YDR239C

Protein of unknown function that may interact with ribosomes, based on co-purification experiments

Zygosity: Homozygous strain
fixedexpanded
Profile for YDR239C / YDR239C

Click on Significant Values for Screen Details ID:SGTC_58|Compound:0957-0393|FD-Score:6.25|P-value:2.56E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:3.24|P-value:6.33E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.92|P-value:4.86E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.27|P-value:5.55E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.11|P-value:2.19E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.62|P-value:1.55E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.52|P-value:2.29E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.37|P-value:3.97E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:5.82|P-value:3.47E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:9.00|P-value:1.60E-19 ID:SGTC_456|Compound:gingerol|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.31|P-value:4.81E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.20|P-value:7.45E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.29|P-value:5.34E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.24|P-value:6.28E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.69|P-value:1.22E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-5.71|P-value:6.34E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:6.10|P-value:6.38E-10 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.88|P-value:5.87E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.33|P-value:4.54E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-4.46|P-value:4.29E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.77|P-value:8.60E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.21|P-value:7.08E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.33|P-value:4.57E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.20|P-value:7.24E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.16|P-value:8.35E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.59|P-value:1.73E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.00|P-value:3.37E-7 ID:SGTC_1614|Compound:st002383|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.78|P-value:8.41E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.99|P-value:3.50E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:-4.10|P-value:2.14E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.27|P-value:5.49E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.44|P-value:3.18E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.82|P-value:7.41E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:7.47|P-value:5.13E-14 ID:SGTC_2803|Compound:7707263|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.87|P-value:5.87E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.38|P-value:3.87E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.10|P-value:9.88E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.13|P-value:9.26E-4 ID:SGTC_58|Compound:0957-0393|FD-Score:6.25|P-value:2.56E-10 ID:SGTC_156|Compound:3474-0145|FD-Score:3.24|P-value:6.33E-4 ID:SGTC_163|Compound:1327-0036|FD-Score:3.92|P-value:4.86E-5 ID:SGTC_167|Compound:3672-0051|FD-Score:-3.27|P-value:5.55E-4 ID:SGTC_168|Compound:3970-0862|FD-Score:4.11|P-value:2.19E-5 ID:SGTC_290|Compound:2043-6722|FD-Score:-3.62|P-value:1.55E-4 ID:SGTC_299|Compound:1273-0059|FD-Score:3.52|P-value:2.29E-4 ID:SGTC_304|Compound:1310-0298|FD-Score:3.37|P-value:3.97E-4 ID:SGTC_305|Compound:1682-2595|FD-Score:5.82|P-value:3.47E-9 ID:SGTC_310|Compound:1273-0058|FD-Score:9.00|P-value:1.60E-19 ID:SGTC_456|Compound:gingerol|FD-Score:3.42|P-value:3.32E-4 ID:SGTC_489|Compound:paxilline|FD-Score:-3.31|P-value:4.81E-4 ID:SGTC_506|Compound:n9-isopropylolomoucine|FD-Score:3.20|P-value:7.45E-4 ID:SGTC_582|Compound:0987-0078|FD-Score:3.29|P-value:5.34E-4 ID:SGTC_797|Compound:k781-0471|FD-Score:3.24|P-value:6.28E-4 ID:SGTC_801|Compound:0866-0028|FD-Score:3.69|P-value:1.22E-4 ID:SGTC_812|Compound:4251-0442|FD-Score:-5.71|P-value:6.34E-9 ID:SGTC_955|Compound:1216-0110|FD-Score:6.10|P-value:6.38E-10 ID:SGTC_961|Compound:1252-1571|FD-Score:-4.88|P-value:5.87E-7 ID:SGTC_990|Compound:3985-0011|FD-Score:-3.33|P-value:4.54E-4 ID:SGTC_1093|Compound:fluphenazine|FD-Score:-4.46|P-value:4.29E-6 ID:SGTC_1141|Compound:3253-0389|FD-Score:-3.77|P-value:8.60E-5 ID:SGTC_1144|Compound:3486-0183|FD-Score:3.21|P-value:7.08E-4 ID:SGTC_1154|Compound:4088-0362|FD-Score:3.33|P-value:4.57E-4 ID:SGTC_1157|Compound:4092-0394|FD-Score:3.71|P-value:1.11E-4 ID:SGTC_1190|Compound:1486-1332|FD-Score:3.20|P-value:7.24E-4 ID:SGTC_1202|Compound:1988-0068|FD-Score:3.16|P-value:8.35E-4 ID:SGTC_1301|Compound:naphtanilide LB|FD-Score:-3.59|P-value:1.73E-4 ID:SGTC_1604|Compound:st002052|FD-Score:5.00|P-value:3.37E-7 ID:SGTC_1614|Compound:st002383|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_2055|Compound:5235184|FD-Score:3.78|P-value:8.41E-5 ID:SGTC_2481|Compound:5478948|FD-Score:3.13|P-value:9.24E-4 ID:SGTC_2517|Compound:totarol|FD-Score:-3.99|P-value:3.50E-5 ID:SGTC_2521|Compound:angolensin|FD-Score:-4.10|P-value:2.14E-5 ID:SGTC_2526|Compound:patulin|FD-Score:-3.27|P-value:5.49E-4 ID:SGTC_2586|Compound:curcumin|FD-Score:3.44|P-value:3.18E-4 ID:SGTC_2741|Compound:miltefosine|FD-Score:3.82|P-value:7.41E-5 ID:SGTC_2756|Compound:carbadox|FD-Score:7.47|P-value:5.13E-14 ID:SGTC_2803|Compound:7707263|FD-Score:3.64|P-value:1.45E-4 ID:SGTC_2890|Compound:9046729|FD-Score:3.87|P-value:5.87E-5 ID:SGTC_2920|Compound:7982904|FD-Score:3.38|P-value:3.87E-4 ID:SGTC_3156|Compound:9099931|FD-Score:-3.10|P-value:9.88E-4 ID:SGTC_3263|Compound:9137018|FD-Score:3.13|P-value:9.26E-4

