YDR212W / TCP1

Alpha subunit of chaperonin-containing T-complex, which mediates protein folding in the cytosol; involved in actin cytoskeleton maintenance; overexpression in neurons suppresses formation of pathogenic conformations of huntingtin protein

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR212W / TCP1

Click on Significant Values for Screen Details ID:SGTC_65|Compound:0798-0905|FD-Score:3.82|P-value:7.41E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.85|P-value:6.74E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:6.92|P-value:3.77E-9 ID:SGTC_124|Compound:0136-0217|FD-Score:4.32|P-value:1.63E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:5.21|P-value:7.10E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:4.11|P-value:3.14E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.30|P-value:1.71E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:6.79|P-value:7.16E-9 ID:SGTC_229|Compound:benomyl|FD-Score:9.82|P-value:1.09E-16 ID:SGTC_252|Compound:miconazole|FD-Score:3.86|P-value:6.58E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.25|P-value:1.69E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:5.40|P-value:3.39E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:4.39|P-value:1.28E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.80|P-value:7.94E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.78|P-value:8.36E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.60|P-value:1.77E-8 ID:SGTC_640|Compound:3381-0960|FD-Score:3.81|P-value:7.59E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:4.03|P-value:4.03E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.94|P-value:5.28E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.69|P-value:4.60E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:4.00|P-value:4.30E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:6.77|P-value:7.97E-9 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.05|P-value:3.74E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:6.17|P-value:1.32E-7 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:5.38|P-value:3.70E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.28|P-value:1.81E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.38|P-value:1.33E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.80|P-value:3.22E-5 ID:SGTC_1643|Compound:st009866|FD-Score:4.52|P-value:8.38E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.80|P-value:7.76E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:17.10|P-value:1.61E-46 ID:SGTC_2101|Compound:5377231|FD-Score:3.74|P-value:9.23E-4 ID:SGTC_2151|Compound:5563267|FD-Score:9.38|P-value:2.33E-15 ID:SGTC_2393|Compound:9031399|FD-Score:3.79|P-value:8.08E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.79|P-value:8.16E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.67|P-value:4.05E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.75|P-value:7.75E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.30|P-value:4.88E-6 ID:SGTC_2601|Compound:securinine|FD-Score:4.31|P-value:1.66E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.84|P-value:6.99E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.75|P-value:9.01E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.09|P-value:1.11E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.00|P-value:3.67E-4 ID:SGTC_2993|Compound:9054257|FD-Score:6.10|P-value:1.77E-7 ID:SGTC_3056|Compound:9094900|FD-Score:5.68|P-value:1.07E-6 ID:SGTC_3071|Compound:9117417|FD-Score:3.99|P-value:4.56E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.50|P-value:8.85E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-3.88|P-value:5.27E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.30|P-value:1.71E-4 ID:SGTC_65|Compound:0798-0905|FD-Score:3.82|P-value:7.41E-4 ID:SGTC_104|Compound:0074-0074|FD-Score:3.85|P-value:6.74E-4 ID:SGTC_115|Compound:0527-0192|FD-Score:6.92|P-value:3.77E-9 ID:SGTC_124|Compound:0136-0217|FD-Score:4.32|P-value:1.63E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:5.21|P-value:7.10E-6 ID:SGTC_140|Compound:0062-0056|FD-Score:4.11|P-value:3.14E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:4.30|P-value:1.71E-4 ID:SGTC_212|Compound:3807-4682|FD-Score:6.79|P-value:7.16E-9 ID:SGTC_229|Compound:benomyl|FD-Score:9.82|P-value:1.09E-16 ID:SGTC_252|Compound:miconazole|FD-Score:3.86|P-value:6.58E-4 ID:SGTC_280|Compound:3448-3607|FD-Score:-4.25|P-value:1.69E-4 ID:SGTC_313|Compound:3474-0040|FD-Score:5.40|P-value:3.39E-6 ID:SGTC_316|Compound:k060-0003|FD-Score:4.39|P-value:1.28E-4 ID:SGTC_397|Compound:arbidol|FD-Score:3.80|P-value:7.94E-4 ID:SGTC_434|Compound:1-hexadecyl-2-methylglycero-3 PC|FD-Score:3.78|P-value:8.36E-4 ID:SGTC_514|Compound:4466-0038|FD-Score:6.60|P-value:1.77E-8 ID:SGTC_640|Compound:3381-0960|FD-Score:3.81|P-value:7.59E-4 ID:SGTC_675|Compound:1309-0189|FD-Score:4.03|P-value:4.03E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.94|P-value:5.28E-4 ID:SGTC_928|Compound:2764-0428|FD-Score:4.69|P-value:4.60E-5 ID:SGTC_958|Compound:1222-0007|FD-Score:4.00|P-value:4.30E-4 ID:SGTC_962|Compound:1254-0300|FD-Score:6.77|P-value:7.97E-9 ID:SGTC_1042|Compound:0350-0096|FD-Score:4.05|P-value:3.74E-4 ID:SGTC_1062|Compound:mesoridazine|FD-Score:6.17|P-value:1.32E-7 ID:SGTC_1065|Compound:prochlorperazine maleate|FD-Score:5.38|P-value:3.70E-6 ID:SGTC_1179|Compound:1021-1431|FD-Score:4.28|P-value:1.81E-4 ID:SGTC_1293|Compound:1000-1278|FD-Score:4.38|P-value:1.33E-4 ID:SGTC_1348|Compound:1493-0373|FD-Score:4.80|P-value:3.22E-5 ID:SGTC_1643|Compound:st009866|FD-Score:4.52|P-value:8.38E-5 ID:SGTC_1804|Compound:st050076|FD-Score:3.80|P-value:7.76E-4 ID:SGTC_1875|Compound:nocodazole|FD-Score:17.10|P-value:1.61E-46 ID:SGTC_2101|Compound:5377231|FD-Score:3.74|P-value:9.23E-4 ID:SGTC_2151|Compound:5563267|FD-Score:9.38|P-value:2.33E-15 ID:SGTC_2393|Compound:9031399|FD-Score:3.79|P-value:8.08E-4 ID:SGTC_2465|Compound:5809242|FD-Score:3.79|P-value:8.16E-4 ID:SGTC_2552|Compound:juarezic acid|FD-Score:-4.67|P-value:4.05E-5 ID:SGTC_2554|Compound:13-methyl-4,4-bisnor-8,11,13-podocarpatrien-3-one|FD-Score:-3.75|P-value:7.75E-4 ID:SGTC_2579|Compound:2',5'-dihydroxy-4-methoxychalcone|FD-Score:5.30|P-value:4.88E-6 ID:SGTC_2601|Compound:securinine|FD-Score:4.31|P-value:1.66E-4 ID:SGTC_2706|Compound:st078239|FD-Score:3.84|P-value:6.99E-4 ID:SGTC_2823|Compound:7987624|FD-Score:3.75|P-value:9.01E-4 ID:SGTC_2912|Compound:7964298|FD-Score:5.09|P-value:1.11E-5 ID:SGTC_2913|Compound:7966556|FD-Score:-4.00|P-value:3.67E-4 ID:SGTC_2993|Compound:9054257|FD-Score:6.10|P-value:1.77E-7 ID:SGTC_3056|Compound:9094900|FD-Score:5.68|P-value:1.07E-6 ID:SGTC_3071|Compound:9117417|FD-Score:3.99|P-value:4.56E-4 ID:SGTC_3126|Compound:9127922|FD-Score:4.50|P-value:8.85E-5 ID:SGTC_3189|Compound:9110682|FD-Score:-3.88|P-value:5.27E-4 ID:SGTC_3351|Compound:9150312|FD-Score:4.30|P-value:1.71E-4

Top fitness defect scores for YDR212W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature		Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_1875 nocodazole 17.10 6.0 µM 1.61E-46 tubulin folding & SWR complex 3 1.59E-65 0.28
2 SGTC_229 benomyl 9.82 22.9 µM 1.09E-16 tubulin folding & SWR complex 4 4.41E-23 1.64
3 SGTC_2151 5563267 9.38 85.4 µM 2.33E-15 6 3.41E-21 0.48
4 SGTC_115 0527-0192 6.92 112.0 µM 3.77E-9 2 2.22E-12 0.69
5 SGTC_212 3807-4682 6.79 38.8 µM 7.16E-9 tubulin folding & SWR complex 11 5.52E-12 0.56
6 SGTC_962 1254-0300 6.77 21.5 µM 7.97E-9 1 6.41E-12 2.38
7 SGTC_514 4466-0038 6.60 2.6 nM 1.77E-8 cell wall 11 1.99E-11 0.08
8 SGTC_1062 mesoridazine 6.17 14.2 µM 1.32E-7 1 3.44E-10 1.55
9 SGTC_2993 9054257 6.10 71.4 µM 1.77E-7 fatty acid desaturase (OLE1) 11 5.19E-10 0.00
10 SGTC_3056 9094900 5.68 49.5 µM 1.07E-6 1 6.63E-9 0.62
11 SGTC_313 3474-0040 5.40 5.0 µM 3.39E-6 NEO1-PIK1 3 3.38E-8 1.11
12 SGTC_1065 prochlorperazine maleate 5.38 2.5 µM 3.70E-6 2 3.82E-8 0.37
13 SGTC_2579 2',5'-dihydroxy-4-methoxychalcone 5.30 13.2 µM 4.88E-6 5 5.64E-8 0.19
14 SGTC_136 0097-0015 5.21 404.5 µM 7.10E-6 60S ribosome export 3 9.59E-8 0.10
15 SGTC_2912 7964298 5.09 10.9 µM 1.11E-5 cell wall 29 1.81E-7 0.16
16 SGTC_1348 1493-0373 4.80 93.8 µM 3.22E-5 1 8.08E-7 0.48
17 SGTC_928 2764-0428 4.69 58.7 µM 4.60E-5 cell wall 14 1.34E-6 0.26
18 SGTC_1643 st009866 4.52 20.2 µM 8.38E-5 19 3.11E-6 0.20
19 SGTC_3126 9127922 4.50 49.5 µM 8.85E-5 fatty acid desaturase (OLE1) 23 3.36E-6 0.04
20 SGTC_316 k060-0003 4.39 58.6 µM 1.28E-4 3 5.68E-6 0.27

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.375 8.17E-113 YIL142W CCT2 het Subunit beta of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.355 5.06E-100 YGL094C PAN2 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.341 9.40E-92 YJL014W CCT3 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.336 2.23E-89 YJL008C CCT8 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.336 2.46E-89 YDR187C_d YDR187C_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified, essential ORF CCT6/YDR188W
0.333 7.11E-88 YJR064W CCT5 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.296 9.36E-69 YJL009W_d YJL009W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps CCT8/YJL008C, a verified gene encoding a subunit of the cytosolic chaperonin Cct ring complex
0.273 1.56E-58 YDL143W CCT4 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, required for the assembly of actin and tubulins in vivo
0.270 4.62E-57 YDR188W CCT6 het Subunit of the cytosolic chaperonin Cct ring complex, related to Tcp1p, essential protein that is required for the assembly of actin and tubulins in vivo; contains an ATP-binding motif
0.253 2.88E-50 YER007W PAC2 hom Microtubule effector required for tubulin heterodimer formation, binds alpha-tubulin, required for normal microtubule function, null mutant exhibits cold-sensitive microtubules and sensitivity to benomyl
0.247 9.54E-48 YKL025C PAN3 hom Essential subunit of the Pan2p-Pan3p poly(A)-ribonuclease complex, which acts to control poly(A) tail length and regulate the stoichiometry and activity of postreplication repair complexes
0.235 2.07E-43 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.230 1.51E-41 YOR349W CIN1 hom Tubulin folding factor D involved in beta-tubulin (Tub2p) folding; isolated as mutant with increased chromosome loss and sensitivity to benomyl
0.217 5.89E-37 YPL241C CIN2 hom GTPase-activating protein (GAP) for Cin4p; tubulin folding factor C involved in beta-tubulin (Tub2p) folding; mutants display increased chromosome loss and benomyl sensitivity; deletion complemented by human GAP, retinitis pigmentosa 2
0.206 1.58E-33 YBR231C SWC5 hom Component of the SWR1 complex; complex exchanges histone variant H2AZ (Htz1p) for chromatin-bound histone H2A; protein abundance increases in response to DNA replication stress