YDR213W / UPC2

Sterol regulatory element binding protein; induces transcription of sterol biosynthetic genes and of DAN/TIR gene products; relocates from intracellular membranes to perinuclear foci on sterol depletion; UPC2 has a paralog, ECM22, that arose from the whole genome duplication

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR213W / UPC2

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:4.09|P-value:2.85E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:5.56|P-value:2.11E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:5.68E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:10.10|P-value:1.05E-23 ID:SGTC_193|Compound:1273-0060|FD-Score:3.37|P-value:4.74E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.80|P-value:1.16E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:7.81|P-value:6.72E-15 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.94|P-value:5.38E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:7.08|P-value:1.49E-12 ID:SGTC_299|Compound:1273-0059|FD-Score:5.94|P-value:2.41E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:4.93|P-value:6.17E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:3.88|P-value:6.81E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.75|P-value:1.16E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:7.32|P-value:2.52E-13 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.64|P-value:1.95E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:5.89|P-value:3.18E-9 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.78|P-value:1.02E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:7.00|P-value:2.61E-12 ID:SGTC_768|Compound:0384-0033|FD-Score:3.69|P-value:1.44E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.17|P-value:9.44E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.12|P-value:9.06E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.92|P-value:5.74E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.48|P-value:2.82E-17 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.54|P-value:2.51E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.60|P-value:1.63E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.26|P-value:1.11E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.58|P-value:1.76E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.43|P-value:3.06E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.59|P-value:2.12E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.24|P-value:1.50E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.33|P-value:4.37E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.15|P-value:9.81E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.27|P-value:6.73E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.35|P-value:9.28E-6 ID:SGTC_2021|Compound:4019055|FD-Score:8.40|P-value:5.68E-17 ID:SGTC_2057|Compound:5236571|FD-Score:3.16|P-value:9.63E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.91|P-value:6.68E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.53|P-value:2.58E-8 ID:SGTC_2398|Compound:5228213|FD-Score:3.33|P-value:5.45E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.31|P-value:4.69E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.52|P-value:4.42E-6 ID:SGTC_2525|Compound:harmine|FD-Score:3.63|P-value:1.78E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.91|P-value:6.10E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.74|P-value:1.17E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.32|P-value:4.56E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.93|P-value:5.97E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.64|P-value:2.50E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.37|P-value:4.71E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.27|P-value:5.43E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.15|P-value:8.28E-4 