HIPHOP chemogenomics database

YDR181C / SAS4

Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; required for the HAT activity of Sas2p

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR181C / SAS4

Click on Significant Values for Screen Details

Top fitness defect scores for YDR181C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_1121	fusaric acid	26.10	630.5 nM	5.10E-127		2	1.26E-150
2	SGTC_862	0452-0056	13.00	10.2 µM	4.47E-33	azole & statin	1	3.51E-39
3	SGTC_363	0455-0021	12.20	3.1 µM	2.35E-29	azole & statin	7	9.24E-35
4	SGTC_1317	1273-0028	11.40	910.0 nM	1.17E-25	azole & statin	11	2.28E-30
5	SGTC_1786	berberine	11.20	21.6 µM	7.44E-25	60S ribosome export	2	2.06E-29
6	SGTC_67	0335-0847	10.70	266.0 µM	5.93E-23	ubiquinone biosynthesis & proteasome	17	3.75E-27
7	SGTC_2016	5121758	7.49	140.0 µM	4.79E-12	redox potentiating	8	3.55E-14
8	SGTC_310	1273-0058	7.00	1.1 µM	9.82E-11	mitochondrial stress	116	1.30E-12
9	SGTC_2511	berberine	6.23	10.5 µM	7.83E-9	60S ribosome export	4	2.39E-10
10	SGTC_2181	6316240	5.42	54.3 µM	4.53E-7		6	3.01E-8
11	SGTC_1782	st039423	4.99	80.6 µM	3.10E-6		6	2.98E-7
12	SGTC_1246	0422-0085	4.94	105.0 µM	3.93E-6		11	3.95E-7
13	SGTC_382	3229-0966	4.93	23.2 µM	4.15E-6		4	4.21E-7
14	SGTC_1921	5740136	4.92	50.0 µM	4.20E-6	TRP & mitochondrial translation	34	4.28E-7
15	SGTC_36	0335-0881	4.64	14.2 µM	1.37E-5	ubiquinone biosynthesis & proteasome	91	1.76E-6
16	SGTC_2501	sodium tetradecyl sulfate	4.62	13.4 µM	1.47E-5		21	1.91E-6
17	SGTC_2088	5278280	4.42	127.4 µM	3.29E-5		14	4.99E-6
18	SGTC_64	000l-0018	4.18	272.1 µM	7.95E-5	ubiquinone biosynthesis & proteasome	137	1.43E-5
19	SGTC_115	0527-0192	4.14	112.0 µM	9.47E-5		60	1.76E-5
20	SGTC_1829	berberine	4.13	14.4 µM	9.75E-5	60S ribosome export	16	1.82E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.633	0	YMR127C	SAS2	hom	Histone acetyltransferase (HAT) catalytic subunit of the SAS complex (Sas2p-Sas4p-Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; member of the MYSTacetyltransferase family
0.376	2.49E-113	YLR359W	ADE13	het	Adenylosuccinate lyase, catalyzes two steps in the 'de novo' purine nucleotide biosynthetic pathway; expression is repressed by adenine and activated by Bas1p and Pho2p; mutations in human ortholog ADSL cause adenylosuccinase deficiency
0.340	2.76E-91	YDR315C	IPK1	hom	Inositol 1,3,4,5,6-pentakisphosphate 2-kinase, nuclear protein required for synthesis of 1,2,3,4,5,6-hexakisphosphate (phytate), which is integral to cell function; has 2 motifs conserved in other fungi; ipk1 gle1 double mutant is inviable
0.324	9.27E-83	YKL221W	MCH2	hom	Protein with similarity to mammalian monocarboxylate permeases, which are involved in transport of monocarboxylic acids across the plasma membrane; mutant is not deficient in monocarboxylate transport
0.321	1.95E-81	YOR213C	SAS5	hom	Subunit of the SAS complex (Sas2p, Sas4p, Sas5p), which acetylates free histones and nucleosomes and regulates transcriptional silencing; stimulates Sas2p HAT activity
0.294	1.00E-67	YPR197C_d	YPR197C_d	hom	Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.292	5.06E-67	YKL222C	YKL222C	hom	Protein of unknown function that may interact with ribosomes, based on co-purification experiments; similar to transcriptional regulators from the zinc cluster (binuclear cluster) family; null mutant is sensitive to caffeine
0.291	2.44E-66	YPR198W	SGE1	hom	Plasma membrane multidrug transporter of the major facilitator superfamily, acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
0.232	3.00E-42	YOR254C	SEC63	het	Essential subunit of Sec63 complex (Sec63p, Sec62p, Sec66p and Sec72p); with Sec61 complex, Kar2p/BiP and Lhs1p forms a channel competent for SRP-dependent and post-translational SRP-independent protein targeting and import into the ER
0.228	9.05E-41	YMR110C	HFD1	hom	Hexadecenal dehydrogenase; involved in the conversion of sphingosine 1-phosphate breakdown product hexadecenal to hexadecenoic acid; located in the mitochondrial outer membrane and also in lipid particles; has similarity to ALDH3A2, a human fatty aldehyde dehydrogenase (FALDH) mutated in Sjogren-Larsson syndrome, a neurocutaneous disorder
0.225	9.38E-40	YBR003W	COQ1	hom	Hexaprenyl pyrophosphate synthetase, catalyzes the first step in ubiquinone (coenzyme Q) biosynthesis
0.208	5.18E-34	YNR042W_d	YNR042W_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; completely overlaps verified gene COQ2
0.205	3.03E-33	YPR024W	YME1	hom	Catalytic subunit of the mitochondrial inner membrane i-AAA protease complex, which is responsible for degradation of unfolded or misfolded mitochondrial gene products; also has a role in intermembrane space protein folding; mutation causes an elevated rate of mitochondrial turnover
0.202	3.36E-32	YLR201C	COQ9	hom	Protein required for ubiquinone (coenzyme Q) biosynthesis and respiratory growth; localizes to the matrix face of the mitochondrial inner membrane in a large complex with ubiquinone biosynthetic enzymes
0.193	1.43E-29	YDR204W	COQ4	hom	Protein with a role in ubiquinone (Coenzyme Q) biosynthesis, possibly functioning in stabilization of Coq7p; located on the matrix face of the mitochondrial inner membrane; component of a mitochondrial ubiquinone-synthesizing complex