HIPHOP chemogenomics database

YDR187C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR187C / YDR187C

Click on Significant Values for Screen Details

Top fitness defect scores for YDR187C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_229	benomyl	11.40	22.9 µM	2.96E-24	tubulin folding & SWR complex	1	3.40E-30	1.64
2	SGTC_1875	nocodazole	10.60	6.0 µM	2.43E-21	tubulin folding & SWR complex	8	1.62E-26	1.32
3	SGTC_212	3807-4682	10.10	38.8 µM	1.78E-19	tubulin folding & SWR complex	2	3.67E-24	0.14
4	SGTC_1643	st009866	6.62	20.2 µM	2.06E-9		9	1.78E-11	0.84
5	SGTC_1049	3226-0134	6.26	66.0 µM	1.39E-8		3	1.96E-10	1.21
6	SGTC_325	2810-4341	6.06	181.0 µM	3.64E-8	amide catabolism	1	6.61E-10	0.92
7	SGTC_2405	ticlatone	5.92	3.5 µM	7.50E-8		7	1.64E-9	0.35
8	SGTC_3266	9136860	5.89	49.5 µM	8.58E-8	cell wall	5	1.95E-9	0.32
9	SGTC_2883	9059145	5.55	45.5 µM	4.18E-7		1	1.43E-8	0.88
10	SGTC_228	caffeine	5.47	993.1 µM	6.03E-7		1	2.26E-8	0.99
11	SGTC_375	3970-0961	5.40	9.3 µM	8.12E-7	tubulin folding & SWR complex	4	3.28E-8	0.53
12	SGTC_2526	patulin	5.40	37.6 µM	8.33E-7		5	3.39E-8	0.03
13	SGTC_1557	sumaresinolic acid	5.30	42.3 µM	1.25E-6		3	5.65E-8	1.39
14	SGTC_1545	lovastatin	5.23	49.4 µM	1.71E-6		3	8.38E-8	0.50
15	SGTC_861	0443-0273	5.21	110.0 µM	1.85E-6		2	9.21E-8	0.32
16	SGTC_287	k060-0039	5.18	29.6 µM	2.11E-6		3	1.09E-7	0.43
17	SGTC_194	1486-1323	5.15	56.9 µM	2.42E-6		1	1.29E-7	0.39
18	SGTC_2787	5284540	5.06	71.4 µM	3.53E-6		4	2.08E-7	0.04
19	SGTC_2214	7179297	5.01	48.3 µM	4.41E-6	superoxide	1	2.75E-7	0.53
20	SGTC_747	3448-8087	4.91	38.7 µM	6.49E-6		4	4.47E-7	0.01

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.336	2.46E-89	YDR212W	TCP1	het	Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.327	1.59E-84	YJL008C	CCT8	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.297	2.26E-69	YIL142W	CCT2	het	Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.278	1.09E-60	YJL014W	CCT3	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.249	1.13E-48	YDR188W	CCT6	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.248	4.20E-48	YER007W	PAC2	hom	Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.235	1.74E-43	YDL143W	CCT4	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.234	6.26E-43	YLR163C	MAS1	het	Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.230	1.47E-41	YJR064W	CCT5	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.223	3.34E-39	YGL094C	PAN2	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.223	4.77E-39	YJL009W_d	YJL009W_d	het	Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.222	8.33E-39	YOR349W	CIN1	hom	Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.193	2.17E-29	YPL241C	CIN2	hom	GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.189	2.13E-28	YJL111W	CCT7	het	Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.168	1.37E-22	YKL025C	PAN3	hom	Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes