YDR183W / PLP1

Protein that interacts with CCT (chaperonin containing TCP-1) complex and has a role in actin and tubulin folding; has weak similarity to phosducins, which are G-protein regulators

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR183W / PLP1

Click on Significant Values for Screen Details ID:SGTC_77|Compound:0828-0286|FD-Score:-3.48|P-value:2.32E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.12|P-value:1.62E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.65|P-value:8.70E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:3.17|P-value:5.40E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:6.13|P-value:1.73E-10 ID:SGTC_676|Compound:falcarinol|FD-Score:3.62|P-value:9.77E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.43|P-value:2.83E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:6.12|P-value:1.81E-10 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.11|P-value:8.84E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.99|P-value:2.07E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.13|P-value:8.30E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.93|P-value:2.67E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.05|P-value:8.37E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.31|P-value:3.22E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.25|P-value:4.07E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.69|P-value:1.04E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.05|P-value:8.17E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.10|P-value:9.12E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.12|P-value:6.58E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.82|P-value:6.14E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.12|P-value:7.67E-8 ID:SGTC_1742|Compound:st038235|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.66|P-value:3.23E-9 ID:SGTC_1983|Compound:st071813|FD-Score:-3.26|P-value:5.24E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.97|P-value:2.24E-5 ID:SGTC_2226|Compound:7298446|FD-Score:3.29|P-value:3.44E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.02|P-value:1.84E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.88|P-value:3.32E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.03|P-value:9.00E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.48|P-value:2.15E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.76|P-value:1.80E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-6.58|P-value:1.46E-11 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.58|P-value:1.14E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.38|P-value:2.49E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.26|P-value:5.30E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.23|P-value:4.32E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.47|P-value:2.18E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.67|P-value:7.94E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.61|P-value:1.08E-6 ID:SGTC_3011|Compound:9081274|FD-Score:3.13|P-value:6.19E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.15|P-value:1.46E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-4.46|P-value:3.52E-6 ID:SGTC_3155|Compound:9099265|FD-Score:3.40|P-value:2.34E-4 ID:SGTC_77|Compound:0828-0286|FD-Score:-3.48|P-value:2.32E-4 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.21|P-value:4.62E-4 ID:SGTC_277|Compound:nystatin|FD-Score:-4.12|P-value:1.62E-5 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.65|P-value:8.70E-5 ID:SGTC_616|Compound:4092-0450|FD-Score:3.17|P-value:5.40E-4 ID:SGTC_670|Compound:4204-0025|FD-Score:6.13|P-value:1.73E-10 