HIPHOP chemogenomics database

YDR236C / FMN1

Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane

Zygosity: Heterozygous strain

fixedexpanded
Profile for YDR236C / FMN1

Click on Significant Values for Screen Details

Top fitness defect scores for YDR236C deletion by condition

Rank	Screen ID	Condition	FD Score	Conc	P-value	Response Signature	Screen Rank	Screen P-value	Screen Clearance
1	SGTC_2810	7959871	5.16	45.5 µM	7.18E-9	copper-dependent oxidative stress	11	1.26E-7	0.63
2	SGTC_1716	st033144	5.05	30.6 µM	1.38E-8		3	2.16E-7	0.14
3	SGTC_2894	9048625	4.92	32.5 µM	3.25E-8		4	4.41E-7	0.31
4	SGTC_16	erodoxin	4.58	22.8 µM	2.41E-7	unfolded protein response	23	2.34E-6	0.04
5	SGTC_884	0851-0618	4.52	334.0 µM	3.46E-7		3	3.16E-6	0.66
6	SGTC_1919	st067113	4.48	52.3 µM	4.34E-7	TSC3-RPN4	6	3.81E-6	0.18
7	SGTC_2335	9018011	4.42	154.2 µM	6.02E-7		5	5.01E-6	0.07
8	SGTC_2104	5389443	4.08	200.0 µM	3.67E-6		4	2.26E-5	0.03
9	SGTC_896	0964-0007	4.00	44.5 µM	5.51E-6		9	3.17E-5	0.04
10	SGTC_1467	k284-1082	4.00	293.0 µM	5.60E-6		4	3.21E-5	0.58
11	SGTC_1715	st032160	3.73	10.2 µM	2.06E-5		8	9.53E-5	0.09
12	SGTC_2409	alverine citrate	3.68	64.0 µM	2.66E-5		17	1.18E-4	0.09
13	SGTC_2226	7298446	3.57	200.0 µM	4.28E-5		5	1.75E-4	0.12
14	SGTC_2347	9049783	3.55	174.8 µM	4.90E-5		2	1.96E-4	0.03
15	SGTC_3269	9137823	3.44	49.5 µM	7.94E-5	60S ribosome export	6	2.94E-4	0.03
16	SGTC_3284	9108171	3.43	64.9 µM	8.16E-5		6	3.00E-4	0.06
17	SGTC_2354	9060492	3.35	162.0 µM	1.18E-4		9	4.08E-4	0.01
18	SGTC_886	0866-0150	3.35	153.0 µM	1.18E-4		8	4.10E-4	0.05
19	SGTC_100	0086-0128	3.33	49.6 µM	1.26E-4	copper-dependent oxidative stress	14	4.31E-4	0.04
20	SGTC_1315	1237-0019	3.31	3.7 µM	1.38E-4		11	4.66E-4	0.01

Download Fitness data (tab-delimited text) (excel)

Cofit Genes

Download Cofitness data (tab-delimited text) (excel)

Correlation	pval	ORF	Gene	Zygosity	Description
0.182	1.98E-26	YBR083W	TEC1	hom	Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.134	6.33E-15	YML076C	WAR1	hom	Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.126	2.71E-13	YGL075C	MPS2	het	Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.121	2.28E-12	YML130C	ERO1	het	Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.112	1.01E-10	YPL244C	HUT1	hom	Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.109	2.41E-10	YDL045C	FAD1	het	Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.105	1.15E-9	YDR371W_p	CTS2_p	hom	Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.105	1.08E-9	YMR290C	HAS1	het	ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.102	3.04E-9	YOR056C	NOB1	het	Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.100	7.30E-9	YGR286C	BIO2	hom	Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
0.099	9.98E-9	YFL034C-B	MOB2	het	Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.098	1.32E-8	YOR017W	PET127	hom	Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane
0.096	2.81E-8	YEL001C	IRC22	hom	Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.092	9.45E-8	YPL099C	AIM43	hom	Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.091	1.19E-7	YML119W_p	YML119W_p	hom	Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate