YDR235W / PRP42

U1 snRNP protein involved in splicing, required for U1 snRNP biogenesis; contains multiple tetriatricopeptide repeats

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR235W / PRP42

Click on Significant Values for Screen Details ID:SGTC_24|Compound:0417-1663|FD-Score:-4.75|P-value:2.93E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.33|P-value:2.67E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-8.45|P-value:2.14E-19 ID:SGTC_124|Compound:0136-0217|FD-Score:2.93|P-value:7.73E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.05|P-value:4.99E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.09|P-value:4.30E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.35|P-value:2.24E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-5.28|P-value:1.33E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.08|P-value:6.32E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.95|P-value:7.16E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.04|P-value:7.33E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.00|P-value:8.36E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.11|P-value:5.60E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:3.23|P-value:2.44E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.77|P-value:3.75E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.08|P-value:4.48E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-2.95|P-value:9.98E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.12|P-value:5.48E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.40|P-value:1.25E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.32|P-value:2.53E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.21|P-value:3.93E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.60|P-value:7.98E-5 ID:SGTC_1694|Compound:st024011|FD-Score:3.74|P-value:2.80E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.91|P-value:1.98E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.72|P-value:4.75E-5 ID:SGTC_2225|Compound:6654152|FD-Score:3.47|P-value:9.08E-5 ID:SGTC_2240|Compound:6690706|FD-Score:3.73|P-value:2.93E-5 ID:SGTC_2243|Compound:6634756|FD-Score:4.02|P-value:7.75E-6 ID:SGTC_2335|Compound:9018011|FD-Score:-2.96|P-value:9.87E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.48|P-value:8.76E-5 ID:SGTC_2450|Compound:5739737|FD-Score:2.96|P-value:6.86E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.17|P-value:3.06E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-2.99|P-value:8.89E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.80|P-value:1.29E-7 ID:SGTC_2811|Compound:7967822|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.75|P-value:2.70E-5 ID:SGTC_3335|Compound:9143315|FD-Score:5.46|P-value:2.33E-9 ID:SGTC_24|Compound:0417-1663|FD-Score:-4.75|P-value:2.93E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.33|P-value:2.67E-6 ID:SGTC_116|Compound:0155-0182|FD-Score:-8.45|P-value:2.14E-19 ID:SGTC_124|Compound:0136-0217|FD-Score:2.93|P-value:7.73E-4 ID:SGTC_127|Compound:0180-0333|FD-Score:3.05|P-value:4.99E-4 ID:SGTC_132|Compound:0417-1715|FD-Score:3.09|P-value:4.30E-4 ID:SGTC_136|Compound:0097-0015|FD-Score:-3.35|P-value:2.24E-4 ID:SGTC_138|Compound:0850-0259|FD-Score:-5.28|P-value:1.33E-8 ID:SGTC_142|Compound:0335-0849|FD-Score:-3.08|P-value:6.32E-4 ID:SGTC_214|Compound:4373-3496|FD-Score:2.95|P-value:7.16E-4 ID:SGTC_221|Compound:trifluoperazine|FD-Score:-3.04|P-value:7.33E-4 ID:SGTC_240|Compound:5hr heat shock (37°C) + Streptovitacin|FD-Score:-3.00|P-value:8.36E-4 ID:SGTC_672|Compound:1441-0018|FD-Score:-3.11|P-value:5.60E-4 ID:SGTC_678|Compound:1218-2179|FD-Score:3.23|P-value:2.44E-4 ID:SGTC_679|Compound:0422-0091|FD-Score:-3.77|P-value:3.75E-5 ID:SGTC_693|Compound:4161-2696|FD-Score:3.08|P-value:4.48E-4 ID:SGTC_694|Compound:1315-0438|FD-Score:-2.95|P-value:9.98E-4 ID:SGTC_836|Compound:0330-0104|FD-Score:3.35|P-value:1.53E-4 ID:SGTC_911|Compound:3456-4043|FD-Score:-3.12|P-value:5.48E-4 ID:SGTC_920|Compound:mycophenolic acid|FD-Score:3.40|P-value:1.25E-4 ID:SGTC_927|Compound:2425-1185|FD-Score:-3.32|P-value:2.53E-4 ID:SGTC_998|Compound:3996-0085|FD-Score:-3.21|P-value:3.93E-4 ID:SGTC_1024|Compound:4507-0395|FD-Score:3.43|P-value:1.07E-4 ID:SGTC_1675|Compound:st018485|FD-Score:-3.60|P-value:7.98E-5 ID:SGTC_1694|Compound:st024011|FD-Score:3.74|P-value:2.80E-5 ID:SGTC_1717|Compound:st033143|FD-Score:-3.91|P-value:1.98E-5 ID:SGTC_1723|Compound:st034307|FD-Score:-3.72|P-value:4.75E-5 ID:SGTC_2225|Compound:6654152|FD-Score:3.47|P-value:9.08E-5 ID:SGTC_2240|Compound:6690706|FD-Score:3.73|P-value:2.93E-5 ID:SGTC_2243|Compound:6634756|FD-Score:4.02|P-value:7.75E-6 ID:SGTC_2335|Compound:9018011|FD-Score:-2.96|P-value:9.87E-4 ID:SGTC_2344|Compound:7990960|FD-Score:3.48|P-value:8.76E-5 ID:SGTC_2450|Compound:5739737|FD-Score:2.96|P-value:6.86E-4 ID:SGTC_2540|Compound:epiandrosterone|FD-Score:3.17|P-value:3.06E-4 ID:SGTC_2555|Compound:cholic acid|FD-Score:-2.99|P-value:8.89E-4 ID:SGTC_2804|Compound:7954240|FD-Score:4.80|P-value:1.29E-7 ID:SGTC_2811|Compound:7967822|FD-Score:3.02|P-value:5.58E-4 ID:SGTC_2835|Compound:9006588|FD-Score:3.75|P-value:2.70E-5 ID:SGTC_3335|Compound:9143315|FD-Score:5.46|P-value:2.33E-9

Top fitness defect scores for YDR235W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3335 9143315 5.46 29.6 µM 2.33E-9 fatty acid desaturase (OLE1) 4 2.36E-8 0.95
2 SGTC_2804 7954240 4.80 19.5 µM 1.29E-7 6 8.02E-7 0.16
3 SGTC_2243 6634756 4.02 200.0 µM 7.75E-6 4 2.95E-5 0.53
4 SGTC_2835 9006588 3.75 71.4 µM 2.70E-5 10 8.88E-5 6.55E-4
5 SGTC_1694 st024011 3.74 44.9 µM 2.80E-5 ERG2 8 9.16E-5 0.06
6 SGTC_2240 6690706 3.73 185.9 µM 2.93E-5 7 9.52E-5 0.17
7 SGTC_2344 7990960 3.48 77.0 µM 8.76E-5 49 2.50E-4 0.12
8 SGTC_2225 6654152 3.47 15.4 µM 9.08E-5 30 2.58E-4 0.30
9 SGTC_1024 4507-0395 3.43 26.0 µM 1.07E-4 TSC3-RPN4 16 2.97E-4 0.21
10 SGTC_920 mycophenolic acid 3.40 780.4 nM 1.25E-4 7 3.41E-4 0.09
11 SGTC_836 0330-0104 3.35 1.4 µM 1.53E-4 7 4.07E-4 0.00
12 SGTC_678 1218-2179 3.23 85.9 µM 2.44E-4 RNA pol III & RNase P/MRP 4 6.14E-4 0.13
13 SGTC_2540 epiandrosterone 3.17 100.0 µM 3.06E-4 10 7.51E-4 0.00
14 SGTC_132 0417-1715 3.09 25.8 µM 4.30E-4 RPP1 & pyrimidine depletion 17 0.00101 0.08
15 SGTC_693 4161-2696 3.08 114.0 µM 4.48E-4 10 0.00105 0.04
16 SGTC_127 0180-0333 3.05 59.1 µM 4.99E-4 mitochondrial response to ROS 5 0.00115 0.13
17 SGTC_2811 7967822 3.02 32.5 µM 5.58E-4 18 0.00127 0.13
18 SGTC_2450 5739737 2.96 12.9 µM 6.86E-4 12 0.00153 0.08
19 SGTC_214 4373-3496 2.95 70.0 µM 7.16E-4 36 0.00159 0.00
20 SGTC_124 0136-0217 2.93 7.1 µM 7.73E-4 mitochondrial stress 41 0.00170 0.03

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 2.53E-26 YKL152C GPM1 het Tetrameric phosphoglycerate mutase, mediates the conversion of 3-phosphoglycerate to 2-phosphoglycerate during glycolysis and the reverse reaction during gluconeogenesis
0.175 2.32E-24 YLR195C NMT1 het N-myristoyl transferase, catalyzes the cotranslational, covalent attachment of myristic acid to the N-terminal glycine residue of several proteins involved in cellular growth and signal transduction
0.169 7.69E-23 YBR155W CNS1 het TPR-containing co-chaperone; binds both Hsp82p (Hsp90) and Ssa1p (Hsp70) and stimulates the ATPase activity of SSA1, ts mutants reduce Hsp82p function while over expression suppresses the phenotypes of an HSP82 ts allele and a cpr7 deletion
0.167 2.95E-22 YDL153C SAS10 het Essential subunit of U3-containing Small Subunit (SSU) processome complex involved in production of 18S rRNA and assembly of small ribosomal subunit; disrupts silencing when overproduced; mutant has increased aneuploidy tolerance
0.161 7.74E-21 YER043C SAH1 het S-adenosyl-L-homocysteine hydrolase, catabolizes S-adenosyl-L-homocysteine which is formed after donation of the activated methyl group of S-adenosyl-L-methionine (AdoMet) to an acceptor
0.147 8.77E-18 YGR029W ERV1 het Flavin-linked sulfhydryl oxidase of the mitochondrial intermembrane space (IMS), oxidizes Mia40p as part of a disulfide relay system that promotes IMS retention of imported proteins; ortholog of human hepatopoietin (ALR)
0.138 1.27E-15 YNL163C RIA1 het Cytoplasmic GTPase/eEF2-like factor involved in ribosomal biogenesis; with Sdo1p, promotes release of Tif6p from 60S ribosomal subunits in the cytoplasm so that they can assemble with 40S subunits to generate mature ribosomes; required for quality control check of newly made large ribosomal subunits before they are released into the pool of translating ribosomes
0.134 7.58E-15 YOR159C SME1 het Core Sm protein Sm E; part of heteroheptameric complex (with Smb1p, Smd1p, Smd2p, Smd3p, Smx3p, and Smx2p) that is part of the spliceosomal U1, U2, U4, and U5 snRNPs; homolog of human Sm E
0.133 8.54E-15 YNL262W POL2 het Catalytic subunit of DNA polymerase (II) epsilon, a chromosomal DNA replication polymerase that exhibits processivity and proofreading exonuclease activity; also involved in DNA synthesis during DNA repair; interacts extensively with Mrc1p
0.133 1.31E-14 YHR019C DED81 het Cytosolic asparaginyl-tRNA synthetase, required for protein synthesis, catalyzes the specific attachment of asparagine to its cognate tRNA
0.127 1.30E-13 YDR054C CDC34 het Ubiquitin-conjugating enzyme (E2); catalytic subunit of SCF ubiquitin-protein ligase complex (together with Skp1p, Rbx1p, Cdc53p, and an F-box protein) that regulates cell cycle progression by targeting key substrates for degradation; protein abundance increases in response to DNA replication stress
0.121 1.99E-12 YIR011C STS1 het Protein required for localizing proteasomes to the nucleus; interacts with the karyopherin Srp1p; involved in ubiquitin-mediated protein degradation
0.120 3.50E-12 YBL004W UTP20 het Component of the small-subunit (SSU) processome, which is involved in the biogenesis of the 18S rRNA
0.119 3.99E-12 YJL174W KRE9 het Glycoprotein involved in cell wall beta-glucan assembly; null mutation leads to severe growth defects, aberrant multibudded morphology, and mating defects
0.117 1.01E-11 YOR103C OST2 het Epsilon subunit of the oligosaccharyltransferase complex of the ER lumen, which catalyzes asparagine-linked glycosylation of newly synthesized proteins