YDR182W / CDC1

Putative lipid phosphatase of the endoplasmic reticulum; shows Mn2+ dependence and may affect Ca2+ signaling; mutants display actin and general growth defects and pleiotropic defects in cell cycle progression and organelle distribution

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR182W / CDC1

Click on Significant Values for Screen Details ID:SGTC_150|Compound:3970-0969|FD-Score:3.83|P-value:4.29E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.28|P-value:2.75E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:5.57|P-value:4.35E-11 ID:SGTC_169|Compound:k015-0017|FD-Score:2.86|P-value:4.45E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:-2.88|P-value:3.65E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:2.84|P-value:4.85E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:2.89|P-value:4.02E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:2.93|P-value:3.30E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.65|P-value:1.12E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:4.10|P-value:9.39E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:3.21|P-value:9.41E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:2.96|P-value:2.89E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.14|P-value:1.35E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.80|P-value:4.87E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:3.45|P-value:2.99E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.34|P-value:5.25E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.22|P-value:9.13E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:4.87|P-value:7.51E-9 ID:SGTC_874|Compound:0599-0792|FD-Score:3.28|P-value:6.82E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.34|P-value:5.12E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.45|P-value:3.03E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.33|P-value:5.60E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.08|P-value:1.50E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.95|P-value:3.07E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.68|P-value:9.40E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:2.86|P-value:4.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.50|P-value:8.37E-8 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.49|P-value:2.56E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:2.76|P-value:6.65E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.51|P-value:1.95E-5 ID:SGTC_1701|Compound:st028638|FD-Score:2.69|P-value:8.96E-4 ID:SGTC_1720|Compound:st037298|FD-Score:2.74|P-value:7.42E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:2.86|P-value:4.46E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.40|P-value:3.98E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.69|P-value:8.79E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:2.75|P-value:7.08E-4 ID:SGTC_2026|Compound:5148700|FD-Score:2.86|P-value:4.52E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.72|P-value:7.81E-6 ID:SGTC_2083|Compound:5306046|FD-Score:-2.85|P-value:4.13E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-2.91|P-value:3.28E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.54|P-value:1.99E-5 ID:SGTC_2273|Compound:7815444|FD-Score:2.87|P-value:4.28E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.52|P-value:2.17E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-2.64|P-value:9.68E-4 