ID:SGTC_2703|Compound:st077852|FD-Score:6.19|P-value:5.17E-10 ID:SGTC_2715|Compound:st079500|FD-Score:4.19|P-value:1.92E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.44|P-value:3.70E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:-3.48|P-value:2.62E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.60|P-value:1.71E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:3.47|P-value:3.23E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.12|P-value:9.01E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.56|P-value:2.17E-8 ID:SGTC_2802|Compound:7925815|FD-Score:-5.57|P-value:1.50E-8 ID:SGTC_2804|Compound:7954240|FD-Score:-3.45|P-value:2.92E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.32|P-value:4.53E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.39|P-value:7.88E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.62|P-value:1.85E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.23|P-value:1.58E-5 ID:SGTC_3018|Compound:9082602|FD-Score:6.05|P-value:1.25E-9 ID:SGTC_3037|Compound:9091026|FD-Score:5.71|P-value:8.98E-9 ID:SGTC_3152|Compound:9099253|FD-Score:4.88|P-value:7.58E-7 ID:SGTC_3214|Compound:9129694|FD-Score:-4.07|P-value:2.44E-5 ID:SGTC_3239|Compound:9133757|FD-Score:3.69|P-value:1.43E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:4.09|P-value:2.85E-5 ID:SGTC_40|Compound:0327-0103|FD-Score:5.56|P-value:2.11E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.87|P-value:5.68E-5 ID:SGTC_178|Compound:4092-0806|FD-Score:10.10|P-value:1.05E-23 ID:SGTC_193|Compound:1273-0060|FD-Score:3.37|P-value:4.74E-4 ID:SGTC_201|Compound:4262-0159|FD-Score:4.80|P-value:1.16E-6 ID:SGTC_207|Compound:4185-0010|FD-Score:7.81|P-value:6.72E-15 ID:SGTC_218|Compound:alverine citrate|FD-Score:3.94|P-value:5.38E-5 ID:SGTC_278|Compound:4092-0821|FD-Score:7.08|P-value:1.49E-12 ID:SGTC_299|Compound:1273-0059|FD-Score:5.94|P-value:2.41E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:4.93|P-value:6.17E-7 ID:SGTC_312|Compound:4092-0653|FD-Score:3.88|P-value:6.81E-5 ID:SGTC_320|Compound:4092-0846|FD-Score:3.75|P-value:1.16E-4 ID:SGTC_346|Compound:4513-0042|FD-Score:7.32|P-value:2.52E-13 ID:SGTC_354|Compound:2783-3500|FD-Score:-4.64|P-value:1.95E-6 ID:SGTC_363|Compound:0455-0021|FD-Score:5.89|P-value:3.18E-9 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:3.46|P-value:3.44E-4 ID:SGTC_457|Compound:grayanotoxin iii|FD-Score:3.78|P-value:1.02E-4 ID:SGTC_658|Compound:3253-0951|FD-Score:7.00|P-value:2.61E-12 ID:SGTC_768|Compound:0384-0033|FD-Score:3.69|P-value:1.44E-4 ID:SGTC_954|Compound:1189-0853|FD-Score:3.17|P-value:9.44E-4 ID:SGTC_1003|Compound:4049-0218|FD-Score:-3.12|P-value:9.06E-4 ID:SGTC_1005|Compound:4092-0690|FD-Score:3.92|P-value:5.74E-5 ID:SGTC_1019|Compound:4262-0212|FD-Score:8.48|P-value:2.82E-17 ID:SGTC_1072|Compound:oxiconazole|FD-Score:3.54|P-value:2.51E-4 ID:SGTC_1148|Compound:3909-7663|FD-Score:-3.60|P-value:1.63E-4 ID:SGTC_1150|Compound:3909-7983|FD-Score:-4.26|P-value:1.11E-5 ID:SGTC_1164|Compound:k060-0068|FD-Score:-3.58|P-value:1.76E-4 ID:SGTC_1307|Compound:1187-1599|FD-Score:-3.43|P-value:3.06E-4 ID:SGTC_1436|Compound:4092-1007|FD-Score:3.78|P-value:1.01E-4 ID:SGTC_1531|Compound:st059297|FD-Score:3.59|P-value:2.12E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.24|P-value:1.50E-5 ID:SGTC_1582|Compound:3',3',6'-trihydroxyflavone|FD-Score:-3.33|P-value:4.37E-4 ID:SGTC_1611|Compound:st001856|FD-Score:3.15|P-value:9.81E-4 ID:SGTC_1913|Compound:st060213|FD-Score:3.27|P-value:6.73E-4 ID:SGTC_2006|Compound:4011487|FD-Score:4.35|P-value:9.28E-6 ID:SGTC_2021|Compound:4019055|FD-Score:8.40|P-value:5.68E-17 ID:SGTC_2057|Compound:5236571|FD-Score:3.16|P-value:9.63E-4 ID:SGTC_2249|Compound:haloperidol|FD-Score:4.91|P-value:6.68E-7 ID:SGTC_2250|Compound:alverine citrate|FD-Score:5.53|P-value:2.58E-8 ID:SGTC_2398|Compound:5228213|FD-Score:3.33|P-value:5.45E-4 ID:SGTC_2439|Compound:5492030|FD-Score:-3.31|P-value:4.69E-4 ID:SGTC_2449|Compound:5812982|FD-Score:4.52|P-value:4.42E-6 ID:SGTC_2525|Compound:harmine|FD-Score:3.63|P-value:1.78E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:3.91|P-value:6.10E-5 ID:SGTC_2549|Compound:cedrol|FD-Score:3.74|P-value:1.17E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-3.32|P-value:4.56E-4 ID:SGTC_2570|Compound:licareol|FD-Score:4.93|P-value:5.97E-7 ID:SGTC_2598|Compound:perillyl alcohol|FD-Score:4.64|P-value:2.50E-6 ID:SGTC_2607|Compound:solasodine|FD-Score:3.37|P-value:4.71E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-3.27|P-value:5.43E-4 ID:SGTC_2679|Compound:rapamycin|FD-Score:-3.15|P-value:8.28E-4 ID:SGTC_2703|Compound:st077852|FD-Score:6.19|P-value:5.17E-10 ID:SGTC_2715|Compound:st079500|FD-Score:4.19|P-value:1.92E-5 ID:SGTC_2721|Compound:ifenprodil|FD-Score:3.44|P-value:3.70E-4 ID:SGTC_2748|Compound:diazoxide|FD-Score:-3.48|P-value:2.62E-4 ID:SGTC_2776|Compound:terbinafine|FD-Score:5.60|P-value:1.71E-8 ID:SGTC_2777|Compound:climbazole|FD-Score:3.47|P-value:3.23E-4 ID:SGTC_2795|Compound:7780010|FD-Score:-3.12|P-value:9.01E-4 ID:SGTC_2801|Compound:7907800|FD-Score:5.56|P-value:2.17E-8 ID:SGTC_2802|Compound:7925815|FD-Score:-5.57|P-value:1.50E-8 ID:SGTC_2804|Compound:7954240|FD-Score:-3.45|P-value:2.92E-4 ID:SGTC_2809|Compound:7964133|FD-Score:-3.32|P-value:4.53E-4 ID:SGTC_2850|Compound:9015429|FD-Score:4.39|P-value:7.88E-6 ID:SGTC_2887|Compound:9044784|FD-Score:3.62|P-value:1.85E-4 ID:SGTC_2896|Compound:9052656|FD-Score:4.23|P-value:1.58E-5 ID:SGTC_3018|Compound:9082602|FD-Score:6.05|P-value:1.25E-9 ID:SGTC_3037|Compound:9091026|FD-Score:5.71|P-value:8.98E-9 ID:SGTC_3152|Compound:9099253|FD-Score:4.88|P-value:7.58E-7 ID:SGTC_3214|Compound:9129694|FD-Score:-4.07|P-value:2.44E-5 ID:SGTC_3239|Compound:9133757|FD-Score:3.69|P-value:1.43E-4

Top fitness defect scores for YDR213W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_178 4092-0806 10.10 87.5 µM 1.05E-23 ergosterol depletion effects on membrane 9 2.89E-24
2 SGTC_1019 4262-0212 8.48 3.4 µM 2.82E-17 ergosterol depletion effects on membrane 12 1.09E-17
3 SGTC_2021 4019055 8.40 173.0 µM 5.68E-17 endomembrane recycling 19 2.24E-17
4 SGTC_207 4185-0010 7.81 4.5 µM 6.72E-15 endomembrane recycling 27 2.96E-15
5 SGTC_346 4513-0042 7.32 7.2 µM 2.52E-13 azole & statin 4 1.20E-13
6 SGTC_278 4092-0821 7.08 23.9 µM 1.49E-12 plasma membrane duress 11 7.41E-13
7 SGTC_658 3253-0951 7.00 102.0 µM 2.61E-12 calcium & mitochondrial duress 10 1.32E-12
8 SGTC_2703 st077852 6.19 53.4 µM 5.17E-10 3 2.97E-10
9 SGTC_3018 9082602 6.05 49.5 µM 1.25E-9 27 7.33E-10
10 SGTC_299 1273-0059 5.94 1.4 µM 2.41E-9 7 1.43E-9
11 SGTC_363 0455-0021 5.89 3.1 µM 3.18E-9 azole & statin 34 1.90E-9
12 SGTC_3037 9091026 5.71 49.5 µM 8.98E-9 NEO1-PIK1 55 5.51E-9
13 SGTC_2776 terbinafine 5.60 19.9 µM 1.71E-8 cell wall signaling 24 1.07E-8
14 SGTC_40 0327-0103 5.56 19.8 µM 2.11E-8 8 1.32E-8
15 SGTC_2801 7907800 5.56 81.8 µM 2.17E-8 7 1.36E-8
16 SGTC_2250 alverine citrate 5.53 130.0 µM 2.58E-8 72 1.62E-8
17 SGTC_2570 licareol 4.93 100.0 µM 5.97E-7 12 4.06E-7
18 SGTC_310 1273-0058 4.93 1.1 µM 6.17E-7 mitochondrial stress 187 4.20E-7
