YDR214W / AHA1

Co-chaperone that binds to Hsp82p and activates its ATPase activity; similar to Hch1p; expression is regulated by stresses such as heat shock; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR214W / AHA1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.21|P-value:9.79E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.47|P-value:4.34E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.50|P-value:3.89E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.93|P-value:7.33E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:3.26|P-value:8.71E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.82|P-value:1.22E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.22|P-value:9.92E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.35|P-value:6.05E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.09|P-value:4.18E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.84|P-value:1.12E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.95|P-value:6.79E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-3.29|P-value:7.55E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-3.65|P-value:2.11E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.35|P-value:6.40E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.22|P-value:9.81E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.57|P-value:5.60E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.32|P-value:6.70E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.52|P-value:3.56E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.30|P-value:7.65E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.42|P-value:9.25E-8 ID:SGTC_2686|Compound:alizarin|FD-Score:3.33|P-value:6.89E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.84|P-value:1.67E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.25|P-value:8.99E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.05|P-value:4.89E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.22|P-value:9.89E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.30|P-value:7.20E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-4.00|P-value:5.78E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.23|P-value:9.00E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-5.64|P-value:2.65E-8 ID:SGTC_2947|Compound:9072639|FD-Score:3.36|P-value:6.22E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.42|P-value:1.09E-5 ID:SGTC_2958|Compound:9077254|FD-Score:6.24|P-value:9.85E-10 ID:SGTC_2963|Compound:9082507|FD-Score:3.58|P-value:2.87E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.27|P-value:8.40E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.37|P-value:5.72E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.40|P-value:5.37E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.34|P-value:6.59E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.56|P-value:3.17E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.96|P-value:6.95E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.60|P-value:2.68E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.28|P-value:8.03E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.25|P-value:8.58E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.83|P-value:1.10E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.21|P-value:9.79E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.47|P-value:4.34E-4 ID:SGTC_228|Compound:caffeine|FD-Score:3.50|P-value:3.89E-4 ID:SGTC_505|Compound:gw-5074|FD-Score:-3.93|P-value:7.33E-5 ID:SGTC_509|Compound:pifithrin|FD-Score:3.26|P-value:8.71E-4 ID:SGTC_754|Compound:3474-0146|FD-Score:3.82|P-value:1.22E-4 ID:SGTC_1034|Compound:k072-0165|FD-Score:3.22|P-value:9.92E-4 ID:SGTC_1271|Compound:0832-2808|FD-Score:-3.35|P-value:6.05E-4 ID:SGTC_1324|Compound:1418-0026|FD-Score:4.09|P-value:4.18E-5 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.84|P-value:1.12E-4 ID:SGTC_1649|Compound:st011737|FD-Score:-3.95|P-value:6.79E-5 ID:SGTC_1652|Compound:st011932|FD-Score:-3.29|P-value:7.55E-4 ID:SGTC_1667|Compound:st014849|FD-Score:-3.65|P-value:2.11E-4 ID:SGTC_1703|Compound:st026983|FD-Score:3.35|P-value:6.40E-4 ID:SGTC_1868|Compound:st057644|FD-Score:3.22|P-value:9.81E-4 ID:SGTC_1941|Compound:st076221|FD-Score:4.57|P-value:5.60E-6 ID:SGTC_1954|Compound:st077032|FD-Score:-3.32|P-value:6.70E-4 ID:SGTC_1956|Compound:st077085|FD-Score:3.48|P-value:4.15E-4 ID:SGTC_2006|Compound:4011487|FD-Score:3.55|P-value:3.24E-4 ID:SGTC_2386|Compound:9075165|FD-Score:3.52|P-value:3.56E-4 ID:SGTC_2537|Compound:larixol|FD-Score:3.30|P-value:7.65E-4 ID:SGTC_2564|Compound:betulinic acid|FD-Score:5.42|P-value:9.25E-8 ID:SGTC_2686|Compound:alizarin|FD-Score:3.33|P-value:6.89E-4 ID:SGTC_2723|Compound:salbutamol|FD-Score:4.84|P-value:1.67E-6 ID:SGTC_2754|Compound:granisetron|FD-Score:3.25|P-value:8.99E-4 ID:SGTC_2770|Compound:toltrazuril|FD-Score:4.05|P-value:4.89E-5 ID:SGTC_2774|Compound:tamoxifen|FD-Score:3.22|P-value:9.89E-4 ID:SGTC_2851|Compound:9015922|FD-Score:-3.30|P-value:7.20E-4 ID:SGTC_2852|Compound:9023854|FD-Score:-4.00|P-value:5.78E-5 ID:SGTC_2853|Compound:9015042|FD-Score:-3.23|P-value:9.00E-4 ID:SGTC_2856|Compound:9022925|FD-Score:-5.64|P-value:2.65E-8 ID:SGTC_2947|Compound:9072639|FD-Score:3.36|P-value:6.22E-4 ID:SGTC_2957|Compound:9076800|FD-Score:4.42|P-value:1.09E-5 ID:SGTC_2958|Compound:9077254|FD-Score:6.24|P-value:9.85E-10 ID:SGTC_2963|Compound:9082507|FD-Score:3.58|P-value:2.87E-4 ID:SGTC_2974|Compound:9094440|FD-Score:3.27|P-value:8.40E-4 ID:SGTC_3001|Compound:9076041|FD-Score:-3.37|P-value:5.72E-4 ID:SGTC_3007|Compound:9078383|FD-Score:3.40|P-value:5.37E-4 ID:SGTC_3014|Compound:9081533|FD-Score:3.34|P-value:6.59E-4 ID:SGTC_3070|Compound:9117005|FD-Score:3.56|P-value:3.17E-4 ID:SGTC_3141|Compound:9094609|FD-Score:3.96|P-value:6.95E-5 ID:SGTC_3143|Compound:9086658|FD-Score:3.60|P-value:2.68E-4 ID:SGTC_3205|Compound:9113483|FD-Score:3.28|P-value:8.03E-4 ID:SGTC_3281|Compound:9140613|FD-Score:-3.25|P-value:8.58E-4 ID:SGTC_3282|Compound:9108498|FD-Score:-3.83|P-value:1.10E-4

Top fitness defect scores for YDR214W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2958 9077254 6.24 16.7 µM 9.85E-10 5 2.20E-10
2 SGTC_2564 betulinic acid 5.42 100.0 µM 9.25E-8 9 2.94E-8
3 SGTC_2723 salbutamol 4.84 83.6 µM 1.67E-6 3 6.64E-7
4 SGTC_1941 st076221 4.57 61.8 µM 5.60E-6 sphingolipid biosynthesis & PDR1 57 2.44E-6
5 SGTC_2957 9076800 4.42 11.5 µM 1.09E-5 19 4.98E-6
6 SGTC_1324 1418-0026 4.09 34.4 µM 4.18E-5 10 2.13E-5
7 SGTC_2770 toltrazuril 4.05 17.5 µM 4.89E-5 24 2.52E-5
8 SGTC_3141 9094609 3.96 49.5 µM 6.95E-5 iron homeostasis 37 3.68E-5
9 SGTC_1412 3909-8563 3.84 178.0 µM 1.12E-4 10 6.16E-5
10 SGTC_754 3474-0146 3.82 171.0 µM 1.22E-4 copper-dependent oxidative stress 27 6.74E-5
11 SGTC_3143 9086658 3.60 49.5 µM 2.68E-4 61 1.57E-4
12 SGTC_2963 9082507 3.58 9.0 µM 2.87E-4 35 1.69E-4
13 SGTC_3070 9117005 3.56 49.5 µM 3.17E-4 6 1.88E-4
14 SGTC_2006 4011487 3.55 200.0 µM 3.24E-4 endomembrane recycling 101 1.93E-4
15 SGTC_2386 9075165 3.52 157.4 µM 3.56E-4 18 2.13E-4
16 SGTC_228 caffeine 3.50 993.1 µM 3.89E-4 15 2.35E-4
17 SGTC_1956 st077085 3.48 54.0 µM 4.15E-4 30 2.51E-4
18 SGTC_143 4032-1194 3.47 15.7 µM 4.34E-4 92 2.64E-4
19 SGTC_3007 9078383 3.40 71.4 µM 5.37E-4 36 3.32E-4
