YDR216W / ADR1

Carbon source-responsive zinc-finger transcription factor, required for transcription of the glucose-repressed gene ADH2, of peroxisomal protein genes, and of genes required for ethanol, glycerol, and fatty acid utilization

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR216W / ADR1

Click on Significant Values for Screen Details ID:SGTC_118|Compound:0083-0097|FD-Score:-3.18|P-value:7.37E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.21|P-value:8.53E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.09|P-value:3.13E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.86|P-value:7.99E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.13|P-value:2.62E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.74|P-value:1.24E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.71|P-value:1.32E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.71|P-value:1.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.09|P-value:9.99E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.52|P-value:2.85E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.75|P-value:1.20E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.62|P-value:1.99E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.65|P-value:2.52E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.95|P-value:4.04E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.35|P-value:4.05E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.18|P-value:7.25E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.52|P-value:2.92E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.91|P-value:4.76E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.60|P-value:1.64E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.10|P-value:2.20E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.10|P-value:2.98E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.43|P-value:3.97E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.06|P-value:3.45E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.24|P-value:5.99E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.70|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.36|P-value:5.12E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.34|P-value:1.05E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.02|P-value:4.11E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.58|P-value:1.77E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.19|P-value:7.20E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.50|P-value:3.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.92|P-value:6.23E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.10|P-value:2.96E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.14|P-value:8.31E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.36|P-value:5.06E-4 ID:SGTC_118|Compound:0083-0097|FD-Score:-3.18|P-value:7.37E-4 ID:SGTC_296|Compound:1222-0039|FD-Score:3.21|P-value:8.53E-4 ID:SGTC_368|Compound:fentichlor|FD-Score:4.09|P-value:3.13E-5 ID:SGTC_415|Compound:dibenzyl ketone|FD-Score:3.86|P-value:7.99E-5 ID:SGTC_427|Compound:1354-0053|FD-Score:4.13|P-value:2.62E-5 ID:SGTC_438|Compound:sphingosine|FD-Score:3.74|P-value:1.24E-4 ID:SGTC_440|Compound:fluspirilene|FD-Score:-4.71|P-value:1.32E-6 ID:SGTC_585|Compound:0kpi-0023|FD-Score:3.71|P-value:1.41E-4 ID:SGTC_607|Compound:4491-0986|FD-Score:-3.09|P-value:9.99E-4 ID:SGTC_633|Compound:0437-0093|FD-Score:3.52|P-value:2.85E-4 ID:SGTC_742|Compound:0kpi-0133|FD-Score:3.75|P-value:1.20E-4 