HIPHOP chemogenomics database

YDR184C / ATC1

Nuclear protein; possibly involved in regulation of cation stress responses and/or in the establishment of bipolar budding pattern; relative distribution to the nucleus decreases upon DNA replication stress

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR184C / ATC1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR184C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_2321	7390090	8.84	138.8 µM	3.05E-16		1	4.82E-19
2	SGTC_2837	9008476	6.74	45.5 µM	3.64E-10		2	8.12E-12
3	SGTC_660	4031-1742	6.01	102.0 µM	2.00E-8	redox potentiating	11	9.51E-10
4	SGTC_2854	9024559	5.74	71.4 µM	7.91E-8		5	4.86E-9
5	SGTC_2507	purpurin	5.12	79.7 µM	1.42E-6	copper-dependent oxidative stress	18	1.50E-7
6	SGTC_691	1548-0686	5.00	185.0 µM	2.45E-6		14	2.86E-7
7	SGTC_925	2064-1272	4.94	59.6 µM	3.22E-6		8	3.96E-7
8	SGTC_1446	4239-0190	4.89	62.0 µM	3.98E-6		19	5.08E-7
9	SGTC_1537	2',6'-dihydroxyflavanone	4.79	78.0 µM	6.08E-6		4	8.41E-7
10	SGTC_3050	9093513	4.63	49.5 µM	1.19E-5		10	1.87E-6
11	SGTC_1453	4237-0541	4.62	195.0 µM	1.22E-5	heme biosynthesis & mitochondrial translocase	17	1.92E-6
12	SGTC_1456	k015-0012	4.59	13.0 µM	1.37E-5		18	2.21E-6
13	SGTC_1168	k815-0004	4.50	80.5 µM	1.95E-5	DNA damage response	10	3.34E-6
14	SGTC_1255	0566-0045	4.47	221.0 µM	2.27E-5	excess fatty acid	22	4.00E-6
15	SGTC_3051	9093778	4.40	49.5 µM	2.97E-5		1	5.52E-6
16	SGTC_2210	7115885	4.30	190.4 µM	4.37E-5	cell wall signaling	28	8.70E-6
17	SGTC_441	propafenone	4.29	146.0 µM	4.41E-5		3	8.81E-6
18	SGTC_2067	5224629	4.29	34.1 µM	4.53E-5		16	9.10E-6
19	SGTC_1503	4585-0012	4.17	61.3 µM	7.08E-5		10	1.54E-5
20	SGTC_1452	4194-0072	4.15	190.0 µM	7.58E-5		8	1.67E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.087	4.52E-7	YOR249C	APC5	het	Subunit of the Anaphase-Promoting Complex/Cyclosome (APC/C); APC/C is a ubiquitin-protein ligase required for degradation of anaphase inhibitors, including mitotic cyclins, during the metaphase/anaphase transition; component of the platform domain of the APC/C, based on structural analysis; relative distribution to nuclear foci decreases upon DNA replication stress
0.086	5.38E-7	YGL060W	YBP2	hom	Central kinetochore associated protein; mediates mitotic progression; interacts with several central kinetochore proteins and centromeric histone Cse4p; role in resistance to oxidative stress; similar to Slk19p; YBP2 has a paralog, YBP1, that arose from the whole genome duplication
0.086	6.04E-7	YLL010C	PSR1	hom	Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.086	6.15E-7	YDR387C_p	YDR387C_p	hom	Putative transporter, member of the sugar porter family; YDR387C is not an essential gene
0.083	1.39E-6	YPL163C	SVS1	hom	Cell wall and vacuolar protein; required for wild-type resistance to vanadate; SVS1 has a paralog, SRL1, that arose from the whole genome duplication
0.083	1.56E-6	YBR217W	ATG12	hom	Conserved ubiquitin-like modifier involved in autophagy and the Cvt pathway; conjugated to Atg5p to form a complex involved in Atg8p lipidation; Atg12p-Atg5p also forms a complex with Atg16p that is required for autophagosome formation
0.078	5.36E-6	YDR427W	RPN9	het	Non-ATPase regulatory subunit of the 26S proteasome; has similarity to putative proteasomal subunits in other species; null mutant is temperature sensitive and exhibits cell cycle and proteasome assembly defects; protein abundance increases in response to DNA replication stress
0.073	2.07E-5	YDR357C_p	CNL1_p	hom	Protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.072	3.31E-5	YGR034W	RPL26B	hom	Ribosomal 60S subunit protein L26B; binds to 5.8S rRNA; homologous to mammalian ribosomal protein L26 and bacterial L24; RPL26B has a paralog, RPL26A, that arose from the whole genome duplication
0.071	3.80E-5	YOR251C	TUM1	hom	Rhodanese domain sulfur transferase, accepts persulfite from Nfs1p and transfers it to Uba4p in the pathway for 2-thiolation of the wobble uridine base of tRNAs; also stimulates sulfur transfer by Nfs1p; may be mitochondrially localized
0.071	3.84E-5	YOR278W	HEM4	het	Uroporphyrinogen III synthase, catalyzes the conversion of hydroxymethylbilane to uroporphyrinogen III, the fourth step in heme biosynthesis; deficiency in the human homolog can result in the disease congenital erythropoietic porphyria
0.071	4.14E-5	YPR137W	RRP9	het	Protein involved in pre-rRNA processing, associated with U3 snRNP; component of small ribosomal subunit (SSU) processosome; ortholog of the human U3-55k protein
0.071	4.14E-5	YDR434W	GPI17	het	Transmembrane protein subunit of the glycosylphosphatidylinositol transamidase complex that adds GPIs to newly synthesized proteins; human PIG-S homolog
0.069	5.85E-5	YBR148W	YSW1	hom	Protein required for normal prospore membrane formation; interacts with Gip1p, which is the meiosis-specific regulatory subunit of the Glc7p protein phosphatase; expressed specifically in spores and localizes to the prospore membrane
0.069	6.28E-5	YDR010C_d	YDR010C_d	hom	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data