ID:SGTC_2437|Compound:5741531|FD-Score:2.79|P-value:5.94E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.93|P-value:3.28E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.20|P-value:8.76E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.74|P-value:6.78E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.04|P-value:2.10E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.94|P-value:3.22E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.89|P-value:3.91E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.44|P-value:1.19E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.79|P-value:5.35E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.17|P-value:6.18E-7 ID:SGTC_2795|Compound:7780010|FD-Score:-2.93|P-value:3.01E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-7.67|P-value:1.51E-19 ID:SGTC_2834|Compound:9001755|FD-Score:3.89|P-value:3.04E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.57|P-value:1.65E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.93|P-value:4.95E-9 ID:SGTC_3136|Compound:9095672|FD-Score:4.26|P-value:3.56E-7 ID:SGTC_3148|Compound:9097893|FD-Score:-2.78|P-value:5.44E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.26|P-value:7.51E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.85|P-value:3.19E-6 ID:SGTC_3207|Compound:9114163|FD-Score:5.42|P-value:1.37E-10 ID:SGTC_3212|Compound:9128307|FD-Score:4.17|P-value:6.07E-7 ID:SGTC_3248|Compound:9135562|FD-Score:2.96|P-value:2.92E-4 ID:SGTC_3255|Compound:9139072|FD-Score:2.67|P-value:9.72E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-2.96|P-value:2.59E-4 ID:SGTC_150|Compound:3970-0969|FD-Score:3.83|P-value:4.29E-6 ID:SGTC_160|Compound:3453-0671|FD-Score:-4.28|P-value:2.75E-7 ID:SGTC_161|Compound:4065-0411|FD-Score:5.57|P-value:4.35E-11 ID:SGTC_169|Compound:k015-0017|FD-Score:2.86|P-value:4.45E-4 ID:SGTC_234|Compound:nsc-17383|FD-Score:-2.88|P-value:3.65E-4 ID:SGTC_244|Compound:nsc-207895|FD-Score:2.84|P-value:4.85E-4 ID:SGTC_253|Compound:dyclonine|FD-Score:2.89|P-value:4.02E-4 ID:SGTC_272|Compound:doxorubicin|FD-Score:2.93|P-value:3.30E-4 ID:SGTC_294|Compound:k038-0071|FD-Score:3.65|P-value:1.12E-5 ID:SGTC_356|Compound:1634-0012|FD-Score:4.10|P-value:9.39E-7 ID:SGTC_357|Compound:1325-0123|FD-Score:3.21|P-value:9.41E-5 ID:SGTC_646|Compound:4092-0839|FD-Score:2.96|P-value:2.89E-4 ID:SGTC_659|Compound:k018-0002|FD-Score:3.14|P-value:1.35E-4 ID:SGTC_731|Compound:3966-0296|FD-Score:3.80|P-value:4.87E-6 ID:SGTC_769|Compound:0302-0231|FD-Score:3.45|P-value:2.99E-5 ID:SGTC_770|Compound:0389-1121|FD-Score:3.34|P-value:5.25E-5 ID:SGTC_841|Compound:0251-0215|FD-Score:3.22|P-value:9.13E-5 ID:SGTC_844|Compound:0330-0132|FD-Score:4.87|P-value:7.51E-9 ID:SGTC_874|Compound:0599-0792|FD-Score:3.28|P-value:6.82E-5 ID:SGTC_979|Compound:1426-2828|FD-Score:3.34|P-value:5.12E-5 ID:SGTC_992|Compound:3909-8734|FD-Score:3.45|P-value:3.03E-5 ID:SGTC_1082|Compound:camptothecin|FD-Score:3.33|P-value:5.60E-5 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:-3.08|P-value:1.50E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:2.95|P-value:3.07E-4 ID:SGTC_1214|Compound:0358-0031|FD-Score:2.68|P-value:9.40E-4 ID:SGTC_1240|Compound:0356-0016|FD-Score:2.86|P-value:4.57E-4 ID:SGTC_1242|Compound:0402-0103|FD-Score:4.50|P-value:8.37E-8 ID:SGTC_1321|Compound:1326-2144|FD-Score:3.49|P-value:2.56E-5 ID:SGTC_1423|Compound:4048-0112|FD-Score:2.76|P-value:6.65E-4 ID:SGTC_1627|Compound:st003713|FD-Score:-3.51|P-value:1.95E-5 ID:SGTC_1701|Compound:st028638|FD-Score:2.69|P-value:8.96E-4 ID:SGTC_1720|Compound:st037298|FD-Score:2.74|P-value:7.42E-4 ID:SGTC_1874|Compound:staurosporine|FD-Score:2.86|P-value:4.46E-4 ID:SGTC_1881|Compound:5652484|FD-Score:3.40|P-value:3.98E-5 