YDR225W / HTA1

Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR225W / HTA1

Click on Significant Values for Screen Details ID:SGTC_9|Compound:0092-0002|FD-Score:4.04|P-value:3.71E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:3.16|P-value:9.83E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.44|P-value:3.74E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.40|P-value:7.85E-6 ID:SGTC_93|Compound:0109-0045|FD-Score:8.92|P-value:9.81E-19 ID:SGTC_110|Compound:0850-0284|FD-Score:3.22|P-value:7.96E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.09|P-value:2.98E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:3.28|P-value:6.65E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.43|P-value:7.05E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.21|P-value:8.22E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:5.86|P-value:4.31E-9 ID:SGTC_343|Compound:4130-2827|FD-Score:5.29|P-value:1.05E-7 ID:SGTC_372|Compound:0155-0182|FD-Score:3.25|P-value:7.30E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.37|P-value:4.80E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.28|P-value:5.99E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.60|P-value:2.13E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:9.92|P-value:9.76E-23 ID:SGTC_574|Compound:1315-0397|FD-Score:4.11|P-value:2.73E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:10.90|P-value:4.02E-27 ID:SGTC_605|Compound:1315-0399|FD-Score:6.92|P-value:5.24E-12 ID:SGTC_632|Compound:0781-2353|FD-Score:4.26|P-value:1.50E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:6.08|P-value:1.20E-9 ID:SGTC_698|Compound:k064-0052|FD-Score:4.14|P-value:2.43E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:7.55|P-value:6.22E-14 ID:SGTC_829|Compound:1635-0120|FD-Score:5.30|P-value:9.89E-8 ID:SGTC_838|Compound:0109-0203|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.95|P-value:5.93E-7 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.50|P-value:3.02E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.55|P-value:4.01E-6 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.77|P-value:1.08E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.12|P-value:2.72E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:10.30|P-value:2.39E-24 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.02|P-value:4.03E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.21|P-value:8.40E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.70|P-value:1.10E-8 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.97|P-value:4.89E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.10|P-value:2.89E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.66|P-value:1.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.55|P-value:6.19E-11 ID:SGTC_1547|Compound:harmine|FD-Score:8.03|P-value:1.53E-15 ID:SGTC_1693|Compound:xanthone|FD-Score:3.85|P-value:8.14E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.29|P-value:6.44E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.41|P-value:4.60E-8 ID:SGTC_1853|Compound:st056710|FD-Score:4.25|P-value:1.54E-5 ID:SGTC_1915|Compound:st067105|FD-Score:29.30|P-value:7.17E-183 ID:SGTC_1933|Compound:st074711|FD-Score:3.24|P-value:7.54E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.67|P-value:1.58E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_2166|Compound:5933061|FD-Score:8.35|P-value:1.13E-16 ID:SGTC_2194|Compound:5927483|FD-Score:6.90|P-value:6.04E-12 