Top fitness defect scores for YDR239C deletion by condition

RankScreen IDConditionFD ScoreConc
P-value
Response
Signature
Screen
Rank
Screen
P-value
1 SGTC_310 1273-0058 9.00 1.1 µM 1.60E-19 mitochondrial stress 64 1.08E-19
2 SGTC_2756 carbadox 7.47 75.1 µM 5.13E-14 8 3.89E-14
3 SGTC_58 0957-0393 6.25 9.0 µM 2.56E-10 cell wall 200 2.10E-10
4 SGTC_955 1216-0110 6.10 33.0 µM 6.38E-10 sphingolipid biosynthesis & PDR1 30 5.27E-10
5 SGTC_305 1682-2595 5.82 20.8 µM 3.47E-9 RNA processing & uracil transport 6 2.91E-9
6 SGTC_1604 st002052 5.00 72.4 µM 3.37E-7 TSC3-RPN4 11 2.94E-7
7 SGTC_168 3970-0862 4.11 530.5 µM 2.19E-5 111 1.99E-5
8 SGTC_163 1327-0036 3.92 7.5 µM 4.86E-5 107 4.45E-5
9 SGTC_2890 9046729 3.87 58.4 µM 5.87E-5 Golgi 24 5.38E-5
10 SGTC_2741 miltefosine 3.82 3.0 µM 7.41E-5 44 6.81E-5
11 SGTC_2055 5235184 3.78 200.0 µM 8.41E-5 ERG2 41 7.73E-5
12 SGTC_1157 4092-0394 3.71 27.6 µM 1.11E-4 34 1.02E-4
13 SGTC_801 0866-0028 3.69 10.1 µM 1.22E-4 38 1.12E-4
14 SGTC_2803 7707263 3.64 71.4 µM 1.45E-4 35 1.34E-4
15 SGTC_299 1273-0059 3.52 1.4 µM 2.29E-4 36 2.13E-4
16 SGTC_2586 curcumin 3.44 80.0 µM 3.18E-4 iron homeostasis 81 2.96E-4
17 SGTC_456 gingerol 3.42 170.0 µM 3.32E-4 36 3.09E-4
18 SGTC_2920 7982904 3.38 15.8 µM 3.87E-4 40 3.60E-4
19 SGTC_304 1310-0298 3.37 97.0 µM 3.97E-4 cell wall 85 3.70E-4
20 SGTC_1154 4088-0362 3.33 150.0 µM 4.57E-4 48 4.27E-4

Download Fitness data (tab-delimited text)  (excel)
Cofit Genes
Download Cofitness data (tab-delimited text)  (excel)

Correlation pval ORF Gene Zygosity Description
0.223 6.36E-39 YGR217W CCH1 hom Voltage-gated high-affinity calcium channel involved in calcium influx in response to some environmental stresses as well as exposure to mating pheromones; interacts and co-localizes with Mid1p, suggesting Cch1p and Mid1p function together
0.186 1.53E-27 YDL189W RBS1 hom Protein of unknown function, identified as a high copy suppressor of psk1 psk2 mutations that confer temperature-sensitivity for galactose utilization; proposed to bind single-stranded nucleic acids via its R3H domain
0.186 1.68E-27 YNL291C MID1 hom N-glycosylated integral membrane protein of the ER membrane and plasma membrane, functions as a stretch-activated Ca2+-permeable cation channel required for Ca2+ influx stimulated by pheromone; interacts with Cch1p; forms an oligomer
0.185 4.05E-27 YOR093C_p YOR093C_p hom Putative protein of unknown function; deletion causes sensitivity to unfolded protein response-inducing agents
0.170 3.54E-23 YDR205W MSC2 hom Endoplasmic reticulum zinc transporter; part of a heterodimeric transporter with Zrg17p that transfers zinc from the cytosol to the ER lumen; member of the cation diffusion facilitator family of efflux pumps; localizes to ER and nucleus; mutations affect the cellular distribution of zinc and also confer defects in meiotic recombination between homologous chromatids
0.169 5.01E-23 YLR412W BER1 hom Protein involved in microtubule-related processes, N-acetylation; GFP-fusion protein localizes to the cytoplasm and is induced in response to the DNA-damaging agent MMS; YLR412W is not an essential gene; similar to Arabidopsis SRR1 gene
0.159 1.76E-20 YML016C PPZ1 hom Serine/threonine protein phosphatase Z, isoform of Ppz2p; involved in regulation of potassium transport, which affects osmotic stability, cell cycle progression, and halotolerance
0.152 8.29E-19 YCL005W LDB16 hom Protein of unknown function; null mutants have decreased net negative cell surface charge; GFP-fusion protein expression is induced in response to the DNA-damaging agent MMS; native protein is detected in purified mitochondria
0.151 1.35E-18 YER028C MIG3 hom Transcriptional regulator; partially nonfunctional in S288C strains but has a major role in catabolite repression and ethanol response in some other strains; involved in response to toxic agents; phosphorylation by Snf1p or the Mec1p pathway inactivates Mig3p, allowing induction of damage response genes; MIG3 has a paralog, MIG2, that arose from the whole genome duplication
0.145 3.14E-17 YBR282W MRPL27 hom Mitochondrial ribosomal protein of the large subunit; homolog of human Bcl-2 interacting protein BMRP
0.144 4.81E-17 YOR276W CAF20 hom Phosphoprotein of the mRNA cap-binding complex involved in translational control, repressor of cap-dependent translation initiation, competes with eIF4G for binding to eIF4E
0.143 1.05E-16 YOR231W MKK1 hom MAPKK involved in the protein kinase C signaling pathway; involved in control of cell integrity; upon activation by Bck1p phosphorylates downstream target, Slt2p; functionally redundant with Mkk2p; MKK1 has a paralog, MKK2, that arose from the whole genome duplication
0.140 4.61E-16 YLR331C_d JIP3_d hom Dubious open reading frame, unlikely to encode a protein; not conserved in closely related Saccharomyces species; 98% of ORF overlaps the verified gene MID2
0.138 1.04E-15 YIL123W SIM1 hom Protein of the SUN family (Sim1p, Uth1p, Nca3p, Sun4p) that may participate in DNA replication, promoter contains SCB regulation box at -300 bp indicating that expression may be cell cycle-regulated
0.137 1.37E-15 YNL084C END3 hom EH domain-containing protein involved in endocytosis, actin cytoskeletal organization and cell wall morphogenesis; forms a complex with Sla1p and Pan1p