YDR184C / ATC1

Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR184C / ATC1

Click on Significant Values for Screen Details ID:SGTC_441|Compound:propafenone|FD-Score:4.29|P-value:4.41E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.62|P-value:4.34E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.87|P-value:2.07E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_469|Compound:w7|FD-Score:3.51|P-value:6.80E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.81|P-value:2.53E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:6.01|P-value:2.00E-8 ID:SGTC_691|Compound:1548-0686|FD-Score:5.00|P-value:2.45E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.47|P-value:7.09E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.50|P-value:7.05E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.04|P-value:1.01E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.52|P-value:6.50E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-4.05|P-value:9.86E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:4.94|P-value:3.22E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.92|P-value:1.54E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.50|P-value:1.95E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.55|P-value:5.90E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.47|P-value:2.27E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.81|P-value:2.56E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.89|P-value:3.98E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.15|P-value:7.58E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.62|P-value:1.22E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.59|P-value:1.37E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.64|P-value:4.46E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.82|P-value:2.44E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.57|P-value:5.10E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.17|P-value:7.08E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.79|P-value:6.08E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.78|P-value:2.79E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.73|P-value:3.00E-4 ID:SGTC_1664|Compound:st014217|FD-Score:-3.42|P-value:8.22E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.46|P-value:7.89E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.56|P-value:5.31E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.84|P-value:2.08E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.89|P-value:1.70E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.29|P-value:4.53E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-4.26|P-value:4.53E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_2210|Compound:7115885|FD-Score:4.30|P-value:4.37E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.60|P-value:5.09E-4 ID:SGTC_2321|Compound:7390090|FD-Score:8.84|P-value:3.05E-16 ID:SGTC_2328|Compound:6201408|FD-Score:4.01|P-value:1.28E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.45|P-value:8.21E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.41|P-value:8.61E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.12|P-value:1.42E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.42|P-value:9.09E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.86|P-value:3.94E-6 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.62|P-value:4.74E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.80|P-value:2.62E-4 ID:SGTC_2837|Compound:9008476|FD-Score:6.74|P-value:3.64E-10 ID:SGTC_2841|Compound:9004761|FD-Score:-4.56|P-value:1.40E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.50|P-value:7.01E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-4.60|P-value:1.18E-5 ID:SGTC_2854|Compound:9024559|FD-Score:5.74|P-value:7.91E-8 ID:SGTC_2858|Compound:9025781|FD-Score:-7.94|P-value:1.50E-13 ID:SGTC_2859|Compound:9028643|FD-Score:-3.90|P-value:1.69E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.63|P-value:1.19E-5 ID:SGTC_3051|Compound:9093778|FD-Score:4.40|P-value:2.97E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-4.05|P-value:9.81E-5 ID:SGTC_441|Compound:propafenone|FD-Score:4.29|P-value:4.41E-5 ID:SGTC_443|Compound:clozapine|FD-Score:-3.62|P-value:4.34E-4 ID:SGTC_454|Compound:lyso-paf C-16|FD-Score:3.87|P-value:2.07E-4 ID:SGTC_463|Compound:ikarugamyin|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_469|Compound:w7|FD-Score:3.51|P-value:6.80E-4 ID:SGTC_536|Compound:3852-0578|FD-Score:3.81|P-value:2.53E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:6.01|P-value:2.00E-8 ID:SGTC_691|Compound:1548-0686|FD-Score:5.00|P-value:2.45E-6 ID:SGTC_734|Compound:2023-0417|FD-Score:-3.47|P-value:7.09E-4 ID:SGTC_741|Compound:4582-0002|FD-Score:3.50|P-value:7.05E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:-4.04|P-value:1.01E-4 ID:SGTC_816|Compound:0325-0417|FD-Score:3.52|P-value:6.50E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:-4.05|P-value:9.86E-5 ID:SGTC_925|Compound:2064-1272|FD-Score:4.94|P-value:3.22E-6 ID:SGTC_941|Compound:3237-0776|FD-Score:-3.92|P-value:1.54E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.50|P-value:1.95E-5 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.55|P-value:5.90E-4 ID:SGTC_1255|Compound:0566-0045|FD-Score:4.47|P-value:2.27E-5 ID:SGTC_1442|Compound:4112-3290|FD-Score:3.81|P-value:2.56E-4 ID:SGTC_1446|Compound:4239-0190|FD-Score:4.89|P-value:3.98E-6 ID:SGTC_1452|Compound:4194-0072|FD-Score:4.15|P-value:7.58E-5 ID:SGTC_1453|Compound:4237-0541|FD-Score:4.62|P-value:1.22E-5 ID:SGTC_1456|Compound:k015-0012|FD-Score:4.59|P-value:1.37E-5 ID:SGTC_1459|Compound:k035-0031|FD-Score:3.64|P-value:4.46E-4 ID:SGTC_1461|Compound:k072-0203|FD-Score:3.82|P-value:2.44E-4 ID:SGTC_1464|Compound:k208-0027|FD-Score:-3.57|P-value:5.10E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:4.17|P-value:7.08E-5 ID:SGTC_1537|Compound:2',6'-dihydroxyflavanone|FD-Score:4.79|P-value:6.08E-6 ID:SGTC_1538|Compound:2',3',6-trimethoxyflavanone|FD-Score:3.78|P-value:2.79E-4 ID:SGTC_1657|Compound:st012939|FD-Score:-3.73|P-value:3.00E-4 ID:SGTC_1664|Compound:st014217|FD-Score:-3.42|P-value:8.22E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:3.46|P-value:7.89E-4 ID:SGTC_1739|Compound:st037196|FD-Score:-3.56|P-value:5.31E-4 ID:SGTC_1750|Compound:st081859|FD-Score:-3.84|P-value:2.08E-4 ID:SGTC_1808|Compound:st050063|FD-Score:-3.89|P-value:1.70E-4 ID:SGTC_2067|Compound:5224629|FD-Score:4.29|P-value:4.53E-5 ID:SGTC_2188|Compound:6126565|FD-Score:-4.26|P-value:4.53E-5 ID:SGTC_2203|Compound:7227154|FD-Score:3.97|P-value:1.45E-4 ID:SGTC_2210|Compound:7115885|FD-Score:4.30|P-value:4.37E-5 ID:SGTC_2316|Compound:5844804|FD-Score:3.60|P-value:5.09E-4 ID:SGTC_2321|Compound:7390090|FD-Score:8.84|P-value:3.05E-16 ID:SGTC_2328|Compound:6201408|FD-Score:4.01|P-value:1.28E-4 ID:SGTC_2370|Compound:9071495|FD-Score:3.45|P-value:8.21E-4 ID:SGTC_2426|Compound:5582046|FD-Score:-3.41|P-value:8.61E-4 ID:SGTC_2507|Compound:purpurin|FD-Score:5.12|P-value:1.42E-6 ID:SGTC_2572|Compound:astragaloside iv|FD-Score:3.42|P-value:9.09E-4 ID:SGTC_2573|Compound:2',4'-dihydroxychalcone|FD-Score:-4.86|P-value:3.94E-6 ID:SGTC_2665|Compound:lovastatin|FD-Score:3.62|P-value:4.74E-4 ID:SGTC_2832|Compound:7992762|FD-Score:3.80|P-value:2.62E-4 ID:SGTC_2837|Compound:9008476|FD-Score:6.74|P-value:3.64E-10 ID:SGTC_2841|Compound:9004761|FD-Score:-4.56|P-value:1.40E-5 ID:SGTC_2845|Compound:9003024|FD-Score:3.50|P-value:7.01E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-4.60|P-value:1.18E-5 ID:SGTC_2854|Compound:9024559|FD-Score:5.74|P-value:7.91E-8 ID:SGTC_2858|Compound:9025781|FD-Score:-7.94|P-value:1.50E-13 ID:SGTC_2859|Compound:9028643|FD-Score:-3.90|P-value:1.69E-4 ID:SGTC_3050|Compound:9093513|FD-Score:4.63|P-value:1.19E-5 ID:SGTC_3051|Compound:9093778|FD-Score:4.40|P-value:2.97E-5 ID:SGTC_3091|Compound:9116372|FD-Score:-4.05|P-value:9.81E-5