ID:SGTC_1938|Compound:st074717|FD-Score:3.69|P-value:8.79E-6 ID:SGTC_1955|Compound:wogonin|FD-Score:2.75|P-value:7.08E-4 ID:SGTC_2026|Compound:5148700|FD-Score:2.86|P-value:4.52E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.72|P-value:7.81E-6 ID:SGTC_2083|Compound:5306046|FD-Score:-2.85|P-value:4.13E-4 ID:SGTC_2099|Compound:5377090|FD-Score:-2.91|P-value:3.28E-4 ID:SGTC_2122|Compound:5258151|FD-Score:3.54|P-value:1.99E-5 ID:SGTC_2273|Compound:7815444|FD-Score:2.87|P-value:4.28E-4 ID:SGTC_2301|Compound:7769476|FD-Score:3.52|P-value:2.17E-5 ID:SGTC_2338|Compound:7999974|FD-Score:-2.64|P-value:9.68E-4 ID:SGTC_2437|Compound:5741531|FD-Score:2.79|P-value:5.94E-4 ID:SGTC_2487|Compound:5918373|FD-Score:2.93|P-value:3.28E-4 ID:SGTC_2508|Compound:celastrol|FD-Score:-3.20|P-value:8.76E-5 ID:SGTC_2563|Compound:tomatine|FD-Score:3.74|P-value:6.78E-6 ID:SGTC_2564|Compound:betulinic acid|FD-Score:3.04|P-value:2.10E-4 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:2.94|P-value:3.22E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:2.89|P-value:3.91E-4 ID:SGTC_2606|Compound:farnesol|FD-Score:4.44|P-value:1.19E-7 ID:SGTC_2611|Compound:pyromycin|FD-Score:3.79|P-value:5.35E-6 ID:SGTC_2756|Compound:carbadox|FD-Score:4.17|P-value:6.18E-7 ID:SGTC_2795|Compound:7780010|FD-Score:-2.93|P-value:3.01E-4 ID:SGTC_2833|Compound:9001315|FD-Score:-7.67|P-value:1.51E-19 ID:SGTC_2834|Compound:9001755|FD-Score:3.89|P-value:3.04E-6 ID:SGTC_3065|Compound:9113888|FD-Score:3.57|P-value:1.65E-5 ID:SGTC_3072|Compound:9116419|FD-Score:4.93|P-value:4.95E-9 ID:SGTC_3136|Compound:9095672|FD-Score:4.26|P-value:3.56E-7 ID:SGTC_3148|Compound:9097893|FD-Score:-2.78|P-value:5.44E-4 ID:SGTC_3187|Compound:9109394|FD-Score:3.26|P-value:7.51E-5 ID:SGTC_3204|Compound:9114183|FD-Score:-3.85|P-value:3.19E-6 ID:SGTC_3207|Compound:9114163|FD-Score:5.42|P-value:1.37E-10 ID:SGTC_3212|Compound:9128307|FD-Score:4.17|P-value:6.07E-7 ID:SGTC_3248|Compound:9135562|FD-Score:2.96|P-value:2.92E-4 ID:SGTC_3255|Compound:9139072|FD-Score:2.67|P-value:9.72E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-2.96|P-value:2.59E-4

Top fitness defect scores for YDR182W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_161 4065-0411 5.57 162.2 µM 4.35E-11 8 1.24E-8 0.86
2 SGTC_3207 9114163 5.42 49.5 µM 1.37E-10 3 2.91E-8 0.14
3 SGTC_3072 9116419 4.93 49.5 µM 4.95E-9 ERG2 2 4.17E-7 0.41
4 SGTC_844 0330-0132 4.87 15.3 µM 7.51E-9 3 5.70E-7 0.53
5 SGTC_1242 0402-0103 4.50 60.1 µM 8.37E-8 5 3.43E-6 0.46
6 SGTC_2606 farnesol 4.44 9.8 µM 1.19E-7 9 4.45E-6 0.29
7 SGTC_3136 9095672 4.26 49.5 µM 3.56E-7 4 1.01E-5 0.08
8 SGTC_3212 9128307 4.17 49.5 µM 6.07E-7 10 1.50E-5 0.08
9 SGTC_2756 carbadox 4.17 75.1 µM 6.18E-7 20 1.52E-5 0.05
10 SGTC_356 1634-0012 4.10 32.5 µM 9.39E-7 8 2.08E-5 0.22
11 SGTC_2834 9001755 3.89 58.4 µM 3.04E-6 4 4.99E-5 0.20
12 SGTC_150 3970-0969 3.83 77.2 µM 4.29E-6 16 6.45E-5 0.02
13 SGTC_731 3966-0296 3.80 387.0 µM 4.87E-6 4 7.10E-5 0.35
14 SGTC_2611 pyromycin 3.79 23.9 µM 5.35E-6 7 7.61E-5 0.02
15 SGTC_2563 tomatine 3.74 8.5 µM 6.78E-6 15 9.09E-5 0.13
16 SGTC_2045 5106652 3.72 78.0 µM 7.81E-6 3 1.01E-4 0.32
17 SGTC_1938 st074717 3.69 56.4 µM 8.79E-6 1 1.10E-4 0.31
18 SGTC_294 k038-0071 3.65 157.0 µM 1.12E-5 ubiquinone biosynthesis & proteasome 17 1.32E-4 0.01
19 SGTC_3065 9113888 3.57 49.5 µM 1.65E-5 9 1.77E-4 0.16
20 SGTC_2122 5258151 3.54 111.7 µM 1.99E-5 9 2.03E-4 0.24

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.131 3.26E-14 YDR251W PAM1 hom Essential protein of unknown function; exhibits variable expression during colony morphogenesis; overexpression permits survival without protein phosphatase 2A, inhibits growth, and induces a filamentous phenotype