20 SGTC_2947 9072639 3.36 7.7 µM 6.22E-4 tubulin folding & SWR complex 73 3.88E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.127 1.55E-13 YER001W MNN1 hom Alpha-1,3-mannosyltransferase, integral membrane glycoprotein of the Golgi complex, required for addition of alpha1,3-mannose linkages to N-linked and O-linked oligosaccharides, one of five S. cerevisiae proteins of the MNN1 family
0.105 1.15E-9 YBR070C ALG14 het Component of UDP-GlcNAc transferase required for the second step of dolichyl-linked oligosaccharide synthesis; anchors the catalytic subunit Alg13p to the ER membrane; similar to bacterial and human glycosyltransferases
0.102 3.56E-9 YLL010C PSR1 hom Plasma membrane associated protein phosphatase involved in the general stress response; required along with binding partner Whi2p for full activation of STRE-mediated gene expression, possibly through dephosphorylation of Msn2p
0.098 1.53E-8 YDR356W SPC110 het Inner plaque spindle pole body (SPB) component, ortholog of human kendrin; involved in connecting nuclear microtubules to SPB; interacts with Tub4p-complex and calmodulin; phosphorylated by Mps1p in cell cycle-dependent manner
0.095 3.65E-8 YBR085W AAC3 hom Mitochondrial inner membrane ADP/ATP translocator; exchanges cytosolic ADP for mitochondrially synthesized ATP; expressed under anaerobic conditions; similar to Aac1p; has roles in maintenance of viability and in respiration; AAC3 has a paralog, PET9, that arose from the whole genome duplication
0.094 4.54E-8 YGR043C NQM1 hom Transaldolase of unknown function; transcription is repressed by Mot1p and induced by alpha-factor and during diauxic shift
0.093 5.92E-8 YBR211C AME1 het Essential kinetochore protein associated with microtubules and SPBs; component of the kinetochore sub-complex COMA (Ctf19p, Okp1p, Mcm21p, Ame1p); involved in spindle checkpoint maintenance; orthologous to human centromere constitutive-associated network (CCAN) subunit CENP-U and fission yeast Mis17; relative distribution to the nucleus increases upon DNA replication stress
0.091 1.24E-7 YBR089W_d YBR089W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; almost completely overlaps the verified gene POL30
0.091 1.32E-7 YGR047C TFC4 het One of six subunits of the RNA polymerase III transcription initiation factor complex (TFIIIC); part of the TauA domain of TFIIIC that binds BoxA DNA promoter sites of tRNA and similar genes; has TPR motifs; human homolog is TFIIIC-102
0.086 5.71E-7 YLR206W ENT2 hom Epsin-like protein required for endocytosis and actin patch assembly and functionally redundant with Ent1p; contains clathrin-binding motif at C-terminus
0.086 6.38E-7 YDR077W SED1 hom Major stress-induced structural GPI-cell wall glycoprotein in stationary-phase cells, associates with translating ribosomes, possible role in mitochondrial genome maintenance; ORF contains two distinct variable minisatellites
0.084 1.03E-6 YDL186W_p YDL186W_p hom Putative protein of unknown function; YDL186W is not an essential gene
0.084 1.05E-6 YOL097C WRS1 het Cytoplasmic tryptophanyl-tRNA synthetase, aminoacylates tryptophanyl-tRNA
0.084 1.16E-6 YDR376W ARH1 het Oxidoreductase of the mitochondrial inner membrane, involved in cytoplasmic and mitochondrial iron homeostasis and required for activity of Fe-S cluster-containing enzymes; one of the few mitochondrial proteins essential for viability
0.083 1.33E-6 YDR346C SVF1 hom Protein with a potential role in cell survival pathways, required for the diauxic growth shift; expression in mammalian cells increases survival under conditions inducing apoptosis; mutant has increased aneuploidy tolerance