Top fitness defect scores for YDR184C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2321 7390090 8.84 138.8 µM 3.05E-16 1 4.82E-19
2 SGTC_2837 9008476 6.74 45.5 µM 3.64E-10 2 8.12E-12
3 SGTC_660 4031-1742 6.01 102.0 µM 2.00E-8 redox potentiating 11 9.51E-10
4 SGTC_2854 9024559 5.74 71.4 µM 7.91E-8 5 4.86E-9
5 SGTC_2507 purpurin 5.12 79.7 µM 1.42E-6 copper-dependent oxidative stress 18 1.50E-7
6 SGTC_691 1548-0686 5.00 185.0 µM 2.45E-6 14 2.86E-7
7 SGTC_925 2064-1272 4.94 59.6 µM 3.22E-6 8 3.96E-7
8 SGTC_1446 4239-0190 4.89 62.0 µM 3.98E-6 19 5.08E-7
9 SGTC_1537 2',6'-dihydroxyflavanone 4.79 78.0 µM 6.08E-6 4 8.41E-7
10 SGTC_3050 9093513 4.63 49.5 µM 1.19E-5 10 1.87E-6
11 SGTC_1453 4237-0541 4.62 195.0 µM 1.22E-5 heme biosynthesis & mitochondrial translocase 17 1.92E-6
12 SGTC_1456 k015-0012 4.59 13.0 µM 1.37E-5 18 2.21E-6
13 SGTC_1168 k815-0004 4.50 80.5 µM 1.95E-5 DNA damage response 10 3.34E-6
14 SGTC_1255 0566-0045 4.47 221.0 µM 2.27E-5 excess fatty acid 22 4.00E-6
15 SGTC_3051 9093778 4.40 49.5 µM 2.97E-5 1 5.52E-6
16 SGTC_2210 7115885 4.30 190.4 µM 4.37E-5 cell wall signaling 28 8.70E-6
17 SGTC_441 propafenone 4.29 146.0 µM 4.41E-5 3 8.81E-6
18 SGTC_2067 5224629 4.29 34.1 µM 4.53E-5 16 9.10E-6
19 SGTC_1503 4585-0012 4.17 61.3 µM 7.08E-5 10 1.54E-5
20 SGTC_1452 4194-0072 4.15 190.0 µM 7.58E-5 8 1.67E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.087 4.52E-7 YOR249C APC5 het Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.086 5.38E-7 YGL060W YBP2 hom Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication
0.086 6.04E-7 YLL010C PSR1 hom Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.086 6.15E-7 YDR387C_p YDR387C_p hom Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.083 1.39E-6 YPL163C SVS1 hom Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.083 1.56E-6 YBR217W ATG12 hom Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.078 5.36E-6 YDR427W RPN9 het Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.073 2.07E-5 YDR357C_p CNL1_p hom Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.072 3.31E-5 YGR034W RPL26B hom Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.071 3.80E-5 YOR251C TUM1 hom Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized
0.071 3.84E-5 YOR278W HEM4 het Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.071 4.14E-5 YPR137W RRP9 het Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.071 4.14E-5 YDR434W GPI17 het Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.069 5.85E-5 YBR148W YSW1 hom Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.069 6.28E-5 YDR010C_d YDR010C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data