HIPHOP chemogenomics database

YDR194C / MSS116

DEAD-box protein required for efficient splicing of mitochondrial Group I and II introns; non-polar RNA helicase that also facilities strand annealing

Zygosity: Homozygous strain

fixedexpanded
Profile for YDR194C / MSS116

Click on Significant Values for Screen Details

Top fitness defect scores for YDR194C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value
1	SGTC_236	1509-0011	9.72	5.3 µM	6.61E-21		200	1.24E-22
2	SGTC_173	1273-0061	8.63	2.7 µM	7.26E-17	mitochondrial stress	56	3.08E-18
3	SGTC_310	1273-0058	7.64	1.1 µM	1.34E-13	mitochondrial stress	101	1.10E-14
4	SGTC_275	trichlorophene	6.68	5.7 µM	8.28E-11	mitochondrial stress	96	1.19E-11
5	SGTC_2232	chlorophetanol	5.77	41.5 µM	1.72E-8	TRP & mitochondrial translation	46	3.97E-9
6	SGTC_2932	9016711	5.74	44.5 µM	2.06E-8		14	4.81E-9
7	SGTC_1017	4239-0030	5.72	168.0 µM	2.21E-8		5	5.20E-9
8	SGTC_1456	k015-0012	5.44	13.0 µM	9.81E-8		6	2.63E-8
9	SGTC_1742	st038235	5.33	28.9 µM	1.74E-7	mitochondrial stress	66	4.91E-8
10	SGTC_1622	st003707	5.24	19.4 µM	2.68E-7	calcium & mitochondrial duress	15	7.84E-8
11	SGTC_767	0929-0023	5.09	86.0 µM	5.66E-7	TRP & mitochondrial translation	34	1.77E-7
12	SGTC_63	0099-0242	4.80	26.7 µM	2.25E-6	mitochondrial stress	64	7.94E-7
13	SGTC_3140	9094243	4.61	49.5 µM	5.24E-6		18	1.99E-6
14	SGTC_2250	alverine citrate	4.61	130.0 µM	5.38E-6		114	2.04E-6
15	SGTC_10	0279-0212	4.52	42.6 µM	7.93E-6	TRP & mitochondrial translation	92	3.12E-6
16	SGTC_28	pentachloropyridine N-oxide	4.52	1.6 µM	7.96E-6	TSC3-RPN4	45	3.13E-6
17	SGTC_314	1671-0008	4.30	2.7 µM	2.04E-5		37	8.71E-6
18	SGTC_1623	st003709	4.21	20.3 µM	2.92E-5	calcium & mitochondrial duress	58	1.29E-5
19	SGTC_2617	dihydrotanshinone i	4.19	20.8 µM	3.10E-5	copper-dependent oxidative stress	35	1.37E-5
20	SGTC_708	3448-5400	4.19	146.0 µM	3.16E-5		39	1.40E-5

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.522	7.44E-234	YGR215W	RSM27	hom	Mitochondrial ribosomal protein of the small subunit
0.518	2.19E-229	YER050C	RSM18	hom	Mitochondrial ribosomal protein of the small subunit, has similarity to E. coli S18 ribosomal protein
0.488	1.03E-199	YMR287C	DSS1	hom	3'-5' exoribonuclease, component of the mitochondrial degradosome along with the ATP-dependent RNA helicase Suv3p; the degradosome associates with the ribosome and mediates turnover of aberrant or unprocessed RNAs
0.478	9.36E-191	YMR282C	AEP2	hom	Mitochondrial protein, likely involved in translation of the mitochondrial OLI1 mRNA; exhibits genetic interaction with the OLI1 mRNA 5'-untranslated leader
0.476	2.74E-189	YML061C	PIF1	hom	DNA helicase; exists in a nuclear form that acts as a catalytic inhibitor of telomerase; and as a mitochondrial form involved in repair and recombination of mitochondrial DNA; mutations affect zinc and iron homeostasis; regulated by Rad53p-dependent phosphorylation in rho0 cells
0.472	2.33E-185	YPR100W	MRPL51	hom	Mitochondrial ribosomal protein of the large subunit
0.466	2.56E-180	YPL040C	ISM1	hom	Mitochondrial isoleucyl-tRNA synthetase, null mutant is deficient in respiratory growth
0.465	5.84E-180	YEL050C	RML2	hom	Mitochondrial ribosomal protein of the large subunit, has similarity to E. coli L2 ribosomal protein; fat21 mutant allele causes inability to utilize oleate and may interfere with activity of the Adr1p transcription factor
0.464	2.23E-178	YDR268W	MSW1	hom	Mitochondrial tryptophanyl-tRNA synthetase
0.463	8.78E-178	YMR193W	MRPL24	hom	Mitochondrial ribosomal protein of the large subunit; two mitochondrial ribosomal proteins, YmL14 and YmL24, have been assigned to the same gene
0.452	5.25E-169	YNL177C	MRPL22	hom	Mitochondrial ribosomal protein of the large subunit
0.451	8.81E-168	YJL063C	MRPL8	hom	Mitochondrial ribosomal protein of the large subunit
0.449	3.98E-166	YER077C_p	YER077C_p	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the mitochondrion; null mutation results in a decrease in plasma membrane electron transport
0.445	7.22E-163	YGR102C	GTF1	hom	Subunit of the trimeric GatFAB AmidoTransferase(AdT) complex; involved in the formation of Q-tRNAQ; transposon insertion mutant is salt sensitive and null mutant has growth defects; non-tagged protein is detected in purified mitochondria
0.443	5.16E-161	YER087W	AIM10	hom	Protein with similarity to tRNA synthetases; non-tagged protein is detected in purified mitochondria; null mutant is viable and displays elevated frequency of mitochondrial genome loss