YDR207C / UME6

Key transcriptional regulator of early meiotic genes, binds URS1 upstream regulatory sequence, couples metabolic responses to nutritional cues with initiation and progression of meiosis, forms complex with Ime1p, and also with Sin3p-Rpd3p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR207C / UME6

Click on Significant Values for Screen Details ID:SGTC_86|Compound:0417-1630|FD-Score:4.48|P-value:3.91E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:5.20|P-value:4.61E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:4.25|P-value:7.30E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.76|P-value:7.21E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.13|P-value:9.95E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:9.30|P-value:9.53E-13 ID:SGTC_210|Compound:3551-0445|FD-Score:5.43|P-value:2.16E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.99|P-value:8.90E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.10|P-value:3.84E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:6.72|P-value:1.99E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.07|P-value:7.52E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.95|P-value:1.01E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.07|P-value:2.39E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:7.67|P-value:3.37E-9 ID:SGTC_623|Compound:k072-0108|FD-Score:4.21|P-value:8.09E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.13|P-value:1.91E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:5.34|P-value:2.93E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:4.18|P-value:8.60E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.31|P-value:6.24E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:5.98|P-value:3.31E-6 ID:SGTC_1773|Compound:st048542|FD-Score:6.39|P-value:7.12E-7 ID:SGTC_1828|Compound:st055811|FD-Score:-4.56|P-value:1.98E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.60|P-value:2.80E-4 ID:SGTC_1845|Compound:st056753|FD-Score:6.10|P-value:2.13E-6 ID:SGTC_1855|Compound:st056195|FD-Score:-4.13|P-value:6.46E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.44|P-value:2.78E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.67|P-value:2.28E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.69|P-value:2.15E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.50|P-value:3.67E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-4.15|P-value:6.14E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.95|P-value:3.64E-6 ID:SGTC_2235|Compound:salicylic acid|FD-Score:4.16|P-value:9.05E-4 ID:SGTC_2241|Compound:6772625|FD-Score:7.85|P-value:1.44E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.12|P-value:6.64E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.80|P-value:1.56E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.72|P-value:1.98E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-5.57|P-value:8.02E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.74|P-value:1.86E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.24|P-value:4.06E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.40|P-value:2.80E-21 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.51|P-value:1.67E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.37|P-value:2.69E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.00|P-value:6.34E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:8.03|P-value:6.39E-10 ID:SGTC_2623|Compound:humulene|FD-Score:-6.29|P-value:5.63E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:6.65|P-value:2.64E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.49|P-value:1.80E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.03|P-value:2.75E-6 ID:SGTC_2836|Compound:9010338|FD-Score:4.86|P-value:1.29E-4 ID:SGTC_2867|Compound:9039098|FD-Score:6.65|P-value:2.58E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.26|P-value:2.24E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.72|P-value:8.32E-6 ID:SGTC_3110|Compound:9122132|FD-Score:4.49|P-value:3.78E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.51|P-value:1.68E-5 ID:SGTC_3188|Compound:9110789|FD-Score:7.87|P-value:1.32E-9 ID:SGTC_86|Compound:0417-1630|FD-Score:4.48|P-value:3.91E-4 ID:SGTC_90|Compound:0870-0863|FD-Score:5.20|P-value:4.61E-5 ID:SGTC_108|Compound:0509-0257|FD-Score:4.25|P-value:7.30E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:5.76|P-value:7.21E-6 ID:SGTC_158|Compound:k038-0087|FD-Score:4.13|P-value:9.95E-4 ID:SGTC_207|Compound:4185-0010|FD-Score:9.30|P-value:9.53E-13 ID:SGTC_210|Compound:3551-0445|FD-Score:5.43|P-value:2.16E-5 ID:SGTC_273|Compound:hydroxyurea|FD-Score:4.99|P-value:8.90E-5 ID:SGTC_312|Compound:4092-0653|FD-Score:-5.10|P-value:3.84E-5 ID:SGTC_319|Compound:1348-1596|FD-Score:6.72|P-value:1.99E-7 ID:SGTC_320|Compound:4092-0846|FD-Score:-4.07|P-value:7.52E-4 ID:SGTC_455|Compound:paf C-16|FD-Score:4.95|P-value:1.01E-4 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:6.07|P-value:2.39E-6 ID:SGTC_513|Compound:4245-1575|FD-Score:7.67|P-value:3.37E-9 ID:SGTC_623|Compound:k072-0108|FD-Score:4.21|P-value:8.09E-4 ID:SGTC_673|Compound:1082-0474|FD-Score:6.13|P-value:1.91E-6 ID:SGTC_764|Compound:1951-2361|FD-Score:5.34|P-value:2.93E-5 ID:SGTC_985|Compound:1493-0307|FD-Score:4.18|P-value:8.60E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.31|P-value:6.24E-4 ID:SGTC_1499|Compound:4480-0877|FD-Score:5.98|P-value:3.31E-6 ID:SGTC_1773|Compound:st048542|FD-Score:6.39|P-value:7.12E-7 ID:SGTC_1828|Compound:st055811|FD-Score:-4.56|P-value:1.98E-4 ID:SGTC_1834|Compound:st055981|FD-Score:4.60|P-value:2.80E-4 ID:SGTC_1845|Compound:st056753|FD-Score:6.10|P-value:2.13E-6 ID:SGTC_1855|Compound:st056195|FD-Score:-4.13|P-value:6.46E-4 ID:SGTC_1859|Compound:st055998|FD-Score:-4.44|P-value:2.78E-4 ID:SGTC_1890|Compound:3',4',7',8'-tetrahydroxyflavone|FD-Score:4.67|P-value:2.28E-4 ID:SGTC_2009|Compound:4012297|FD-Score:4.69|P-value:2.15E-4 ID:SGTC_2028|Compound:5153890|FD-Score:4.50|P-value:3.67E-4 ID:SGTC_2061|Compound:5245884|FD-Score:-4.15|P-value:6.14E-4 ID:SGTC_2167|Compound:5876490|FD-Score:5.95|P-value:3.64E-6 ID:SGTC_2235|Compound:salicylic acid|FD-Score:4.16|P-value:9.05E-4 ID:SGTC_2241|Compound:6772625|FD-Score:7.85|P-value:1.44E-9 ID:SGTC_2250|Compound:alverine citrate|FD-Score:-4.12|P-value:6.64E-4 ID:SGTC_2289|Compound:7946404|FD-Score:4.80|P-value:1.56E-4 ID:SGTC_2302|Compound:7771753|FD-Score:4.72|P-value:1.98E-4 ID:SGTC_2338|Compound:7999974|FD-Score:-5.57|P-value:8.02E-6 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:4.74|P-value:1.86E-4 ID:SGTC_2580|Compound:diallyl disulphide|FD-Score:5.24|P-value:4.06E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:12.40|P-value:2.80E-21 ID:SGTC_2597|Compound:laccaic acid a|FD-Score:5.51|P-value:1.67E-5 ID:SGTC_2609|Compound:2,3,4-trihydroxy-4'-ethoxybenzophenone|FD-Score:5.37|P-value:2.69E-5 ID:SGTC_2617|Compound:dihydrotanshinone i|FD-Score:7.00|P-value:6.34E-8 ID:SGTC_2619|Compound:obliquin|FD-Score:8.03|P-value:6.39E-10 ID:SGTC_2623|Compound:humulene|FD-Score:-6.29|P-value:5.63E-7 ID:SGTC_2645|Compound:abamectin|FD-Score:6.65|P-value:2.64E-7 ID:SGTC_2651|Compound:1327-0036|FD-Score:5.49|P-value:1.80E-5 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.03|P-value:2.75E-6 ID:SGTC_2836|Compound:9010338|FD-Score:4.86|P-value:1.29E-4 ID:SGTC_2867|Compound:9039098|FD-Score:6.65|P-value:2.58E-7 ID:SGTC_2896|Compound:9052656|FD-Score:-5.26|P-value:2.24E-5 ID:SGTC_2912|Compound:7964298|FD-Score:5.72|P-value:8.32E-6 ID:SGTC_3110|Compound:9122132|FD-Score:4.49|P-value:3.78E-4 ID:SGTC_3137|Compound:9097352|FD-Score:5.51|P-value:1.68E-5 ID:SGTC_3188|Compound:9110789|FD-Score:7.87|P-value:1.32E-9

Top fitness defect scores for YDR207C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2582 agaric acid 12.40 100.0 µM 2.80E-21 redox potentiating 36 1.63E-35
2 SGTC_207 4185-0010 9.30 4.5 µM 9.53E-13 endomembrane recycling 22 7.17E-21
3 SGTC_2619 obliquin 8.03 87.9 µM 6.39E-10 cell wall 42 5.01E-16
4 SGTC_3188 9110789 7.87 49.5 µM 1.32E-9 iron homeostasis 2 1.73E-15
5 SGTC_2241 6772625 7.85 37.8 µM 1.44E-9 4 2.02E-15
6 SGTC_513 4245-1575 7.67 41.7 µM 3.37E-9 unfolded protein response 29 8.63E-15
7 SGTC_2617 dihydrotanshinone i 7.00 20.8 µM 6.34E-8 copper-dependent oxidative stress 10 1.31E-12
8 SGTC_319 1348-1596 6.72 45.5 µM 1.99E-7 RSC & ERG11 2 9.28E-12
9 SGTC_2867 9039098 6.65 71.4 µM 2.58E-7 iron homeostasis 5 1.44E-11
10 SGTC_2645 abamectin 6.65 100.0 µM 2.64E-7 heme requiring 4 1.50E-11
11 SGTC_1773 st048542 6.39 73.6 µM 7.12E-7 14 8.17E-11
12 SGTC_673 1082-0474 6.13 110.0 µM 1.91E-6 RSC complex & mRNA processing 22 4.40E-10
13 SGTC_1845 st056753 6.10 3.0 µM 2.13E-6 TSC3-RPN4 9 5.33E-10
14 SGTC_498 2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ) 6.07 150.0 µM 2.39E-6 Golgi 18 6.44E-10
15 SGTC_2741 miltefosine 6.03 3.0 µM 2.75E-6 20 8.22E-10
16 SGTC_1499 4480-0877 5.98 67.3 µM 3.31E-6 1 1.13E-9
17 SGTC_2167 5876490 5.95 200.0 µM 3.64E-6 4 1.33E-9
18 SGTC_115 0527-0192 5.76 112.0 µM 7.21E-6 15 4.24E-9
19 SGTC_2912 7964298 5.72 10.9 µM 8.32E-6 cell wall 54 5.42E-9
20 SGTC_2597 laccaic acid a 5.51 100.0 µM 1.67E-5 12 1.78E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.193 1.34E-29 YML103C NUP188 hom Subunit of the inner ring of the nuclear pore complex (NPC); contributes to NPC organization and nucleocytoplasmic transport; homologous to human NUP188
0.173 5.01E-24 YNL105W_d RRT16_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene INP52; identified in a screen for mutants with decreased levels of rDNA transcription
0.164 1.36E-21 YNL106C INP52 hom Polyphosphatidylinositol phosphatase, dephosphorylates a number of phosphatidylinositols (PIs) to PI; involved in endocytosis; hyperosmotic stress causes translocation to actin patches; synaptojanin-like protein with a Sac1 domain
0.162 4.86E-21 YER086W ILV1 hom Threonine deaminase, catalyzes the first step in isoleucine biosynthesis; expression is under general amino acid control; ILV1 locus exhibits highly positioned nucleosomes whose organization is independent of known ILV1 regulation
0.157 5.98E-20 YNL027W CRZ1 hom Transcription factor, activates transcription of stress response genes; nuclear localization is positively regulated by calcineurin-mediated dephosphorylation; rapidly localizes to the nucleus under blue light stress
0.151 1.45E-18 YOR141C ARP8 hom Nuclear actin-related protein involved in chromatin remodeling, component of chromatin-remodeling enzyme complexes; has mRNA binding activity
0.149 3.37E-18 YEL007W MIT1 hom Transcriptional regulator of pseudohyphal growth; protein with sequence similarity to S. pombe gti1+ (gluconate transport inducer 1) and C. albicans Wor1
0.148 7.65E-18 YBR082C UBC4 hom Ubiquitin-conjugating enzyme (E2); mediates degradation of abnormal or excess proteins, including calmodulin and histone H3; interacts with many SCF ubiquitin protein ligases; component of the cellular stress response; UBC4 has a paralog, UBC5, that arose from the whole genome duplication
0.146 1.58E-17 YPL232W SSO1 hom Plasma membrane t-SNARE involved in fusion of secretory vesicles at the plasma membrane and in vesicle fusion during sporulation; forms a complex with Sec9p that binds v-SNARE Snc2p; syntaxin homolog; functionally redundant with Sso2p
0.145 3.73E-17 YJL159W HSP150 hom O-mannosylated heat shock protein; secreted and covalently attached to the cell wall via beta-1,3-glucan and disulfide bridges; required for cell wall stability; induced by heat shock, oxidative stress, and nitrogen limitation; HSP150 has a paralog, PIR3, that arose from the whole genome duplication
0.141 2.64E-16 YIL003W CFD1 het Highly conserved, iron-sulfur cluster binding protein localized in the cytoplasm; forms a complex with Nbp35p that is involved in iron-sulfur protein assembly in the cytosol
0.141 2.72E-16 YCR088W ABP1 hom Actin-binding protein of the cortical actin cytoskeleton, important for activation of the Arp2/3 complex that plays a key role actin in cytoskeleton organization; phosphorylation within its PRR (Proline-Rich Region), mediated by Cdc28p and Pho85p, protects Abp1p from proteolysis mediated by its own PEST sequences
0.139 5.94E-16 YJL099W CHS6 hom Member of the ChAPs (Chs5p-Arf1p-binding proteins) family; part of the exomer complex that mediates export of specific cargo proteins, including Chs3p, from the Golgi to the plasma membrane; CHS6 has a paralog, BCH2, that arose from the whole genome duplication
0.139 7.79E-16 YIL129C TAO3 het Component of the RAM signaling network that is involved in regulation of Ace2p activity and cellular morphogenesis, interacts with protein kinase Cbk1p and also with Kic1p
0.139 8.56E-16 YNL215W IES2 hom Protein that associates with the INO80 chromatin remodeling complex; associates with the INO80 complex under low-salt conditions; essential for growth under anaerobic conditions; protein abundance increases in response to DNA replication stress