YDR194W-A_p

Putative protein of unknown function; identified by fungal homology and RT-PCR

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR194W-A / YDR194W-A

Click on Significant Values for Screen Details ID:SGTC_100|Compound:0086-0128|FD-Score:3.44|P-value:5.21E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.47|P-value:9.22E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.38|P-value:6.52E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.56|P-value:1.53E-13 ID:SGTC_334|Compound:1502-1024|FD-Score:3.57|P-value:3.34E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.95|P-value:4.29E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.50|P-value:4.28E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.80|P-value:7.83E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.77|P-value:1.64E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:4.47|P-value:9.24E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:3.78|P-value:1.55E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.85|P-value:9.48E-9 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.31|P-value:8.33E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.75|P-value:1.71E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.52|P-value:3.93E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.59|P-value:3.12E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.37|P-value:6.64E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.59|P-value:1.77E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.95|P-value:8.08E-5 ID:SGTC_2292|Compound:7671323|FD-Score:-3.43|P-value:3.07E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.17|P-value:7.63E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.20|P-value:3.00E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.54|P-value:3.72E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.09|P-value:9.89E-4 ID:SGTC_2448|Compound:5185112|FD-Score:6.30|P-value:6.75E-10 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.98|P-value:8.94E-7 ID:SGTC_2504|Compound:purpurogallin|FD-Score:6.25|P-value:9.26E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.03|P-value:5.95E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.48|P-value:4.55E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.29|P-value:2.04E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.32|P-value:4.61E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.79|P-value:1.51E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:6.45|P-value:2.72E-10 ID:SGTC_2874|Compound:9043904|FD-Score:-3.77|P-value:8.72E-5 ID:SGTC_2882|Compound:9058044|FD-Score:4.20|P-value:2.92E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.90|P-value:5.14E-5 ID:SGTC_2928|Compound:9011484|FD-Score:4.09|P-value:4.71E-5 ID:SGTC_2945|Compound:9067681|FD-Score:5.29|P-value:1.94E-7 ID:SGTC_2953|Compound:9074162|FD-Score:3.69|P-value:2.15E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.58|P-value:3.26E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.69|P-value:2.19E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.25|P-value:9.89E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.49|P-value:2.54E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.37|P-value:3.80E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.34|P-value:7.33E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.44|P-value:5.21E-4 ID:SGTC_126|Compound:0417-1624|FD-Score:4.47|P-value:9.22E-6 ID:SGTC_145|Compound:3737-0113|FD-Score:3.38|P-value:6.52E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:7.56|P-value:1.53E-13 ID:SGTC_334|Compound:1502-1024|FD-Score:3.57|P-value:3.34E-4 ID:SGTC_383|Compound:2324-0395|FD-Score:-3.95|P-value:4.29E-5 ID:SGTC_600|Compound:1495-0418|FD-Score:3.50|P-value:4.28E-4 ID:SGTC_704|Compound:1310-0270|FD-Score:-3.80|P-value:7.83E-5 ID:SGTC_720|Compound:r052-1644|FD-Score:3.77|P-value:1.64E-4 ID:SGTC_762|Compound:1165-0429|FD-Score:4.47|P-value:9.24E-6 ID:SGTC_940|Compound:3232-1287|FD-Score:3.78|P-value:1.55E-4 ID:SGTC_1257|Compound:0669-0121|FD-Score:5.85|P-value:9.48E-9 ID:SGTC_1294|Compound:1000-1494|FD-Score:3.31|P-value:8.33E-4 ID:SGTC_1408|Compound:3909-7976|FD-Score:3.75|P-value:1.71E-4 ID:SGTC_1503|Compound:4585-0012|FD-Score:3.46|P-value:4.89E-4 ID:SGTC_1539|Compound:benzyladenosine|FD-Score:3.52|P-value:3.93E-4 ID:SGTC_1668|Compound:st014914|FD-Score:3.59|P-value:3.12E-4 ID:SGTC_2005|Compound:4024620|FD-Score:3.37|P-value:6.64E-4 ID:SGTC_2006|Compound:4011487|FD-Score:-3.59|P-value:1.77E-4 ID:SGTC_2288|Compound:7946289|FD-Score:3.95|P-value:8.08E-5 ID:SGTC_2292|Compound:7671323|FD-Score:-3.43|P-value:3.07E-4 ID:SGTC_2296|Compound:7971656|FD-Score:-3.17|P-value:7.63E-4 ID:SGTC_2328|Compound:6201408|FD-Score:4.20|P-value:3.00E-5 ID:SGTC_2367|Compound:9070478|FD-Score:3.54|P-value:3.72E-4 ID:SGTC_2384|Compound:9036245|FD-Score:-3.10|P-value:9.81E-4 ID:SGTC_2407|Compound:paclitaxel|FD-Score:-3.09|P-value:9.89E-4 ID:SGTC_2448|Compound:5185112|FD-Score:6.30|P-value:6.75E-10 ID:SGTC_2501|Compound:sodium tetradecyl sulfate|FD-Score:4.98|P-value:8.94E-7 ID:SGTC_2504|Compound:purpurogallin|FD-Score:6.25|P-value:9.26E-10 ID:SGTC_2530|Compound:3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene|FD-Score:4.03|P-value:5.95E-5 ID:SGTC_2561|Compound:acetosyringone|FD-Score:3.48|P-value:4.55E-4 ID:SGTC_2562|Compound:3',7'-dimethoxyflavone|FD-Score:4.29|P-value:2.04E-5 ID:SGTC_2620|Compound:irigenin|FD-Score:-3.32|P-value:4.61E-4 ID:SGTC_2623|Compound:humulene|FD-Score:3.79|P-value:1.51E-4 ID:SGTC_2626|Compound:ethyl orsellinate|FD-Score:6.45|P-value:2.72E-10 ID:SGTC_2874|Compound:9043904|FD-Score:-3.77|P-value:8.72E-5 ID:SGTC_2882|Compound:9058044|FD-Score:4.20|P-value:2.92E-5 ID:SGTC_2927|Compound:9011802|FD-Score:-3.90|P-value:5.14E-5 ID:SGTC_2928|Compound:9011484|FD-Score:4.09|P-value:4.71E-5 ID:SGTC_2945|Compound:9067681|FD-Score:5.29|P-value:1.94E-7 ID:SGTC_2953|Compound:9074162|FD-Score:3.69|P-value:2.15E-4 ID:SGTC_2982|Compound:9019404|FD-Score:3.58|P-value:3.26E-4 ID:SGTC_3073|Compound:9114972|FD-Score:3.69|P-value:2.19E-4 ID:SGTC_3115|Compound:9123671|FD-Score:3.25|P-value:9.89E-4 ID:SGTC_3175|Compound:9106517|FD-Score:-3.49|P-value:2.54E-4 ID:SGTC_3182|Compound:9108849|FD-Score:-3.37|P-value:3.80E-4 ID:SGTC_3218|Compound:9131285|FD-Score:3.34|P-value:7.33E-4

Top fitness defect scores for YDR194W-A deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 7.56 5.3 µM 1.53E-13 257 2.01E-14
2 SGTC_2626 ethyl orsellinate 6.45 100.0 µM 2.72E-10 3 5.73E-11
3 SGTC_2448 5185112 6.30 27.2 µM 6.75E-10 2 1.51E-10
4 SGTC_2504 purpurogallin 6.25 52.3 µM 9.26E-10 RPP1 & pyrimidine depletion 2 2.11E-10
5 SGTC_1257 0669-0121 5.85 16.0 µM 9.48E-9 1 2.51E-9
6 SGTC_2945 9067681 5.29 61.8 µM 1.94E-7 5 6.25E-8
7 SGTC_2501 sodium tetradecyl sulfate 4.98 13.4 µM 8.94E-7 17 3.19E-7
8 SGTC_126 0417-1624 4.47 672.5 µM 9.22E-6 DNA intercalators 18 3.84E-6
9 SGTC_762 1165-0429 4.47 115.0 µM 9.24E-6 TSC3-RPN4 10 3.85E-6
10 SGTC_2562 3',7'-dimethoxyflavone 4.29 64.9 µM 2.04E-5 22 8.96E-6
11 SGTC_2882 9058044 4.20 58.4 µM 2.92E-5 12 1.32E-5
12 SGTC_2328 6201408 4.20 200.0 µM 3.00E-5 16 1.36E-5
13 SGTC_2928 9011484 4.09 9.8 µM 4.71E-5 heme biosynthesis & mitochondrial translocase 36 2.20E-5
14 SGTC_2530 3-alpha-hydroxy-4,4-bisnor-8,11,13-podocarpatriene 4.03 92.6 µM 5.95E-5 25 2.82E-5
15 SGTC_2288 7946289 3.95 167.3 µM 8.08E-5 26 3.91E-5
16 SGTC_2623 humulene 3.79 100.0 µM 1.51E-4 23 7.63E-5
17 SGTC_940 3232-1287 3.78 54.8 µM 1.55E-4 NEO1 47 7.85E-5
18 SGTC_720 r052-1644 3.77 49.9 µM 1.64E-4 TSC3-RPN4 28 8.32E-5
19 SGTC_1408 3909-7976 3.75 48.8 µM 1.71E-4 Golgi 27 8.69E-5
20 SGTC_2953 9074162 3.69 66.5 µM 2.15E-4 34 1.11E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.213 7.79E-36 YHR050W-A_p YHR050W-A_p hom Protein of unknown function; identified by expression profiling and mass spectrometry
0.206 2.35E-33 YGL237C HAP2 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; contains sequences sufficient for both complex assembly and DNA binding
0.198 6.86E-31 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.183 9.08E-27 YML129C COX14 hom Mitochondrial membrane protein, involved in translational regulation of Cox1p and assembly of cytochrome c oxidase (complex IV); associates with complex IV assembly intermediates and complex III/complex IV supercomplexes
0.183 1.42E-26 YMR286W MRPL33 hom Mitochondrial ribosomal protein of the large subunit
0.182 2.52E-26 YJR120W YJR120W hom Protein of unknown function; essential for growth under anaerobic conditions; mutation causes decreased expression of ATP2, impaired respiration, defective sterol uptake, and altered levels/localization of ABC transporters Aus1p and Pdr11p
0.179 1.81E-25 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.177 5.90E-25 YKL109W HAP4 hom Subunit of the heme-activated, glucose-repressed Hap2p/3p/4p/5p CCAAT-binding complex, a transcriptional activator and global regulator of respiratory gene expression; provides the principal activation function of the complex
0.177 6.13E-25 YJL166W QCR8 hom Subunit 8 of ubiquinol cytochrome-c reductase complex, which is a component of the mitochondrial inner membrane electron transport chain; oriented facing the intermembrane space; expression is regulated by Abf1p and Cpf1p
0.170 3.64E-23 YMR035W IMP2 hom Catalytic subunit of the mitochondrial inner membrane peptidase complex, required for maturation of mitochondrial proteins of the intermembrane space; complex contains Imp1p and Imp2p (both catalytic subunits), and Som1p
0.168 1.27E-22 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.168 1.37E-22 YPL215W CBP3 hom Mitochondrial protein required for assembly of cytochrome bc1 complex; forms a complex with Cbp6p that binds to mt ribosomes near the polypeptide tunnel exit and promotes efficient translation of the COB mRNA; Cbp3p-Cbp6p complex also interacts with newly synthesized cytochrome b (Cobp) and Cbp4p to promote assembly of Cobp into the cytochrome bc1 complex
0.167 2.11E-22 YDR230W_d YDR230W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified gene COX20
0.161 5.63E-21 YDR375C BCS1 hom Protein translocase and chaperone required for Complex III assembly; member of the AAA ATPase family; forms a homo-oligomeric complex in the mitochondrial inner membrane that translocates the C-terminal domain of Rip1p from the matrix across the inner membrane, and then delivers it to an assembly intermediate of respiratory Complex III in an ATP-dependent reaction; also required for assembly of the Qcr10p subunit; mutations in human homolog BCS1L linked to neonatal diseases
0.157 6.90E-20 YER141W COX15 hom Protein required for the hydroxylation of heme O to form heme A, which is an essential prosthetic group for cytochrome c oxidase