0.110 2.02E-10 YHL003C LAG1 hom Ceramide synthase component; involved in synthesis of ceramide from C26(acyl)-coenzyme A and dihydrosphingosine or phytosphingosine, functionally equivalent to Lac1p; forms ER foci upon DNA replication stress
0.109 2.17E-10 YJL074C SMC3 het Subunit of the multiprotein cohesin complex required for sister chromatid cohesion in mitotic cells; also required, with Rec8p, for cohesion and recombination during meiosis; phylogenetically conserved SMC chromosomal ATPase family member
0.095 3.21E-8 YPL167C REV3 hom Catalytic subunit of DNA polymerase zeta, involved in translesion synthesis during post-replication repair; required for mutagenesis induced by DNA damage; involved in double-strand break repair
0.094 5.79E-8 YGL210W YPT32 hom Rab family GTPase involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; protein abundance increases in response to DNA replication stress; YPT32 has a paralog, YPT31, that arose from the whole genome duplication
0.091 1.31E-7 YJR012C_p YJR012C_p het Essential protein of unknown function; proposed involvement in transport based on mass spectrometry analysis of copurifying proteins; partially overlaps neighboring ORF, GPI14/YJR013W
0.085 7.19E-7 YNL134C YNL134C hom Protein of unknown function; similar to dehydrogenases from other model organisms; green fluorescent protein (GFP)-fusion protein localizes to both the cytoplasm and nucleus; protein abundance increases in response to DNA replication stress
0.084 1.02E-6 YLR451W LEU3 hom Zinc-knuckle transcription factor, repressor and activator; regulates genes involved in branched chain amino acid biosynthesis and ammonia assimilation; acts as a repressor in leucine-replete conditions and as an activator in the presence of alpha-isopropylmalate, an intermediate in leucine biosynthesis that accumulates during leucine starvation
0.084 1.13E-6 YDR361C BCP1 het Essential protein involved in nuclear export of Mss4p, which is a lipid kinase that generates phosphatidylinositol 4,5-biphosphate and plays a role in actin cytoskeleton organization and vesicular transport
0.084 1.25E-6 YAL020C ATS1 hom Protein required, with Elongator complex, Kti11p, and Kti12p, for modification of wobble nucleosides in tRNA; has a potential role in regulatory interactions between microtubules and the cell cycle
0.083 1.72E-6 YMR274C RCE1 hom Type II CAAX prenyl protease involved in the proteolysis and maturation of Ras and the a-factor mating pheromone
0.081 2.38E-6 YKR106W GEX2 hom Proton:glutathione antiporter localized to the vacuolar and plasma membranes; expressed at a very low level; almost identical to paralog Gex1p; potential role in resistance to oxidative stress and modulation of the PKA pathway
0.080 3.96E-6 YCR087W_d YCR087W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YCR087C-A; YCR087W is not an essential gene
0.079 4.06E-6 YNL094W APP1 hom Phosphatidate phosphatase, converts phosphatidate to diacylglycerol; App1p, Pah1p, Dpp1p, and Lpp1p are responsible for all the phosphatidate phosphatase activity; component of cortical actin patches; interacts with components of endocytic pathway
0.078 6.58E-6 YML123C PHO84 hom High-affinity inorganic phosphate (Pi) transporter and low-affinity manganese transporter; regulated by Pho4p and Spt7p; mutation confers resistance to arsenate; exit from the ER during maturation requires Pho86p; cells overexpressing Pho84p accumulate heavy metals but do not develop symptoms of metal toxicity