YDR201W / SPC19

Essential subunit of the Dam1 complex (aka DASH complex), couples kinetochores to the force produced by MT depolymerization thereby aiding in chromosome segregation; also localized to nuclear side of spindle pole body

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR201W / SPC19

Click on Significant Values for Screen Details ID:SGTC_141|Compound:0443-0274|FD-Score:-5.30|P-value:1.41E-10 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.50|P-value:1.71E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.84|P-value:3.44E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.88|P-value:2.99E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.53|P-value:1.44E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:2.68|P-value:7.55E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.99|P-value:1.14E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.83|P-value:3.70E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.59|P-value:1.09E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.82|P-value:2.98E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:5.54|P-value:2.63E-11 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.72|P-value:4.67E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:3.04|P-value:1.65E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-2.69|P-value:6.51E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.71|P-value:6.83E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.66|P-value:7.56E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.62|P-value:8.81E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.07|P-value:1.43E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.97|P-value:1.54E-9 ID:SGTC_1119|Compound:parthenolide|FD-Score:-2.78|P-value:4.55E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.40|P-value:2.46E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.20|P-value:6.84E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.99|P-value:1.76E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.19|P-value:8.15E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.48|P-value:1.87E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.72|P-value:5.88E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.66|P-value:7.43E-6 ID:SGTC_1753|Compound:st043925|FD-Score:3.33|P-value:4.14E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.02|P-value:1.54E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-2.61|P-value:9.23E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.67|P-value:8.06E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.47|P-value:1.70E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.93|P-value:1.59E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.03|P-value:1.48E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.16|P-value:9.17E-5 ID:SGTC_2301|Compound:7769476|FD-Score:2.79|P-value:4.83E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.05|P-value:1.39E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-2.96|P-value:2.09E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.43|P-value:2.10E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.65|P-value:7.95E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.76|P-value:4.99E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.79|P-value:3.66E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.01|P-value:1.88E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.07|P-value:3.12E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-2.96|P-value:2.05E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.78|P-value:5.17E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.03|P-value:7.72E-7 ID:SGTC_2846|Compound:9008642|FD-Score:3.97|P-value:1.33E-6 ID:SGTC_2862|Compound:9027634|FD-Score:-3.00|P-value:1.72E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.21|P-value:7.46E-5 ID:SGTC_2880|Compound:9042983|FD-Score:2.81|P-value:4.47E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.09|P-value:1.13E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.92|P-value:2.50E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.35|P-value:3.26E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.31|P-value:4.48E-5 ID:SGTC_3015|Compound:9080845|FD-Score:3.20|P-value:7.56E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.62|P-value:9.06E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.14|P-value:8.97E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.08|P-value:5.93E-7 ID:SGTC_3153|Compound:9100258|FD-Score:-2.81|P-value:4.00E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.37|P-value:9.55E-8 ID:SGTC_3316|Compound:9136639|FD-Score:2.97|P-value:2.23E-4 ID:SGTC_141|Compound:0443-0274|FD-Score:-5.30|P-value:1.41E-10 ID:SGTC_474|Compound:dl-dihydrosphingosine|FD-Score:3.50|P-value:1.71E-5 ID:SGTC_519|Compound:k048-0011|FD-Score:-2.84|P-value:3.44E-4 ID:SGTC_527|Compound:4476-4215|FD-Score:-2.88|P-value:2.99E-4 ID:SGTC_533|Compound:1222-0222|FD-Score:3.53|P-value:1.44E-5 ID:SGTC_597|Compound:k018-0003|FD-Score:2.68|P-value:7.55E-4 ID:SGTC_787|Compound:4152-0075|FD-Score:3.99|P-value:1.14E-6 ID:SGTC_867|Compound:0518-0118|FD-Score:-2.83|P-value:3.70E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:3.59|P-value:1.09E-5 ID:SGTC_949|Compound:1165-0505|FD-Score:3.82|P-value:2.98E-6 ID:SGTC_972|Compound:1319-0219|FD-Score:5.54|P-value:2.63E-11 ID:SGTC_982|Compound:1491-0518|FD-Score:-3.72|P-value:4.67E-6 ID:SGTC_997|Compound:3996-0078|FD-Score:3.04|P-value:1.65E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-2.69|P-value:6.51E-4 ID:SGTC_1012|Compound:4112-3522|FD-Score:2.71|P-value:6.83E-4 ID:SGTC_1027|Compound:k015-0025|FD-Score:-2.66|P-value:7.56E-4 ID:SGTC_1030|Compound:k029-0042|FD-Score:-2.62|P-value:8.81E-4 ID:SGTC_1059|Compound:3448-6867|FD-Score:3.07|P-value:1.43E-4 ID:SGTC_1107|Compound:amlodipine|FD-Score:-4.97|P-value:1.54E-9 ID:SGTC_1119|Compound:parthenolide|FD-Score:-2.78|P-value:4.55E-4 ID:SGTC_1120|Compound:ficusin|FD-Score:-3.40|P-value:2.46E-5 ID:SGTC_1123|Compound:mangostin|FD-Score:-3.20|P-value:6.84E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:-2.99|P-value:1.76E-4 ID:SGTC_1155|Compound:4088-0394|FD-Score:3.19|P-value:8.15E-5 ID:SGTC_1170|Compound:0310-0127|FD-Score:3.48|P-value:1.87E-5 ID:SGTC_1504|Compound:k297-0033|FD-Score:-2.72|P-value:5.88E-4 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.66|P-value:7.43E-6 ID:SGTC_1753|Compound:st043925|FD-Score:3.33|P-value:4.14E-5 ID:SGTC_1767|Compound:st044992|FD-Score:-3.02|P-value:1.54E-4 ID:SGTC_1866|Compound:st057638|FD-Score:-2.61|P-value:9.23E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:2.67|P-value:8.06E-4 ID:SGTC_2054|Compound:5233173|FD-Score:-3.47|P-value:1.70E-5 ID:SGTC_2188|Compound:6126565|FD-Score:3.93|P-value:1.59E-6 ID:SGTC_2247|Compound:cerulenin|FD-Score:-3.03|P-value:1.48E-4 ID:SGTC_2272|Compound:7805186|FD-Score:3.16|P-value:9.17E-5 ID:SGTC_2301|Compound:7769476|FD-Score:2.79|P-value:4.83E-4 ID:SGTC_2302|Compound:7771753|FD-Score:-3.05|P-value:1.39E-4 ID:SGTC_2320|Compound:7373003|FD-Score:-2.96|P-value:2.09E-4 ID:SGTC_2325|Compound:6158266|FD-Score:-3.43|P-value:2.10E-5 ID:SGTC_2359|Compound:9039622|FD-Score:3.65|P-value:7.95E-6 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-2.76|P-value:4.99E-4 ID:SGTC_2568|Compound:diosmetin|FD-Score:3.79|P-value:3.66E-6 ID:SGTC_2583|Compound:asiatic acid|FD-Score:3.01|P-value:1.88E-4 ID:SGTC_2686|Compound:alizarin|FD-Score:6.07|P-value:3.12E-13 ID:SGTC_2688|Compound:kanamycin b|FD-Score:-2.96|P-value:2.05E-4 ID:SGTC_2724|Compound:maprotiline|FD-Score:2.78|P-value:5.17E-4 ID:SGTC_2841|Compound:9004761|FD-Score:-4.03|P-value:7.72E-7 ID:SGTC_2846|Compound:9008642|FD-Score:3.97|P-value:1.33E-6 ID:SGTC_2862|Compound:9027634|FD-Score:-3.00|P-value:1.72E-4 ID:SGTC_2871|Compound:9038510|FD-Score:3.21|P-value:7.46E-5 ID:SGTC_2880|Compound:9042983|FD-Score:2.81|P-value:4.47E-4 ID:SGTC_2883|Compound:9059145|FD-Score:-3.09|P-value:1.13E-4 ID:SGTC_2888|Compound:9058547|FD-Score:-2.92|P-value:2.50E-4 ID:SGTC_2889|Compound:9059656|FD-Score:-3.35|P-value:3.26E-5 ID:SGTC_2977|Compound:9011197|FD-Score:3.31|P-value:4.48E-5 ID:SGTC_3015|Compound:9080845|FD-Score:3.20|P-value:7.56E-5 ID:SGTC_3125|Compound:9127534|FD-Score:3.62|P-value:9.06E-6 ID:SGTC_3140|Compound:9094243|FD-Score:-3.14|P-value:8.97E-5 ID:SGTC_3148|Compound:9097893|FD-Score:-4.08|P-value:5.93E-7 ID:SGTC_3153|Compound:9100258|FD-Score:-2.81|P-value:4.00E-4 ID:SGTC_3263|Compound:9137018|FD-Score:-4.37|P-value:9.55E-8 ID:SGTC_3316|Compound:9136639|FD-Score:2.97|P-value:2.23E-4

Top fitness defect scores for YDR201W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2686 alizarin 6.07 95.4 µM 3.12E-13 RPP1 & pyrimidine depletion 2 6.42E-10 0.12
2 SGTC_972 1319-0219 5.54 195.0 µM 2.63E-11 3 1.53E-8 0.48
3 SGTC_787 4152-0075 3.99 138.0 µM 1.14E-6 4 3.27E-5 0.08
4 SGTC_2846 9008642 3.97 19.5 µM 1.33E-6 5 3.67E-5 0.01
5 SGTC_2188 6126565 3.93 140.7 µM 1.59E-6 mitochondrial processes 6 4.17E-5 0.35
6 SGTC_949 1165-0505 3.82 146.0 µM 2.98E-6 8 6.56E-5 0.71
7 SGTC_2568 diosmetin 3.79 100.0 µM 3.66E-6 11 7.60E-5 0.03
8 SGTC_1587 estradiol valerate 3.66 56.1 µM 7.43E-6 5 1.27E-4 0.25
9 SGTC_2359 9039622 3.65 200.0 µM 7.95E-6 endomembrane recycling 5 1.33E-4 0.23
10 SGTC_3125 9127534 3.62 49.5 µM 9.06E-6 5 1.46E-4 0.30
11 SGTC_915 methyl methanesulfonate (MMS) 3.59 110.0 mM 1.09E-5 DNA damage response 11 1.67E-4 0.08
12 SGTC_533 1222-0222 3.53 6.7 µM 1.44E-5 PDR1 15 2.05E-4 0.24
13 SGTC_474 dl-dihydrosphingosine 3.50 5.0 µM 1.71E-5 10 2.32E-4 0.04
14 SGTC_1170 0310-0127 3.48 64.8 µM 1.87E-5 14 2.47E-4 0.04
15 SGTC_1753 st043925 3.33 64.0 µM 4.14E-5 6 4.40E-4 0.06
16 SGTC_2977 9011197 3.31 71.4 µM 4.48E-5 15 4.66E-4 0.19
17 SGTC_2871 9038510 3.21 13.0 µM 7.46E-5 12 6.74E-4 0.07
18 SGTC_3015 9080845 3.20 49.5 µM 7.56E-5 6 6.81E-4 0.22
19 SGTC_1155 4088-0394 3.19 48.2 µM 8.15E-5 12 7.19E-4 0.00
20 SGTC_2272 7805186 3.16 180.0 µM 9.17E-5 cell wall signaling 8 7.84E-4 0.26

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.217 3.54E-37 YJR072C NPA3 het Member of the conserved GPN-loop GTPase family; has a role in transport of RNA polymerase II to the nucleus; exhibits GTP-dependent binding to PolII; has ATPase activity; involved in sister chromatid cohesion; phosphorylated by the Pcl1p-Pho85p kinase complex; human homolog XAB1 interacts with human RNA polymerase II; protein abundance increases in response to DNA replication stress
0.193 1.22E-29 YGL165C_d YGL165C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CUP2/YGL166W
0.165 5.53E-22 YPR026W ATH1 hom Acid trehalase required for utilization of extracellular trehalose
0.155 1.54E-19 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.155 1.78E-19 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.153 6.16E-19 YOR304W ISW2 hom ATP-dependent DNA translocase involved in chromatin remodeling; ATPase component that, with Itc1p, forms a complex required for repression of a-specific genes, INO1, and early meiotic genes during mitotic growth
0.152 7.93E-19 YDL060W TSR1 het Protein required for processing of 20S pre-rRNA in the cytoplasm; associates with pre-40S ribosomal particles; inhibits the premature association of 60S subunits with assembling 40S subunits in the cytoplasm; similar to Bms1p; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.151 1.27E-18 YKL220C FRE2 hom Ferric reductase and cupric reductase, reduces siderophore-bound iron and oxidized copper prior to uptake by transporters; expression induced by low iron levels but not by low copper levels
0.148 8.57E-18 YDR088C SLU7 het RNA splicing factor, required for ATP-independent portion of 2nd catalytic step of spliceosomal RNA splicing; interacts with Prp18p; contains zinc knuckle domain
0.136 2.11E-15 YDR013W PSF1 het Subunit of the GINS complex (Sld5p, Psf1p, Psf2p, Psf3p), which is localized to DNA replication origins and implicated in assembly of the DNA replication machinery
0.135 5.01E-15 YLR353W BUD8 hom Protein involved in bud-site selection; diploid mutants display a unipolar budding pattern instead of the wild-type bipolar pattern, and bud at the proximal pole
0.134 5.52E-15 YDL007W RPT2 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; required for normal peptide hydrolysis by the core 20S particle
0.129 6.73E-14 YJL002C OST1 het Alpha subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins
0.128 1.16E-13 YLR205C HMX1 hom ER localized heme oxygenase, involved in heme degradation during iron starvation and in the oxidative stress response; expression is regulated by AFT1 and oxidative stress; relocates to the perinuclear region in the presence of oxidants
0.127 1.89E-13 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha