YDR182W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR182W-A / YDR182W-A

Click on Significant Values for Screen Details ID:SGTC_40|Compound:0327-0103|FD-Score:4.16|P-value:4.09E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.32|P-value:2.20E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.70|P-value:2.25E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.78|P-value:1.74E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.86|P-value:1.46E-8 ID:SGTC_828|Compound:2074-0507|FD-Score:3.32|P-value:8.25E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.82|P-value:2.50E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.65|P-value:2.74E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.57|P-value:6.88E-8 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.66|P-value:2.64E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.57|P-value:3.64E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.72|P-value:2.34E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.57|P-value:3.87E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-4.05|P-value:6.84E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.46|P-value:5.28E-4 ID:SGTC_1949|Compound:st076024|FD-Score:4.11|P-value:5.08E-5 ID:SGTC_2010|Compound:4012422|FD-Score:-3.51|P-value:4.76E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.57|P-value:3.57E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.45|P-value:5.48E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.74|P-value:1.99E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.42|P-value:6.00E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.38|P-value:6.86E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.31|P-value:9.28E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.97|P-value:8.64E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.86|P-value:1.40E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.32|P-value:2.18E-5 ID:SGTC_3097|Compound:9117246|FD-Score:3.28|P-value:9.50E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.74|P-value:2.00E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.73|P-value:2.04E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.41|P-value:6.14E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.36|P-value:7.19E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.48|P-value:4.98E-4 ID:SGTC_40|Compound:0327-0103|FD-Score:4.16|P-value:4.09E-5 ID:SGTC_43|Compound:0570-0105|FD-Score:3.50|P-value:4.66E-4 ID:SGTC_220|Compound:paclitaxel|FD-Score:4.32|P-value:2.20E-5 ID:SGTC_236|Compound:1509-0011|FD-Score:3.70|P-value:2.25E-4 ID:SGTC_755|Compound:1995-0008|FD-Score:3.78|P-value:1.74E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:5.86|P-value:1.46E-8 ID:SGTC_828|Compound:2074-0507|FD-Score:3.32|P-value:8.25E-4 ID:SGTC_924|Compound:2046-0044|FD-Score:4.82|P-value:2.50E-6 ID:SGTC_954|Compound:1189-0853|FD-Score:3.34|P-value:7.83E-4 ID:SGTC_966|Compound:1300-0360|FD-Score:3.65|P-value:2.74E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:5.57|P-value:6.88E-8 ID:SGTC_1042|Compound:0350-0096|FD-Score:3.66|P-value:2.64E-4 ID:SGTC_1134|Compound:3477-0009|FD-Score:3.57|P-value:3.64E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:-3.72|P-value:2.34E-4 ID:SGTC_1641|Compound:st009299|FD-Score:-3.57|P-value:3.87E-4 ID:SGTC_1813|Compound:st051246|FD-Score:-4.05|P-value:6.84E-5 ID:SGTC_1931|Compound:st074438|FD-Score:3.46|P-value:5.28E-4 ID:SGTC_1949|Compound:st076024|FD-Score:4.11|P-value:5.08E-5 ID:SGTC_2010|Compound:4012422|FD-Score:-3.51|P-value:4.76E-4 ID:SGTC_2060|Compound:5238662|FD-Score:3.57|P-value:3.57E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.45|P-value:5.48E-4 ID:SGTC_2360|Compound:9040895|FD-Score:3.74|P-value:1.99E-4 ID:SGTC_2438|Compound:5259590|FD-Score:3.42|P-value:6.00E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.38|P-value:6.86E-4 ID:SGTC_2751|Compound:anetholtrithion|FD-Score:-3.31|P-value:9.28E-4 ID:SGTC_2892|Compound:9047358|FD-Score:3.97|P-value:8.64E-5 ID:SGTC_2951|Compound:9072950|FD-Score:-3.86|P-value:1.40E-4 ID:SGTC_2952|Compound:9073731|FD-Score:4.32|P-value:2.18E-5 ID:SGTC_3097|Compound:9117246|FD-Score:3.28|P-value:9.50E-4 ID:SGTC_3129|Compound:9127257|FD-Score:3.74|P-value:2.00E-4 ID:SGTC_3135|Compound:9127742|FD-Score:3.73|P-value:2.04E-4 ID:SGTC_3173|Compound:9105693|FD-Score:3.41|P-value:6.14E-4 ID:SGTC_3254|Compound:9136651|FD-Score:3.36|P-value:7.19E-4 ID:SGTC_3257|Compound:9139206|FD-Score:3.48|P-value:4.98E-4

Top fitness defect scores for YDR182W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_773 4358-1457 5.86 44.6 µM 1.46E-8 13 2.28E-9
2 SGTC_1024 4507-0395 5.57 26.0 µM 6.88E-8 TSC3-RPN4 7 1.28E-8
3 SGTC_924 2046-0044 4.82 21.3 µM 2.50E-6 5 7.07E-7
4 SGTC_2952 9073731 4.32 13.8 µM 2.18E-5 tubulin folding & SWR complex 31 7.87E-6
5 SGTC_220 paclitaxel 4.32 373.4 µM 2.20E-5 5 7.97E-6
6 SGTC_40 0327-0103 4.16 19.8 µM 4.09E-5 26 1.59E-5
7 SGTC_1949 st076024 4.11 69.1 µM 5.08E-5 21 2.02E-5
8 SGTC_2892 9047358 3.97 58.4 µM 8.64E-5 8 3.65E-5
9 SGTC_755 1995-0008 3.78 37.3 µM 1.74E-4 26 7.92E-5
10 SGTC_2360 9040895 3.74 200.0 µM 1.99E-4 RPP1 & pyrimidine depletion 19 9.21E-5
11 SGTC_3129 9127257 3.74 49.5 µM 2.00E-4 29 9.26E-5
12 SGTC_3135 9127742 3.73 49.5 µM 2.04E-4 29 9.48E-5
13 SGTC_236 1509-0011 3.70 5.3 µM 2.25E-4 398 1.06E-4
14 SGTC_1042 0350-0096 3.66 82.0 µM 2.64E-4 TSC3-RPN4 33 1.26E-4
15 SGTC_966 1300-0360 3.65 30.2 µM 2.74E-4 heme requiring 31 1.32E-4
16 SGTC_2060 5238662 3.57 140.0 µM 3.57E-4 37 1.76E-4
17 SGTC_1134 3477-0009 3.57 42.5 µM 3.64E-4 59 1.80E-4
18 SGTC_43 0570-0105 3.50 72.5 µM 4.66E-4 ERG2 132 2.37E-4
19 SGTC_3257 9139206 3.48 33.0 µM 4.98E-4 12 2.55E-4
20 SGTC_1931 st074438 3.46 57.1 µM 5.28E-4 34 2.73E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.126 3.01E-13 YAL043C PTA1 het Subunit of holo-CPF, a multiprotein complex and functional homolog of mammalian CPSF, required for the cleavage and polyadenylation of mRNA and snoRNA 3' ends; involved in pre-tRNA processing; binds to the phosphorylated CTD of RNAPII
0.108 2.90E-10 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.108 3.82E-10 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.107 5.04E-10 YGR112W SHY1 hom Mitochondrial inner membrane protein required for assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes; similar to human SURF1 involved in Leigh Syndrome
0.102 2.77E-9 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.101 4.60E-9 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.100 5.56E-9 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.098 1.18E-8 YDR197W CBS2 hom Mitochondrial translational activator of the COB mRNA; interacts with translating ribosomes, acts on the COB mRNA 5'-untranslated leader
0.097 1.79E-8 YLR271W_p YLR271W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm and the nucleus and is induced in response to the DNA-damaging agent MMS
0.097 1.75E-8 YJR077C MIR1 hom Mitochondrial phosphate carrier, imports inorganic phosphate into mitochondria; functionally redundant with Pic2p but more abundant than Pic2p under normal conditions; phosphorylated
0.096 2.16E-8 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.095 3.12E-8 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.095 3.35E-8 YBL021C HAP3 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences contributing to both complex assembly and DNA binding
0.095 3.91E-8 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.094 4.63E-8 YAL044W-A_p YAL044W-A_p hom Putative protein of unknown function; similar to S. pombe uvi31 which is a putative DNA repair protein