YDR237W / MRPL7

Mitochondrial ribosomal protein of the large subunit; MRPL7 produces both YmL5 and YmL7, which are two different modified forms of the same protein

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR237W / MRPL7

Click on Significant Values for Screen Details ID:SGTC_10|Compound:0279-0212|FD-Score:3.62|P-value:4.51E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:10.40|P-value:7.08E-22 ID:SGTC_87|Compound:0100-0052|FD-Score:3.45|P-value:7.67E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.80|P-value:2.45E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.99|P-value:2.37E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.41|P-value:2.14E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.96|P-value:1.39E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.42|P-value:3.39E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.97|P-value:1.50E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.45|P-value:2.25E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.66|P-value:5.37E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:6.65|P-value:5.76E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:9.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:22.60|P-value:3.81E-95 ID:SGTC_275|Compound:trichlorophene|FD-Score:12.70|P-value:2.00E-31 ID:SGTC_283|Compound:0987-0079|FD-Score:4.51|P-value:1.81E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.60|P-value:1.35E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.53|P-value:6.50E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.50|P-value:7.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.67|P-value:1.12E-12 ID:SGTC_314|Compound:1671-0008|FD-Score:3.60|P-value:4.79E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.33|P-value:3.64E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.19|P-value:8.30E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:3.72|P-value:3.21E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:11.60|P-value:8.13E-27 ID:SGTC_444|Compound:curcumin|FD-Score:-3.55|P-value:6.17E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.72|P-value:3.52E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.28|P-value:6.64E-7 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.55|P-value:6.06E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.84|P-value:2.35E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:5.24|P-value:8.05E-7 ID:SGTC_596|Compound:1155-0152|FD-Score:3.81|P-value:2.34E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.17|P-value:7.25E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.62|P-value:1.12E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.70|P-value:9.06E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.38|P-value:2.98E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.81|P-value:5.13E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.90|P-value:1.74E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.14|P-value:7.29E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:7.70|P-value:8.72E-13 ID:SGTC_767|Compound:0929-0023|FD-Score:3.76|P-value:2.80E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.52|P-value:6.22E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.01|P-value:1.85E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:3.75|P-value:2.92E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-4.18|P-value:7.03E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.40|P-value:9.17E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:4.45|P-value:2.25E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.95|P-value:1.45E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.56|P-value:5.92E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.71|P-value:4.12E-10 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.78|P-value:2.62E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.30|P-value:2.97E-25 ID:SGTC_1658|Compound:st012944|FD-Score:-3.65|P-value:4.43E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.80|P-value:2.63E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.14|P-value:1.08E-8 