YDR238C / SEC26

Essential beta-coat protein of the COPI coatomer, involved in ER-to-Golgi protein trafficking and maintenance of normal ER morphology; shares 43% sequence identity with mammalian beta-coat protein (beta-COP)

Zygosity: Heterozygous strain
fixedexpanded
Profile for YDR238C / SEC26

Click on Significant Values for Screen Details ID:SGTC_3|Compound:0833-0587|FD-Score:6.96|P-value:9.77E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.02|P-value:6.07E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.90|P-value:8.12E-7 ID:SGTC_81|Compound:0411-0046|FD-Score:-4.90|P-value:3.37E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:11.90|P-value:3.40E-22 ID:SGTC_123|Compound:0083-0120|FD-Score:6.39|P-value:1.26E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-7.71|P-value:1.91E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:4.68|P-value:8.05E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:6.35|P-value:1.48E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:5.60|P-value:3.19E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.19|P-value:5.79E-14 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.44|P-value:1.52E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.04|P-value:5.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.33|P-value:1.35E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.17|P-value:1.32E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.87|P-value:8.16E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.63|P-value:2.78E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.26|P-value:2.62E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-11.40|P-value:1.56E-20 ID:SGTC_370|Compound:0180-0345|FD-Score:-5.27|P-value:9.21E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:5.60|P-value:3.17E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:4.71|P-value:7.27E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.17|P-value:3.89E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.10|P-value:1.67E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.73|P-value:6.79E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:-4.67|P-value:7.32E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.19|P-value:3.27E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:5.46|P-value:5.38E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:-4.18|P-value:3.36E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.79|P-value:5.71E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:6.65|P-value:3.99E-8 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.24|P-value:3.22E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.21|P-value:3.52E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.46|P-value:5.38E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:-5.30|P-value:8.22E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.70|P-value:7.60E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.88|P-value:8.84E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:10.80|P-value:1.77E-18 ID:SGTC_1635|Compound:st007035|FD-Score:4.41|P-value:1.90E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.03|P-value:5.80E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.09|P-value:4.95E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.38|P-value:2.10E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-5.50|P-value:3.98E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.64|P-value:9.16E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.88|P-value:8.80E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.38|P-value:7.17E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.80|P-value:4.30E-29 ID:SGTC_1800|Compound:st050079|FD-Score:-4.49|P-value:1.30E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.78|P-value:5.16E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.73|P-value:6.02E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-4.06|P-value:4.80E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.96|P-value:3.14E-5 ID:SGTC_2482|Compound:5981709|FD-Score:5.95|P-value:7.81E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.89|P-value:8.68E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-5.03|P-value:2.19E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.50|P-value:1.26E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-6.55|P-value:5.27E-8 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.91|P-value:9.42E-7 ID:SGTC_2855|Compound:9016525|FD-Score:4.40|P-value:1.98E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.86|P-value:4.47E-5 ID:SGTC_2943|Compound:9068529|FD-Score:6.01|P-value:6.24E-7 ID:SGTC_2946|Compound:9065502|FD-Score:-5.64|P-value:2.32E-6 ID:SGTC_3057|Compound:9095946|FD-Score:4.67|P-value:8.45E-5 ID:SGTC_3142|Compound:9086498|FD-Score:14.00|P-value:5.45E-30 ID:SGTC_3170|Compound:9103054|FD-Score:-4.27|P-value:2.55E-4 ID:SGTC_3177|Compound:9107506|FD-Score:-4.95|P-value:2.84E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-4.10|P-value:4.26E-4 ID:SGTC_3222|Compound:9128301|FD-Score:7.08|P-value:5.42E-9 ID:SGTC_3266|Compound:9136860|FD-Score:-4.40|P-value:1.75E-4 ID:SGTC_3268|Compound:9137683|FD-Score:4.30|P-value:2.63E-4 ID:SGTC_3273|Compound:9137859|FD-Score:4.29|P-value:2.71E-4 ID:SGTC_3|Compound:0833-0587|FD-Score:6.96|P-value:9.77E-9 ID:SGTC_70|Compound:0141-0289|FD-Score:4.02|P-value:6.07E-4 ID:SGTC_73|Compound:0327-0325|FD-Score:-5.90|P-value:8.12E-7 ID:SGTC_81|Compound:0411-0046|FD-Score:-4.90|P-value:3.37E-5 ID:SGTC_103|Compound:0844-0104|FD-Score:11.90|P-value:3.40E-22 ID:SGTC_123|Compound:0083-0120|FD-Score:6.39|P-value:1.26E-7 ID:SGTC_141|Compound:0443-0274|FD-Score:-7.71|P-value:1.91E-10 ID:SGTC_168|Compound:3970-0862|FD-Score:4.68|P-value:8.05E-5 ID:SGTC_207|Compound:4185-0010|FD-Score:6.35|P-value:1.48E-7 ID:SGTC_245|Compound:methotrexate|FD-Score:5.60|P-value:3.19E-6 ID:SGTC_255|Compound:tunicamycin|FD-Score:9.19|P-value:5.79E-14 ID:SGTC_256|Compound:clotrimazole|FD-Score:-4.44|P-value:1.52E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:-4.04|P-value:5.01E-4 ID:SGTC_310|Compound:1273-0058|FD-Score:-6.33|P-value:1.35E-7 ID:SGTC_314|Compound:1671-0008|FD-Score:-5.17|P-value:1.32E-5 ID:SGTC_327|Compound:1273-0057|FD-Score:-3.87|P-value:8.16E-4 ID:SGTC_339|Compound:3091-4833|FD-Score:5.63|P-value:2.78E-6 ID:SGTC_360|Compound:0957-0399|FD-Score:-4.26|P-value:2.62E-4 ID:SGTC_363|Compound:0455-0021|FD-Score:-11.40|P-value:1.56E-20 ID:SGTC_370|Compound:0180-0345|FD-Score:-5.27|P-value:9.21E-6 ID:SGTC_372|Compound:0155-0182|FD-Score:5.60|P-value:3.17E-6 ID:SGTC_384|Compound:k007-0144|FD-Score:4.71|P-value:7.27E-5 ID:SGTC_467|Compound:ro 31-8220|FD-Score:4.17|P-value:3.89E-4 ID:SGTC_568|Compound:1193-0097|FD-Score:-5.10|P-value:1.67E-5 ID:SGTC_601|Compound:0986-0029|FD-Score:4.73|P-value:6.79E-5 ID:SGTC_637|Compound:1181-0519|FD-Score:-4.67|P-value:7.32E-5 ID:SGTC_692|Compound:k241-0027|FD-Score:-4.19|P-value:3.27E-4 ID:SGTC_706|Compound:4262-0057|FD-Score:5.46|P-value:5.38E-6 ID:SGTC_968|Compound:1309-0633|FD-Score:-4.18|P-value:3.36E-4 ID:SGTC_1161|Compound:k007-0610|FD-Score:4.79|P-value:5.71E-5 ID:SGTC_1206|Compound:3978-0017|FD-Score:6.65|P-value:3.99E-8 ID:SGTC_1238|Compound:0333-0287|FD-Score:4.24|P-value:3.22E-4 ID:SGTC_1249|Compound:0481-0015|FD-Score:4.21|P-value:3.52E-4 ID:SGTC_1258|Compound:0671-0043|FD-Score:5.46|P-value:5.38E-6 ID:SGTC_1261|Compound:0712-0010|FD-Score:-5.30|P-value:8.22E-6 ID:SGTC_1359|Compound:1582-0056|FD-Score:4.70|P-value:7.60E-5 ID:SGTC_1394|Compound:3474-0001|FD-Score:3.88|P-value:8.84E-4 ID:SGTC_1597|Compound:7-benzyloxygramine|FD-Score:10.80|P-value:1.77E-18 ID:SGTC_1635|Compound:st007035|FD-Score:4.41|P-value:1.90E-4 ID:SGTC_1682|Compound:st012968|FD-Score:4.03|P-value:5.80E-4 ID:SGTC_1687|Compound:st020778|FD-Score:4.09|P-value:4.95E-4 ID:SGTC_1724|Compound:st037281|FD-Score:4.38|P-value:2.10E-4 ID:SGTC_1754|Compound:st042065|FD-Score:-5.50|P-value:3.98E-6 ID:SGTC_1780|Compound:st038448|FD-Score:4.64|P-value:9.16E-5 ID:SGTC_1784|Compound:st039334|FD-Score:3.88|P-value:8.80E-4 ID:SGTC_1785|Compound:bathophenanthroline|FD-Score:5.38|P-value:7.17E-6 ID:SGTC_1789|Compound:tunicamycin|FD-Score:13.80|P-value:4.30E-29 ID:SGTC_1800|Compound:st050079|FD-Score:-4.49|P-value:1.30E-4 ID:SGTC_1818|Compound:st052136|FD-Score:-4.78|P-value:5.16E-5 ID:SGTC_1844|Compound:rapamycin|FD-Score:-4.73|P-value:6.02E-5 ID:SGTC_1851|Compound:st056236|FD-Score:-4.06|P-value:4.80E-4 ID:SGTC_2038|Compound:4100038|FD-Score:4.96|P-value:3.14E-5 ID:SGTC_2482|Compound:5981709|FD-Score:5.95|P-value:7.81E-7 ID:SGTC_2528|Compound:xanthyletin|FD-Score:3.89|P-value:8.68E-4 ID:SGTC_2576|Compound:guaiol|FD-Score:-5.03|P-value:2.19E-5 ID:SGTC_2679|Compound:rapamycin|FD-Score:-4.50|P-value:1.26E-4 ID:SGTC_2778|Compound:tioconazole|FD-Score:-6.55|P-value:5.27E-8 ID:SGTC_2779|Compound:methotrexate|FD-Score:5.91|P-value:9.42E-7 ID:SGTC_2855|Compound:9016525|FD-Score:4.40|P-value:1.98E-4 ID:SGTC_2937|Compound:9044753|FD-Score:4.86|P-value:4.47E-5 ID:SGTC_2943|Compound:9068529|FD-Score:6.01|P-value:6.24E-7 ID:SGTC_2946|Compound:9065502|FD-Score:-5.64|P-value:2.32E-6 ID:SGTC_3057|Compound:9095946|FD-Score:4.67|P-value:8.45E-5 ID:SGTC_3142|Compound:9086498|FD-Score:14.00|P-value:5.45E-30 ID:SGTC_3170|Compound:9103054|FD-Score:-4.27|P-value:2.55E-4 ID:SGTC_3177|Compound:9107506|FD-Score:-4.95|P-value:2.84E-5 ID:SGTC_3219|Compound:9131112|FD-Score:-4.10|P-value:4.26E-4 ID:SGTC_3222|Compound:9128301|FD-Score:7.08|P-value:5.42E-9 ID:SGTC_3266|Compound:9136860|FD-Score:-4.40|P-value:1.75E-4 ID:SGTC_3268|Compound:9137683|FD-Score:4.30|P-value:2.63E-4 ID:SGTC_3273|Compound:9137859|FD-Score:4.29|P-value:2.71E-4

Top fitness defect scores for YDR238C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
Screen
Clearance
1 SGTC_3142 9086498 14.00 49.5 µM 5.45E-30 iron homeostasis 3 7.80E-45 0.84
2 SGTC_1789 tunicamycin 13.80 25.0 nM 4.30E-29 unfolded protein response 3 1.82E-43 0.40
3 SGTC_103 0844-0104 11.90 51.8 µM 3.40E-22 ERAD & cell cycle 8 5.91E-33 1.73
4 SGTC_1597 7-benzyloxygramine 10.80 47.5 µM 1.77E-18 calcium & mitochondrial duress 15 2.69E-27 0.30
5 SGTC_255 tunicamycin 9.19 200.5 nM 5.79E-14 unfolded protein response 4 1.99E-20 0.53
6 SGTC_3222 9128301 7.08 49.5 µM 5.42E-9 60S ribosome export 4 7.05E-13 2.18
7 SGTC_3 0833-0587 6.96 95.6 µM 9.77E-9 redox potentiating 1 1.72E-12 0.76
8 SGTC_1206 3978-0017 6.65 132.0 µM 3.99E-8 ERG2 2 1.45E-11 2.12
9 SGTC_123 0083-0120 6.39 66.7 µM 1.26E-7 3 8.28E-11 0.77
10 SGTC_207 4185-0010 6.35 4.5 µM 1.48E-7 endomembrane recycling 7 1.05E-10 0.27
11 SGTC_2943 9068529 6.01 45.3 µM 6.24E-7 3 9.31E-10 0.31
12 SGTC_2482 5981709 5.95 142.7 µM 7.81E-7 PDR1 3 1.31E-9 0.49
13 SGTC_2779 methotrexate 5.91 400.0 µM 9.42E-7 4 1.74E-9 0.17
14 SGTC_339 3091-4833 5.63 71.4 µM 2.78E-6 iron homeostasis 2 8.91E-9 0.32
15 SGTC_372 0155-0182 5.60 15.9 µM 3.17E-6 mitochondrial response to ROS 3 1.09E-8 0.35
16 SGTC_245 methotrexate 5.60 289.6 µM 3.19E-6 8 1.10E-8 0.70
17 SGTC_706 4262-0057 5.46 46.9 µM 5.38E-6 fatty acid desaturase (OLE1) 4 2.41E-8 0.25
18 SGTC_1258 0671-0043 5.46 57.1 µM 5.38E-6 2 2.41E-8 0.99
19 SGTC_1785 bathophenanthroline 5.38 24.0 µM 7.17E-6 heme requiring 9 3.72E-8 0.08
20 SGTC_2038 4100038 4.96 31.0 µM 3.14E-5 plasma membrane duress 8 3.45E-7 0.01

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.436 3.80E-156 YNL287W SEC21 het Gamma subunit of coatomer, a heptameric protein complex that together with Arf1p forms the COPI coat; involved in ER to Golgi transport of selective cargo
0.326 5.99E-84 YFR051C RET2 het Delta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.311 3.56E-76 YDL145C COP1 het Alpha subunit of COPI vesicle coatomer complex, which surrounds transport vesicles in the early secretory pathway
0.259 9.74E-53 YPL010W RET3 het Zeta subunit of the coatomer complex (COPI), which coats Golgi-derived transport vesicles; involved in retrograde transport between Golgi and ER
0.235 2.60E-43 YBR243C ALG7 het UDP-N-acetyl-glucosamine-1-P transferase, transfers Glc-Nac-P from UDP-GlcNac to Dol-P in the ER in the first step of the dolichol pathway of protein asparagine-linked glycosylation; inhibited by tunicamycin
0.174 3.08E-24 YDL148C NOP14 het Nucleolar protein, forms a complex with Noc4p that mediates maturation and nuclear export of 40S ribosomal subunits; also present in the small subunit processome complex, which is required for processing of pre-18S rRNA
0.164 1.51E-21 YOR246C ENV9 hom Protein proposed to be involved in vacuolar functions; mutant shows defect in CPY processing and defects in vacuolar morphology; has similarity to oxidoreductases, found in lipid particles; required for replication of Brome mosaic virus in S. cerevisiae, a model system for studying replication of positive-strand RNA viruses in their natural hosts
0.162 3.35E-21 YDR186C YDR186C hom Putative protein of unknown function; may interact with ribosomes, based on co-purification experiments; green fluorescent protein (GFP)-fusion protein localizes to the cytoplasm
0.162 4.11E-21 YER151C UBP3 hom Ubiquitin-specific protease involved in transport and osmotic response; interacts with Bre5p to co-regulate anterograde and retrograde transport between the ER and Golgi; involved in transcription elongation in response to osmostress through phosphorylation at Ser695 by Hog1p; inhibitor of gene silencing; cleaves ubiquitin fusions but not polyubiquitin; also has mRNA binding activity; protein abundance increases in response to DNA replication stress
0.159 1.97E-20 YLR163C MAS1 het Smaller subunit of the mitochondrial processing protease (MPP), essential processing enzyme that cleaves the N-terminal targeting sequences from mitochondrially imported proteins
0.149 3.99E-18 YMR029C FAR8 hom Protein involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far3p, Far7p, Far9p, Far10p, and Far11p
0.134 7.63E-15 YGR092W DBF2 hom Ser/Thr kinase involved in transcription and stress response; functions as part of a network of genes in exit from mitosis; localization is cell cycle regulated; activated by Cdc15p during the exit from mitosis; also plays a role in regulating the stability of SWI5 and CLB2 mRNAs; phosphorylates Chs2p to regulate primary septum formation and Hof1p to regulate cytokinesis
0.126 2.07E-13 YIL030C SSM4 hom Ubiquitin-protein ligase involved in ER-associated protein degradation; located in the ER/nuclear envelope; ssm4 mutation suppresses mRNA instability caused by an rna14 mutation
0.126 2.75E-13 YGR098C ESP1 het Separase, a caspase-like cysteine protease; promotes sister chromatid separation by mediating dissociation of the cohesin Scc1p from chromatin; inhibits protein phosphatase 2A-Cdc55p to promote mitotic exit; inhibited by Pds1p; relative distribution to the nucleus increases upon DNA replication stress
0.126 2.95E-13 YMR052W FAR3 hom Protein of unknown function; involved in recovery from cell cycle arrest in response to pheromone, in a Far1p-independent pathway; interacts with Far7p, Far8p, Far9p, Far10p, and Far11p; localizes to the endoplasmic reticulum; protein abundance increases in response to DNA replication stress