YDR188W / CCT6

Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR188W / CCT6

Click on Significant Values for Screen Details ID:SGTC_136|Compound:0097-0015|FD-Score:5.10|P-value:7.05E-5 ID:SGTC_229|Compound:benomyl|FD-Score:5.52|P-value:1.97E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-4.25|P-value:9.86E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.41|P-value:4.90E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.23|P-value:7.76E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:4.16|P-value:9.31E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.60|P-value:4.05E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:6.10|P-value:2.83E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.45|P-value:5.92E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.63|P-value:3.75E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.88|P-value:1.86E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.42|P-value:4.79E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-5.50|P-value:2.97E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:4.44|P-value:4.62E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.39|P-value:5.26E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-4.68|P-value:3.29E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.77|P-value:1.85E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.30|P-value:3.94E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-4.44|P-value:6.14E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-6.51|P-value:9.78E-7 ID:SGTC_1750|Compound:st081859|FD-Score:-4.59|P-value:4.14E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.58|P-value:3.16E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.84|P-value:2.85E-9 ID:SGTC_2111|Compound:5486399|FD-Score:-4.63|P-value:3.70E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.33|P-value:8.22E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.17|P-value:9.12E-4 ID:SGTC_2214|Compound:7179297|FD-Score:4.26|P-value:7.27E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-5.03|P-value:1.23E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.91|P-value:1.87E-11 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.66|P-value:1.83E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.60|P-value:4.07E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-5.30|P-value:5.61E-5 ID:SGTC_2809|Compound:7964133|FD-Score:5.81|P-value:7.67E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-7.15|P-value:8.34E-8 ID:SGTC_2852|Compound:9023854|FD-Score:-5.12|P-value:9.51E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.28|P-value:9.19E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.77|P-value:1.87E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.82|P-value:2.22E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-4.33|P-value:8.20E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.46|P-value:5.81E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-5.77|P-value:1.26E-5 ID:SGTC_3244|Compound:9134489|FD-Score:-4.87|P-value:1.92E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-6.10|P-value:4.23E-6 ID:SGTC_136|Compound:0097-0015|FD-Score:5.10|P-value:7.05E-5 ID:SGTC_229|Compound:benomyl|FD-Score:5.52|P-value:1.97E-5 ID:SGTC_269|Compound:exalamide|FD-Score:-4.25|P-value:9.86E-4 ID:SGTC_287|Compound:k060-0039|FD-Score:4.41|P-value:4.90E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:4.23|P-value:7.76E-4 ID:SGTC_325|Compound:2810-4341|FD-Score:4.16|P-value:9.31E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-4.60|P-value:4.05E-4 ID:SGTC_375|Compound:3970-0961|FD-Score:6.10|P-value:2.83E-6 ID:SGTC_490|Compound:phenamil|FD-Score:-4.45|P-value:5.92E-4 ID:SGTC_551|Compound:k048-0028|FD-Score:-4.63|P-value:3.75E-4 ID:SGTC_566|Compound:0958-0068|FD-Score:-4.88|P-value:1.86E-4 ID:SGTC_579|Compound:4491-1009|FD-Score:4.42|P-value:4.79E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-5.50|P-value:2.97E-5 ID:SGTC_982|Compound:1491-0518|FD-Score:4.44|P-value:4.62E-4 ID:SGTC_1212|Compound:0520-0165|FD-Score:4.39|P-value:5.26E-4 ID:SGTC_1451|Compound:4152-0210|FD-Score:-4.68|P-value:3.29E-4 ID:SGTC_1520|Compound:flindersine|FD-Score:4.77|P-value:1.85E-4 ID:SGTC_1643|Compound:st009866|FD-Score:5.30|P-value:3.94E-5 ID:SGTC_1716|Compound:st033144|FD-Score:-4.44|P-value:6.14E-4 ID:SGTC_1731|Compound:st035964|FD-Score:-6.51|P-value:9.78E-7 ID:SGTC_1750|Compound:st081859|FD-Score:-4.59|P-value:4.14E-4 ID:SGTC_1859|Compound:st055998|FD-Score:4.58|P-value:3.16E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:7.84|P-value:2.85E-9 ID:SGTC_2111|Compound:5486399|FD-Score:-4.63|P-value:3.70E-4 ID:SGTC_2127|Compound:5253358|FD-Score:-4.33|P-value:8.22E-4 ID:SGTC_2151|Compound:5563267|FD-Score:4.17|P-value:9.12E-4 ID:SGTC_2214|Compound:7179297|FD-Score:4.26|P-value:7.27E-4 ID:SGTC_2275|Compound:7947463|FD-Score:-5.03|P-value:1.23E-4 ID:SGTC_2405|Compound:ticlatone|FD-Score:8.91|P-value:1.87E-11 ID:SGTC_2640|Compound:pentamidine|FD-Score:-5.66|P-value:1.83E-5 ID:SGTC_2689|Compound:tacrolimus|FD-Score:-4.60|P-value:4.07E-4 ID:SGTC_2807|Compound:7945238|FD-Score:-5.30|P-value:5.61E-5 ID:SGTC_2809|Compound:7964133|FD-Score:5.81|P-value:7.67E-6 ID:SGTC_2810|Compound:7959871|FD-Score:-7.15|P-value:8.34E-8 ID:SGTC_2852|Compound:9023854|FD-Score:-5.12|P-value:9.51E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.28|P-value:9.19E-4 ID:SGTC_2917|Compound:7979103|FD-Score:4.77|P-value:1.87E-4 ID:SGTC_2926|Compound:9010726|FD-Score:-4.82|P-value:2.22E-4 ID:SGTC_3049|Compound:9092223|FD-Score:-4.33|P-value:8.20E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-4.46|P-value:5.81E-4 ID:SGTC_3105|Compound:9121040|FD-Score:-5.77|P-value:1.26E-5 ID:SGTC_3244|Compound:9134489|FD-Score:-4.87|P-value:1.92E-4 ID:SGTC_3329|Compound:9141233|FD-Score:-6.10|P-value:4.23E-6

Top fitness defect scores for YDR188W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2405 ticlatone 8.91 3.5 µM 1.87E-11 3 2.52E-19 1.55
2 SGTC_1875 nocodazole 7.84 6.0 µM 2.85E-9 tubulin folding & SWR complex 13 2.21E-15 1.05
3 SGTC_375 3970-0961 6.10 9.3 µM 2.83E-6 tubulin folding & SWR complex 2 5.38E-10 0.08
4 SGTC_2809 7964133 5.81 13.0 µM 7.67E-6 60S ribosome export 4 3.20E-9 0.72
5 SGTC_229 benomyl 5.52 22.9 µM 1.97E-5 tubulin folding & SWR complex 11 1.73E-8 0.41
6 SGTC_1643 st009866 5.30 20.2 µM 3.94E-5 14 5.89E-8 0.28
7 SGTC_136 0097-0015 5.10 404.5 µM 7.05E-5 60S ribosome export 4 1.66E-7 0.02
8 SGTC_1520 flindersine 4.77 88.0 µM 1.85E-4 4 9.14E-7 0.01
9 SGTC_2917 7979103 4.77 53.8 µM 1.87E-4 5 9.36E-7 0.52
10 SGTC_1859 st055998 4.58 20.0 µM 3.16E-4 3 2.35E-6 0.60
11 SGTC_982 1491-0518 4.44 27.5 µM 4.62E-4 1 4.59E-6 0.52
12 SGTC_579 4491-1009 4.42 110.0 µM 4.79E-4 60S ribosome export 5 4.91E-6 0.36
13 SGTC_287 k060-0039 4.41 29.6 µM 4.90E-4 7 5.11E-6 0.27
14 SGTC_1212 0520-0165 4.39 585.0 µM 5.26E-4 5 5.79E-6 0.18
15 SGTC_2214 7179297 4.26 48.3 µM 7.27E-4 superoxide 4 1.02E-5 0.53
16 SGTC_313 3474-0040 4.23 5.0 µM 7.76E-4 NEO1-PIK1 5 1.15E-5 0.27
17 SGTC_2151 5563267 4.17 85.4 µM 9.12E-4 16 1.52E-5 0.01
18 SGTC_325 2810-4341 4.16 181.0 µM 9.31E-4 amide catabolism 4 1.58E-5 0.13
19 SGTC_3145 9085516 4.13 49.5 µM 0.00102 fatty acid desaturase (OLE1) 11 1.85E-5 0.20
20 SGTC_1931 st074438 4.12 57.1 µM 0.00105 8 1.94E-5 0.14

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.270 4.62E-57 YDR212W TCP1 het Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein
0.249 1.13E-48 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.245 5.58E-47 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.236 1.05E-43 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.222 9.74E-39 YJL111W CCT7 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo; mutant has increased aneuploidy tolerance
0.213 1.10E-35 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.194 1.02E-29 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.191 9.60E-29 YLR197W NOP56 het Essential evolutionarily-conserved nucleolar protein component of the box C/D snoRNP complexes that direct 2'-O-methylation of pre-rRNA during its maturation; overexpression causes spindle orientation defects
0.182 2.51E-26 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.181 4.86E-26 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.174 3.19E-24 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.165 8.10E-22 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.158 3.59E-20 YPR016C TIF6 het Constituent of 66S pre-ribosomal particles, has similarity to human translation initiation factor 6 (eIF6); may be involved in the biogenesis and or stability of 60S ribosomal subunits
0.158 4.19E-20 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.157 6.75E-20 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes