YDR236C / FMN1

Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR236C / FMN1

Click on Significant Values for Screen Details ID:SGTC_16|Compound:erodoxin|FD-Score:4.58|P-value:2.41E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.13|P-value:2.64E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.31|P-value:1.32E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.33|P-value:1.26E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:2.95|P-value:6.07E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:2.83|P-value:9.33E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.82|P-value:9.86E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.21|P-value:2.11E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.52|P-value:3.46E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.00|P-value:5.51E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:2.85|P-value:8.73E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.07|P-value:3.58E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.31|P-value:1.38E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.00|P-value:5.60E-6 ID:SGTC_1714|Compound:st033236|FD-Score:3.15|P-value:2.71E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.73|P-value:2.06E-5 ID:SGTC_1716|Compound:st033144|FD-Score:5.05|P-value:1.38E-8 ID:SGTC_1721|Compound:st082152|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.29|P-value:1.50E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.48|P-value:4.34E-7 ID:SGTC_2003|Compound:4023581|FD-Score:-2.86|P-value:8.03E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.86|P-value:8.02E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.08|P-value:3.67E-6 ID:SGTC_2125|Compound:5246583|FD-Score:2.95|P-value:5.97E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-2.94|P-value:5.93E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.57|P-value:4.28E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.03|P-value:4.31E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.19|P-value:2.16E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.42|P-value:6.02E-7 ID:SGTC_2337|Compound:9009472|FD-Score:-2.96|P-value:5.55E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.55|P-value:4.90E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.49|P-value:5.94E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.01|P-value:4.53E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.68|P-value:2.66E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.38|P-value:9.55E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-2.95|P-value:5.78E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.30|P-value:1.41E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.28|P-value:1.56E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.59|P-value:3.72E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.16|P-value:7.18E-9 ID:SGTC_2812|Compound:7970281|FD-Score:3.10|P-value:3.26E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.82|P-value:9.46E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.03|P-value:4.17E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.92|P-value:3.25E-8 ID:SGTC_2898|Compound:9056270|FD-Score:2.93|P-value:6.36E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.00|P-value:4.83E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-7.72|P-value:9.25E-18 ID:SGTC_2923|Compound:7992654|FD-Score:-8.27|P-value:4.08E-20 ID:SGTC_2924|Compound:9010168|FD-Score:-6.03|P-value:1.51E-11 ID:SGTC_2927|Compound:9011802|FD-Score:-5.33|P-value:2.10E-9 ID:SGTC_2975|Compound:9084847|FD-Score:3.04|P-value:4.23E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.70|P-value:2.27E-5 ID:SGTC_3017|Compound:9080681|FD-Score:2.97|P-value:5.55E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.29|P-value:1.13E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.44|P-value:7.94E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.43|P-value:8.16E-5 ID:SGTC_16|Compound:erodoxin|FD-Score:4.58|P-value:2.41E-7 ID:SGTC_44|Compound:0929-0055|FD-Score:-4.13|P-value:2.64E-6 ID:SGTC_95|Compound:0471-0001|FD-Score:-3.31|P-value:1.32E-4 ID:SGTC_100|Compound:0086-0128|FD-Score:3.33|P-value:1.26E-4 ID:SGTC_170|Compound:4197-0004|FD-Score:2.95|P-value:6.07E-4 ID:SGTC_541|Compound:4513-1321|FD-Score:2.83|P-value:9.33E-4 ID:SGTC_567|Compound:1080-0542|FD-Score:2.82|P-value:9.86E-4 ID:SGTC_626|Compound:0214-0009|FD-Score:3.21|P-value:2.11E-4 ID:SGTC_884|Compound:0851-0618|FD-Score:4.52|P-value:3.46E-7 ID:SGTC_886|Compound:0866-0150|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_896|Compound:0964-0007|FD-Score:4.00|P-value:5.51E-6 ID:SGTC_1047|Compound:2043-3044|FD-Score:2.85|P-value:8.73E-4 ID:SGTC_1058|Compound:3448-5425|FD-Score:3.29|P-value:1.49E-4 ID:SGTC_1299|Compound:1079-1439|FD-Score:-3.07|P-value:3.58E-4 ID:SGTC_1315|Compound:1237-0019|FD-Score:3.31|P-value:1.38E-4 ID:SGTC_1467|Compound:k284-1082|FD-Score:4.00|P-value:5.60E-6 ID:SGTC_1714|Compound:st033236|FD-Score:3.15|P-value:2.71E-4 ID:SGTC_1715|Compound:st032160|FD-Score:3.73|P-value:2.06E-5 ID:SGTC_1716|Compound:st033144|FD-Score:5.05|P-value:1.38E-8 ID:SGTC_1721|Compound:st082152|FD-Score:3.17|P-value:2.44E-4 ID:SGTC_1918|Compound:oxolan-2-ylmethyl 3-bromobenzoate|FD-Score:3.29|P-value:1.50E-4 ID:SGTC_1919|Compound:st067113|FD-Score:4.48|P-value:4.34E-7 ID:SGTC_2003|Compound:4023581|FD-Score:-2.86|P-value:8.03E-4 ID:SGTC_2051|Compound:5263410|FD-Score:-2.86|P-value:8.02E-4 ID:SGTC_2104|Compound:5389443|FD-Score:4.08|P-value:3.67E-6 ID:SGTC_2125|Compound:5246583|FD-Score:2.95|P-value:5.97E-4 ID:SGTC_2174|Compound:5790901|FD-Score:-2.94|P-value:5.93E-4 ID:SGTC_2226|Compound:7298446|FD-Score:3.57|P-value:4.28E-5 ID:SGTC_2229|Compound:7354935|FD-Score:3.03|P-value:4.31E-4 ID:SGTC_2290|Compound:7904846|FD-Score:-3.19|P-value:2.16E-4 ID:SGTC_2335|Compound:9018011|FD-Score:4.42|P-value:6.02E-7 ID:SGTC_2337|Compound:9009472|FD-Score:-2.96|P-value:5.55E-4 ID:SGTC_2347|Compound:9049783|FD-Score:3.55|P-value:4.90E-5 ID:SGTC_2354|Compound:9060492|FD-Score:3.35|P-value:1.18E-4 ID:SGTC_2364|Compound:9055074|FD-Score:-3.49|P-value:5.94E-5 ID:SGTC_2365|Compound:9042475|FD-Score:-3.01|P-value:4.53E-4 ID:SGTC_2409|Compound:alverine citrate|FD-Score:3.68|P-value:2.66E-5 ID:SGTC_2467|Compound:5474540|FD-Score:-3.38|P-value:9.55E-5 ID:SGTC_2686|Compound:alizarin|FD-Score:-2.95|P-value:5.78E-4 ID:SGTC_2692|Compound:st077426|FD-Score:3.30|P-value:1.41E-4 ID:SGTC_2782|Compound:7736369|FD-Score:3.28|P-value:1.56E-4 ID:SGTC_2806|Compound:7952793|FD-Score:-3.59|P-value:3.72E-5 ID:SGTC_2810|Compound:7959871|FD-Score:5.16|P-value:7.18E-9 ID:SGTC_2812|Compound:7970281|FD-Score:3.10|P-value:3.26E-4 ID:SGTC_2830|Compound:7992007|FD-Score:-2.82|P-value:9.46E-4 ID:SGTC_2832|Compound:7992762|FD-Score:-3.03|P-value:4.17E-4 ID:SGTC_2894|Compound:9048625|FD-Score:4.92|P-value:3.25E-8 ID:SGTC_2898|Compound:9056270|FD-Score:2.93|P-value:6.36E-4 