YDR234W / LYS4

Homoaconitase, catalyzes the conversion of homocitrate to homoisocitrate, which is a step in the lysine biosynthesis pathway

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR234W / LYS4

Click on Significant Values for Screen Details ID:SGTC_25|Compound:0118-0223|FD-Score:3.14|P-value:9.97E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.11|P-value:8.99E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.57|P-value:3.22E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.34|P-value:4.09E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.23|P-value:5.94E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.22|P-value:1.23E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.61|P-value:1.91E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-5.31|P-value:5.62E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.52|P-value:2.61E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.16|P-value:7.68E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.48|P-value:2.49E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.22|P-value:1.61E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.11|P-value:2.00E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.37|P-value:4.53E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.18|P-value:8.81E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.39|P-value:4.21E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.45|P-value:3.38E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:6.30|P-value:2.40E-10 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.47|P-value:5.19E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.83|P-value:7.91E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.79|P-value:1.12E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.58|P-value:1.68E-4 ID:SGTC_1777|Compound:st045864|FD-Score:5.29|P-value:8.93E-8 ID:SGTC_1802|Compound:st050112|FD-Score:-3.19|P-value:6.92E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.45|P-value:4.39E-6 ID:SGTC_2145|Compound:5634607|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.66|P-value:1.57E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.47|P-value:3.17E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.92|P-value:5.52E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.70|P-value:1.73E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.18|P-value:7.22E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.70|P-value:9.22E-9 ID:SGTC_2917|Compound:7979103|FD-Score:3.40|P-value:4.07E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.09|P-value:2.78E-5 ID:SGTC_3015|Compound:9080845|FD-Score:3.42|P-value:3.76E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.16|P-value:7.59E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.27|P-value:6.41E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.27|P-value:6.55E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.44|P-value:2.83E-4 ID:SGTC_25|Compound:0118-0223|FD-Score:3.14|P-value:9.97E-4 ID:SGTC_148|Compound:3253-0744|FD-Score:-3.11|P-value:8.99E-4 ID:SGTC_152|Compound:4469-0003|FD-Score:4.57|P-value:3.22E-6 ID:SGTC_155|Compound:k072-0202|FD-Score:3.59|P-value:2.02E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:-3.34|P-value:4.09E-4 ID:SGTC_376|Compound:3970-0862|FD-Score:-3.23|P-value:5.94E-4 ID:SGTC_619|Compound:1652-1634|FD-Score:-4.22|P-value:1.23E-5 ID:SGTC_776|Compound:4476-4378|FD-Score:3.61|P-value:1.91E-4 ID:SGTC_791|Compound:1348-1292|FD-Score:-5.31|P-value:5.62E-8 ID:SGTC_917|Compound:harmaline|FD-Score:3.52|P-value:2.61E-4 ID:SGTC_937|Compound:3122-0005|FD-Score:-3.16|P-value:7.68E-4 ID:SGTC_1010|Compound:4112-3296|FD-Score:-3.48|P-value:2.49E-4 ID:SGTC_1026|Compound:k007-1105|FD-Score:4.22|P-value:1.61E-5 ID:SGTC_1132|Compound:3456-3614|FD-Score:-4.11|P-value:2.00E-5 ID:SGTC_1137|Compound:ixabepilone|FD-Score:3.37|P-value:4.53E-4 ID:SGTC_1277|Compound:0873-0036|FD-Score:3.18|P-value:8.81E-4 ID:SGTC_1300|Compound:1094-0077|FD-Score:3.39|P-value:4.21E-4 ID:SGTC_1412|Compound:3909-8563|FD-Score:3.45|P-value:3.38E-4 ID:SGTC_1431|Compound:4049-0260|FD-Score:6.30|P-value:2.40E-10 ID:SGTC_1439|Compound:4092-1168|FD-Score:4.47|P-value:5.19E-6 ID:SGTC_1476|Compound:4112-3294|FD-Score:3.83|P-value:7.91E-5 ID:SGTC_1477|Compound:0139-0234|FD-Score:4.79|P-value:1.12E-6 ID:SGTC_1637|Compound:st007924|FD-Score:-3.58|P-value:1.68E-4 ID:SGTC_1777|Compound:st045864|FD-Score:5.29|P-value:8.93E-8 ID:SGTC_1802|Compound:st050112|FD-Score:-3.19|P-value:6.92E-4 ID:SGTC_1957|Compound:st077035|FD-Score:3.36|P-value:4.77E-4 ID:SGTC_2056|Compound:5235370|FD-Score:-4.45|P-value:4.39E-6 ID:SGTC_2145|Compound:5634607|FD-Score:3.20|P-value:8.27E-4 ID:SGTC_2343|Compound:7990716|FD-Score:3.66|P-value:1.57E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.47|P-value:3.17E-4 ID:SGTC_2419|Compound:paclitaxel|FD-Score:3.92|P-value:5.52E-5 ID:SGTC_2542|Compound:2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene|FD-Score:4.70|P-value:1.73E-6 ID:SGTC_2588|Compound:indole-3-carbinol|FD-Score:-3.18|P-value:7.22E-4 ID:SGTC_2601|Compound:securinine|FD-Score:5.70|P-value:9.22E-9 ID:SGTC_2917|Compound:7979103|FD-Score:3.40|P-value:4.07E-4 ID:SGTC_2943|Compound:9068529|FD-Score:4.09|P-value:2.78E-5 ID:SGTC_3015|Compound:9080845|FD-Score:3.42|P-value:3.76E-4 ID:SGTC_3096|Compound:9117468|FD-Score:-3.16|P-value:7.59E-4 ID:SGTC_3146|Compound:9095609|FD-Score:3.27|P-value:6.41E-4 ID:SGTC_3147|Compound:9097027|FD-Score:3.27|P-value:6.55E-4 ID:SGTC_3202|Compound:9113761|FD-Score:-3.44|P-value:2.83E-4

Top fitness defect scores for YDR234W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_1431 4049-0260 6.30 9.1 µM 2.40E-10 1 1.50E-10
2 SGTC_2601 securinine 5.70 100.0 µM 9.22E-9 6 6.16E-9
3 SGTC_1777 st045864 5.29 34.8 µM 8.93E-8 2 6.23E-8
4 SGTC_1477 0139-0234 4.79 16.0 µM 1.12E-6 3 8.16E-7
5 SGTC_2542 2-hydroxy-5 (6)epoxy-tetrahydrocaryophyllene 4.70 100.0 µM 1.73E-6 4 1.28E-6
6 SGTC_152 4469-0003 4.57 551.2 µM 3.22E-6 14 2.41E-6
7 SGTC_1439 4092-1168 4.47 46.0 µM 5.19E-6 4 3.92E-6
8 SGTC_1026 k007-1105 4.22 30.6 µM 1.61E-5 ERAD & cell cycle 89 1.24E-5
9 SGTC_2943 9068529 4.09 45.3 µM 2.78E-5 18 2.17E-5
10 SGTC_2419 paclitaxel 3.92 166.5 µM 5.52E-5 43 4.36E-5
11 SGTC_1476 4112-3294 3.83 3.3 µM 7.91E-5 60S ribosome export 17 6.30E-5
12 SGTC_2343 7990716 3.66 14.8 µM 1.57E-4 27 1.26E-4
13 SGTC_776 4476-4378 3.61 112.0 µM 1.91E-4 ERG2 27 1.55E-4
14 SGTC_155 k072-0202 3.59 43.6 µM 2.02E-4 23 1.64E-4
15 SGTC_917 harmaline 3.52 728.1 nM 2.61E-4 ergosterol biosynthesis 44 2.13E-4
16 SGTC_2344 7990960 3.47 77.0 µM 3.17E-4 41 2.60E-4
17 SGTC_1412 3909-8563 3.45 178.0 µM 3.38E-4 18 2.77E-4
18 SGTC_3015 9080845 3.42 49.5 µM 3.76E-4 17 3.09E-4
19 SGTC_2917 7979103 3.40 53.8 µM 4.07E-4 50 3.35E-4
20 SGTC_1300 1094-0077 3.39 113.0 µM 4.21E-4 22 3.47E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.201 7.80E-32 YNR013C PHO91 hom Low-affinity phosphate transporter of the vacuolar membrane; deletion of pho84, pho87, pho89, pho90, and pho91 causes synthetic lethality; transcription independent of Pi and Pho4p activity; overexpression results in vigorous growth
0.175 1.93E-24 YKL094W YJU3 hom Monoglyceride lipase (MGL), functional ortholog of mammalian MGL, localizes to lipid particles and membranes, also member of the eukaryotic serine hydrolase family
0.151 1.55E-18 YDR222W_p YDR222W_p hom Protein of unknown function; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm in a punctate pattern
0.145 3.33E-17 YFL042C_p YFL042C_p hom Putative protein of unknown function; YFL042C is not an essential gene
0.143 7.40E-17 YGL242C_p YGL242C_p hom Putative protein of unknown function; deletion mutant is viable
0.135 4.84E-15 YGL156W AMS1 hom Vacuolar alpha mannosidase, involved in free oligosaccharide (fOS) degradation; delivered to the vacuole in a novel pathway separate from the secretory pathway
0.131 2.46E-14 YGL203C KEX1 hom Protease involved in the processing of killer toxin and alpha factor precursor; cleaves Lys and Arg residues from the C-terminus of peptides and proteins
0.124 5.93E-13 YGR039W_d YGR039W_d hom Dubious open reading frame unlikely to encode a protein, based on available experimental and comparative sequence data; partially overlaps the Autonomously Replicating Sequence ARS722
0.113 5.56E-11 YKL030W_d YKL030W_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; partially overlaps the verified gene MAE1
0.111 9.92E-11 YIL099W SGA1 hom Intracellular sporulation-specific glucoamylase involved in glycogen degradation; induced during starvation of a/a diploids late in sporulation, but dispensable for sporulation
0.110 1.42E-10 YLR421C RPN13 hom Subunit of the 19S regulatory particle of the 26S proteasome lid; acts as a ubiquitin receptor for the proteasome; null mutants accumulate ubiquitinated Gcn4p and display decreased 26S proteasome stability; protein abundance increases in response to DNA replication stress
0.110 1.72E-10 YDL227C HO hom Site-specific endonuclease required for gene conversion at the MAT locus (homothallic switching) through the generation of a ds DNA break; expression restricted to mother cells in late G1 as controlled by Swi4p-Swi6p, Swi5p and Ash1p
0.109 2.63E-10 YPL249C GYP5 hom GTPase-activating protein (GAP) for yeast Rab family members; involved in ER to Golgi trafficking; exhibits GAP activity toward Ypt1p that is stimulated by Gyl1p, also acts on Sec4p; interacts with Gyl1p, Rvs161p and Rvs167p; involved in recruiting Rvs167p to the bud tip during polarized growth; relocalizes from bud neck to cytoplasm upon DNA replication stress
0.107 4.28E-10 YLR229C CDC42 het Small rho-like GTPase, essential for establishment and maintenance of cell polarity; mutants have defects in the organization of actin and septins
0.100 6.42E-9 YDL057W_p YDL057W_p hom Putative protein of unknown function; YDL057W is not an essential gene