ID:SGTC_1723|Compound:st034307|FD-Score:4.75|P-value:6.81E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.37|P-value:9.82E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.66|P-value:9.93E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.65|P-value:1.14E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.65|P-value:4.43E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.69|P-value:3.55E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.36|P-value:3.53E-5 ID:SGTC_1948|Compound:st076329|FD-Score:4.03|P-value:1.11E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.39|P-value:9.39E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.47|P-value:7.87E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-4.43|P-value:2.74E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.88|P-value:3.91E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-5.57|P-value:1.87E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.87|P-value:2.12E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.44|P-value:4.83E-12 ID:SGTC_2322|Compound:7413319|FD-Score:-4.05|P-value:1.11E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.64|P-value:4.15E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.92|P-value:1.78E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.78|P-value:2.90E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.49|P-value:1.96E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.72|P-value:3.49E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.86|P-value:2.21E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.62|P-value:4.46E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.48|P-value:2.05E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-8.17|P-value:4.44E-14 ID:SGTC_2896|Compound:9052656|FD-Score:-8.62|P-value:1.75E-15 ID:SGTC_2939|Compound:9044578|FD-Score:-3.50|P-value:7.04E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.90|P-value:1.91E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.75|P-value:3.13E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.22|P-value:5.45E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.51|P-value:6.47E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.84|P-value:2.16E-4 ID:SGTC_10|Compound:0279-0212|FD-Score:3.62|P-value:4.51E-4 ID:SGTC_70|Compound:0141-0289|FD-Score:10.40|P-value:7.08E-22 ID:SGTC_87|Compound:0100-0052|FD-Score:3.45|P-value:7.67E-4 ID:SGTC_108|Compound:0509-0257|FD-Score:3.80|P-value:2.45E-4 ID:SGTC_116|Compound:0155-0182|FD-Score:4.99|P-value:2.37E-6 ID:SGTC_119|Compound:0121-0043|FD-Score:6.41|P-value:2.14E-9 ID:SGTC_120|Compound:rhodamine 6G|FD-Score:3.96|P-value:1.39E-4 ID:SGTC_134|Compound:0269-0018|FD-Score:5.42|P-value:3.39E-7 ID:SGTC_151|Compound:3013-0144|FD-Score:-3.97|P-value:1.50E-4 ID:SGTC_161|Compound:4065-0411|FD-Score:4.45|P-value:2.25E-5 ID:SGTC_168|Compound:3970-0862|FD-Score:6.66|P-value:5.37E-10 ID:SGTC_173|Compound:1273-0061|FD-Score:6.65|P-value:5.76E-10 ID:SGTC_214|Compound:4373-3496|FD-Score:3.38|P-value:9.59E-4 ID:SGTC_236|Compound:1509-0011|FD-Score:22.60|P-value:3.81E-95 ID:SGTC_275|Compound:trichlorophene|FD-Score:12.70|P-value:2.00E-31 ID:SGTC_283|Compound:0987-0079|FD-Score:4.51|P-value:1.81E-5 ID:SGTC_293|Compound:4049-0273|FD-Score:-4.60|P-value:1.35E-5 ID:SGTC_299|Compound:1273-0059|FD-Score:-3.53|P-value:6.50E-4 ID:SGTC_308|Compound:4092-1169|FD-Score:-3.50|P-value:7.16E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:7.67|P-value:1.12E-12 ID:SGTC_314|Compound:1671-0008|FD-Score:3.60|P-value:4.79E-4 ID:SGTC_327|Compound:1273-0057|FD-Score:4.33|P-value:3.64E-5 ID:SGTC_339|Compound:3091-4833|FD-Score:-6.19|P-value:8.30E-9 ID:SGTC_365|Compound:0121-0052|FD-Score:3.72|P-value:3.21E-4 ID:SGTC_386|Compound:1509-0011|FD-Score:11.60|P-value:8.13E-27 ID:SGTC_444|Compound:curcumin|FD-Score:-3.55|P-value:6.17E-4 ID:SGTC_453|Compound:enantio-paf c16|FD-Score:-3.72|P-value:3.52E-4 ID:SGTC_462|Compound:ag-879|FD-Score:5.28|P-value:6.64E-7 ID:SGTC_498|Compound:2,5-di-tert-butyl-1,4-hydroquinone (DTBHQ)|FD-Score:-3.55|P-value:6.06E-4 ID:SGTC_500|Compound:h-89|FD-Score:-3.84|P-value:2.35E-4 ID:SGTC_520|Compound:3584-0023|FD-Score:5.24|P-value:8.05E-7 ID:SGTC_596|Compound:1155-0152|FD-Score:3.81|P-value:2.34E-4 ID:SGTC_612|Compound:0302-0167|FD-Score:-4.17|P-value:7.25E-5 ID:SGTC_614|Compound:0462-0418|FD-Score:4.62|P-value:1.12E-5 ID:SGTC_649|Compound:1123-0311|FD-Score:-4.70|P-value:9.06E-6 ID:SGTC_721|Compound:1187-1332|FD-Score:4.38|P-value:2.98E-5 ID:SGTC_734|Compound:2023-0417|FD-Score:4.81|P-value:5.13E-6 ID:SGTC_735|Compound:3076-0345|FD-Score:3.90|P-value:1.74E-4 ID:SGTC_745|Compound:0469-0705|FD-Score:4.14|P-value:7.29E-5 ID:SGTC_748|Compound:0136-0228|FD-Score:7.70|P-value:8.72E-13 ID:SGTC_767|Compound:0929-0023|FD-Score:3.76|P-value:2.80E-4 ID:SGTC_850|Compound:0388-0143|FD-Score:3.52|P-value:6.22E-4 ID:SGTC_908|Compound:3448-7491|FD-Score:6.01|P-value:1.85E-8 ID:SGTC_936|Compound:3005-4620|FD-Score:3.75|P-value:2.92E-4 ID:SGTC_955|Compound:1216-0110|FD-Score:-4.18|P-value:7.03E-5 ID:SGTC_968|Compound:1309-0633|FD-Score:3.40|P-value:9.17E-4 ID:SGTC_990|Compound:3985-0011|FD-Score:4.45|P-value:2.25E-5 ID:SGTC_991|Compound:3996-0057|FD-Score:3.95|P-value:1.45E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:-3.56|P-value:5.92E-4 ID:SGTC_1188|Compound:1403-0014|FD-Score:6.71|P-value:4.12E-10 ID:SGTC_1353|Compound:1498-1206|FD-Score:3.78|P-value:2.62E-4 ID:SGTC_1635|Compound:st007035|FD-Score:11.30|P-value:2.97E-25 ID:SGTC_1658|Compound:st012944|FD-Score:-3.65|P-value:4.43E-4 ID:SGTC_1707|Compound:st032323|FD-Score:-3.80|P-value:2.63E-4 ID:SGTC_1718|Compound:roemerine|FD-Score:-6.14|P-value:1.08E-8 ID:SGTC_1723|Compound:st034307|FD-Score:4.75|P-value:6.81E-6 ID:SGTC_1741|Compound:st038134|FD-Score:3.37|P-value:9.82E-4 ID:SGTC_1742|Compound:st038235|FD-Score:4.66|P-value:9.93E-6 ID:SGTC_1787|Compound:fluconazole|FD-Score:-4.65|P-value:1.14E-5 ID:SGTC_1818|Compound:st052136|FD-Score:-3.65|P-value:4.43E-4 ID:SGTC_1882|Compound:5615643|FD-Score:3.69|P-value:3.55E-4 ID:SGTC_1941|Compound:st076221|FD-Score:-4.36|P-value:3.53E-5 ID:SGTC_1948|Compound:st076329|FD-Score:4.03|P-value:1.11E-4 ID:SGTC_1970|Compound:st070122|FD-Score:3.39|P-value:9.39E-4 ID:SGTC_1982|Compound:st072467|FD-Score:-3.47|P-value:7.87E-4 ID:SGTC_2036|Compound:5160441|FD-Score:-4.43|P-value:2.74E-5 ID:SGTC_2052|Compound:5265182|FD-Score:4.88|P-value:3.91E-6 ID:SGTC_2128|Compound:5255449|FD-Score:-5.57|P-value:1.87E-7 ID:SGTC_2249|Compound:haloperidol|FD-Score:-3.87|P-value:2.12E-4 ID:SGTC_2250|Compound:alverine citrate|FD-Score:7.44|P-value:4.83E-12 ID:SGTC_2322|Compound:7413319|FD-Score:-4.05|P-value:1.11E-4 ID:SGTC_2454|Compound:5-benzylidenerhodanine|FD-Score:3.64|P-value:4.15E-4 ID:SGTC_2482|Compound:5981709|FD-Score:-3.92|P-value:1.78E-4 ID:SGTC_2527|Compound:2',3'-dihydroxy-4-methoxy-4'-ethoxybenzophenone|FD-Score:-3.78|P-value:2.90E-4 ID:SGTC_2537|Compound:larixol|FD-Score:4.49|P-value:1.96E-5 ID:SGTC_2640|Compound:pentamidine|FD-Score:-3.72|P-value:3.49E-4 ID:SGTC_2752|Compound:diclazuril|FD-Score:-3.86|P-value:2.21E-4 ID:SGTC_2753|Compound:fluvastatin|FD-Score:3.62|P-value:4.46E-4 ID:SGTC_2782|Compound:7736369|FD-Score:4.48|P-value:2.05E-5 ID:SGTC_2858|Compound:9025781|FD-Score:-8.17|P-value:4.44E-14 ID:SGTC_2896|Compound:9052656|FD-Score:-8.62|P-value:1.75E-15 ID:SGTC_2939|Compound:9044578|FD-Score:-3.50|P-value:7.04E-4 ID:SGTC_3059|Compound:1327-0034|FD-Score:-3.90|P-value:1.91E-4 ID:SGTC_3153|Compound:9100258|FD-Score:-3.75|P-value:3.13E-4 ID:SGTC_3190|Compound:9110366|FD-Score:4.22|P-value:5.45E-5 ID:SGTC_3194|Compound:9111903|FD-Score:3.51|P-value:6.47E-4 ID:SGTC_3346|Compound:9158254|FD-Score:3.84|P-value:2.16E-4

Top fitness defect scores for YDR237W deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_236 1509-0011 22.60 5.3 µM 3.81E-95 42 2.64E-113
2 SGTC_275 trichlorophene 12.70 5.7 µM 2.00E-31 mitochondrial stress 18 3.78E-37
3 SGTC_386 1509-0011 11.60 3.1 µM 8.13E-27 37 1.21E-31
4 SGTC_1635 st007035 11.30 42.4 µM 2.97E-25 66 8.87E-30
5 SGTC_70 0141-0289 10.40 43.3 µM 7.08E-22 mitochondrial stress 18 9.51E-26
6 SGTC_748 0136-0228 7.70 77.9 µM 8.72E-13 redox potentiating 22 6.58E-15
7 SGTC_310 1273-0058 7.67 1.1 µM 1.12E-12 mitochondrial stress 100 8.87E-15
8 SGTC_2250 alverine citrate 7.44 130.0 µM 4.83E-12 28 5.06E-14
9 SGTC_1188 1403-0014 6.71 4.6 µM 4.12E-10 mitochondrial stress 12 1.01E-11
10 SGTC_168 3970-0862 6.66 530.5 µM 5.37E-10 32 1.38E-11
11 SGTC_173 1273-0061 6.65 2.7 µM 5.76E-10 mitochondrial stress 95 1.50E-11
12 SGTC_119 0121-0043 6.41 24.8 µM 2.14E-9 mitochondrial stress 23 7.15E-11
13 SGTC_908 3448-7491 6.01 47.7 µM 1.85E-8 mitochondrial stress 47 9.28E-10
14 SGTC_134 0269-0018 5.42 6.9 µM 3.39E-7 90 2.95E-8
15 SGTC_462 ag-879 5.28 158.0 µM 6.64E-7 11 6.54E-8
16 SGTC_520 3584-0023 5.24 682.0 µM 8.05E-7 10 8.22E-8
17 SGTC_116 0155-0182 4.99 31.8 µM 2.37E-6 mitochondrial response to ROS 42 2.96E-7
18 SGTC_2052 5265182 4.88 7.1 µM 3.91E-6 11 5.36E-7
19 SGTC_734 2023-0417 4.81 80.0 µM 5.13E-6 ergosterol biosynthesis 5 7.40E-7
20 SGTC_1723 st034307 4.75 2.5 µM 6.81E-6 mitochondrial processes 14 1.03E-6

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.636 0 YDR462W MRPL28 hom Mitochondrial ribosomal protein of the large subunit; protein abundance increases in response to DNA replication stress
0.619 0 YJL023C PET130 hom Protein required for respiratory growth; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.604 0 YOR330C MIP1 hom Mitochondrial DNA polymerase; conserved C-terminal segment is required for the maintenance of mitochondrial genome; mutations in the human ortholog POLG are associated with Alpers-Huttenlocher syndrome (AHS) and other mitochondrial diseases; Mip1p is the single subunit of mitochondrial DNA polymerase in yeast, in contrast to metazoans in which there is a complex of a catalytic subunit and an accessory subunit
0.596 3.36E-322 YDR518W EUG1 hom Protein disulfide isomerase of the endoplasmic reticulum lumen; EUG1 has a paralog, PDI1, that arose from the whole genome duplication; function overlaps with that of Pdi1p; may interact with nascent polypeptides in the ER
0.589 3.14E-313 YNL252C MRPL17 hom Mitochondrial ribosomal protein of the large subunit
0.571 1.46E-289 YDR079W PET100 hom Chaperone that specifically facilitates the assembly of cytochrome c oxidase, integral to the mitochondrial inner membrane; interacts with a subcomplex of subunits VII, VIIa, and VIII (Cox7p, Cox9p, and Cox8p) but not with the holoenzyme
0.570 4.55E-288 YNL213C RRG9 hom Protein of unknown function; null mutant lacks mitochondrial DNA and cannot grow on glycerol; the authentic, non-tagged protein is detected in highly purified mitochondria in high-throughput studies
0.563 7.96E-280 YDR533C HSP31 hom Possible chaperone and cysteine protease; has similarity to E. coli Hsp31; member of the DJ-1/ThiJ/PfpI superfamily, which includes human DJ-1 involved in Parkinson's disease; exists as a dimer and contains a putative metal-binding site; protein abundance increases in response to DNA replication stress
0.560 3.78E-276 YGR220C MRPL9 hom Mitochondrial ribosomal protein of the large subunit
0.555 3.20E-270 YPR166C MRP2 hom Mitochondrial ribosomal protein of the small subunit
0.546 5.60E-260 YCR024C SLM5 hom Mitochondrial asparaginyl-tRNA synthetase
0.543 1.20E-256 YBR179C FZO1 hom Mitofusin; integral membrane protein involved in mitochondrial outer membrane tethering and fusion; role in mitochondrial genome maintenance; efficient tethering and degradation of Fzo1p requires an intact N-terminal GTPase domain; targeted for destruction by the ubiquitin ligase SCF-Mdm30p and the cytosolic ubiquitin-proteasome system
0.538 9.91E-252 YKL068W-A_p YKL068W-A_p hom Putative protein of unknown function; identified by homology to Ashbya gossypii
0.538 8.70E-251 YPL013C MRPS16 hom Mitochondrial ribosomal protein of the small subunit
0.535 3.58E-247 YGR150C CCM1 hom Mitochondrial 15s rRNA-binding protein; required for intron removal of COB and COX1 pre-mRNAs; contains pentatricopeptide repeat (PPR) motifs; mutant is respiratory deficient and has defective plasma membrane electron transport