ID:SGTC_804|Compound:1595-0054|FD-Score:3.79|P-value:1.02E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:3.62|P-value:1.99E-4 ID:SGTC_915|Compound:methyl methanesulfonate (MMS)|FD-Score:4.65|P-value:2.52E-6 ID:SGTC_1042|Compound:0350-0096|FD-Score:-3.95|P-value:4.04E-5 ID:SGTC_1244|Compound:0416-0015|FD-Score:-3.35|P-value:4.05E-4 ID:SGTC_1251|Compound:0490-5699|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_1351|Compound:1496-0003|FD-Score:-3.18|P-value:7.25E-4 ID:SGTC_1452|Compound:4194-0072|FD-Score:3.52|P-value:2.92E-4 ID:SGTC_1504|Compound:k297-0033|FD-Score:3.48|P-value:3.31E-4 ID:SGTC_1567|Compound:st069303|FD-Score:-3.91|P-value:4.76E-5 ID:SGTC_1568|Compound:digitonin|FD-Score:-3.60|P-value:1.64E-4 ID:SGTC_1570|Compound:verbenone|FD-Score:-4.10|P-value:2.20E-5 ID:SGTC_1571|Compound:st070080|FD-Score:4.10|P-value:2.98E-5 ID:SGTC_1572|Compound:epiandrosterone|FD-Score:3.43|P-value:3.97E-4 ID:SGTC_1579|Compound:chlormadinone acetate|FD-Score:4.06|P-value:3.45E-5 ID:SGTC_1585|Compound:2',4'-dihydroxychalcone|FD-Score:-3.24|P-value:5.99E-4 ID:SGTC_1682|Compound:st012968|FD-Score:3.57|P-value:2.43E-4 ID:SGTC_2010|Compound:4012422|FD-Score:-3.70|P-value:1.11E-4 ID:SGTC_2021|Compound:4019055|FD-Score:3.36|P-value:5.12E-4 ID:SGTC_2099|Compound:5377090|FD-Score:4.34|P-value:1.05E-5 ID:SGTC_2187|Compound:6125751|FD-Score:4.02|P-value:4.11E-5 ID:SGTC_2213|Compound:7173844|FD-Score:3.56|P-value:2.46E-4 ID:SGTC_2218|Compound:6965428|FD-Score:-3.58|P-value:1.77E-4 ID:SGTC_2538|Compound:3',7'-epoxycaryophyllan-6-one|FD-Score:-3.19|P-value:7.20E-4 ID:SGTC_2693|Compound:st077581|FD-Score:3.50|P-value:3.12E-4 ID:SGTC_2722|Compound:naftopidil|FD-Score:3.92|P-value:6.23E-5 ID:SGTC_2736|Compound:butenafine|FD-Score:4.10|P-value:2.96E-5 ID:SGTC_2798|Compound:7813637|FD-Score:3.80|P-value:1.01E-4 ID:SGTC_2878|Compound:9043973|FD-Score:-3.14|P-value:8.31E-4 ID:SGTC_3302|Compound:9125395|FD-Score:3.36|P-value:5.06E-4

Top fitness defect scores for YDR216W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_915 methyl methanesulfonate (MMS) 4.65 110.0 mM 2.52E-6 DNA damage response 22 1.62E-6
2 SGTC_2099 5377090 4.34 177.4 µM 1.05E-5 14 7.08E-6
3 SGTC_427 1354-0053 4.13 47.3 µM 2.62E-5 17 1.81E-5
4 SGTC_2736 butenafine 4.10 14.7 µM 2.96E-5 26 2.06E-5
5 SGTC_1571 st070080 4.10 73.4 µM 2.98E-5 12 2.07E-5
6 SGTC_368 fentichlor 4.09 4.6 µM 3.13E-5 23 2.18E-5
7 SGTC_1579 chlormadinone acetate 4.06 49.4 µM 3.45E-5 8 2.41E-5
8 SGTC_2187 6125751 4.02 200.0 µM 4.11E-5 RSC complex & mRNA processing 15 2.89E-5
9 SGTC_2722 naftopidil 3.92 47.2 µM 6.23E-5 9 4.44E-5
10 SGTC_415 dibenzyl ketone 3.86 100.0 µM 7.99E-5 10 5.73E-5
11 SGTC_2798 7813637 3.80 45.5 µM 1.01E-4 37 7.33E-5
12 SGTC_804 1595-0054 3.79 20.9 µM 1.02E-4 sphingolipid biosynthesis & PDR1 39 7.38E-5
13 SGTC_742 0kpi-0133 3.75 140.0 µM 1.20E-4 ERG2 28 8.70E-5
14 SGTC_438 sphingosine 3.74 6.7 µM 1.24E-4 28 9.02E-5
15 SGTC_585 0kpi-0023 3.71 191.0 µM 1.41E-4 23 1.03E-4
16 SGTC_905 2-aminofluorene 3.62 215.0 µM 1.99E-4 cell wall signaling 42 1.47E-4
17 SGTC_1682 st012968 3.57 530.0 nM 2.43E-4 29 1.81E-4
18 SGTC_1251 0490-5699 3.57 265.0 µM 2.43E-4 47 1.81E-4
19 SGTC_2213 7173844 3.56 200.0 µM 2.46E-4 23 1.83E-4
20 SGTC_633 0437-0093 3.52 97.7 µM 2.85E-4 DNA intercalators 22 2.13E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.122 1.09E-12 YDR294C DPL1 hom Dihydrosphingosine phosphate lyase, regulates intracellular levels of sphingolipid long-chain base phosphates (LCBPs), degrades phosphorylated long chain bases, prefers C16 dihydrosphingosine-l-phosphate as a substrate
0.098 1.52E-8 YDR210W_p YDR210W_p hom Predicted tail-anchored plasma membrane protein containing a conserved CYSTM module; related proteins in other organisms may be involved in response to stress; green fluorescent protein (GFP)-fusion protein localizes to the cell periphery
0.094 5.64E-8 YDL138W RGT2 hom Plasma membrane high glucose sensor that regulates glucose transport; contains 12 predicted transmembrane segments and a long C-terminal tail required for induction of hexose transporters; RGT2 has a paralog, SNF3, that arose from the whole genome duplication
0.082 1.78E-6 YDL164C CDC9 het DNA ligase found in the nucleus and mitochondria, an essential enzyme that joins Okazaki fragments during DNA replication; also acts in nucleotide excision repair, base excision repair, and recombination
0.082 2.26E-6 YOR228C YOR228C hom Protein of unknown function, localized to the mitochondrial outer membrane
0.076 1.14E-5 YPR045C THP3 hom Protein that forms a complex with Csn12p that is recruited to transcribed genes and may have a role in transcription elongation; possibly involved in splicing based on pre-mRNA accumulation defect for many intron-containing genes
0.075 1.39E-5 YDL085W NDE2 hom Mitochondrial external NADH dehydrogenase, catalyzes the oxidation of cytosolic NADH; Nde1p and Nde2p are involved in providing the cytosolic NADH to the mitochondrial respiratory chain
0.075 1.44E-5 YOL099C_d YOL099C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps verified gene PKH2/YOL100W; may interact with ribosomes
0.074 1.84E-5 YGL079W_p KXD1_p hom Putative protein of unknown function; likely member of BLOC complex involved in endosomal cargo sorting; null mutant is sensitive to drug inducing secretion of vacuolar cargo; GFP-fusion protein localizes to the endosome
0.073 2.21E-5 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.073 2.33E-5 YPR020W ATP20 hom Subunit g of the mitochondrial F1F0 ATP synthase; reversibly phosphorylated on two residues; unphosphorylated form is required for dimerization of the ATP synthase complex
0.073 2.55E-5 YAL060W BDH1 hom NAD-dependent (R,R)-butanediol dehydrogenase, catalyzes oxidation of (R,R)-2,3-butanediol to (3R)-acetoin, oxidation of meso-butanediol to (3S)-acetoin, and reduction of acetoin; enhances use of 2,3-butanediol as an aerobic carbon source
0.072 2.64E-5 YDR135C YCF1 hom Vacuolar glutathione S-conjugate transporter; member of the ATP-binding cassette family; has a role in detoxifying metals such as cadmium, mercury, and arsenite; also transports unconjugated bilirubin, selenodigluthatione, and oxidized glutathione; similar to human cystic fibrosis protein CFTR
0.070 4.46E-5 YGL087C MMS2 hom Ubiquitin-conjugating enzyme variant; involved in error-free postreplication repair; forms a heteromeric complex with Ubc13p, an active ubiquitin-conjugating enzyme; cooperates with chromatin-associated RING finger proteins, Rad18p and Rad5p; protein abundance increases in response to DNA replication stress
0.068 7.63E-5 YDR310C SUM1 hom Transcriptional repressor required for mitotic repression of middle sporulation-specific genes; also acts as general replication initiation factor; involved in telomere maintenance, chromatin silencing; regulated by pachytene checkpoint