19 SGTC_2249 haloperidol 4.91 116.4 µM 6.68E-7 ergosterol depletion effects on membrane 67 4.56E-7
20 SGTC_3152 9099253 4.88 49.5 µM 7.58E-7 NEO1-PIK1 82 5.19E-7

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.344 1.18E-93 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.322 1.16E-81 YMR071C TVP18 hom Integral membrane protein localized to late Golgi vesicles along with the v-SNARE Tlg2p; may interact with ribosomes, based on co-purification experiments
0.304 9.16E-73 YHL019C APM2 hom Protein of unknown function, homologous to the medium chain of mammalian clathrin-associated protein complex; involved in vesicular transport
0.298 8.08E-70 YLR171W_d YLR171W_d hom Dubious open reading frame unlikely to encode a functional protein, based on available experimental and comparative sequence data
0.276 1.58E-59 YLR170C APS1 hom Small subunit of the clathrin-associated adaptor complex AP-1, which is involved in protein sorting at the trans-Golgi network; homolog of the sigma subunit of the mammalian clathrin AP-1 complex
0.275 2.88E-59 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.264 1.50E-54 YER031C YPT31 hom Rab family GTPase; involved in the exocytic pathway; mediates intra-Golgi traffic or the budding of post-Golgi vesicles from the trans-Golgi; YPT31 has a paralog, YPT32, that arose from the whole genome duplication
0.256 2.08E-51 YBL010C_p YBL010C_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein colocalizes with clathrin-coated vesicles
0.255 5.62E-51 YLR350W ORM2 hom Evolutionarily conserved protein, similar to Orm1p; required for resistance to agents that induce unfolded protein response; Orm1p and Orm2p together control membrane biogenesis by coordinating lipid homeostasis with protein quality control; protein abundance increases in response to DNA replication stress
0.243 1.83E-46 YDL226C GCS1 hom ADP-ribosylation factor GTPase activating protein (ARF GAP), involved in ER-Golgi transport; shares functional similarity with Glo3p
0.243 2.45E-46 YOR030W DFG16 hom Probable multiple transmembrane protein; involved in diploid invasive and pseudohyphal growth upon nitrogen starvation; is glycosylated and phosphorylated; interacts with Rim21p and Rim9p in the plasma membrane to form a pH-sensing complex in the Rim101 pathway and is required to maintain Rim21p levels; required for accumulation of processed Rim101p
0.223 3.74E-39 YML007C-A_p YML007C-A_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to mitochondria
0.223 4.95E-39 YJR060W CBF1 hom Dual function helix-loop-helix protein; binds the motif CACRTG present at several sites including MET gene promoters and centromere DNA element I (CDEI); affects nucleosome positioning at this motif; associates with other transcription factors such as Met4p and Isw1p to mediate transcriptional activation or repression; associates with kinetochore proteins and required for efficient chromosome segregation; protein abundance increases in response to DNA replication stress
0.212 1.43E-35 YNL294C RIM21 hom pH sensor molecule, component of the RIM101 pathway; has a role in cell wall construction and alkaline pH response; is glycosylated and phosphorylated; interacts with Dfg16p and Rim9p to form a pH-sensing complex; localization to the plasma membrane is dependent on Dfg16p and Rim9p; has similarity to A. nidulans PalH
0.209 1.39E-34 YOR275C RIM20 hom Protein involved in proteolytic activation of Rim101p in response to alkaline pH; PalA/AIP1/Alix family member; interaction with the ESCRT-III subunit Snf7p suggests a relationship between pH response and multivesicular body formation