ID:SGTC_2211|Compound:7117706|FD-Score:3.23|P-value:7.74E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.25|P-value:1.57E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.40|P-value:7.95E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.31|P-value:5.92E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.29|P-value:6.41E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.29|P-value:5.77E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:8.06|P-value:1.21E-15 ID:SGTC_2544|Compound:sphondin|FD-Score:13.30|P-value:2.24E-39 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.12|P-value:2.65E-5 ID:SGTC_2671|Compound:danthron|FD-Score:16.50|P-value:3.08E-59 ID:SGTC_2681|Compound:menadione|FD-Score:3.42|P-value:3.97E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.35|P-value:9.75E-6 ID:SGTC_2692|Compound:st077426|FD-Score:6.18|P-value:6.48E-10 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_2800|Compound:7887935|FD-Score:5.07|P-value:3.23E-7 ID:SGTC_2834|Compound:9001755|FD-Score:3.17|P-value:9.52E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.58|P-value:2.00E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.64|P-value:1.59E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.86|P-value:7.70E-5 ID:SGTC_3108|Compound:9121785|FD-Score:5.27|P-value:1.18E-7 ID:SGTC_3200|Compound:9114385|FD-Score:3.67|P-value:1.59E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.67|P-value:1.64E-4 ID:SGTC_3247|Compound:9135149|FD-Score:7.05|P-value:2.17E-12 ID:SGTC_3320|Compound:9137005|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.45|P-value:3.61E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.19|P-value:8.76E-4 ID:SGTC_9|Compound:0092-0002|FD-Score:4.04|P-value:3.71E-5 ID:SGTC_20|Compound:0481-0013|FD-Score:3.16|P-value:9.83E-4 ID:SGTC_29|Compound:0299-0004|FD-Score:3.44|P-value:3.74E-4 ID:SGTC_71|Compound:0417-1750|FD-Score:4.40|P-value:7.85E-6 ID:SGTC_93|Compound:0109-0045|FD-Score:8.92|P-value:9.81E-19 ID:SGTC_110|Compound:0850-0284|FD-Score:3.22|P-value:7.96E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:5.09|P-value:2.98E-7 ID:SGTC_146|Compound:3448-8650|FD-Score:3.28|P-value:6.65E-4 ID:SGTC_151|Compound:3013-0144|FD-Score:4.43|P-value:7.05E-6 ID:SGTC_313|Compound:3474-0040|FD-Score:3.43|P-value:3.94E-4 ID:SGTC_314|Compound:1671-0008|FD-Score:3.21|P-value:8.22E-4 ID:SGTC_315|Compound:k915-0449|FD-Score:5.86|P-value:4.31E-9 ID:SGTC_343|Compound:4130-2827|FD-Score:5.29|P-value:1.05E-7 ID:SGTC_372|Compound:0155-0182|FD-Score:3.25|P-value:7.30E-4 ID:SGTC_381|Compound:3461-2219|FD-Score:3.37|P-value:4.80E-4 ID:SGTC_436|Compound:n,n-dimethylsphingosine|FD-Score:-3.28|P-value:5.99E-4 ID:SGTC_450|Compound:aminopyrene|FD-Score:3.60|P-value:2.13E-4 ID:SGTC_546|Compound:peri-Naphthalide|FD-Score:9.92|P-value:9.76E-23 ID:SGTC_574|Compound:1315-0397|FD-Score:4.11|P-value:2.73E-5 ID:SGTC_580|Compound:1123-0028|FD-Score:10.90|P-value:4.02E-27 ID:SGTC_605|Compound:1315-0399|FD-Score:6.92|P-value:5.24E-12 ID:SGTC_632|Compound:0781-2353|FD-Score:4.26|P-value:1.50E-5 ID:SGTC_672|Compound:1441-0018|FD-Score:6.08|P-value:1.20E-9 ID:SGTC_698|Compound:k064-0052|FD-Score:4.14|P-value:2.43E-5 ID:SGTC_744|Compound:1594-0068|FD-Score:7.55|P-value:6.22E-14 ID:SGTC_829|Compound:1635-0120|FD-Score:5.30|P-value:9.89E-8 ID:SGTC_838|Compound:0109-0203|FD-Score:3.27|P-value:6.79E-4 ID:SGTC_905|Compound:2-aminofluorene|FD-Score:4.95|P-value:5.93E-7 ID:SGTC_1071|Compound:trifluoperazine|FD-Score:3.50|P-value:3.02E-4 ID:SGTC_1114|Compound:scopoletin|FD-Score:4.55|P-value:4.01E-6 ID:SGTC_1117|Compound:retinoic acid|FD-Score:3.77|P-value:1.08E-4 ID:SGTC_1168|Compound:k815-0004|FD-Score:4.12|P-value:2.72E-5 ID:SGTC_1213|Compound:1315-0166|FD-Score:10.30|P-value:2.39E-24 ID:SGTC_1243|Compound:0416-0003|FD-Score:4.02|P-value:4.03E-5 ID:SGTC_1267|Compound:0828-0272|FD-Score:3.21|P-value:8.40E-4 ID:SGTC_1309|Compound:pyrazolanthrone|FD-Score:5.70|P-value:1.10E-8 ID:SGTC_1327|Compound:1436-0082|FD-Score:3.97|P-value:4.89E-5 ID:SGTC_1353|Compound:1498-1206|FD-Score:4.10|P-value:2.89E-5 ID:SGTC_1438|Compound:4092-1045|FD-Score:3.66|P-value:1.65E-4 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.55|P-value:6.19E-11 ID:SGTC_1547|Compound:harmine|FD-Score:8.03|P-value:1.53E-15 ID:SGTC_1693|Compound:xanthone|FD-Score:3.85|P-value:8.14E-5 ID:SGTC_1765|Compound:st044815|FD-Score:3.29|P-value:6.44E-4 ID:SGTC_1787|Compound:fluconazole|FD-Score:-5.41|P-value:4.60E-8 ID:SGTC_1853|Compound:st056710|FD-Score:4.25|P-value:1.54E-5 ID:SGTC_1915|Compound:st067105|FD-Score:29.30|P-value:7.17E-183 ID:SGTC_1933|Compound:st074711|FD-Score:3.24|P-value:7.54E-4 ID:SGTC_2012|Compound:4023501|FD-Score:3.67|P-value:1.58E-4 ID:SGTC_2156|Compound:5649887|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_2166|Compound:5933061|FD-Score:8.35|P-value:1.13E-16 ID:SGTC_2194|Compound:5927483|FD-Score:6.90|P-value:6.04E-12 ID:SGTC_2211|Compound:7117706|FD-Score:3.23|P-value:7.74E-4 ID:SGTC_2214|Compound:7179297|FD-Score:3.24|P-value:7.44E-4 ID:SGTC_2229|Compound:7354935|FD-Score:4.25|P-value:1.57E-5 ID:SGTC_2283|Compound:7944793|FD-Score:4.40|P-value:7.95E-6 ID:SGTC_2336|Compound:9001819|FD-Score:3.40|P-value:4.30E-4 ID:SGTC_2378|Compound:9074213|FD-Score:3.72|P-value:1.35E-4 ID:SGTC_2481|Compound:5478948|FD-Score:3.31|P-value:5.92E-4 ID:SGTC_2500|Compound:5-alpha-androstan-3,17-dione|FD-Score:3.29|P-value:6.41E-4 ID:SGTC_2526|Compound:patulin|FD-Score:-3.29|P-value:5.77E-4 ID:SGTC_2532|Compound:xanthone|FD-Score:8.06|P-value:1.21E-15 ID:SGTC_2544|Compound:sphondin|FD-Score:13.30|P-value:2.24E-39 ID:SGTC_2611|Compound:pyromycin|FD-Score:4.12|P-value:2.65E-5 ID:SGTC_2671|Compound:danthron|FD-Score:16.50|P-value:3.08E-59 ID:SGTC_2681|Compound:menadione|FD-Score:3.42|P-value:3.97E-4 ID:SGTC_2682|Compound:pyrogallin|FD-Score:4.35|P-value:9.75E-6 ID:SGTC_2692|Compound:st077426|FD-Score:6.18|P-value:6.48E-10 ID:SGTC_2764|Compound:methyldopa|FD-Score:3.76|P-value:1.14E-4 ID:SGTC_2800|Compound:7887935|FD-Score:5.07|P-value:3.23E-7 ID:SGTC_2834|Compound:9001755|FD-Score:3.17|P-value:9.52E-4 ID:SGTC_2838|Compound:9002687|FD-Score:-3.58|P-value:2.00E-4 ID:SGTC_2936|Compound:9038235|FD-Score:-3.64|P-value:1.59E-4 ID:SGTC_3058|Compound:9093861|FD-Score:3.86|P-value:7.70E-5 ID:SGTC_3108|Compound:9121785|FD-Score:5.27|P-value:1.18E-7 ID:SGTC_3200|Compound:9114385|FD-Score:3.67|P-value:1.59E-4 ID:SGTC_3234|Compound:9132280|FD-Score:3.67|P-value:1.64E-4 ID:SGTC_3247|Compound:9135149|FD-Score:7.05|P-value:2.17E-12 ID:SGTC_3320|Compound:9137005|FD-Score:4.10|P-value:2.93E-5 ID:SGTC_3323|Compound:9138564|FD-Score:3.45|P-value:3.61E-4 ID:SGTC_3344|Compound:9148862|FD-Score:3.19|P-value:8.76E-4

Top fitness defect scores for YDR225W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1915 st067105 29.30 30.6 µM 7.17E-183 RNA pol III & RNase P/MRP 1 6.46E-189
2 SGTC_2671 danthron 16.50 100.0 µM 3.08E-59 DNA damage response 1 3.37E-61
3 SGTC_2544 sphondin 13.30 68.5 µM 2.24E-39 RNA pol III & RNase P/MRP 1 1.12E-40
4 SGTC_580 1123-0028 10.90 41.0 µM 4.02E-27 DNA damage response 1 5.20E-28
5 SGTC_1213 1315-0166 10.30 115.0 µM 2.39E-24 2 3.84E-25
6 SGTC_546 peri-Naphthalide 9.92 147.0 µM 9.76E-23 DNA damage response 1 1.77E-23
7 SGTC_93 0109-0045 8.92 59.2 µM 9.81E-19 DNA damage response 1 2.43E-19
8 SGTC_2166 5933061 8.35 31.5 µM 1.13E-16 tubulin folding & SWR complex 4 3.27E-17
9 SGTC_2532 xanthone 8.06 78.9 µM 1.21E-15 1 3.80E-16
10 SGTC_1547 harmine 8.03 94.2 µM 1.53E-15 ergosterol biosynthesis 11 4.86E-16
11 SGTC_744 1594-0068 7.55 283.0 µM 6.22E-14 amide catabolism 3 2.24E-14
12 SGTC_3247 9135149 7.05 49.5 µM 2.17E-12 DNA damage response 8 8.81E-13
13 SGTC_605 1315-0399 6.92 119.0 µM 5.24E-12 Golgi 4 2.19E-12
14 SGTC_2194 5927483 6.90 104.5 µM 6.04E-12 5 2.54E-12
15 SGTC_1525 8-methoxypsoralen 6.55 92.5 µM 6.19E-11 DNA damage response 9 2.82E-11
16 SGTC_2692 st077426 6.18 47.7 µM 6.48E-10 3 3.19E-10
17 SGTC_672 1441-0018 6.08 53.7 µM 1.20E-9 1 6.04E-10
18 SGTC_315 k915-0449 5.86 187.0 µM 4.31E-9 22 2.27E-9
19 SGTC_1309 pyrazolanthrone 5.70 13.4 µM 1.10E-8 9 5.98E-9
20 SGTC_829 1635-0120 5.30 117.0 µM 9.89E-8 DNA damage response 16 5.78E-8

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.329 1.79E-85 YOR116C RPO31 het RNA polymerase III largest subunit C160, part of core enzyme; similar to bacterial beta-prime subunit and to RPA190 and RPO21
0.244 1.57E-46 YOR207C RET1 het Second-largest subunit of RNA polymerase III, which is responsible for the transcription of tRNA and 5S RNA genes, and other low molecular weight RNAs
0.243 2.31E-46 YBR202W MCM7 het Component of the heterohexameric MCM2-7 complex, which primes origins of DNA replication in G1 and becomes an active ATP-dependent helicase that promotes DNA melting and elongation in S-phase; forms an Mcm4p-6p-7p subcomplex
0.237 3.49E-44 YOR191W ULS1 hom Protein involved in proteolytic control of sumoylated substrates; contains RING finger domain; interacts with SUMO (Smt3p); member of the SWI/SNF family of DNA-dependent ATPases; plays a role in antagonizing silencing during mating-type switching; relocalizes from nucleus to cytoplasm upon DNA replication stress
0.237 4.28E-44 YNL248C RPA49 hom RNA polymerase I subunit A49
0.233 1.69E-42 YBR154C RPB5 het RNA polymerase subunit ABC27, common to RNA polymerases I, II, and III; contacts DNA and affects transactivation
0.213 7.79E-36 YER165W PAB1 het Poly(A) binding protein, part of the 3'-end RNA-processing complex, mediates interactions between the 5' cap structure and the 3' mRNA poly(A) tail, involved in control of poly(A) tail length, interacts with translation factor eIF-4G
0.194 1.06E-29 YDL152W_d YDL152W_d het Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the verified ORF SAS10/YDL153C, a component of the small ribosomal subunit processosome
0.175 1.98E-24 YDR076W RAD55 hom Protein that stimulates strand exchange by stabilizing the binding of Rad51p to single-stranded DNA; involved in the recombinational repair of double-strand breaks in DNA during vegetative growth and meiosis; forms heterodimer with Rad57p
0.172 1.48E-23 YMR033W ARP9 het Component of both the SWI/SNF and RSC chromatin remodeling complexes; actin-related protein involved in transcriptional regulation
0.171 1.60E-23 YDR439W LRS4 hom Nucleolar protein that forms a complex with Csm1p, and then Mam1p at kinetochores during meiosis I to mediate accurate homolog segregation; required for condensin recruitment to the replication fork barrier site and rDNA repeat segregation
0.170 3.32E-23 YJL148W RPA34 hom RNA polymerase I subunit A34.5
0.170 3.54E-23 YDL150W RPC53 het RNA polymerase III subunit C53
0.169 5.28E-23 YFL002C SPB4 het Putative ATP-dependent RNA helicase, nucleolar protein required for synthesis of 60S ribosomal subunits at a late step in the pathway; sediments with 66S pre-ribosomes in sucrose gradients
0.167 2.00E-22 YJL092W SRS2 hom DNA helicase and DNA-dependent ATPase involved in DNA repair and checkpoint recovery, needed for proper timing of commitment to meiotic recombination and transition from Meiosis I to II; blocks trinucleotide repeat expansion; affects genome stability