ID:SGTC_2899|Compound:9053889|FD-Score:3.00|P-value:4.83E-4 ID:SGTC_2922|Compound:7999257|FD-Score:-7.72|P-value:9.25E-18 ID:SGTC_2923|Compound:7992654|FD-Score:-8.27|P-value:4.08E-20 ID:SGTC_2924|Compound:9010168|FD-Score:-6.03|P-value:1.51E-11 ID:SGTC_2927|Compound:9011802|FD-Score:-5.33|P-value:2.10E-9 ID:SGTC_2975|Compound:9084847|FD-Score:3.04|P-value:4.23E-4 ID:SGTC_3005|Compound:9076496|FD-Score:-3.70|P-value:2.27E-5 ID:SGTC_3017|Compound:9080681|FD-Score:2.97|P-value:5.55E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-4.29|P-value:1.13E-6 ID:SGTC_3269|Compound:9137823|FD-Score:3.44|P-value:7.94E-5 ID:SGTC_3284|Compound:9108171|FD-Score:3.43|P-value:8.16E-5

Top fitness defect scores for YDR236C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_2810 7959871 5.16 45.5 µM 7.18E-9 copper-dependent oxidative stress 11 1.26E-7 0.63
2 SGTC_1716 st033144 5.05 30.6 µM 1.38E-8 3 2.16E-7 0.14
3 SGTC_2894 9048625 4.92 32.5 µM 3.25E-8 4 4.41E-7 0.31
4 SGTC_16 erodoxin 4.58 22.8 µM 2.41E-7 unfolded protein response 23 2.34E-6 0.04
5 SGTC_884 0851-0618 4.52 334.0 µM 3.46E-7 3 3.16E-6 0.66
6 SGTC_1919 st067113 4.48 52.3 µM 4.34E-7 TSC3-RPN4 6 3.81E-6 0.18
7 SGTC_2335 9018011 4.42 154.2 µM 6.02E-7 5 5.01E-6 0.07
8 SGTC_2104 5389443 4.08 200.0 µM 3.67E-6 4 2.26E-5 0.03
9 SGTC_896 0964-0007 4.00 44.5 µM 5.51E-6 9 3.17E-5 0.04
10 SGTC_1467 k284-1082 4.00 293.0 µM 5.60E-6 4 3.21E-5 0.58
11 SGTC_1715 st032160 3.73 10.2 µM 2.06E-5 8 9.53E-5 0.09
12 SGTC_2409 alverine citrate 3.68 64.0 µM 2.66E-5 17 1.18E-4 0.09
13 SGTC_2226 7298446 3.57 200.0 µM 4.28E-5 5 1.75E-4 0.12
14 SGTC_2347 9049783 3.55 174.8 µM 4.90E-5 2 1.96E-4 0.03
15 SGTC_3269 9137823 3.44 49.5 µM 7.94E-5 60S ribosome export 6 2.94E-4 0.03
16 SGTC_3284 9108171 3.43 64.9 µM 8.16E-5 6 3.00E-4 0.06
17 SGTC_2354 9060492 3.35 162.0 µM 1.18E-4 9 4.08E-4 0.01
18 SGTC_886 0866-0150 3.35 153.0 µM 1.18E-4 8 4.10E-4 0.05
19 SGTC_100 0086-0128 3.33 49.6 µM 1.26E-4 copper-dependent oxidative stress 14 4.31E-4 0.04
20 SGTC_1315 1237-0019 3.31 3.7 µM 1.38E-4 11 4.66E-4 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.182 1.98E-26 YBR083W TEC1 hom Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member
0.134 6.33E-15 YML076C WAR1 hom Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively
0.126 2.71E-13 YGL075C MPS2 het Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p
0.121 2.28E-12 YML130C ERO1 het Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds
0.112 1.01E-10 YPL244C HUT1 hom Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1
0.109 2.41E-10 YDL045C FAD1 het Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin
0.105 1.15E-9 YDR371W_p CTS2_p hom Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect
0.105 1.08E-9 YMR290C HAS1 het ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles
0.102 3.04E-9 YOR056C NOB1 het Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress
0.100 7.30E-9 YGR286C BIO2 hom Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant
0.099 9.98E-9 YFL034C-B MOB2 het Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p
0.098 1.32E-8 YOR017W PET127 hom Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane
0.096 2.81E-8 YEL001C IRC22 hom Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci
0.092 9.45E-8 YPL099C AIM43 hom Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss
0.091 1.19E-7 YML119W_p YML119W_p hom Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate