YDR219C / MFB1

Mitochondria-associated F-box protein involved in maintenance of normal mitochondrial morphology; interacts with Skp1p through the F-box motif; preferentially localizes to the mother cell during budding

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR219C / MFB1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-2.97|P-value:5.31E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.59|P-value:3.85E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.49|P-value:5.84E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.74|P-value:1.90E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-4.19|P-value:1.97E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:-2.98|P-value:5.01E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.99|P-value:4.95E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.07|P-value:3.63E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:2.96|P-value:5.52E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.20|P-value:1.86E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.28|P-value:1.49E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.38|P-value:9.97E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:2.86|P-value:8.20E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.00|P-value:4.82E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.95|P-value:5.75E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.97|P-value:6.28E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.17|P-value:2.32E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.15|P-value:2.35E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.17|P-value:2.38E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-2.88|P-value:7.33E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.11|P-value:3.08E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.09|P-value:3.40E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.47|P-value:6.60E-5 ID:SGTC_1690|Compound:st023502|FD-Score:-3.09|P-value:3.28E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.69|P-value:2.48E-5 ID:SGTC_1837|Compound:st055472|FD-Score:2.88|P-value:7.65E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.17|P-value:2.41E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.36|P-value:1.08E-4 ID:SGTC_1968|Compound:st069590|FD-Score:2.87|P-value:7.97E-4 ID:SGTC_1995|Compound:st072814|FD-Score:2.87|P-value:7.82E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-2.99|P-value:4.80E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-4.28|P-value:1.19E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.11|P-value:3.10E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.99|P-value:1.96E-8 ID:SGTC_2432|Compound:5630864|FD-Score:3.73|P-value:2.00E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.91|P-value:8.26E-6 ID:SGTC_2534|Compound:helenine|FD-Score:-3.82|P-value:1.24E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.20|P-value:2.05E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.58|P-value:2.24E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-5.08|P-value:1.08E-8 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.63|P-value:3.12E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.36|P-value:1.05E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.99|P-value:4.96E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.59|P-value:3.72E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-3.20|P-value:2.10E-4 ID:SGTC_3024|Compound:9090631|FD-Score:2.87|P-value:7.91E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.80|P-value:6.42E-8 ID:SGTC_3035|Compound:9091303|FD-Score:-3.47|P-value:6.56E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.22|P-value:2.00E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.86|P-value:8.12E-4 ID:SGTC_3194|Compound:9111903|FD-Score:2.81|P-value:9.85E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.11|P-value:3.05E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.90|P-value:3.43E-8 ID:SGTC_58|Compound:0957-0393|FD-Score:-2.97|P-value:5.31E-4 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.59|P-value:3.85E-5 ID:SGTC_200|Compound:k038-0079|FD-Score:-3.49|P-value:5.84E-5 ID:SGTC_212|Compound:3807-4682|FD-Score:3.74|P-value:1.90E-5 ID:SGTC_433|Compound:pimozide|FD-Score:-4.19|P-value:1.97E-6 ID:SGTC_554|Compound:4483-2211|FD-Score:-2.98|P-value:5.01E-4 ID:SGTC_564|Compound:3555-0129|FD-Score:3.27|P-value:1.60E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.99|P-value:4.95E-4 ID:SGTC_577|Compound:r071-0003|FD-Score:3.07|P-value:3.63E-4 ID:SGTC_646|Compound:4092-0839|FD-Score:2.96|P-value:5.52E-4 ID:SGTC_674|Compound:0498-0004|FD-Score:4.20|P-value:1.86E-6 ID:SGTC_706|Compound:4262-0057|FD-Score:-3.28|P-value:1.49E-4 ID:SGTC_795|Compound:0685-0265|FD-Score:3.38|P-value:9.97E-5 ID:SGTC_802|Compound:4112-3352|FD-Score:2.86|P-value:8.20E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.00|P-value:4.82E-4 ID:SGTC_965|Compound:1291-5240|FD-Score:-2.95|P-value:5.75E-4 ID:SGTC_976|Compound:1348-1067|FD-Score:3.97|P-value:6.28E-6 ID:SGTC_1068|Compound:loratadine|FD-Score:-3.17|P-value:2.32E-4 ID:SGTC_1121|Compound:fusaric acid|FD-Score:-4.15|P-value:2.35E-6 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:-3.17|P-value:2.38E-4 ID:SGTC_1136|Compound:pergolide|FD-Score:-2.88|P-value:7.33E-4 ID:SGTC_1322|Compound:1348-1070|FD-Score:3.11|P-value:3.08E-4 ID:SGTC_1357|Compound:1503-1303|FD-Score:3.09|P-value:3.40E-4 ID:SGTC_1396|Compound:3511-0007|FD-Score:3.32|P-value:1.29E-4 ID:SGTC_1450|Compound:4112-4260|FD-Score:3.47|P-value:6.60E-5 ID:SGTC_1690|Compound:st023502|FD-Score:-3.09|P-value:3.28E-4 ID:SGTC_1752|Compound:st044819|FD-Score:3.69|P-value:2.48E-5 ID:SGTC_1837|Compound:st055472|FD-Score:2.88|P-value:7.65E-4 ID:SGTC_1840|Compound:st055363|FD-Score:3.17|P-value:2.41E-4 ID:SGTC_1932|Compound:st074806|FD-Score:3.36|P-value:1.08E-4 ID:SGTC_1968|Compound:st069590|FD-Score:2.87|P-value:7.97E-4 ID:SGTC_1995|Compound:st072814|FD-Score:2.87|P-value:7.82E-4 ID:SGTC_2023|Compound:5144124|FD-Score:-2.99|P-value:4.80E-4 ID:SGTC_2110|Compound:5483698|FD-Score:-4.28|P-value:1.19E-6 ID:SGTC_2405|Compound:ticlatone|FD-Score:4.11|P-value:3.10E-6 ID:SGTC_2426|Compound:5582046|FD-Score:4.99|P-value:1.96E-8 ID:SGTC_2432|Compound:5630864|FD-Score:3.73|P-value:2.00E-5 ID:SGTC_2531|Compound:methyl deoxycholate|FD-Score:-3.91|P-value:8.26E-6 ID:SGTC_2534|Compound:helenine|FD-Score:-3.82|P-value:1.24E-5 ID:SGTC_2582|Compound:agaric acid|FD-Score:-3.20|P-value:2.05E-4 ID:SGTC_2624|Compound:nerol|FD-Score:-4.58|P-value:2.24E-7 ID:SGTC_2750|Compound:bromebric acid|FD-Score:-5.08|P-value:1.08E-8 ID:SGTC_2754|Compound:granisetron|FD-Score:-3.63|P-value:3.12E-5 ID:SGTC_2768|Compound:sulfasalazine|FD-Score:3.32|P-value:1.27E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-3.36|P-value:1.05E-4 ID:SGTC_2834|Compound:9001755|FD-Score:2.99|P-value:4.96E-4 ID:SGTC_2855|Compound:9016525|FD-Score:-3.59|P-value:3.72E-5 ID:SGTC_2883|Compound:9059145|FD-Score:-3.20|P-value:2.10E-4 ID:SGTC_3024|Compound:9090631|FD-Score:2.87|P-value:7.91E-4 ID:SGTC_3029|Compound:9088683|FD-Score:4.80|P-value:6.42E-8 ID:SGTC_3035|Compound:9091303|FD-Score:-3.47|P-value:6.56E-5 ID:SGTC_3041|Compound:9091929|FD-Score:3.22|P-value:2.00E-4 ID:SGTC_3061|Compound:glucosamine|FD-Score:2.86|P-value:8.12E-4 ID:SGTC_3194|Compound:9111903|FD-Score:2.81|P-value:9.85E-4 ID:SGTC_3233|Compound:9132340|FD-Score:3.11|P-value:3.05E-4 ID:SGTC_3303|Compound:9125618|FD-Score:4.90|P-value:3.43E-8

Top fitness defect scores for YDR219C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2426 5582046 4.99 32.2 µM 1.96E-8 10 3.02E-7
2 SGTC_3303 9125618 4.90 40.6 µM 3.43E-8 24 4.80E-7
3 SGTC_3029 9088683 4.80 49.5 µM 6.42E-8 12 8.07E-7
4 SGTC_674 0498-0004 4.20 451.0 µM 1.86E-6 heme requiring 20 1.32E-5
5 SGTC_2405 ticlatone 4.11 3.5 µM 3.10E-6 65 2.02E-5
6 SGTC_976 1348-1067 3.97 47.6 µM 6.28E-6 60S ribosome export 29 3.64E-5
7 SGTC_212 3807-4682 3.74 38.8 µM 1.90E-5 tubulin folding & SWR complex 78 9.14E-5
8 SGTC_2432 5630864 3.73 12.2 µM 2.00E-5 28 9.53E-5
9 SGTC_1752 st044819 3.69 83.0 µM 2.48E-5 30 1.14E-4
10 SGTC_1450 4112-4260 3.47 37.6 µM 6.60E-5 calcium & mitochondrial duress 44 2.58E-4
11 SGTC_795 0685-0265 3.38 78.0 µM 9.97E-5 excess fatty acid 43 3.63E-4
12 SGTC_1932 st074806 3.36 40.9 µM 1.08E-4 50 3.88E-4
13 SGTC_2768 sulfasalazine 3.32 50.2 µM 1.27E-4 37 4.44E-4
14 SGTC_1396 3511-0007 3.32 98.6 µM 1.29E-4 mitochondrial processes 28 4.50E-4
15 SGTC_564 3555-0129 3.27 330.0 µM 1.60E-4 19 5.38E-4
16 SGTC_3041 9091929 3.22 49.5 µM 2.00E-4 redox potentiating 47 6.48E-4
17 SGTC_1840 st055363 3.17 71.0 µM 2.41E-4 42 7.59E-4
18 SGTC_3233 9132340 3.11 49.5 µM 3.05E-4 52 9.24E-4
19 SGTC_1322 1348-1070 3.11 12.0 µM 3.08E-4 27 9.32E-4
20 SGTC_1357 1503-1303 3.09 39.5 µM 3.40E-4 86 0.00101

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.155 2.05E-19 YOR282W_d YOR282W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps essential, verified gene PLP2/YOR281C
0.104 1.49E-9 YIL014W MNT3 hom Alpha-1,3-mannosyltransferase, adds the fourth and fifth alpha-1,3-linked mannose residues to O-linked glycans during protein O-glycosylation
0.103 2.08E-9 YDR333C RQC1 hom Component of the ribosome quality control complex (RQC); RQC (Rqc1p-Ltn1p-Tae2p-Cdc48p-Npl4p-Ufd1p), is a ribosome-bound complex required for the degradation of polypeptides arising from stalled translation; required along with Ltn1p for recruitment of the Cdc48p-Npl4p-Ufd1p AAA ATPase complex to the RQC
0.101 5.04E-9 YBL034C STU1 het Component of the mitotic spindle that binds to interpolar microtubules via its association with beta-tubulin (Tub2p); required for interpolar microtubules to provide an outward force on the spindle poles
0.090 1.71E-7 YMR155W_p YMR155W_p hom Putative protein of unknown function; identified as interacting with Hsp82p in a high-throughput two-hybrid screen
0.090 1.78E-7 YNL313C EMW1 het Essential conserved protein with a role in cell wall integrity; contains six TPR (tetratricopeptide repeat) domains clustered in the C-terminal region; conditional mutant is suppressed by overexpression of GFA1; protein abundance increases in response to DNA replication stress
0.083 1.47E-6 YBR040W FIG1 hom Integral membrane protein required for efficient mating; may participate in or regulate the low affinity Ca2+ influx system, which affects intracellular signaling and cell-cell fusion during mating
0.082 1.77E-6 YMR305C SCW10 hom Cell wall protein with similarity to glucanases; may play a role in conjugation during mating based on mutant phenotype and its regulation by Ste12p
0.081 2.67E-6 YLR348C DIC1 hom Mitochondrial dicarboxylate carrier, integral membrane protein, catalyzes a dicarboxylate-phosphate exchange across the inner mitochondrial membrane, transports cytoplasmic dicarboxylates into the mitochondrial matrix
0.079 4.15E-6 YHR193C EGD2 hom Alpha subunit of the heteromeric nascent polypeptide-associated complex (NAC) involved in protein sorting and translocation, associated with cytoplasmic ribosomes
0.079 4.71E-6 YER074W RPS24A hom Protein component of the small (40S) ribosomal subunit; homologous to mammalian ribosomal protein S24, no bacterial homolog; RPS24A has a paralog, RPS24B, that arose from the whole genome duplication
0.078 6.15E-6 YPL060W MFM1 hom Mitochondrial inner membrane magnesium transporter, involved in maintenance of mitochondrial magnesium concentrations and membrane potential; indirectly affects splicing of group II introns; functionally and structurally related to Mrs2p
0.077 8.62E-6 YDR262W_p YDR262W_p hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the vacuole and is induced in response to the DNA-damaging agent MMS; gene expression increases in response to Zymoliase treatment
0.075 1.35E-5 YHR046C INM1 hom Inositol monophosphatase, involved in biosynthesis of inositol and in phosphoinositide second messenger signaling; INM1 expression increases in the presence of inositol and decreases upon exposure to antibipolar drugs lithium and valproate
0.073 2.40E-5 YGL230C_p YGL230C_p hom Putative protein of unknown function; non-essential gene