ID:SGTC_676|Compound:falcarinol|FD-Score:3.62|P-value:9.77E-5 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.43|P-value:2.83E-4 ID:SGTC_684|Compound:1140-0066|FD-Score:6.12|P-value:1.81E-10 ID:SGTC_782|Compound:0083-0095|FD-Score:-3.11|P-value:8.84E-4 ID:SGTC_881|Compound:0833-0569|FD-Score:3.99|P-value:2.07E-5 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:-3.13|P-value:8.30E-4 ID:SGTC_1206|Compound:3978-0017|FD-Score:3.93|P-value:2.67E-5 ID:SGTC_1212|Compound:0520-0165|FD-Score:3.05|P-value:8.37E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:3.31|P-value:3.22E-4 ID:SGTC_1382|Compound:3002-2117|FD-Score:3.25|P-value:4.07E-4 ID:SGTC_1462|Compound:k081-0014|FD-Score:-3.69|P-value:1.04E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.05|P-value:8.17E-4 ID:SGTC_1557|Compound:sumaresinolic acid|FD-Score:-3.10|P-value:9.12E-4 ID:SGTC_1594|Compound:piperine|FD-Score:3.12|P-value:6.58E-4 ID:SGTC_1601|Compound:4'-hydroxyflavanone|FD-Score:3.49|P-value:1.64E-4 ID:SGTC_1691|Compound:st019933|FD-Score:-3.82|P-value:6.14E-5 ID:SGTC_1714|Compound:st033236|FD-Score:3.25|P-value:4.11E-4 ID:SGTC_1717|Compound:st033143|FD-Score:5.12|P-value:7.67E-8 ID:SGTC_1742|Compound:st038235|FD-Score:3.58|P-value:1.13E-4 ID:SGTC_1948|Compound:st076329|FD-Score:5.66|P-value:3.23E-9 ID:SGTC_1983|Compound:st071813|FD-Score:-3.26|P-value:5.24E-4 ID:SGTC_2040|Compound:5100729|FD-Score:3.97|P-value:2.24E-5 ID:SGTC_2226|Compound:7298446|FD-Score:3.29|P-value:3.44E-4 ID:SGTC_2282|Compound:7944268|FD-Score:4.02|P-value:1.84E-5 ID:SGTC_2283|Compound:7944793|FD-Score:3.88|P-value:3.32E-5 ID:SGTC_2288|Compound:7946289|FD-Score:3.03|P-value:9.00E-4 ID:SGTC_2528|Compound:xanthyletin|FD-Score:4.48|P-value:2.15E-6 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:5.76|P-value:1.80E-9 ID:SGTC_2534|Compound:helenine|FD-Score:-6.58|P-value:1.46E-11 ID:SGTC_2587|Compound:piperic acid|FD-Score:3.58|P-value:1.14E-4 ID:SGTC_2657|Compound:nystatin|FD-Score:3.44|P-value:2.02E-4 ID:SGTC_2757|Compound:clomiphene|FD-Score:3.38|P-value:2.49E-4 ID:SGTC_2774|Compound:tamoxifen|FD-Score:-3.26|P-value:5.30E-4 ID:SGTC_2792|Compound:7535235|FD-Score:3.23|P-value:4.32E-4 ID:SGTC_2811|Compound:7967822|FD-Score:4.47|P-value:2.18E-6 ID:SGTC_2836|Compound:9010338|FD-Score:3.67|P-value:7.94E-5 ID:SGTC_2837|Compound:9008476|FD-Score:4.61|P-value:1.08E-6 ID:SGTC_3011|Compound:9081274|FD-Score:3.13|P-value:6.19E-4 ID:SGTC_3043|Compound:9092303|FD-Score:-4.15|P-value:1.46E-5 ID:SGTC_3140|Compound:9094243|FD-Score:-4.46|P-value:3.52E-6 ID:SGTC_3155|Compound:9099265|FD-Score:3.40|P-value:2.34E-4

Top fitness defect scores for YDR183W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_670 4204-0025 6.13 119.0 µM 1.73E-10 copper-dependent oxidative stress 10 4.47E-10
2 SGTC_684 1140-0066 6.12 328.0 µM 1.81E-10 Golgi 3 4.67E-10
3 SGTC_2529 gangaleoidin 5.76 93.6 µM 1.80E-9 4 4.24E-9
4 SGTC_1948 st076329 5.66 66.6 µM 3.23E-9 5 7.41E-9
5 SGTC_1717 st033143 5.12 58.0 µM 7.67E-8 22 1.55E-7
6 SGTC_2837 9008476 4.61 45.5 µM 1.08E-6 17 1.97E-6
7 SGTC_2528 xanthyletin 4.48 44.8 µM 2.15E-6 16 3.79E-6
8 SGTC_2811 7967822 4.47 32.5 µM 2.18E-6 9 3.84E-6
9 SGTC_2282 7944268 4.02 200.0 µM 1.84E-5 RPP1 & pyrimidine depletion 29 2.97E-5
10 SGTC_881 0833-0569 3.99 170.0 µM 2.07E-5 28 3.34E-5
11 SGTC_2040 5100729 3.97 123.0 µM 2.24E-5 42 3.59E-5
12 SGTC_1206 3978-0017 3.93 132.0 µM 2.67E-5 ERG2 37 4.25E-5
13 SGTC_2283 7944793 3.88 200.0 µM 3.32E-5 46 5.24E-5
14 SGTC_2836 9010338 3.67 19.5 µM 7.94E-5 RPP1 & pyrimidine depletion 40 1.21E-4
15 SGTC_454 lyso-paf C-16 3.65 6.7 µM 8.70E-5 26 1.32E-4
16 SGTC_676 falcarinol 3.62 140.0 µM 9.77E-5 64 1.47E-4
17 SGTC_1742 st038235 3.58 28.9 µM 1.13E-4 mitochondrial stress 132 1.69E-4
18 SGTC_2587 piperic acid 3.58 92.2 µM 1.14E-4 31 1.71E-4
19 SGTC_1601 4'-hydroxyflavanone 3.49 55.5 µM 1.64E-4 RPP1 & pyrimidine depletion 47 2.42E-4
20 SGTC_2657 nystatin 3.44 74.4 µM 2.02E-4 27 2.96E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.125 4.40E-13 YLR401C DUS3 hom Dihydrouridine synthase; member of a widespread family of conserved proteins including Smm1p, Dus1p, and Dus4p; contains a consensus oleate response element (ORE) in its promoter region; forms nuclear foci upon DNA replication stress
0.119 5.21E-12 YDR117C TMA64 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; in mammals the corresponding protein, eIF2D, has been shown to possess translation initiation factor activity
0.107 4.34E-10 YIL010W DOT5 hom Nuclear thiol peroxidase which functions as an alkyl-hydroperoxide reductase during post-diauxic growth
0.107 6.29E-10 YER049W TPA1 hom Poly(rA)-binding protein involved in translation termination efficiency, mRNA poly(A) tail length and mRNA stability; interacts with Sup45p (eRF1), Sup35p (eRF3) and Pab1p; similar to prolyl 4-hydroxylases; binds Fe(III) and 2-oxoglutarate
0.106 7.88E-10 YLR018C POM34 hom Subunit of the transmembrane ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport, NPC biogenesis and spindle pole body duplication
0.096 2.77E-8 YJL171C YJL171C hom GPI-anchored cell wall protein of unknown function; induced in response to cell wall damaging agents and by mutations in genes involved in cell wall biogenesis; sequence similarity to YBR162C/TOS1, a covalently bound cell wall protein; protein abundance increases in response to DNA replication stress
0.094 4.50E-8 YKL166C TPK3 hom cAMP-dependent protein kinase catalytic subunit; promotes vegetative growth in response to nutrients via the Ras-cAMP signaling pathway; partially redundant with Tpk1p and Tpk2p; localizes to P-bodies during stationary phase; TPK3 has a paralog, TPK1, that arose from the whole genome duplication
0.094 5.76E-8 YJL105W SET4 hom Protein of unknown function, contains a SET domain; SET4 has a paralog, SET3, that arose from the whole genome duplication
0.093 6.27E-8 YDL237W AIM6 hom Putative protein of unknown function, required for respiratory growth; YDL237W is not an essential gene
0.091 1.44E-7 YIL161W_p YIL161W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm; mRNA is enriched in Scp160p-associated mRNPs; YIL161W is a non-essential gene
0.089 2.39E-7 YKR058W GLG1 hom Glycogenin glucosyltransferase; self-glucosylating initiator of glycogen synthesis, also glucosylates n-dodecyl-beta-D-maltoside; similar to mammalian glycogenin; GLG1 has a paralog, GLG2, that arose from the whole genome duplication
0.089 2.74E-7 YDR288W NSE3 het Component of the SMC5-SMC6 complex; this complex plays a key role in the removal of X-shaped DNA structures that arise between sister chromatids during DNA replication and repair; protein abundance increases in response to DNA replication stress
0.089 2.66E-7 YMR195W ICY1 hom Protein of unknown function, required for viability in rich media of cells lacking mitochondrial DNA; mutants have an invasive growth defect with elongated morphology; induced by amino acid starvation
0.088 3.99E-7 YNL166C BNI5 hom Protein involved in organization of septins at the mother-bud neck, may interact directly with the Cdc11p septin, localizes to bud neck in a septin-dependent manner
0.086 5.76E-7 YIL093C RSM25 hom Mitochondrial ribosomal protein of the small subunit