YDR191W / HST4

Member of the Sir2 family of NAD(+)-dependent protein deacetylases; involved along with Hst3p in silencing at telomeres, cell cycle progression, radiation resistance, genomic stability and short-chain fatty acid metabolism

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR191W / HST4

Click on Significant Values for Screen Details ID:SGTC_317|Compound:4495-0002|FD-Score:-3.58|P-value:1.59E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.18|P-value:6.90E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:4.11|P-value:1.79E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.22|P-value:6.12E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.29|P-value:4.80E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.59|P-value:2.00E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:3.48|P-value:2.34E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.30|P-value:4.58E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.62|P-value:1.38E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.04|P-value:2.02E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:5.64|P-value:7.15E-9 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.42|P-value:2.90E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.53|P-value:1.90E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.49|P-value:3.16E-6 ID:SGTC_1853|Compound:st056710|FD-Score:-3.78|P-value:7.18E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-4.53|P-value:2.62E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.22|P-value:6.21E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.84|P-value:5.83E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.09|P-value:9.47E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.22|P-value:6.16E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.19|P-value:6.61E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.32|P-value:4.29E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.26|P-value:5.36E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.20|P-value:6.40E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.55|P-value:1.78E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.40|P-value:3.20E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:7.72|P-value:4.23E-15 ID:SGTC_2606|Compound:farnesol|FD-Score:4.62|P-value:1.73E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:8.98|P-value:8.92E-20 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.42|P-value:2.52E-8 ID:SGTC_317|Compound:4495-0002|FD-Score:-3.58|P-value:1.59E-4 ID:SGTC_367|Compound:0335-0881|FD-Score:-3.18|P-value:6.90E-4 ID:SGTC_508|Compound:roscovitine|FD-Score:4.11|P-value:1.79E-5 ID:SGTC_535|Compound:2293-4129|FD-Score:3.22|P-value:6.12E-4 ID:SGTC_628|Compound:1636-0253|FD-Score:3.29|P-value:4.80E-4 ID:SGTC_660|Compound:4031-1742|FD-Score:4.59|P-value:2.00E-6 ID:SGTC_685|Compound:1278-0033|FD-Score:3.48|P-value:2.34E-4 ID:SGTC_729|Compound:4092-0585|FD-Score:3.30|P-value:4.58E-4 ID:SGTC_917|Compound:harmaline|FD-Score:3.62|P-value:1.38E-4 ID:SGTC_939|Compound:1165-0479|FD-Score:5.04|P-value:2.02E-7 ID:SGTC_943|Compound:3253-1379|FD-Score:5.64|P-value:7.15E-9 ID:SGTC_1009|Compound:4106-0057|FD-Score:-3.42|P-value:2.90E-4 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.53|P-value:1.90E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:4.49|P-value:3.16E-6 ID:SGTC_1853|Compound:st056710|FD-Score:-3.78|P-value:7.18E-5 ID:SGTC_1857|Compound:st056007|FD-Score:-4.53|P-value:2.62E-6 ID:SGTC_1888|Compound:azatryptophan|FD-Score:3.22|P-value:6.21E-4 ID:SGTC_1889|Compound:st059080|FD-Score:3.84|P-value:5.83E-5 ID:SGTC_1892|Compound:st058411|FD-Score:3.09|P-value:9.47E-4 ID:SGTC_1903|Compound:st060211|FD-Score:3.22|P-value:6.16E-4 ID:SGTC_2045|Compound:5106652|FD-Score:3.66|P-value:1.18E-4 ID:SGTC_2165|Compound:5727197|FD-Score:-3.19|P-value:6.61E-4 ID:SGTC_2167|Compound:5876490|FD-Score:3.32|P-value:4.29E-4 ID:SGTC_2442|Compound:5158906|FD-Score:3.26|P-value:5.36E-4 ID:SGTC_2485|Compound:5633444|FD-Score:-3.20|P-value:6.40E-4 ID:SGTC_2529|Compound:gangaleoidin|FD-Score:-3.55|P-value:1.78E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:3.40|P-value:3.20E-4 ID:SGTC_2605|Compound:digitonin|FD-Score:7.72|P-value:4.23E-15 ID:SGTC_2606|Compound:farnesol|FD-Score:4.62|P-value:1.73E-6 ID:SGTC_2608|Compound:thymoquinone|FD-Score:8.98|P-value:8.92E-20 ID:SGTC_2615|Compound:purpurogallin-4-carboxylic acid|FD-Score:-5.42|P-value:2.52E-8

Top fitness defect scores for YDR191W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2608 thymoquinone 8.98 42.7 µM 8.92E-20 2 1.34E-19
2 SGTC_2605 digitonin 7.72 300.0 nM 4.23E-15 1 5.71E-15
3 SGTC_943 3253-1379 5.64 105.0 µM 7.15E-9 7 8.35E-9
4 SGTC_939 1165-0479 5.04 45.3 µM 2.02E-7 9 2.28E-7
5 SGTC_2606 farnesol 4.62 9.8 µM 1.73E-6 12 1.91E-6
6 SGTC_660 4031-1742 4.59 102.0 µM 2.00E-6 redox potentiating 28 2.21E-6
7 SGTC_1504 k297-0033 4.49 30.0 µM 3.16E-6 6 3.48E-6
8 SGTC_508 roscovitine 4.11 141.0 µM 1.79E-5 4 1.94E-5
9 SGTC_1889 st059080 3.84 5.2 µM 5.83E-5 20 6.25E-5
10 SGTC_2045 5106652 3.66 78.0 µM 1.18E-4 19 1.26E-4
11 SGTC_917 harmaline 3.62 728.1 nM 1.38E-4 ergosterol biosynthesis 38 1.46E-4
12 SGTC_685 1278-0033 3.48 54.9 µM 2.34E-4 60S ribosome export 40 2.48E-4
13 SGTC_2576 guaiol 3.40 23.1 µM 3.20E-4 48 3.37E-4
14 SGTC_2167 5876490 3.32 200.0 µM 4.29E-4 59 4.51E-4
15 SGTC_729 4092-0585 3.30 94.1 µM 4.58E-4 44 4.81E-4
16 SGTC_628 1636-0253 3.29 16.0 µM 4.80E-4 sphingolipid biosynthesis & PDR1 56 5.05E-4
17 SGTC_2442 5158906 3.26 48.5 µM 5.36E-4 37 5.62E-4
18 SGTC_535 2293-4129 3.22 48.2 µM 6.12E-4 NEO1 104 6.42E-4
19 SGTC_1903 st060211 3.22 78.3 µM 6.16E-4 58 6.45E-4
20 SGTC_1888 azatryptophan 3.22 97.5 µM 6.21E-4 43 6.51E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.195 8.97E-30 YHR153C SPO16 hom Meiosis-specific protein involved in synaptonemal complex assembly; implicated in regulation of crossover formation; required for sporulation
0.180 7.30E-26 YNL129W NRK1 hom Nicotinamide riboside kinase, catalyzes the phosphorylation of nicotinamide riboside and nicotinic acid riboside in salvage pathways for NAD+ biosynthesis
0.155 2.17E-19 YBR125C PTC4 hom Cytoplasmic type 2C protein phosphatase (PP2C); identified as a high-copy number suppressor of cnb1 mpk1 synthetic lethality; overexpression decreases high-osmolarity induced Hog1p phosphorylation and kinase activity
0.154 2.42E-19 YMR213W CEF1 het Essential splicing factor; associated with Prp19p and the spliceosome, contains an N-terminal c-Myb DNA binding motif necessary for cell viability but not for Prp19p association, evolutionarily conserved and homologous to S. pombe Cdc5p
0.143 9.59E-17 YCR072C RSA4 het WD-repeat protein involved in ribosome biogenesis; may interact with ribosomes; required for maturation and efficient intra-nuclear transport or pre-60S ribosomal subunits, localizes to the nucleolus
0.141 2.03E-16 YJR082C EAF6 hom Subunit of the NuA4 acetyltransferase complex that acetylates histone H4 and NuA3 acetyltransferase complex that acetylates histone H3
0.139 7.85E-16 YGL259W_p YPS5_p hom Protein with similarity to GPI-anchored aspartic proteases such as Yap1p and Yap3p
0.133 1.30E-14 YDL103C QRI1 het UDP-N-acetylglucosamine pyrophosphorylase; catalyzes the formation of UDP-N-acetylglucosamine (UDP-GlcNAc), which is important in cell wall biosynthesis, protein N-glycosylation, and GPI anchor biosynthesis; protein abundance increases in response to DNA replication stress
0.130 3.91E-14 YIR014W_p YIR014W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole; expression directly regulated by the metabolic and meiotic transcriptional regulator Ume6p; YIR014W is a non-essential gene
0.127 1.78E-13 YGR093W_p YGR093W_p hom Putative protein of unconfirmed function; green fluorescent protein (GFP)-fusion protein localizes to the nucleus
0.122 1.27E-12 YIL108W YIL108W hom Putative metalloendopeptidase; forms cytoplasmic foci upon DNA replication stress
0.121 2.32E-12 YMR105C PGM2 hom Phosphoglucomutase; catalyzes the conversion from glucose-1-phosphate to glucose-6-phosphate, which is a key step in hexose metabolism; functions as the acceptor for a Glc-phosphotransferase; protein abundance increases in response to DNA replication stress
0.120 2.46E-12 YJR038C_d YJR038C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.118 5.99E-12 YOR010C TIR2 hom Putative cell wall mannoprotein of the Srp1p/Tip1p family of serine-alanine-rich proteins; transcription is induced by cold shock and anaerobiosis
0.113 5.01E-11 YOL011W PLB3 hom Phospholipase B (lysophospholipase) involved in phospholipid metabolism; hydrolyzes phosphatidylinositol and phosphatidylserine and displays transacylase activity in vitro