YDR203W_d

Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR203W / YDR203W

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-7.98|P-value:5.03E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:3.94|P-value:4.10E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:5.03|P-value:9.52E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.36|P-value:1.05E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:10.10|P-value:4.22E-18 ID:SGTC_209|Compound:4077-0173|FD-Score:5.87|P-value:3.01E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:-4.00|P-value:3.11E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.81|P-value:6.13E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.48|P-value:7.03E-5 ID:SGTC_263|Compound:alizarin|FD-Score:9.47|P-value:3.91E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.79|P-value:6.54E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.28|P-value:1.27E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.00|P-value:3.17E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:7.88|P-value:1.05E-11 ID:SGTC_435|Compound:c-PAF|FD-Score:-5.25|P-value:3.71E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.47|P-value:1.48E-6 ID:SGTC_444|Compound:curcumin|FD-Score:7.89|P-value:9.95E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.91|P-value:1.82E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.39|P-value:2.37E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.29|P-value:1.22E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.12|P-value:2.37E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.44|P-value:8.11E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:6.36|P-value:3.25E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:3.73|P-value:7.82E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.94|P-value:4.09E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:6.07|P-value:1.25E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:-4.16|P-value:1.86E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.20|P-value:1.83E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.46|P-value:1.74E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:3.96|P-value:3.86E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-4.14|P-value:2.00E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.20|P-value:6.74E-8 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.31|P-value:1.28E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.06|P-value:2.79E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.18|P-value:1.94E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.72|P-value:7.93E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.02|P-value:3.17E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:6.18|P-value:7.62E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.94|P-value:4.16E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.68|P-value:9.03E-4 ID:SGTC_1658|Compound:st012944|FD-Score:9.78|P-value:4.53E-17 ID:SGTC_1676|Compound:st018489|FD-Score:5.00|P-value:1.08E-5 ID:SGTC_1687|Compound:st020778|FD-Score:12.80|P-value:6.00E-28 ID:SGTC_1712|Compound:st032288|FD-Score:-5.62|P-value:8.03E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.96|P-value:1.12E-5 ID:SGTC_1743|Compound:st037606|FD-Score:5.85|P-value:3.32E-7 ID:SGTC_1750|Compound:st081859|FD-Score:8.48|P-value:2.72E-13 ID:SGTC_1754|Compound:st042065|FD-Score:-5.83|P-value:3.20E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.62|P-value:4.33E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-4.75|P-value:2.50E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-5.80|P-value:3.59E-7 ID:SGTC_1922|Compound:5578187|FD-Score:4.23|P-value:1.64E-4 ID:SGTC_2021|Compound:4019055|FD-Score:8.96|P-value:1.29E-14 ID:SGTC_2090|Compound:5301565|FD-Score:3.78|P-value:6.61E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.77|P-value:6.86E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.97|P-value:3.74E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.65|P-value:3.86E-5 ID:SGTC_2275|Compound:7947463|FD-Score:5.43|P-value:2.00E-6 ID:SGTC_2291|Compound:7917025|FD-Score:9.47|P-value:3.94E-16 ID:SGTC_2389|Compound:9091542|FD-Score:4.87|P-value:1.79E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.69|P-value:8.61E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.06|P-value:2.64E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.88|P-value:1.71E-5 ID:SGTC_2488|Compound:5268135|FD-Score:5.10|P-value:7.39E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.55|P-value:5.53E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.62|P-value:8.85E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.36|P-value:2.63E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:6.78|P-value:4.05E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.86|P-value:5.23E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.20|P-value:1.67E-4 ID:SGTC_2858|Compound:9025781|FD-Score:10.70|P-value:6.20E-20 ID:SGTC_2918|Compound:7977171|FD-Score:-3.98|P-value:3.34E-4 ID:SGTC_2981|Compound:9013952|FD-Score:6.75|P-value:4.82E-9 ID:SGTC_3037|Compound:9091026|FD-Score:-3.89|P-value:4.46E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.00|P-value:3.43E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.17|P-value:1.85E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.06|P-value:2.82E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-7.98|P-value:5.03E-12 ID:SGTC_70|Compound:0141-0289|FD-Score:3.94|P-value:4.10E-4 ID:SGTC_153|Compound:4077-0274|FD-Score:5.03|P-value:9.52E-6 ID:SGTC_157|Compound:1348-1695|FD-Score:4.36|P-value:1.05E-4 ID:SGTC_204|Compound:1543-0184|FD-Score:10.10|P-value:4.22E-18 ID:SGTC_209|Compound:4077-0173|FD-Score:5.87|P-value:3.01E-7 ID:SGTC_210|Compound:3551-0445|FD-Score:-4.00|P-value:3.11E-4 ID:SGTC_256|Compound:clotrimazole|FD-Score:3.81|P-value:6.13E-4 ID:SGTC_262|Compound:fenpropimorph|FD-Score:4.48|P-value:7.03E-5 ID:SGTC_263|Compound:alizarin|FD-Score:9.47|P-value:3.91E-16 ID:SGTC_275|Compound:trichlorophene|FD-Score:3.79|P-value:6.54E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-4.28|P-value:1.27E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:-4.00|P-value:3.17E-4 ID:SGTC_431|Compound:k089-0097|FD-Score:7.88|P-value:1.05E-11 ID:SGTC_435|Compound:c-PAF|FD-Score:-5.25|P-value:3.71E-6 ID:SGTC_439|Compound:amiodarone|FD-Score:-5.47|P-value:1.48E-6 ID:SGTC_444|Compound:curcumin|FD-Score:7.89|P-value:9.95E-12 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-6.91|P-value:1.82E-9 ID:SGTC_488|Compound:nitrendipine|FD-Score:5.39|P-value:2.37E-6 ID:SGTC_514|Compound:4466-0038|FD-Score:-4.29|P-value:1.22E-4 ID:SGTC_528|Compound:3492-0019|FD-Score:4.12|P-value:2.37E-4 ID:SGTC_580|Compound:1123-0028|FD-Score:4.44|P-value:8.11E-5 ID:SGTC_737|Compound:1950-0117|FD-Score:6.36|P-value:3.25E-8 ID:SGTC_767|Compound:0929-0023|FD-Score:3.73|P-value:7.82E-4 ID:SGTC_838|Compound:0109-0203|FD-Score:3.94|P-value:4.09E-4 ID:SGTC_841|Compound:0251-0215|FD-Score:6.07|P-value:1.25E-7 ID:SGTC_862|Compound:0452-0056|FD-Score:-4.16|P-value:1.86E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:4.20|P-value:1.83E-4 ID:SGTC_957|Compound:1187-1561|FD-Score:5.46|P-value:1.74E-6 ID:SGTC_987|Compound:1497-1013|FD-Score:3.96|P-value:3.86E-4 ID:SGTC_1097|Compound:itavastatin|FD-Score:-4.14|P-value:2.00E-4 ID:SGTC_1110|Compound:3-hydroxy-3'-methoxyflavone|FD-Score:6.20|P-value:6.74E-8 ID:SGTC_1112|Compound:tnp00069|FD-Score:4.31|P-value:1.28E-4 ID:SGTC_1118|Compound:chelidonine|FD-Score:4.06|P-value:2.79E-4 ID:SGTC_1153|Compound:4055-0057|FD-Score:4.18|P-value:1.94E-4 ID:SGTC_1159|Compound:4092-0538|FD-Score:3.72|P-value:7.93E-4 ID:SGTC_1264|Compound:0783-0040|FD-Score:4.02|P-value:3.17E-4 ID:SGTC_1373|Compound:2887-0003|FD-Score:6.18|P-value:7.62E-8 ID:SGTC_1388|Compound:3346-4487|FD-Score:3.94|P-value:4.16E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.68|P-value:9.03E-4 ID:SGTC_1658|Compound:st012944|FD-Score:9.78|P-value:4.53E-17 ID:SGTC_1676|Compound:st018489|FD-Score:5.00|P-value:1.08E-5 ID:SGTC_1687|Compound:st020778|FD-Score:12.80|P-value:6.00E-28 ID:SGTC_1712|Compound:st032288|FD-Score:-5.62|P-value:8.03E-7 ID:SGTC_1718|Compound:roemerine|FD-Score:-4.96|P-value:1.12E-5 ID:SGTC_1743|Compound:st037606|FD-Score:5.85|P-value:3.32E-7 ID:SGTC_1750|Compound:st081859|FD-Score:8.48|P-value:2.72E-13 ID:SGTC_1754|Compound:st042065|FD-Score:-5.83|P-value:3.20E-7 ID:SGTC_1788|Compound:fluconazole|FD-Score:4.62|P-value:4.33E-5 ID:SGTC_1800|Compound:st050079|FD-Score:-4.75|P-value:2.50E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-5.80|P-value:3.59E-7 ID:SGTC_1922|Compound:5578187|FD-Score:4.23|P-value:1.64E-4 ID:SGTC_2021|Compound:4019055|FD-Score:8.96|P-value:1.29E-14 ID:SGTC_2090|Compound:5301565|FD-Score:3.78|P-value:6.61E-4 ID:SGTC_2153|Compound:5569715|FD-Score:3.77|P-value:6.86E-4 ID:SGTC_2165|Compound:5727197|FD-Score:3.97|P-value:3.74E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.65|P-value:3.86E-5 ID:SGTC_2275|Compound:7947463|FD-Score:5.43|P-value:2.00E-6 ID:SGTC_2291|Compound:7917025|FD-Score:9.47|P-value:3.94E-16 ID:SGTC_2389|Compound:9091542|FD-Score:4.87|P-value:1.79E-5 ID:SGTC_2398|Compound:5228213|FD-Score:3.69|P-value:8.61E-4 ID:SGTC_2411|Compound:st077133|FD-Score:-4.06|P-value:2.64E-4 ID:SGTC_2416|Compound:tofa|FD-Score:4.88|P-value:1.71E-5 ID:SGTC_2488|Compound:5268135|FD-Score:5.10|P-value:7.39E-6 ID:SGTC_2567|Compound:aureobasidin a|FD-Score:4.55|P-value:5.53E-5 ID:SGTC_2586|Compound:curcumin|FD-Score:5.62|P-value:8.85E-7 ID:SGTC_2666|Compound:tannic acid|FD-Score:5.36|P-value:2.63E-6 ID:SGTC_2675|Compound:theaflavin digallate|FD-Score:6.78|P-value:4.05E-9 ID:SGTC_2752|Compound:diclazuril|FD-Score:3.86|P-value:5.23E-4 ID:SGTC_2854|Compound:9024559|FD-Score:-4.20|P-value:1.67E-4 ID:SGTC_2858|Compound:9025781|FD-Score:10.70|P-value:6.20E-20 ID:SGTC_2918|Compound:7977171|FD-Score:-3.98|P-value:3.34E-4 ID:SGTC_2981|Compound:9013952|FD-Score:6.75|P-value:4.82E-9 ID:SGTC_3037|Compound:9091026|FD-Score:-3.89|P-value:4.46E-4 ID:SGTC_3200|Compound:9114385|FD-Score:4.00|P-value:3.43E-4 ID:SGTC_3266|Compound:9136860|FD-Score:-4.17|P-value:1.85E-4 ID:SGTC_3308|Compound:9128332|FD-Score:4.06|P-value:2.82E-4

Top fitness defect scores for YDR203W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1687 st020778 12.80 55.4 µM 6.00E-28 31 7.72E-38
2 SGTC_2858 9025781 10.70 9.0 µM 6.20E-20 sphingolipid biosynthesis & PDR1 18 8.20E-27
3 SGTC_204 1543-0184 10.10 62.4 µM 4.22E-18 TRP & mitochondrial translation 2 2.72E-24
4 SGTC_1658 st012944 9.78 20.0 µM 4.53E-17 iron homeostasis 3 7.11E-23
5 SGTC_263 alizarin 9.47 107.9 µM 3.91E-16 iron homeostasis 6 1.38E-21
6 SGTC_2291 7917025 9.47 104.3 µM 3.94E-16 iron homeostasis 8 1.39E-21
7 SGTC_2021 4019055 8.96 173.0 µM 1.29E-14 endomembrane recycling 15 1.69E-19
8 SGTC_1750 st081859 8.48 2.4 µM 2.72E-13 endomembrane recycling 60 1.11E-17
9 SGTC_444 curcumin 7.89 90.4 µM 9.95E-12 iron homeostasis 2 1.55E-15
10 SGTC_431 k089-0097 7.88 107.0 µM 1.05E-11 iron homeostasis 3 1.67E-15
11 SGTC_2675 theaflavin digallate 6.78 100.0 µM 4.05E-9 iron homeostasis 10 5.90E-12
12 SGTC_2981 9013952 6.75 39.0 µM 4.82E-9 10 7.47E-12
13 SGTC_737 1950-0117 6.36 57.9 µM 3.25E-8 2 1.02E-10
14 SGTC_1110 3-hydroxy-3'-methoxyflavone 6.20 1.2 µM 6.74E-8 iron homeostasis 13 2.77E-10
15 SGTC_1373 2887-0003 6.18 58.5 µM 7.62E-8 Golgi 2 3.28E-10
16 SGTC_841 0251-0215 6.07 91.2 µM 1.25E-7 36 6.47E-10
17 SGTC_209 4077-0173 5.87 175.6 µM 3.01E-7 4 2.15E-9
18 SGTC_1743 st037606 5.85 46.4 µM 3.32E-7 4 2.46E-9
19 SGTC_2586 curcumin 5.62 80.0 µM 8.85E-7 iron homeostasis 21 9.41E-9
20 SGTC_957 1187-1561 5.46 14.1 µM 1.74E-6 5 2.37E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.470 4.99E-184 YJR033C RAV1 hom Subunit of the RAVE complex (Rav1p, Rav2p, Skp1p), which promotes assembly of the V-ATPase holoenzyme; required for transport between the early and late endosome/PVC and for localization of TGN membrane proteins; potential Cdc28p substrate
0.367 1.80E-107 YDR202C RAV2 hom Subunit of RAVE (Rav1p, Rav2p, Skp1p), a complex that associates with the V1 domain of the vacuolar membrane (H+)-ATPase (V-ATPase) and promotes assembly and reassembly of the holoenzyme
0.349 5.60E-97 YJR040W GEF1 hom Voltage-gated chloride channel localized to the golgi, the endosomal system, and plasma membrane, and involved in cation homeostasis; highly homologous to vertebrate voltage-gated chloride channels; modulates TBSV model (+) RNA virus replication by regulating copper metabolism
0.306 9.53E-74 YJL094C KHA1 hom Putative K+/H+ antiporter with a probable role in intracellular cation homeostasis, localized to Golgi vesicles and detected in highly purified mitochondria in high-throughput studies
0.306 1.59E-73 YDR270W CCC2 hom Cu(+2)-transporting P-type ATPase; required for export of copper from the cytosol into an extracytosolic compartment; has similarity to human proteins involved in Menkes and Wilsons diseases; protein abundance increases in response to DNA replication stress; affects TBSV model (+)RNA virus replication by regulating copper metabolism
0.273 1.93E-58 YDR269C_d YDR269C_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.267 5.92E-56 YMR058W FET3 hom Ferro-O2-oxidoreductase; required for high-affinity iron uptake and involved in mediating resistance to copper ion toxicity, belongs to class of integral membrane multicopper oxidases; protein abundance increases in response to DNA replication stress
0.246 2.22E-47 YDR271C_d YDR271C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF CCC2/YDR270W
0.222 8.93E-39 YGR261C APL6 hom Beta3-like subunit of the yeast AP-3 complex; functions in transport of alkaline phosphatase to the vacuole via the alternate pathway; exists in both cytosolic and peripherally associated membrane-bound pools
0.222 1.97E-38 YMR123W PKR1 hom V-ATPase assembly factor; functions with other V-ATPase assembly factors in the ER to efficiently assemble the V-ATPase membrane sector (V0); protein abundance increases in response to DNA replication stress
0.217 4.14E-37 YJL024C APS3 hom Small subunit of the clathrin-associated adaptor complex AP-3; involved in vacuolar protein sorting; related to the sigma subunit of the mammalian clathrin AP-3 complex; suppressor of loss of casein kinase 1 function; protein abundance increases in response to DNA replication stress
0.216 8.27E-37 YGL008C PMA1 het Plasma membrane H+-ATPase, pumps protons out of the cell; major regulator of cytoplasmic pH and plasma membrane potential; P2-type ATPase; Hsp30p plays a role in Pma1p regulation; interactions with Std1p appear to propagate [GAR+]
0.207 7.33E-34 YKL077W_p YKL077W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole
0.201 6.19E-32 YDL077C VAM6 hom Vacuolar protein that plays a critical role in the tethering steps of vacuolar membrane fusion by facilitating guanine nucleotide exchange on small guanosine triphosphatase Ypt7p
0.199 2.02E-31 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)