YDR190C / RVB1

ATP-dependent DNA helicase, also known as pontin; member of the AAA+ and RuvB-like protein families; similar to Rvb2p; conserved component of multiple complexes including the INO80 complex, the Swr1 complex, and the R2TP complex (Rvb1-Rvb2-Tah1-Pih1); involved in multiple processes such as chromatin remodeling, box C/D snoRNP assembly, and RNA polymerase II assembly

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR190C / RVB1

Click on Significant Values for Screen Details ID:SGTC_73|Compound:0327-0325|FD-Score:-3.15|P-value:4.50E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.64|P-value:7.78E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.00|P-value:9.28E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.52|P-value:1.29E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.56|P-value:8.84E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:3.09|P-value:6.84E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.40|P-value:2.41E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.01|P-value:8.88E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.31|P-value:3.72E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.75|P-value:4.92E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.49|P-value:1.44E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.00|P-value:7.73E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.01|P-value:1.57E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.33|P-value:2.19E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:5.77|P-value:8.98E-10 ID:SGTC_713|Compound:1488-1073|FD-Score:3.13|P-value:5.71E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.72|P-value:5.65E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-4.11|P-value:7.56E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:4.44|P-value:1.95E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.08|P-value:5.76E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.62|P-value:6.87E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.08|P-value:5.82E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.47|P-value:1.59E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.62|P-value:6.90E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.29|P-value:3.16E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.24|P-value:3.20E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.14|P-value:5.54E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.94|P-value:2.08E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.23|P-value:5.35E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.85|P-value:5.33E-10 ID:SGTC_2004|Compound:4023728|FD-Score:4.26|P-value:4.61E-6 ID:SGTC_2061|Compound:5245884|FD-Score:-3.17|P-value:4.19E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.75|P-value:4.79E-5 ID:SGTC_2111|Compound:5486399|FD-Score:2.99|P-value:9.48E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.20|P-value:6.40E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.44|P-value:1.76E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.88|P-value:2.18E-5 ID:SGTC_2413|Compound:inermin|FD-Score:4.22|P-value:5.76E-6 ID:SGTC_2479|Compound:5617353|FD-Score:3.36|P-value:2.42E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.14|P-value:5.55E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.48|P-value:4.97E-12 ID:SGTC_2931|Compound:9014674|FD-Score:-3.05|P-value:6.35E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.54|P-value:1.17E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.02|P-value:7.23E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-3.15|P-value:4.50E-4 ID:SGTC_75|Compound:0159-0059|FD-Score:3.64|P-value:7.78E-5 ID:SGTC_129|Compound:0088-0017|FD-Score:3.00|P-value:9.28E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:4.52|P-value:1.29E-6 ID:SGTC_196|Compound:k015-0023|FD-Score:-3.56|P-value:8.84E-5 ID:SGTC_210|Compound:3551-0445|FD-Score:3.09|P-value:6.84E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.40|P-value:2.41E-6 ID:SGTC_351|Compound:caspofungin|FD-Score:3.01|P-value:8.88E-4 ID:SGTC_513|Compound:4245-1575|FD-Score:4.31|P-value:3.72E-6 ID:SGTC_515|Compound:4092-1064|FD-Score:3.75|P-value:4.92E-5 ID:SGTC_528|Compound:3492-0019|FD-Score:3.49|P-value:1.44E-4 ID:SGTC_534|Compound:k292-0788|FD-Score:-3.00|P-value:7.73E-4 ID:SGTC_548|Compound:1436-0017|FD-Score:4.01|P-value:1.57E-5 ID:SGTC_559|Compound:1550-0661|FD-Score:-3.33|P-value:2.19E-4 ID:SGTC_623|Compound:k072-0108|FD-Score:5.77|P-value:8.98E-10 ID:SGTC_713|Compound:1488-1073|FD-Score:3.13|P-value:5.71E-4 ID:SGTC_810|Compound:3825-7150|FD-Score:3.72|P-value:5.65E-5 ID:SGTC_869|Compound:0564-0080|FD-Score:-4.11|P-value:7.56E-6 ID:SGTC_871|Compound:0574-0004|FD-Score:4.44|P-value:1.95E-6 ID:SGTC_874|Compound:0599-0792|FD-Score:-3.08|P-value:5.76E-4 ID:SGTC_975|Compound:1335-0046|FD-Score:-3.62|P-value:6.87E-5 ID:SGTC_1143|Compound:3454-2408|FD-Score:3.51|P-value:1.34E-4 ID:SGTC_1236|Compound:0330-0013|FD-Score:-3.08|P-value:5.82E-4 ID:SGTC_1465|Compound:k213-0056|FD-Score:3.47|P-value:1.59E-4 ID:SGTC_1565|Compound:sinapyl alcohol|FD-Score:-3.62|P-value:6.90E-5 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.29|P-value:3.16E-6 ID:SGTC_1573|Compound:oleylamine|FD-Score:-3.24|P-value:3.20E-4 ID:SGTC_1583|Compound:clindamycin|FD-Score:3.14|P-value:5.54E-4 ID:SGTC_1749|Compound:st037932|FD-Score:3.94|P-value:2.08E-5 ID:SGTC_1754|Compound:st042065|FD-Score:4.23|P-value:5.35E-6 ID:SGTC_1873|Compound:rapamycin|FD-Score:5.85|P-value:5.33E-10 ID:SGTC_2004|Compound:4023728|FD-Score:4.26|P-value:4.61E-6 ID:SGTC_2061|Compound:5245884|FD-Score:-3.17|P-value:4.19E-4 ID:SGTC_2066|Compound:5222451|FD-Score:3.75|P-value:4.79E-5 ID:SGTC_2111|Compound:5486399|FD-Score:2.99|P-value:9.48E-4 ID:SGTC_2139|Compound:5578692|FD-Score:4.20|P-value:6.40E-6 ID:SGTC_2291|Compound:7917025|FD-Score:3.44|P-value:1.76E-4 ID:SGTC_2316|Compound:5844804|FD-Score:-3.88|P-value:2.18E-5 ID:SGTC_2413|Compound:inermin|FD-Score:4.22|P-value:5.76E-6 ID:SGTC_2479|Compound:5617353|FD-Score:3.36|P-value:2.42E-4 ID:SGTC_2633|Compound:5,7-dihydroxyisoflavone|FD-Score:3.44|P-value:1.75E-4 ID:SGTC_2696|Compound:st077691|FD-Score:3.14|P-value:5.55E-4 ID:SGTC_2925|Compound:9010536|FD-Score:-6.48|P-value:4.97E-12 ID:SGTC_2931|Compound:9014674|FD-Score:-3.05|P-value:6.35E-4 ID:SGTC_3027|Compound:9089541|FD-Score:3.54|P-value:1.17E-4 ID:SGTC_3148|Compound:9097893|FD-Score:-3.02|P-value:7.23E-4

Top fitness defect scores for YDR190C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1873 rapamycin 5.85 2.0 nM 5.33E-10 11 2.39E-9 1.34
2 SGTC_623 k072-0108 5.77 16.9 µM 8.98E-10 heme biosynthesis & mitochondrial translocase 7 3.85E-9 0.42
3 SGTC_138 0850-0259 4.52 40.9 µM 1.29E-6 cell wall 46 3.09E-6 0.26
4 SGTC_871 0574-0004 4.44 149.0 µM 1.95E-6 21 4.53E-6 0.00
5 SGTC_255 tunicamycin 4.40 200.5 nM 2.41E-6 unfolded protein response 13 5.51E-6 0.27
6 SGTC_513 4245-1575 4.31 41.7 µM 3.72E-6 unfolded protein response 23 8.23E-6 0.11
7 SGTC_2004 4023728 4.26 41.9 µM 4.61E-6 24 1.00E-5 0.09
8 SGTC_1754 st042065 4.23 16.1 µM 5.35E-6 NEO1-PIK1 27 1.15E-5 0.03
9 SGTC_2413 inermin 4.22 26.1 µM 5.76E-6 15 1.23E-5 0.24
10 SGTC_2139 5578692 4.20 56.5 µM 6.40E-6 superoxide 12 1.36E-5 0.18
11 SGTC_548 1436-0017 4.01 110.0 µM 1.57E-5 TSC3-RPN4 5 3.10E-5 0.02
12 SGTC_1749 st037932 3.94 54.2 µM 2.08E-5 11 4.02E-5 0.05
13 SGTC_2066 5222451 3.75 176.0 µM 4.79E-5 heme biosynthesis & mitochondrial translocase 26 8.70E-5 0.13
14 SGTC_515 4092-1064 3.75 102.0 µM 4.92E-5 plasma membrane duress 22 8.91E-5 0.03
15 SGTC_810 3825-7150 3.72 143.0 µM 5.65E-5 60S ribosome export 3 1.01E-4 0.27
16 SGTC_75 0159-0059 3.64 199.0 µM 7.78E-5 fatty acid desaturase (OLE1) 14 1.36E-4 0.07
17 SGTC_3027 9089541 3.54 49.5 µM 1.17E-4 fatty acid desaturase (OLE1) 19 1.99E-4 0.02
18 SGTC_1143 3454-2408 3.51 5.1 µM 1.34E-4 60S ribosome export 5 2.25E-4 0.23
19 SGTC_528 3492-0019 3.49 172.0 µM 1.44E-4 calcium & mitochondrial duress 28 2.40E-4 0.05
20 SGTC_1465 k213-0056 3.47 144.0 µM 1.59E-4 DNA intercalators 18 2.63E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.200 1.67E-31 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.135 4.15E-15 YDR475C JIP4 hom Protein of unknown function; previously annotated as two separate ORFs, YDR474C and YDR475C, which were merged as a result of corrections to the systematic reference sequence
0.134 8.58E-15 YJR066W TOR1 hom PIK-related protein kinase and rapamycin target; subunit of TORC1, a complex that controls growth in response to nutrients by regulating translation, transcription, ribosome biogenesis, nutrient transport and autophagy; involved in meiosis; TOR1 has a paralog, TOR2, that arose from the whole genome duplication
0.130 3.50E-14 YFL038C YPT1 het Rab family GTPase, involved in the ER-to-Golgi step of the secretory pathway; complex formation with the Rab escort protein Mrs6p is required for prenylation of Ypt1p by protein geranylgeranyltransferase type II (Bet2p-Bet4p)
0.126 2.74E-13 YBL082C ALG3 hom Dolichol-P-Man dependent alpha(1-3) mannosyltransferase, involved in the synthesis of dolichol-linked oligosaccharide donor for N-linked glycosylation of proteins
0.120 3.59E-12 YPR033C HTS1 het Cytoplasmic and mitochondrial histidine tRNA synthetase; efficient mitochondrial localization requires both a presequence and an amino-terminal sequence; mutations in human ortholog HARS2 are associated with Perrault syndrome
0.112 8.53E-11 YAL021C CCR4 hom Component of the CCR4-NOT transcriptional complex, which is involved in regulation of gene expression; component of the major cytoplasmic deadenylase, which is involved in mRNA poly(A) tail shortening
0.110 2.04E-10 YMR235C RNA1 het GTPase activating protein (GAP) for Gsp1p, involved in nuclear transport
0.110 2.04E-10 YNL233W BNI4 hom Targeting subunit for Glc7p protein phosphatase, localized to the bud neck, required for localization of chitin synthase III to the bud neck via interaction with the chitin synthase III regulatory subunit Skt5p
0.109 2.49E-10 YHR186C KOG1 het Subunit of TORC1, a rapamycin-sensitive complex involved in growth control that contains Tor1p or Tor2p, Lst8p and Tco89p; contains four HEAT repeats and seven WD-40 repeats; may act as a scaffold protein to couple TOR and its effectors
0.105 1.19E-9 YJL039C NUP192 het Essential subunit of the inner ring of the nuclear pore complex (NPC); contributes to nucleocytoplasmic transport; homologous to human NUP205
0.104 1.43E-9 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.102 2.88E-9 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.101 5.13E-9 YJR097W JJJ3 hom Protein of unknown function, contains a CSL Zn finger and a DnaJ-domain; involved in diphthamide biosynthesis; ortholog human Dph4
0.100 5.94E-9 YLL043W FPS1 hom Plasma membrane channel, member of major intrinsic protein (MIP) family; involved in efflux of glycerol and in uptake of acetic acid and the trivalent metalloids arsenite and antimonite; phosphorylated by Hog1p MAPK under acetate stress