Riboflavin kinase, produces riboflavin monophosphate (FMN); FMN is a necessary cofactor for many enzymes; predominantly localizes to the microsomal fraction and also found in the mitochondrial inner membrane
Zygosity: Heterozygous strain
fixedexpanded
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Top fitness defect scores for YDR236C deletion by condition
Download Fitness data (tab-delimited text) (excel) |
Correlation | pval | ORF | Gene | Zygosity | Description |
---|---|---|---|---|---|
0.182 | 1.98E-26 | YBR083W | TEC1 | hom | Transcription factor targeting filamentation genes and Ty1 expression; Ste12p activation of most filamentation gene promoters depends on Tec1p and Tec1p transcriptional activity is dependent on its association with Ste12p; binds to TCS elements upstream of filamentation genes, which are regulated by Tec1p/Ste12p/Dig1p complex; competes with Dig2p for binding to Ste12p/Dig1p; positive regulator of chronological life span; TEA/ATTS DNA-binding domain family member |
0.134 | 6.33E-15 | YML076C | WAR1 | hom | Homodimeric Zn2Cys6 zinc finger transcription factor; binds to a weak acid response element to induce transcription of PDR12 and FUN34, encoding an acid transporter and a putative ammonia transporter, respectively |
0.126 | 2.71E-13 | YGL075C | MPS2 | het | Essential membrane protein localized at the nuclear envelope and spindle pole body (SPB), required for insertion of the newly duplicated SPB into the nuclear envelope; potentially phosphorylated by Cdc28p |
0.121 | 2.28E-12 | YML130C | ERO1 | het | Thiol oxidase required for oxidative protein folding in the ER; essential for maintaining proper redox balance in ER; feedback regulation of Ero1p occurs via reduction and oxidation of Ero1p regulatory bonds; reduced Pdi1p activates Ero1p by direct reduction of Ero1p regulatory bonds; depletion of thiol substrates and accumulation of oxidized Pdi1p results in inactivation of Ero1p by both Pdi1p-mediated oxidation and autonomous oxidation of Ero1p regulatory bonds |
0.112 | 1.01E-10 | YPL244C | HUT1 | hom | Protein with a role in UDP-galactose transport to the Golgi lumen, has similarity to human UDP-galactose transporter UGTrel1, exhibits a genetic interaction with S. cerevisiae ERO1 |
0.109 | 2.41E-10 | YDL045C | FAD1 | het | Flavin adenine dinucleotide (FAD) synthetase, performs the second step in synthesis of FAD from riboflavin |
0.105 | 1.15E-9 | YDR371W_p | CTS2_p | hom | Putative chitinase, functionally complements A. gossypii cts2 mutant sporulation defect |
0.105 | 1.08E-9 | YMR290C | HAS1 | het | ATP-dependent RNA helicase; localizes to both the nuclear periphery and nucleolus; highly enriched in nuclear pore complex fractions; constituent of 66S pre-ribosomal particles |
0.102 | 3.04E-9 | YOR056C | NOB1 | het | Protein involved in proteasomal and 40S ribosomal subunit biogenesis; required for cleavage of the 20S pre-rRNA to generate the mature 18S rRNA; cleavage is activated by Fun12p, a GTPase and translation initiation factor; relocalizes from nucleus to nucleolus upon DNA replication stress |
0.100 | 7.30E-9 | YGR286C | BIO2 | hom | Biotin synthase, catalyzes the conversion of dethiobiotin to biotin, which is the last step of the biotin biosynthesis pathway; complements E. coli bioB mutant |
0.099 | 9.98E-9 | YFL034C-B | MOB2 | het | Activator of Cbk1p kinase; component of the RAM signaling network that regulates cellular polarity and morphogenesis; activation of Cbk1p facilitates the Ace2p-dependent daughter cell-specific transcription of genes involved in cell separation; similar to Mob1p |
0.098 | 1.32E-8 | YOR017W | PET127 | hom | Protein with a role in 5'-end processing of mitochondrial RNAs, located in the mitochondrial membrane |
0.096 | 2.81E-8 | YEL001C | IRC22 | hom | Putative protein of unknown function; green fluorescent protein (GFP)-fusion localizes to the ER; YEL001C is non-essential; null mutant displays increased levels of spontaneous Rad52p foci |
0.092 | 9.45E-8 | YPL099C | AIM43 | hom | Protein of unknown function; the authentic, non-tagged protein is detected in purified mitochondria in high-throughput studies; null mutant displays elevated frequency of mitochondrial genome loss |
0.091 | 1.19E-7 | YML119W_p | YML119W_p | hom | Putative protein of unknown function; YML119W is not an essential gene; potential Cdc28p substrate |