YDR226W / ADK1

Adenylate kinase, required for purine metabolism; localized to the cytoplasm and the mitochondria; lacks cleavable signal sequence; protein abundance increases in response to DNA replication stress

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR226W / ADK1

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:1.97E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.40|P-value:7.44E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.23|P-value:3.85E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-5.36|P-value:3.71E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:4.40|P-value:2.00E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.44|P-value:6.41E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.09|P-value:6.76E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.86|P-value:1.53E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.62|P-value:3.57E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.89|P-value:1.41E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.88|P-value:1.45E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.49|P-value:6.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.85|P-value:2.98E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:5.17|P-value:7.18E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:3.37|P-value:8.15E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.50|P-value:1.31E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.54|P-value:1.12E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.19|P-value:4.55E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.47|P-value:5.88E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.36|P-value:8.36E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.56|P-value:4.42E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.21|P-value:5.89E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.43|P-value:1.77E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.04|P-value:8.04E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.61|P-value:3.74E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.72|P-value:2.54E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.40|P-value:7.37E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.41|P-value:1.90E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.64|P-value:3.10E-10 ID:SGTC_1547|Compound:harmine|FD-Score:3.82|P-value:1.77E-4 ID:SGTC_1648|Compound:st011736|FD-Score:5.07|P-value:1.12E-6 ID:SGTC_1651|Compound:st011928|FD-Score:4.80|P-value:3.80E-6 ID:SGTC_1663|Compound:st014140|FD-Score:3.34|P-value:8.94E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.96|P-value:1.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.00|P-value:1.08E-8 ID:SGTC_1694|Compound:st024011|FD-Score:3.99|P-value:9.66E-5 ID:SGTC_1838|Compound:st055369|FD-Score:4.10|P-value:6.41E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.41|P-value:7.17E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.76|P-value:2.24E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.25|P-value:4.37E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-3.44|P-value:7.60E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.83|P-value:3.28E-6 ID:SGTC_2343|Compound:7990716|FD-Score:4.36|P-value:2.30E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.65|P-value:3.86E-4 ID:SGTC_2358|Compound:9037157|FD-Score:5.67|P-value:6.30E-8 ID:SGTC_2532|Compound:xanthone|FD-Score:3.59|P-value:3.99E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.38|P-value:7.84E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.01|P-value:9.01E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.89|P-value:2.50E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.89|P-value:1.39E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:10.70|P-value:1.82E-23 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.49|P-value:7.40E-10 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.09|P-value:8.22E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.30|P-value:9.93E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.84|P-value:1.68E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.32|P-value:9.60E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.55|P-value:4.50E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.37|P-value:2.28E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.66|P-value:3.14E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.42|P-value:8.29E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-3.85|P-value:1.97E-4 ID:SGTC_143|Compound:4032-1194|FD-Score:3.40|P-value:7.44E-4 ID:SGTC_160|Compound:3453-0671|FD-Score:4.23|P-value:3.85E-5 ID:SGTC_161|Compound:4065-0411|FD-Score:-5.36|P-value:3.71E-7 ID:SGTC_207|Compound:4185-0010|FD-Score:4.40|P-value:2.00E-5 ID:SGTC_254|Compound:nsc-64875|FD-Score:3.44|P-value:6.41E-4 ID:SGTC_255|Compound:tunicamycin|FD-Score:4.09|P-value:6.76E-5 ID:SGTC_309|Compound:k408-0051|FD-Score:3.86|P-value:1.53E-4 ID:SGTC_312|Compound:4092-0653|FD-Score:3.62|P-value:3.57E-4 ID:SGTC_349|Compound:k015-0014|FD-Score:3.89|P-value:1.41E-4 ID:SGTC_364|Compound:0083-0097|FD-Score:3.88|P-value:1.45E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:-3.49|P-value:6.53E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:4.85|P-value:2.98E-6 ID:SGTC_605|Compound:1315-0399|FD-Score:5.17|P-value:7.18E-7 ID:SGTC_614|Compound:0462-0418|FD-Score:3.37|P-value:8.15E-4 ID:SGTC_637|Compound:1181-0519|FD-Score:4.50|P-value:1.31E-5 ID:SGTC_669|Compound:0108-0021|FD-Score:4.54|P-value:1.12E-5 ID:SGTC_782|Compound:0083-0095|FD-Score:4.19|P-value:4.55E-5 ID:SGTC_830|Compound:4076-0286|FD-Score:3.47|P-value:5.88E-4 ID:SGTC_878|Compound:0828-0289|FD-Score:3.36|P-value:8.36E-4 ID:SGTC_919|Compound:tnp00227|FD-Score:3.56|P-value:4.42E-4 ID:SGTC_1001|Compound:4048-4355|FD-Score:5.21|P-value:5.89E-7 ID:SGTC_1014|Compound:4130-3005|FD-Score:3.87|P-value:1.50E-4 ID:SGTC_1049|Compound:3226-0134|FD-Score:4.43|P-value:1.77E-5 ID:SGTC_1120|Compound:ficusin|FD-Score:4.04|P-value:8.04E-5 ID:SGTC_1224|Compound:0823-0416|FD-Score:3.61|P-value:3.74E-4 ID:SGTC_1232|Compound:0279-0259|FD-Score:3.72|P-value:2.54E-4 ID:SGTC_1389|Compound:3405-0187|FD-Score:3.40|P-value:7.37E-4 ID:SGTC_1425|Compound:4048-4433|FD-Score:4.41|P-value:1.90E-5 ID:SGTC_1525|Compound:8-methoxypsoralen|FD-Score:6.64|P-value:3.10E-10 ID:SGTC_1547|Compound:harmine|FD-Score:3.82|P-value:1.77E-4 ID:SGTC_1648|Compound:st011736|FD-Score:5.07|P-value:1.12E-6 ID:SGTC_1651|Compound:st011928|FD-Score:4.80|P-value:3.80E-6 ID:SGTC_1663|Compound:st014140|FD-Score:3.34|P-value:8.94E-4 ID:SGTC_1676|Compound:st018489|FD-Score:3.96|P-value:1.09E-4 ID:SGTC_1687|Compound:st020778|FD-Score:6.00|P-value:1.08E-8 ID:SGTC_1694|Compound:st024011|FD-Score:3.99|P-value:9.66E-5 ID:SGTC_1838|Compound:st055369|FD-Score:4.10|P-value:6.41E-5 ID:SGTC_1915|Compound:st067105|FD-Score:3.41|P-value:7.17E-4 ID:SGTC_2217|Compound:6934799|FD-Score:3.76|P-value:2.24E-4 ID:SGTC_2297|Compound:7971671|FD-Score:-4.25|P-value:4.37E-5 ID:SGTC_2310|Compound:7668677|FD-Score:-3.44|P-value:7.60E-4 ID:SGTC_2332|Compound:7982454|FD-Score:4.83|P-value:3.28E-6 ID:SGTC_2343|Compound:7990716|FD-Score:4.36|P-value:2.30E-5 ID:SGTC_2351|Compound:9026858|FD-Score:-3.65|P-value:3.86E-4 ID:SGTC_2358|Compound:9037157|FD-Score:5.67|P-value:6.30E-8 ID:SGTC_2532|Compound:xanthone|FD-Score:3.59|P-value:3.99E-4 ID:SGTC_2578|Compound:7,8-dihydroxyflavone|FD-Score:3.38|P-value:7.84E-4 ID:SGTC_2582|Compound:agaric acid|FD-Score:4.01|P-value:9.01E-5 ID:SGTC_2618|Compound:avocadyne|FD-Score:4.89|P-value:2.50E-6 ID:SGTC_2622|Compound:2-methoxyxanthone|FD-Score:3.89|P-value:1.39E-4 ID:SGTC_2658|Compound:polymyxin b sulfate|FD-Score:10.70|P-value:1.82E-23 ID:SGTC_2741|Compound:miltefosine|FD-Score:6.49|P-value:7.40E-10 ID:SGTC_2763|Compound:lisinopril|FD-Score:-4.09|P-value:8.22E-5 ID:SGTC_2836|Compound:9010338|FD-Score:3.30|P-value:9.93E-4 ID:SGTC_2909|Compound:7941780|FD-Score:3.84|P-value:1.68E-4 ID:SGTC_2987|Compound:9018338|FD-Score:3.32|P-value:9.60E-4 ID:SGTC_3004|Compound:9076122|FD-Score:3.55|P-value:4.50E-4 ID:SGTC_3027|Compound:9089541|FD-Score:4.37|P-value:2.28E-5 ID:SGTC_3044|Compound:9093193|FD-Score:3.66|P-value:3.14E-4 ID:SGTC_3219|Compound:9131112|FD-Score:-3.42|P-value:8.29E-4

Top fitness defect scores for YDR226W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_2658 polymyxin b sulfate 10.70 77.0 µM 1.82E-23 NEO1 6 8.37E-27
2 SGTC_1525 8-methoxypsoralen 6.64 92.5 µM 3.10E-10 DNA damage response 7 1.60E-11
3 SGTC_2741 miltefosine 6.49 3.0 µM 7.40E-10 17 4.37E-11
4 SGTC_1687 st020778 6.00 55.4 µM 1.08E-8 111 9.58E-10
5 SGTC_2358 9037157 5.67 4.0 µM 6.30E-8 7 7.28E-9
6 SGTC_1001 4048-4355 5.21 44.4 µM 5.89E-7 copper-dependent oxidative stress 17 9.52E-8
7 SGTC_605 1315-0399 5.17 119.0 µM 7.18E-7 Golgi 8 1.20E-7
8 SGTC_1648 st011736 5.07 69.8 µM 1.12E-6 PDR1 4 1.98E-7
9 SGTC_2618 avocadyne 4.89 43.4 µM 2.50E-6 26 5.01E-7
10 SGTC_568 1193-0097 4.85 7.5 µM 2.98E-6 ERAD & cell cycle 92 6.14E-7
11 SGTC_2332 7982454 4.83 138.9 µM 3.28E-6 30 6.85E-7
12 SGTC_1651 st011928 4.80 86.1 µM 3.80E-6 RSC complex & mRNA processing 7 8.11E-7
13 SGTC_669 0108-0021 4.54 26.2 µM 1.12E-5 fatty acid desaturase (OLE1) 56 2.81E-6
14 SGTC_637 1181-0519 4.50 7.3 µM 1.31E-5 fatty acid desaturase (OLE1) 83 3.36E-6
15 SGTC_1049 3226-0134 4.43 66.0 µM 1.77E-5 21 4.73E-6
16 SGTC_1425 4048-4433 4.41 7.3 µM 1.90E-5 copper-dependent oxidative stress 27 5.13E-6
17 SGTC_207 4185-0010 4.40 4.5 µM 2.00E-5 endomembrane recycling 72 5.47E-6
18 SGTC_3027 9089541 4.37 49.5 µM 2.28E-5 fatty acid desaturase (OLE1) 14 6.32E-6
19 SGTC_2343 7990716 4.36 14.8 µM 2.30E-5 12 6.40E-6
20 SGTC_160 3453-0671 4.23 289.7 µM 3.85E-5 32 1.16E-5

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.117 1.15E-11 YOR290C SNF2 hom Catalytic subunit of the SWI/SNF chromatin remodeling complex involved in transcriptional regulation; contains DNA-stimulated ATPase activity; functions interdependently in transcriptional activation with Snf5p and Snf6p
0.115 2.38E-11 YOL051W GAL11 hom Subunit of the RNA polymerase II mediator complex; associates with core polymerase subunits to form the RNA polymerase II holoenzyme; affects transcription by acting as target of activators and repressors; forms part of the tail domain of mediator
0.115 2.42E-11 YPL057C SUR1 hom Mannosylinositol phosphorylceramide (MIPC) synthase catalytic subunit; forms a complex with regulatory subunit Csg2p; function in sphingolipid biosynthesis is overlapping with that of Csh1p; SUR1 has a paralog, CSH1, that arose from the whole genome duplication
0.114 4.06E-11 YNL199C GCR2 hom Transcriptional activator of genes involved in glycolysis; interacts and functions with the DNA-binding protein Gcr1p
0.113 5.29E-11 YDR456W NHX1 hom Na+/H+ and K+/H+ exchanger, required for intracellular sequestration of Na+ and K+; located in the vacuole and late endosome compartments; required for osmotolerance to acute hypertonic shock and for vacuolar fusion
0.113 6.42E-11 YDR372C VPS74 hom Golgi phosphatidylinositol-4-kinase effector and PtdIns4P sensor; interacts with the cytosolic domains of cis and medial glycosyltransferases, and in the PtdIns4P-bound state mediates the targeting of these enzymes to the Golgi; interacts with the catalytic domain of Sac1p, the major cellular PtdIns4P phosphatase, to direct dephosphosphorylation of the Golgi pool of PtdIns4P; tetramerization required for function; ortholog of human GOLPH3/GPP34/GMx33
0.110 1.73E-10 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.110 2.02E-10 YFL034W_p YFL034W_p hom Putative integral membrane protein that interacts with Rpp0p, which is a component of the ribosomal stalk
0.109 2.39E-10 YKL190W CNB1 hom Calcineurin B; the regulatory subunit of calcineurin, a Ca++/calmodulin-regulated type 2B protein phosphatase which regulates Crz1p (a stress-response transcription factor), the other calcineurin subunit is encoded by CNA1 and/or CMP1; protein abundance increases in response to DNA replication stress
0.108 3.30E-10 YDR225W HTA1 hom Histone H2A, core histone protein required for chromatin assembly and chromosome function; one of two nearly identical subtypes (see also HTA2); DNA damage-dependent phosphorylation by Mec1p facilitates DNA repair; acetylated by Nat4p
0.106 7.61E-10 YOL050C_d YOL050C_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; overlaps verified gene GAL11; deletion confers sensitivity to 4-(N-(S-glutathionylacetyl)amino) phenylarsenoxide (GSAO)
0.106 8.55E-10 YNL147W LSM7 hom Lsm (Like Sm) protein; part of heteroheptameric complexes (Lsm2p-7p and either Lsm1p or 8p): cytoplasmic Lsm1p complex involved in mRNA decay; nuclear Lsm8p complex part of U6 snRNP and possibly involved in processing tRNA, snoRNA, and rRNA; protein abundance increases and forms cytoplasmic foci in response to DNA replication stress
0.105 1.09E-9 YKL135C APL2 hom Beta-adaptin subunit of the clathrin-associated protein (AP-1) complex; binds clathrin; involved in clathrin-dependent Golgi protein sorting; protein abundance increases in response to DNA replication stress
0.104 1.30E-9 YAL002W VPS8 hom Membrane-binding component of the CORVET complex; involved in endosomal vesicle tethering and fusion in the endosome to vacuole protein targeting pathway; interacts with Vps21p; contains RING finger motif
0.101 4.76E-9 YDR297W SUR2 hom Sphinganine C4-hydroxylase, catalyses the conversion of sphinganine to phytosphingosine in sphingolipid biosyntheis