Score:4.93|P-value:4.15E-6 ID:SGTC_472|Compound:calcifediol|FD-Score:3.59|P-value:6.11E-4 ID:SGTC_563|Compound:tetrahydrosecaminediol|FD-Score:3.57|P-value:6.64E-4 ID:SGTC_609|Compound:0986-0026|FD-Score:4.01|P-value:1.48E-4 ID:SGTC_743|Compound:1275-0778|FD-Score:-3.33|P-value:8.50E-4 ID:SGTC_753|Compound:1322-0200|FD-Score:-3.49|P-value:5.12E-4 ID:SGTC_849|Compound:0386-0493|FD-Score:3.99|P-value:1.60E-4 ID:SGTC_862|Compound:0452-0056|FD-Score:13.00|P-value:4.47E-33 ID:SGTC_913|Compound:3487-1245|FD-Score:-3.95|P-value:1.07E-4 ID:SGTC_1083|Compound:didemethylchlorpromazine sulfoxide|FD-Score:3.83|P-value:2.80E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:26.10|P-value:5.10E-127 ID:SGTC_1246|Compound:0422-0085|FD-Score:4.94|P-value:3.93E-6 ID:SGTC_1317|Compound:1273-0028|FD-Score:11.40|P-value:1.17E-25 ID:SGTC_1328|Compound:1441-0025|FD-Score:3.91|P-value:2.11E-4 ID:SGTC_1364|Compound:1653-0028|FD-Score:3.87|P-value:2.46E-4 ID:SGTC_1480|Compound:1070-0044|FD-Score:4.03|P-value:1.38E-4 ID:SGTC_1512|Compound:0259-0544|FD-Score:-3.40|P-value:6.97E-4 ID:SGTC_1719|Compound:st032227|FD-Score:3.58|P-value:6.42E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.65|P-value:5.13E-4 ID:SGTC_1782|Compound:st039423|FD-Score:4.99|P-value:3.10E-6 ID:SGTC_1786|Compound:berberine|FD-Score:11.20|P-value:7.44E-25 ID:SGTC_1827|Compound:berberine|FD-Score:4.09|P-value:1.14E-4 ID:SGTC_1829|Compound:berberine|FD-Score:4.13|P-value:9.75E-5 ID:SGTC_1865|Compound:st057639|FD-Score:3.99|P-value:1.59E-4 ID:SGTC_1910|Compound:st062352|FD-Score:3.53|P-value:7.53E-4 ID:SGTC_1921|Compound:5740136|FD-Score:4.92|P-value:4.20E-6 ID:SGTC_2016|Compound:5121758|FD-Score:7.49|P-value:4.79E-12 ID:SGTC_2088|Compound:5278280|FD-Score:4.42|P-value:3.29E-5 ID:SGTC_2149|Compound:5554786|FD-Score:-4.09|P-value:6.40E-5 ID:SGTC_2181|Compound:6316240|FD-Score:5.42|P-value:4.53E-7 ID:SGTC_2283|Compound:7944793|FD-Score:3.69|P-value:4.49E-4 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.62|P-value:1.47E-5 ID:SGTC_2511|Compound:berberine|FD-Score:6.23|P-value:7.83E-9 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.99|P-value:1.58E-4 ID:SGTC_2960|Compound:9079389|FD-Score:-4.43|P-value:1.70E-5 ID:SGTC_3298|Compound:9116858|FD-Score:3.50|P-value:8.22E-4

Top fitness defect scores for YDR181C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1121 fusaric acid 26.10 630.5 nM 5.10E-127 2 1.26E-150
2 SGTC_862 0452-0056 13.00 10.2 µM 4.47E-33 azole & statin 1 3.51E-39
3 SGTC_363 0455-0021 12.20 3.1 µM 2.35E-29 azole & statin 7 9.24E-35
4 SGTC_1317 1273-0028 11.40 910.0 nM 1.17E-25 azole & statin 11 2.28E-30
5 SGTC_1786 berberine 11.20 21.6 µM 7.44E-25 60S ribosome export 2 2.06E-29
6 SGTC_67 0335-0847 10.70 266.0 µM 5.93E-23 ubiquinone biosynthesis & proteasome 17 3.75E-27
7 SGTC_2016 5121758 7.49 140.0 µM 4.79E-12 redox potentiating 8 3.55E-14
8 SGTC_310 1273-0058 7.00 1.1 µM 9.82E-11 mitochondrial stress 116 1.30E-12
9 SGTC_2511 berberine 6.23 10.5 µM 7.83E-9 60S ribosome export 4 2.39E-10
10 SGTC_2181 6316240 5.42 54.3 µM 4.53E-7 6 3.01E-8
11 SGTC_1782 st039423 4.99 80.6 µM 3.10E-6 6 2.98E-7
12 SGTC_1246 0422-0085 4.94 105.0 µM 3.93E-6 11 3.95E-7
13 SGTC_382 3229-0966 4.93 23.2 µM 4.15E-6 4 4.21E-7
14 SGTC_1921 5740136 4.92 50.0 µM 4.20E-6 TRP & mitochondrial translation 34 4.28E-7
15 SGTC_36 0335-0881 4.64 14.2 µM 1.37E-5 ubiquinone biosynthesis & proteasome 91 1.76E-6
16 SGTC_2501 sodium tetradecyl sulfate 4.62 13.4 µM 1.47E-5 21 1.91E-6
17 SGTC_2088 5278280 4.42 127.4 µM 3.29E-5 14 4.99E-6
18 SGTC_64 000l-0018 4.18 272.1 µM 7.95E-5 ubiquinone biosynthesis & proteasome 137 1.43E-5
19 SGTC_115 0527-0192 4.14 112.0 µM 9.47E-5 60 1.76E-5
20 SGTC_1829 berberine 4.13 14.4 µM 9.75E-5 60S ribosome export 16 1.82E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.633 0 YMR127C SAS2 hom Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.376 2.49E-113 YLR359W ADE13 het Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.340 2.76E-91 YDR315C IPK1 hom Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.324 9.27E-83 YKL221W MCH2 hom Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.321 1.95E-81 YOR213C SAS5 hom Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.294 1.00E-67 YPR197C_d YPR197C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.292 5.06E-67 YKL222C YKL222C hom Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.291 2.44E-66 YPR198W SGE1 hom Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.232 3.00E-42 YOR254C SEC63 het Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.228 9.05E-41 YMR110C HFD1 hom Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.225 9.38E-40 YBR003W COQ1 hom Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.208 5.18E-34 YNR042W_d YNR042W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.205 3.03E-33 YPR024W YME1 hom Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.202 3.36E-32 YLR201C COQ9 hom Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.193 1.43E-29 YDR204W COQ4 hom Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex