YDR209C_d

Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps uncharacterized gene YDR210W.

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR209C / YDR209C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.74|P-value:4.27E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.22|P-value:3.54E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.32|P-value:2.25E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.15|P-value:4.35E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.18|P-value:4.16E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.15|P-value:4.38E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.94|P-value:9.96E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.25|P-value:2.96E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.57|P-value:7.06E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.03|P-value:6.86E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.28|P-value:2.87E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.41|P-value:1.61E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.44|P-value:1.43E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.12|P-value:4.89E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.15|P-value:4.46E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.79|P-value:3.22E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.10|P-value:3.77E-8 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.08|P-value:5.77E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.24|P-value:3.15E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.06|P-value:6.11E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.77|P-value:3.46E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.91|P-value:1.10E-7 ID:SGTC_1748|Compound:st037455|FD-Score:4.59|P-value:6.41E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.03|P-value:6.77E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.93|P-value:9.93E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.64|P-value:4.80E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.94|P-value:1.62E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-3.30|P-value:2.58E-4 ID:SGTC_2345|Compound:9052315|FD-Score:2.99|P-value:7.91E-4 ID:SGTC_2346|Compound:9031566|FD-Score:4.12|P-value:6.71E-6 ID:SGTC_2349|Compound:9023730|FD-Score:-5.49|P-value:3.94E-9 ID:SGTC_2424|Compound:5537928|FD-Score:3.39|P-value:1.71E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.06|P-value:6.18E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.13|P-value:5.11E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.07|P-value:6.39E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.27|P-value:2.93E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.29|P-value:2.73E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.54|P-value:9.04E-7 ID:SGTC_3043|Compound:9092303|FD-Score:-3.15|P-value:4.60E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.43|P-value:1.45E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.05|P-value:6.39E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-4.01|P-value:1.22E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.01|P-value:7.93E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.74|P-value:4.27E-5 ID:SGTC_227|Compound:fluconazole|FD-Score:-3.22|P-value:3.54E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.32|P-value:2.25E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.15|P-value:4.35E-4 ID:SGTC_441|Compound:propafenone|FD-Score:-3.18|P-value:4.16E-4 ID:SGTC_532|Compound:1548-0774|FD-Score:3.15|P-value:4.38E-4 ID:SGTC_540|Compound:1187-0821|FD-Score:-2.94|P-value:9.96E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:3.25|P-value:2.96E-4 ID:SGTC_702|Compound:1488-0190|FD-Score:4.57|P-value:7.06E-7 ID:SGTC_738|Compound:1315-0003|FD-Score:3.03|P-value:6.86E-4 ID:SGTC_751|Compound:0833-0568|FD-Score:-3.28|P-value:2.87E-4 ID:SGTC_874|Compound:0599-0792|FD-Score:3.41|P-value:1.61E-4 ID:SGTC_967|Compound:1306-0166|FD-Score:3.44|P-value:1.43E-4 ID:SGTC_968|Compound:1309-0633|FD-Score:3.12|P-value:4.89E-4 ID:SGTC_1115|Compound:galangin|FD-Score:3.15|P-value:4.46E-4 ID:SGTC_1253|Compound:0550-0034|FD-Score:3.79|P-value:3.22E-5 ID:SGTC_1255|Compound:0566-0045|FD-Score:5.10|P-value:3.77E-8 ID:SGTC_1358|Compound:1509-0022|FD-Score:3.08|P-value:5.77E-4 ID:SGTC_1456|Compound:k015-0012|FD-Score:3.24|P-value:3.15E-4 ID:SGTC_1496|Compound:4469-0713|FD-Score:3.06|P-value:6.11E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.77|P-value:3.46E-5 ID:SGTC_1529|Compound:apigenin|FD-Score:4.91|P-value:1.10E-7 ID:SGTC_1748|Compound:st037455|FD-Score:4.59|P-value:6.41E-7 ID:SGTC_1754|Compound:st042065|FD-Score:3.03|P-value:6.77E-4 ID:SGTC_1917|Compound:st066507|FD-Score:2.93|P-value:9.93E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:4.64|P-value:4.80E-7 ID:SGTC_1923|Compound:st058458|FD-Score:3.94|P-value:1.62E-5 ID:SGTC_2030|Compound:5175110|FD-Score:-3.30|P-value:2.58E-4 ID:SGTC_2345|Compound:9052315|FD-Score:2.99|P-value:7.91E-4 ID:SGTC_2346|Compound:9031566|FD-Score:4.12|P-value:6.71E-6 ID:SGTC_2349|Compound:9023730|FD-Score:-5.49|P-value:3.94E-9 ID:SGTC_2424|Compound:5537928|FD-Score:3.39|P-value:1.71E-4 ID:SGTC_2523|Compound:spermine|FD-Score:3.06|P-value:6.18E-4 ID:SGTC_2730|Compound:imipramine|FD-Score:-3.13|P-value:5.11E-4 ID:SGTC_2821|Compound:7996764|FD-Score:-3.07|P-value:6.39E-4 ID:SGTC_2844|Compound:9010103|FD-Score:-3.27|P-value:2.93E-4 ID:SGTC_2944|Compound:9067346|FD-Score:-3.29|P-value:2.73E-4 ID:SGTC_2957|Compound:9076800|FD-Score:-4.54|P-value:9.04E-7 ID:SGTC_3043|Compound:9092303|FD-Score:-3.15|P-value:4.60E-4 ID:SGTC_3142|Compound:9086498|FD-Score:3.43|P-value:1.45E-4 ID:SGTC_3188|Compound:9110789|FD-Score:3.05|P-value:6.39E-4 ID:SGTC_3257|Compound:9139206|FD-Score:-4.01|P-value:1.22E-5 ID:SGTC_3266|Compound:9136860|FD-Score:-3.01|P-value:7.93E-4

Top fitness defect scores for YDR209C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1255 0566-0045 5.10 221.0 µM 3.77E-8 excess fatty acid 10 1.72E-7
2 SGTC_1529 apigenin 4.91 74.0 µM 1.10E-7 14 4.52E-7
3 SGTC_1918 oxolan-2-ylmethyl 3-bromobenzoate 4.64 70.1 µM 4.80E-7 9 1.71E-6
4 SGTC_1748 st037455 4.59 53.6 µM 6.41E-7 15 2.22E-6
5 SGTC_702 1488-0190 4.57 94.0 µM 7.06E-7 amide catabolism 7 2.42E-6
6 SGTC_2346 9031566 4.12 143.8 µM 6.71E-6 Golgi 13 1.85E-5
7 SGTC_1923 st058458 3.94 19.1 µM 1.62E-5 32 4.11E-5
8 SGTC_1253 0550-0034 3.79 176.0 µM 3.22E-5 24 7.66E-5
9 SGTC_1504 k297-0033 3.77 30.0 µM 3.46E-5 19 8.17E-5
10 SGTC_967 1306-0166 3.44 352.0 µM 1.43E-4 57 2.95E-4
11 SGTC_3142 9086498 3.43 49.5 µM 1.45E-4 iron homeostasis 58 2.99E-4
12 SGTC_874 0599-0792 3.41 117.0 µM 1.61E-4 47 3.29E-4
13 SGTC_2424 5537928 3.39 59.2 µM 1.71E-4 58 3.46E-4
14 SGTC_296 1222-0039 3.32 74.9 µM 2.25E-4 28 4.44E-4
15 SGTC_694 1315-0438 3.25 43.2 µM 2.96E-4 30 5.70E-4
16 SGTC_1456 k015-0012 3.24 13.0 µM 3.15E-4 57 6.04E-4
17 SGTC_364 0083-0097 3.15 67.7 µM 4.35E-4 57 8.08E-4
18 SGTC_532 1548-0774 3.15 215.0 µM 4.38E-4 45 8.12E-4
19 SGTC_1115 galangin 3.15 695.7 nM 4.46E-4 RPP1 & pyrimidine depletion 42 8.26E-4
20 SGTC_968 1309-0633 3.12 340.0 µM 4.89E-4 37 8.98E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.165 6.15E-22 YNL145W MFA2 hom Mating pheromone a-factor, made by a cells; interacts with alpha cells to induce cell cycle arrest and other responses leading to mating; biogenesis involves C-terminal modification, N-terminal proteolysis, and export; also encoded by MFA1
0.137 2.00E-15 YBR186W PCH2 hom Nucleolar component of the pachytene checkpoint, which prevents chromosome segregation when recombination and chromosome synapsis are defective; also represses meiotic interhomolog recombination in the rDNA; required for meiotic double-stranded break formation
0.114 4.00E-11 YOR117W RPT5 het One of six ATPases of the 19S regulatory particle of the 26S proteasome involved in the degradation of ubiquitinated substrates; recruited to the GAL1-10 promoter region upon induction of transcription; similar to human TBP1
0.111 1.33E-10 YDR479C PEX29 hom Peroxisomal integral membrane peroxin; involved in the regulation of peroxisomal size, number and distribution; genetic interactions suggest that Pex28p and Pex29p act at steps upstream of those mediated by Pex30p, Pex31p, and Pex32p; forms ER foci upon DNA replication stress
0.101 4.59E-9 YDR130C FIN1 hom Spindle pole body-related intermediate filament protein; forms cell cycle-specific filaments between spindle pole bodies in dividing cells; localizes to poles and microtubules of spindle during anaphase and contributes to spindle stability; involved in Glc7p localization and regulation; relative distribution to the nucleus increases upon DNA replication stress
0.098 1.10E-8 YOL160W_d YOL160W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data
0.094 5.73E-8 YCL033C MXR2 hom Methionine-R-sulfoxide reductase, involved in the response to oxidative stress; protects iron-sulfur clusters from oxidative inactivation along with MXR1; involved in the regulation of lifespan
0.093 7.05E-8 YHR123W EPT1 hom sn-1,2-diacylglycerol ethanolamine- and cholinephosphotranferase; not essential for viability; EPT1 has a paralog, CPT1, that arose from the whole genome duplication
0.091 1.23E-7 YGR152C RSR1 hom GTP-binding protein of the ras superfamily required for bud site selection, morphological changes in response to mating pheromone, and efficient cell fusion; localized to the plasma membrane; significantly similar to mammalian Rap GTPases
0.090 1.95E-7 YPL119C-A_p YPL119C-A_p hom Putative protein of unknown function; identified by expression profiling and mass spectrometry
0.088 2.99E-7 YKR040C_d YKR040C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the uncharacterized ORF YKR041W
0.086 6.15E-7 YDR030C RAD28 hom Protein involved in DNA repair, related to the human CSA protein that is involved in transcription-coupled repair nucleotide excision repair
0.085 7.93E-7 YDL219W DTD1 hom D-Tyr-tRNA(Tyr) deacylase, functions in protein translation, may affect nonsense suppression via alteration of the protein synthesis machinery; ubiquitous among eukaryotes
0.083 1.76E-6 YNR030W ALG12 hom Alpha-1,6-mannosyltransferase localized to the ER; responsible for the addition of the alpha-1,6 mannose to dolichol-linked Man7GlcNAc2, acts in the dolichol pathway for N-glycosylation
0.080 3.29E-6 YOL017W ESC8 hom Protein involved in telomeric and mating-type locus silencing; interacts with Sir2p and also interacts with Gal11p, which is a component of the RNA pol II mediator complex; ESC8 has a paralog, IOC3, that arose from the whole genome duplication