YDR229W / IVY1

Phospholipid-binding protein that interacts with both Ypt7p and Vps33p, may partially counteract the action of Vps33p and vice versa, localizes to the rim of the vacuole as cells approach stationary phase

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR229W / IVY1

Click on Significant Values for Screen Details ID:SGTC_22|Compound:0964-0034|FD-Score:5.39|P-value:8.96E-8 ID:SGTC_26|Compound:0302-0163|FD-Score:3.35|P-value:5.72E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.19|P-value:2.57E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.75|P-value:2.18E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:4.07|P-value:3.91E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.27|P-value:1.89E-5 ID:SGTC_276|Compound:colchicine|FD-Score:-3.57|P-value:2.82E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.23|P-value:8.79E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.36|P-value:5.54E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.24|P-value:8.36E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.37|P-value:5.62E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.22|P-value:2.19E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.23|P-value:2.05E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.20|P-value:9.66E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.22|P-value:2.19E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.44|P-value:6.91E-8 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.12|P-value:3.30E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.91|P-value:7.53E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.20|P-value:9.45E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.68|P-value:2.89E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.36|P-value:5.80E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.19|P-value:9.85E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.36|P-value:1.20E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.27|P-value:7.91E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.34|P-value:5.95E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.94|P-value:6.74E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.65|P-value:2.15E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.54|P-value:2.95E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-5.27|P-value:1.80E-7 ID:SGTC_2897|Compound:9048598|FD-Score:-3.31|P-value:6.99E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.21|P-value:9.77E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.60|P-value:2.56E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.60|P-value:2.39E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.45|P-value:4.08E-4 ID:SGTC_22|Compound:0964-0034|FD-Score:5.39|P-value:8.96E-8 ID:SGTC_26|Compound:0302-0163|FD-Score:3.35|P-value:5.72E-4 ID:SGTC_43|Compound:0570-0105|FD-Score:3.78|P-value:1.26E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:-4.19|P-value:2.57E-5 ID:SGTC_138|Compound:0850-0259|FD-Score:-4.75|P-value:2.18E-6 ID:SGTC_139|Compound:0099-0334|FD-Score:4.07|P-value:3.91E-5 ID:SGTC_158|Compound:k038-0087|FD-Score:-4.27|P-value:1.89E-5 ID:SGTC_276|Compound:colchicine|FD-Score:-3.57|P-value:2.82E-4 ID:SGTC_358|Compound:0075-0058|FD-Score:3.23|P-value:8.79E-4 ID:SGTC_411|Compound:enrofloxacin|FD-Score:3.36|P-value:5.54E-4 ID:SGTC_425|Compound:3825-7017|FD-Score:3.24|P-value:8.36E-4 ID:SGTC_773|Compound:4358-1457|FD-Score:-3.37|P-value:5.62E-4 ID:SGTC_1006|Compound:4099-6547|FD-Score:4.22|P-value:2.19E-5 ID:SGTC_1047|Compound:2043-3044|FD-Score:4.23|P-value:2.05E-5 ID:SGTC_1129|Compound:3453-1384|FD-Score:3.20|P-value:9.66E-4 ID:SGTC_1130|Compound:3454-2858|FD-Score:4.22|P-value:2.19E-5 ID:SGTC_1134|Compound:3477-0009|FD-Score:5.44|P-value:6.91E-8 ID:SGTC_1135|Compound:dihydrocapsaicin|FD-Score:3.58|P-value:2.64E-4 ID:SGTC_1422|Compound:4031-0024|FD-Score:4.12|P-value:3.30E-5 ID:SGTC_1587|Compound:estradiol valerate|FD-Score:3.91|P-value:7.53E-5 ID:SGTC_1616|Compound:st002734|FD-Score:3.20|P-value:9.45E-4 ID:SGTC_1674|Compound:st016616|FD-Score:4.68|P-value:2.89E-6 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:-3.36|P-value:5.80E-4 ID:SGTC_2050|Compound:5263056|FD-Score:3.19|P-value:9.85E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:4.36|P-value:1.20E-5 ID:SGTC_2410|Compound:aloe-emodin-8-o-glycoside|FD-Score:-3.27|P-value:7.91E-4 ID:SGTC_2420|Compound:aureobasidin a|FD-Score:3.34|P-value:5.95E-4 ID:SGTC_2499|Compound:avocadenofuran|FD-Score:3.94|P-value:6.74E-5 ID:SGTC_2596|Compound:sinensetin|FD-Score:-3.65|P-value:2.15E-4 ID:SGTC_2819|Compound:7996655|FD-Score:3.54|P-value:2.95E-4 ID:SGTC_2837|Compound:9008476|FD-Score:-5.27|P-value:1.80E-7 ID:SGTC_2897|Compound:9048598|FD-Score:-3.31|P-value:6.99E-4 ID:SGTC_2923|Compound:7992654|FD-Score:-3.21|P-value:9.77E-4 ID:SGTC_3083|Compound:9117465|FD-Score:-3.60|P-value:2.56E-4 ID:SGTC_3144|Compound:9087057|FD-Score:3.60|P-value:2.39E-4 ID:SGTC_3190|Compound:9110366|FD-Score:3.45|P-value:4.08E-4

Top fitness defect scores for YDR229W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1134 3477-0009 5.44 42.5 µM 6.91E-8 15 2.71E-8
2 SGTC_22 0964-0034 5.39 14.5 µM 8.96E-8 unfolded protein response 23 3.58E-8
3 SGTC_1674 st016616 4.68 23.6 µM 2.89E-6 14 1.44E-6
4 SGTC_2409 alverine citrate 4.36 64.0 µM 1.20E-5 44 6.54E-6
5 SGTC_1047 2043-3044 4.23 82.0 µM 2.05E-5 23 1.16E-5
6 SGTC_1130 3454-2858 4.22 15.9 µM 2.19E-5 NEO1 75 1.24E-5
7 SGTC_1006 4099-6547 4.22 255.0 µM 2.19E-5 13 1.24E-5
8 SGTC_1422 4031-0024 4.12 15.5 µM 3.30E-5 iron homeostasis 16 1.93E-5
9 SGTC_139 0099-0334 4.07 718.6 µM 3.91E-5 27 2.31E-5
10 SGTC_2499 avocadenofuran 3.94 51.5 µM 6.74E-5 37 4.11E-5
11 SGTC_1587 estradiol valerate 3.91 56.1 µM 7.53E-5 13 4.62E-5
12 SGTC_43 0570-0105 3.78 72.5 µM 1.26E-4 ERG2 108 7.99E-5
13 SGTC_3144 9087057 3.60 49.5 µM 2.39E-4 23 1.58E-4
14 SGTC_1135 dihydrocapsaicin 3.58 536.7 nM 2.64E-4 47 1.75E-4
15 SGTC_2819 7996655 3.54 46.4 µM 2.95E-4 31 1.97E-4
16 SGTC_3190 9110366 3.45 49.5 µM 4.08E-4 20 2.78E-4
17 SGTC_411 enrofloxacin 3.36 100.0 µM 5.54E-4 DNA damage response 21 3.85E-4
18 SGTC_26 0302-0163 3.35 425.2 µM 5.72E-4 heme biosynthesis & mitochondrial translocase 21 3.98E-4
19 SGTC_2420 aureobasidin a 3.34 50.0 nM 5.95E-4 70 4.15E-4
20 SGTC_425 3825-7017 3.24 13.1 µM 8.36E-4 52 5.95E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.109 2.55E-10 YHR175W-A_p YHR175W-A_p hom Putative protein of unknown function; identified by fungal homology and RT-PCR
0.093 6.41E-8 YDR367W KEI1 het Component of inositol phosphorylceramide (IPC) synthase; forms a complex with Aur1p and regulates its activity; required for IPC synthase complex localization to the Golgi; post-translationally processed by Kex2p; KEI1 is an essential gene
0.092 9.71E-8 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.089 2.29E-7 YFL031W HAC1 hom Basic leucine zipper (bZIP) transcription factor (ATF/CREB1 homolog); regulates the unfolded protein response, via UPRE binding, and membrane biogenesis; ER stress-induced splicing pathway facilitates efficient Hac1p synthesis; protein abundance increases in response to DNA replication stress
0.087 4.58E-7 YNL219C ALG9 hom Mannosyltransferase, involved in N-linked glycosylation; catalyzes both the transfer of seventh mannose residue on B-arm and ninth mannose residue on the C-arm from Dol-P-Man to lipid-linked oligosaccharides; mutation of the human ortholog causes type 1 congenital disorders of glycosylation
0.086 5.40E-7 YDR313C PIB1 hom RING-type ubiquitin ligase of the endosomal and vacuolar membranes, binds phosphatidylinositol(3)-phosphate; contains a FYVE finger domain
0.086 5.65E-7 YER013W PRP22 het DEAH-box RNA-dependent ATPase/ATP-dependent RNA helicase, associates with lariat intermediates before the second catalytic step of splicing; mediates ATP-dependent mRNA release from the spliceosome and unwinds RNA duplexes
0.086 6.35E-7 YER007C-A TMA20 hom Protein of unknown function that associates with ribosomes; has a putative RNA binding domain; interacts with Tma22p; null mutant exhibits translation defects; has homology to human oncogene MCT-1; protein abundance increases in response to DNA replication stress
0.085 7.92E-7 YOR007C SGT2 hom Glutamine-rich cytoplasmic cochaperone; serves as a scaffold bringing together Get4, Get5p, and other TRC complex members that are required to mediate posttranslational insertion of tail-anchored proteins into the ER membrane; interacts with the prion domain of Sup35p; amyloid sensor; plays a role in targeting chaperones to prion aggregates; has similarity to human cochaperone SGT; forms cytoplasmic foci upon DNA replication stress
0.083 1.31E-6 YLR291C GCD7 het Beta subunit of the translation initiation factor eIF2B, the guanine-nucleotide exchange factor for eIF2; activity subsequently regulated by phosphorylated eIF2; first identified as a negative regulator of GCN4 expression
0.083 1.51E-6 YLL019C KNS1 hom Protein kinase involved in negative regulation of PolIII transcription; effector kinase of the TOR signaling pathway and phosphorylates Rpc53p to regulate ribosome and tRNA biosynthesis; member of the LAMMER family of protein kinases, which are serine/threonine kinases also capable of phosphorylating tyrosine residues; capable of autophosphorylation
0.080 3.38E-6 YNL097C PHO23 hom Probable component of the Rpd3 histone deacetylase complex, involved in transcriptional regulation of PHO5; affects termination of snoRNAs and cryptic unstable transcripts (CUTs); C-terminus has similarity to human candidate tumor suppressor p33(ING1) and its isoform ING3
0.080 3.61E-6 YER159C BUR6 het Subunit of a heterodimeric NC2 transcription regulator complex with Ncb2p; complex binds to TBP and can repress transcription by preventing preinitiation complex assembly or stimulate activated transcription; homologous to human NC2alpha
0.079 4.74E-6 YNL001W DOM34 hom Protein that facilitates ribosomal subunit dissociation; acts when translation is stalled, with binding partner Hbs1p; required for RNA cleavage in no-go decay, but reports conflict on endonuclease activity; Pelota ortholog; protein abundance increases in response to DNA replication stress; DOM34 has a paralog, YCL001W-B, that arose from the whole genome duplication
0.078 6.63E-6 YOL162W_p YOL162W_p hom Putative protein of unknown function; member of the Dal5p subfamily of the major facilitator family